2. Gene
  3. Il6 - interleukin 6 Gene

Il6 - interleukin 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Il-6

Gene ID: 16193 | Gene type: protein coding

About Il6

Chromosome 5: 30,218,112-30,224,979 forward strand.GRCm39:CM000998.3

This gene has 4 transcripts (splice variants), 162 orthologues and is associated with 127 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Il6 Products(2)

mRNA Protein Name
NM_031168.2 NP_112445.1 interleukin-6 isoform 1 precursor
NM_001314054.1 NP_001300983.1 interleukin-6 isoform 2 precursor

Il6 Protein Structure

IL6

IL6: pfam00489 (26 - 209)

  • 0
  • 100
  • 211 a.a.
Protein Preferred Names Protein Names

interleukin-6

B-cell hybridoma growth factor

interleukin HP-1

Recombinant Il6 Proteins

Cat. No. Product Name Accession Purity
HY-P7063 IL-6 Protein, Mouse P08505 (F25-T211) ≥95%
HY-P7378 IL-6 Protein, Mouse (CHO, His) P08505 (F25-T211) ≥95%
HY-P70580 IL-6, Mouse-1 P08505 ≥95%
HY-P78853 IL-6 Protein, Mouse (Biotinylated, HEK293, His-Avi) P08505 (F 25 - T 211) ≥95%
HY-P700216AF Animal-Free IL-6 Protein, Mouse (His) P08505 (F25-T211) ≥95%
HY-P7063A IL-6 Protein, Mouse (His) P08505 (F25-T211) ≥95%

Related Agents

Approval
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0260 Methylprednisolone 99.75% Yes
HY-B1402 Hydrocortisone hemisuccinate 99.76% Unkown
HY-A0031 Bazedoxifene Modulator 98.70% Yes
HY-A0036 Bazedoxifene acetate Modulator 99.98% Yes
HY-B0667 Balsalazide Inhibitor 99.34% Yes
HY-B0446 Naphazoline hydrochloride 98.37% Unkown
HY-B0513 Methylthiouracil Inhibitor ≥98.0% Unkown
HY-111326A Naphazoline nitrate ≥98.0% Unkown
HY-B0667A Balsalazide sodium hydrate Inhibitor 99.61% Yes
HY-B1155 Hydrocortisone phosphate / Unkown
HY-A0031A Bazedoxifene hydrochloride Modulator / Unkown
HY-B1402B Hydrocortisone hemisuccinate sodium Inhibitor / Unkown
HY-111326 Naphazoline / Unkown
HY-B1402R Hydrocortisone hemisuccinate (Standard) / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9917 Tocilizumab Antagonist 99.67% Unkown
HY-P9956 Siltuximab 99.90% Unkown
HY-P99111 Golimumab 99.68% Unkown
HY-P9916 Sarilumab Inhibitor 98.36% Unkown
HY-P99112 Satralizumab Inhibitor 99.82% Unkown
Clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-11109 Resatorvid Inhibitor 99.95% Phase 3
HY-146244 Agatolimod Agonist / Phase 3
HY-145564 Emprumapimod Inhibitor 99.12% Phase 3
HY-13740 Resiquimod 99.95% Phase 2
HY-113066A Guanosine 5'-diphosphate disodium salt Activator 95.09% Phase 2
HY-15509A Semapimod tetrahydrochloride Inhibitor 98.43% Phase 2
HY-108039 Bezisterim Inhibitor ≥95.0% Phase 2
HY-113066 Guanosine 5'-diphosphate Activator / Phase 2
HY-113066C Guanosine 5'-diphosphate sodium Activator / Phase 2
HY-107390A AX-024 hydrochloride Inhibitor 99.75% Phase 1
HY-P3412 MMI-0100 98.83% Phase 1
Inhibitory Antibodies (9)
Cat. No. Product Name Effect
Purity Phase
HY-P99165 Teprotumumab Inhibitor 99.45% Phase 4
HY-P99210 Olokizumab Inhibitor 95.85% Phase 3
HY-P99252 Itolizumab 95.00% Phase 3
HY-P99316 Sirukumab Inhibitor 95.00% Phase 3
HY-P99505 Ziltivekimab Inhibitor 99.75% Phase 3
HY-P990012 Vamikibart Inhibitor / Phase 3
HY-P99012 Clazakizumab Inhibitor / Phase 3
HY-P99702 Levilimab Inhibitor / Phase 3
HY-P99385 Vobarilizumab Inhibitor 97.36% Phase 2
Pre-clinical Phase
Bioactive Molecules (184)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-102084 LMT-28 Inhibitor 98.93% Unkown
HY-15614 SC144 98.50% Unkown
HY-N0633 Muscone Inhibitor ≥98.0% Unkown
HY-110133 JTE-607 Inhibitor 99.27% Unkown
HY-141537 ABR-238901 Inhibitor 99.25% Unkown
HY-100339 GSK583 Inhibitor 98.74% Unkown
HY-N0560 Oroxylin A 99.87% Unkown
HY-N0029 Forsythoside B 99.99% Unkown
HY-19744 T6167923 99.08% Unkown
HY-N0236 Corylin Inhibitor 99.97% Unkown
HY-N0619 Mulberroside A Inhibitor 99.86% Unkown
HY-W007376 Indole-3-carboxaldehyde 99.96% Unkown
HY-N0710 alpha-Cyperone 99.80% Unkown
HY-N0405 Orientin Inhibitor 99.02% Unkown
HY-N1949 Homoplantaginin Inhibitor 99.90% Unkown
HY-150738 ODN 2088 Antagonist 90.41% Unkown
HY-B0141S1 Estradiol-d4 Agonist 99.55% Unkown
HY-100544 FLLL32 99.78% Unkown
HY-N2388 Auraptene Inhibitor 99.86% Unkown
HY-N0936 Coixol Inhibitor 99.58% Unkown
HY-107390 AX-024 Inhibitor 99.29% Yes
HY-15614A SC144 hydrochloride 99.34% Unkown
HY-N0604 Ginsenoside Rh1 Inhibitor ≥98.0% Unkown
HY-19999A PF-CBP1 hydrochloride Inhibitor 99.99% Unkown
HY-N0569 Madecassic acid Inhibitor 99.23% Unkown
HY-110126 AR-C118925XX Antagonist ≥99.0% Unkown
HY-N0897 Corylifol A Inhibitor 99.90% Unkown
HY-N2007 Veratric acid 99.99% Unkown
HY-N7674 Angoline Inhibitor 99.67% Unkown
HY-N0314 Pectolinarin 99.89% Unkown
HY-N4288 4-Methylesculetin Inhibitor 98.21% Unkown
HY-128598 MD2-TLR4-IN-1 Inhibitor 99.62% Unkown
HY-113402A Gamma-glutamylcysteine TFA 95.20% Unkown
HY-124750 NecroX-7 Inhibitor 99.69% Unkown
HY-N2572 Nepetin 99.51% Unkown
HY-114360A Taurohyodeoxycholic acid sodium Inhibitor ≥98.0% Unkown
HY-N1356 Reticuline Inhibitor 98.91% Unkown
HY-113953 Z-Asp-CH2-DCB Inhibitor 99.28% Unkown
HY-150538 STAT3-IN-12 99.92% Unkown
HY-153190 W1131 99.25% Unkown
HY-N9965 2'-Fucosyllactose Inhibitor ≥99.0% Unkown
HY-W041489 Chelidonic acid Inhibitor 99.91% Unkown
HY-B0141S Estradiol-d3 Agonist 98.60% Unkown
HY-145846 iNOs-IN-1 Inhibitor 99.83% Unkown
HY-P0317 Interleukin (IL)-6 Receptor 98.03% Unkown
HY-W082785A L6H21 99.46% Unkown
HY-112338 C188 Inhibitor ≥97.0% Unkown
HY-113330 12S-HHT Agonist ≥99.0% Unkown
HY-126421 Kansuinine A Inhibitor 99.01% Unkown
HY-129113 α-​Chaconine Inhibitor 99.04% Unkown
HY-152956 STING agonist-23 Agonist 99.16% Unkown
HY-B0260R Methylprednisolone (Standard) 99.67% Unkown
HY-N6246 Asperulosidic Acid Inhibitor 99.72% Unkown
HY-N1940 β-Anhydroicaritin 99.09% Unkown
HY-153254 BMS905 Inhibitor 99.59% Unkown
HY-B0141S2 Estradiol-d5 Agonist 99.88% Unkown
HY-N7275 Di-O-methyldemethoxycurcumin Inhibitor 97.64% Unkown
HY-N8146 Bruceantinol Inhibitor 98.89% Unkown
HY-U00460 3,6-DMAD hydrochloride Inhibitor ≥99.0% Unkown
HY-13740S Resiquimod-d5 99.84% Unkown
HY-146066 α7 nAchR-JAK2-STAT3 agonist 1 / Unkown
HY-150745 ODN 24987 Inhibitor / Unkown
HY-N0857 Deoxyandrographolide Activator 99.87% Unkown
HY-N7652 Terminolic acid Inhibitor 99.63% Unkown
HY-N9315 Episappanol Inhibitor 98.57% Unkown
HY-113066S2 Guanosine 5'-diphosphate-d13 dilithium Activator / Unkown
HY-131688 2-Chlorohexadecanoic acid / Unkown
HY-146564 R-HP210 98.21% Unkown
HY-146564A HP210 Modulator 98.96% Unkown
HY-151876 Glucocorticoid receptor modulator 1 99.79% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-B0141S3 Estradiol-d2 Agonist 99.44% Unkown
HY-B0260S3 Methylprednisolone-d7 ≥99.0% Unkown
HY-N0811 Anemarsaponin B Inhibitor / Unkown
HY-N6927 Isoforskolin Inhibitor ≥98.0% Unkown
HY-N7674A Angoline hydrochloride Inhibitor / Unkown
HY-153190A W1131 TFA 99.27% Unkown
HY-23119 Sodium thiocyanate, GR, 99% ≥99.0% Unkown
HY-150738C ODN 2088 sodium / Unkown
HY-103438 BIBU1361 / Unkown
HY-113066S Guanosine 5'-diphosphate-15N5 dilithium Activator / Unkown
HY-113066S1 Guanosine 5'-diphosphate-13C10 dilithium Activator / Unkown
HY-113066S3 Guanosine 5'-diphosphate-13C10,15N5 dilithium Activator / Unkown
HY-115910 Y13g Inhibitor / Unkown
HY-115910A Y13g dihydrochloride Inhibitor 99.89% Unkown
HY-115913 PDE4-IN-6 Inhibitor / Unkown
HY-115976 COX-2-IN-10 Inhibitor / Unkown
HY-116227 (2S,3R)-LP99 Inhibitor / Unkown
HY-122767 Romurtide Activator / Unkown
HY-123522 PAT-048 Inhibitor / Unkown
HY-125019 iJak-381 Inhibitor / Unkown
HY-126420 Kansuinine B Inhibitor ≥99.0% Unkown
HY-128423AS Tylvalosin-d9 / Unkown
HY-131668 9-POHSA / Unkown
HY-131934 9-OAHSA / Unkown
HY-134000 Emodic acid Inhibitor / Unkown
HY-134371 IL-17 modulator 2 Modulator / Unkown
HY-143422 MALT1-IN-3 Inhibitor / Unkown
HY-143422A (R)-MALT1-IN-3 Inhibitor / Unkown
HY-146419 Anti-inflammatory agent 20 Inhibitor / Unkown
HY-146483 Anti-Aβ agent 1A Inhibitor / Unkown
HY-146547 Anti-inflammatory agent 17 Inhibitor / Unkown
HY-146561 S-HP210 Modulator 98.12% Unkown
HY-147506 NOD2 antagonist 1 Antagonist / Unkown
HY-148238 GNE-2256 Inhibitor / Unkown
HY-148706 STAT3-IN-17 Inhibitor / Unkown
HY-149333 BO-1 Inhibitor / Unkown
HY-149391 PROTAC BTK Degrader-6 Degrader / Unkown
HY-149485 JNK2-IN-1 Inhibitor / Unkown
HY-149816 Anti-inflammatory agent 41 Inhibitor / Unkown
HY-149940 SIMR3030 Inhibitor / Unkown
HY-150740 ODN 21595 Inhibitor / Unkown
HY-150740A ODN 21595 sodium Inhibitor / Unkown
HY-150744 ODN 24888 Inhibitor 93.10% Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-152251 CB2R/FAAH modulator-1 / Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-153330 TNF-α-IN-10 Inhibitor / Unkown
HY-153579 Anti-inflammatory agent 42 Inhibitor ≥98.0% Unkown
HY-155027 DPP-4-IN-8 Inhibitor / Unkown
HY-15509 Semapimod Inhibitor / Unkown
HY-155160 COX-2/15-LOX-IN-3 Inhibitor / Unkown
HY-155161 COX-2/15-LOX-IN-4 Inhibitor / Unkown
HY-155199 PDE1-IN-5 Inhibitor / Unkown
HY-155243 12R-LOX-IN-1 Inhibitor / Unkown
HY-155335 FPR2 agonist 3 Agonist / Unkown
HY-155405 Anti-inflammatory agent 64 Inhibitor / Unkown
HY-155753 Anti-inflammatory agent 50 Inhibitor / Unkown
HY-155820 Anti-inflammatory agent 54 Inhibitor / Unkown
HY-155821 Anti-inflammatory agent 55 Inhibitor / Unkown
HY-156025 HCAR2 agonist 1 / Unkown
HY-156297 β5i-IN-1 Inhibitor / Unkown
HY-157546 VEGFR-2-IN-40 Inhibitor / Unkown
HY-157809 Anti-inflammatory agent 74 Inhibitor / Unkown
HY-157992 LM-021 Inhibitor / Unkown
HY-160026 IL-17 modulator 8 Modulator / Unkown
HY-160028 IL-17 modulator 9 Modulator / Unkown
HY-160052 IL-6 aptamer sodium Chemical / Unkown
HY-160231 ssRNA42 sodium Activator / Unkown
HY-161240 MAO-B-IN-30 Inhibitor / Unkown
HY-161396 Anti-inflammatory agent 76 Inhibitor / Unkown
HY-162122 PPARα/γ agonist 3 Agonist / Unkown
HY-162316 NF-κB-IN-15 Inhibitor / Unkown
HY-163458 Anti-inflammatory agent 77 / Unkown
HY-A0031S Bazedoxifene-d4 Modulator / Unkown
HY-A0031S2 Bazedoxifene-d4 acetate / Unkown
HY-B0141S4 Estradiol-13C6 Agonist / Unkown
HY-B0141S5 Estradiol-13C2 Agonist / Unkown
HY-B0141S6 Estradiol-d2-1 Agonist / Unkown
HY-B0260S Methylprednisolone-d3 / Unkown
HY-B0260S2 Methylprednisolone-d4 / Unkown
HY-B0260S4 Methylprednisolone-d2 / Unkown
HY-B0667S1 Balsalazide-d4 Inhibitor / Unkown
HY-N0569R Madecassic acid (Standard) Inhibitor / Unkown
HY-N0604R Ginsenoside Rh1 (Standard) Inhibitor / Unkown
HY-N0619A cis-Mulberroside A Inhibitor / Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin / Unkown
HY-N1140 Torilin Inhibitor / Unkown
HY-N11768 4-Methoxylonchocarpin Inhibitor / Unkown
HY-N12042 Taxamairin B Inhibitor / Unkown
HY-N2007S Veratric acid-d6 Inhibitor / Unkown
HY-N3380 Linderaspirone A Inhibitor / Unkown
HY-N3421 Koaburaside Inhibitor / Unkown
HY-N3552 Catalposide Inhibitor ≥98.0% Unkown
HY-N4061 Hedycoronen A Inhibitor / Unkown
HY-N7630 Rehmapicrogenin Inhibitor / Unkown
HY-N7757 Pedunculagin Inhibitor / Unkown
HY-N8107 Matairesinol monoglucoside / Unkown
HY-N8413 Chlojaponilactone B Inhibitor / Unkown
HY-N8936 Narchinol B / Unkown
HY-N9891 12-Dehydrogingerdione Inhibitor / Unkown
HY-P1117 MMK1 / Unkown
HY-P1117A MMK1 TFA / Unkown
HY-P5836 Citrullinated LL-37 1cit Inhibitor / Unkown
HY-P5837 Citrullinated LL-37 2cit Inhibitor / Unkown
HY-RS06774 IL6 Human Pre-designed siRNA Set A / Unkown
HY-RS06775 Il6 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06776 Il6 Rat Pre-designed siRNA Set A / Unkown
HY-RS06777 IL6R Human Pre-designed siRNA Set A / Unkown
HY-RS06778 IL6ST Human Pre-designed siRNA Set A / Unkown
HY-U00460B 3,6-DMAD dihydrochloride Inhibitor / Unkown
HY-W505984 TPNA10168 Activator / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990008 Atrosab 96.93% Unkown
HY-P99287 Elsilimomab Inhibitor 95.00% Unkown
HY-P99336 Enlimomab Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il6 NCBI NCBI:3569
Macaca fascicularis Il6 NCBI NCBI:102138971
Rattus norvegicus Il6 NCBI NCBI:24498
Macaca mulatta Il6 NCBI NCBI:705819