2. Gene
  3. Il6 - interleukin 6 Gene

Il6 - interleukin 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ILg6; Ifnb2

Gene ID: 24498 | Gene type: protein coding

About Il6

Primary_assembly 4: 5,213,394-5,219,178 reverse strand.mRatBN7.2:CM026977.1

This gene has 3 transcripts (splice variants), 162 orthologues and is associated with 288 phenotypes. Biased expression in Spleen (RPKM 22.5) and Thymus (RPKM 3.4).

Summary

Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cell communication; and response to peptide hormone. Located in cytoplasm and extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; fatty liver disease; hypertension (multiple); and impotence. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); iron deficiency anemia; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6). [provided by Alliance of Genome Resources, Apr 2022]

Il6 Products(1)

mRNA Protein Name
NM_012589.2 NP_036721.1 interleukin-6 precursor

Il6 Protein Structure

IL6

IL6: cl02473 (26 - 209)

  • 0
  • 100
  • 211 a.a.
Protein Preferred Names Protein Names

interleukin-6

IL-6

Interleukin 6 (interferon, beta 2)

Recombinant Il6 Proteins

Cat. No. Product Name Accession Purity
HY-P7103 IL-6 Protein, Rat P20607 ≥95%
HY-P7103A IL-6 Protein, Rat (HEK293) P20607 (F25-T211) ≥95%

Related Agents

Approval
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0260 Methylprednisolone 99.75% Yes
HY-B1402 Hydrocortisone hemisuccinate 99.76% Unkown
HY-A0031 Bazedoxifene Modulator 98.70% Yes
HY-A0036 Bazedoxifene acetate Modulator 99.98% Yes
HY-B0667 Balsalazide Inhibitor 99.34% Yes
HY-B0446 Naphazoline hydrochloride 98.37% Unkown
HY-B0513 Methylthiouracil Inhibitor ≥98.0% Unkown
HY-111326A Naphazoline nitrate ≥98.0% Unkown
HY-B0667A Balsalazide sodium hydrate Inhibitor 99.61% Yes
HY-B1155 Hydrocortisone phosphate / Unkown
HY-A0031A Bazedoxifene hydrochloride Modulator / Unkown
HY-B1402B Hydrocortisone hemisuccinate sodium Inhibitor / Unkown
HY-111326 Naphazoline / Unkown
HY-B1402R Hydrocortisone hemisuccinate (Standard) / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9917 Tocilizumab Antagonist 99.67% Unkown
HY-P9956 Siltuximab 99.90% Unkown
HY-P99111 Golimumab 99.68% Unkown
HY-P9916 Sarilumab Inhibitor 98.36% Unkown
HY-P99112 Satralizumab Inhibitor 99.82% Unkown
Clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-11109 Resatorvid Inhibitor 99.95% Phase 3
HY-146244 Agatolimod Agonist / Phase 3
HY-145564 Emprumapimod Inhibitor 99.12% Phase 3
HY-13740 Resiquimod 99.95% Phase 2
HY-113066A Guanosine 5'-diphosphate disodium salt Activator 95.09% Phase 2
HY-15509A Semapimod tetrahydrochloride Inhibitor 98.43% Phase 2
HY-108039 Bezisterim Inhibitor ≥95.0% Phase 2
HY-113066 Guanosine 5'-diphosphate Activator / Phase 2
HY-113066C Guanosine 5'-diphosphate sodium Activator / Phase 2
HY-107390A AX-024 hydrochloride Inhibitor 99.75% Phase 1
HY-P3412 MMI-0100 98.83% Phase 1
Inhibitory Antibodies (9)
Cat. No. Product Name Effect
Purity Phase
HY-P99165 Teprotumumab Inhibitor 99.45% Phase 4
HY-P99210 Olokizumab Inhibitor 95.85% Phase 3
HY-P99252 Itolizumab 95.00% Phase 3
HY-P99316 Sirukumab Inhibitor 95.00% Phase 3
HY-P99505 Ziltivekimab Inhibitor 99.75% Phase 3
HY-P990012 Vamikibart Inhibitor / Phase 3
HY-P99012 Clazakizumab Inhibitor / Phase 3
HY-P99702 Levilimab Inhibitor / Phase 3
HY-P99385 Vobarilizumab Inhibitor 97.36% Phase 2
Pre-clinical Phase
Bioactive Molecules (182)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-102084 LMT-28 Inhibitor 98.93% Unkown
HY-15614 SC144 98.50% Unkown
HY-N0633 Muscone Inhibitor ≥98.0% Unkown
HY-110133 JTE-607 Inhibitor 99.27% Unkown
HY-141537 ABR-238901 Inhibitor 99.25% Unkown
HY-N0560 Oroxylin A 99.87% Unkown
HY-100339 GSK583 Inhibitor 98.74% Unkown
HY-N0029 Forsythoside B 99.99% Unkown
HY-19744 T6167923 99.08% Unkown
HY-N0236 Corylin Inhibitor 99.97% Unkown
HY-N0619 Mulberroside A Inhibitor 99.86% Unkown
HY-W007376 Indole-3-carboxaldehyde 99.96% Unkown
HY-N0710 alpha-Cyperone 99.80% Unkown
HY-N0405 Orientin Inhibitor 99.02% Unkown
HY-N1949 Homoplantaginin Inhibitor 99.90% Unkown
HY-100544 FLLL32 99.78% Unkown
HY-150738 ODN 2088 Antagonist 90.41% Unkown
HY-B0141S1 Estradiol-d4 Agonist 99.55% Unkown
HY-N2388 Auraptene Inhibitor 99.86% Unkown
HY-N0936 Coixol Inhibitor 99.58% Unkown
HY-107390 AX-024 Inhibitor 99.29% Yes
HY-15614A SC144 hydrochloride 99.34% Unkown
HY-N0604 Ginsenoside Rh1 Inhibitor ≥98.0% Unkown
HY-19999A PF-CBP1 hydrochloride Inhibitor 99.99% Unkown
HY-N0569 Madecassic acid Inhibitor 99.23% Unkown
HY-110126 AR-C118925XX Antagonist ≥99.0% Unkown
HY-N0897 Corylifol A Inhibitor 99.90% Unkown
HY-N2007 Veratric acid 99.99% Unkown
HY-N7674 Angoline Inhibitor 99.67% Unkown
HY-N0314 Pectolinarin 99.89% Unkown
HY-N4288 4-Methylesculetin Inhibitor 98.21% Unkown
HY-128598 MD2-TLR4-IN-1 Inhibitor 99.62% Unkown
HY-124750 NecroX-7 Inhibitor 99.69% Unkown
HY-113402A Gamma-glutamylcysteine TFA 95.20% Unkown
HY-N2572 Nepetin 99.51% Unkown
HY-114360A Taurohyodeoxycholic acid sodium Inhibitor ≥98.0% Unkown
HY-N1356 Reticuline Inhibitor 98.91% Unkown
HY-113953 Z-Asp-CH2-DCB Inhibitor 99.28% Unkown
HY-150538 STAT3-IN-12 99.92% Unkown
HY-153190 W1131 99.25% Unkown
HY-N9965 2'-Fucosyllactose Inhibitor ≥99.0% Unkown
HY-W041489 Chelidonic acid Inhibitor 99.91% Unkown
HY-B0141S Estradiol-d3 Agonist 98.60% Unkown
HY-145846 iNOs-IN-1 Inhibitor 99.83% Unkown
HY-P0317 Interleukin (IL)-6 Receptor 98.03% Unkown
HY-N1940 β-Anhydroicaritin 99.09% Unkown
HY-W082785A L6H21 99.46% Unkown
HY-112338 C188 Inhibitor ≥97.0% Unkown
HY-113330 12S-HHT Agonist ≥99.0% Unkown
HY-126421 Kansuinine A Inhibitor 99.01% Unkown
HY-129113 α-​Chaconine Inhibitor 99.04% Unkown
HY-152956 STING agonist-23 Agonist 99.16% Unkown
HY-B0260R Methylprednisolone (Standard) 99.67% Unkown
HY-N6246 Asperulosidic Acid Inhibitor 99.72% Unkown
HY-153254 BMS905 Inhibitor 99.59% Unkown
HY-B0141S2 Estradiol-d5 Agonist 99.88% Unkown
HY-N7275 Di-O-methyldemethoxycurcumin Inhibitor 97.64% Unkown
HY-N8146 Bruceantinol Inhibitor 98.89% Unkown
HY-U00460 3,6-DMAD hydrochloride Inhibitor ≥99.0% Unkown
HY-13740S Resiquimod-d5 99.84% Unkown
HY-146066 α7 nAchR-JAK2-STAT3 agonist 1 / Unkown
HY-150745 ODN 24987 Inhibitor / Unkown
HY-B0260S3 Methylprednisolone-d7 ≥99.0% Unkown
HY-N0857 Deoxyandrographolide Activator 99.87% Unkown
HY-N7652 Terminolic acid Inhibitor 99.63% Unkown
HY-N9315 Episappanol Inhibitor 98.57% Unkown
HY-113066S2 Guanosine 5'-diphosphate-d13 dilithium Activator / Unkown
HY-131688 2-Chlorohexadecanoic acid / Unkown
HY-146564 R-HP210 98.21% Unkown
HY-146564A HP210 Modulator 98.96% Unkown
HY-151876 Glucocorticoid receptor modulator 1 99.79% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-B0141S3 Estradiol-d2 Agonist 99.44% Unkown
HY-N0811 Anemarsaponin B Inhibitor / Unkown
HY-N6927 Isoforskolin Inhibitor ≥98.0% Unkown
HY-N7674A Angoline hydrochloride Inhibitor / Unkown
HY-153190A W1131 TFA 99.27% Unkown
HY-23119 Sodium thiocyanate, GR, 99% ≥99.0% Unkown
HY-150738C ODN 2088 sodium 90.41% Unkown
HY-103438 BIBU1361 / Unkown
HY-113066S Guanosine 5'-diphosphate-15N5 dilithium Activator / Unkown
HY-113066S1 Guanosine 5'-diphosphate-13C10 dilithium Activator / Unkown
HY-113066S3 Guanosine 5'-diphosphate-13C10,15N5 dilithium Activator / Unkown
HY-115910 Y13g Inhibitor / Unkown
HY-115910A Y13g dihydrochloride Inhibitor 99.89% Unkown
HY-115913 PDE4-IN-6 Inhibitor / Unkown
HY-115976 COX-2-IN-10 Inhibitor / Unkown
HY-116227 (2S,3R)-LP99 Inhibitor / Unkown
HY-122767 Romurtide Activator / Unkown
HY-123522 PAT-048 Inhibitor / Unkown
HY-125019 iJak-381 Inhibitor / Unkown
HY-126420 Kansuinine B Inhibitor ≥99.0% Unkown
HY-128423AS Tylvalosin-d9 / Unkown
HY-131668 9-POHSA / Unkown
HY-131934 9-OAHSA / Unkown
HY-134000 Emodic acid Inhibitor / Unkown
HY-134371 IL-17 modulator 2 Modulator / Unkown
HY-143422 MALT1-IN-3 Inhibitor / Unkown
HY-143422A (R)-MALT1-IN-3 Inhibitor / Unkown
HY-146419 Anti-inflammatory agent 20 Inhibitor / Unkown
HY-146483 Anti-Aβ agent 1A Inhibitor / Unkown
HY-146547 Anti-inflammatory agent 17 Inhibitor / Unkown
HY-146561 S-HP210 Modulator 98.12% Unkown
HY-147506 NOD2 antagonist 1 Antagonist / Unkown
HY-148238 GNE-2256 Inhibitor / Unkown
HY-148706 STAT3-IN-17 Inhibitor / Unkown
HY-149333 BO-1 Inhibitor / Unkown
HY-149391 PROTAC BTK Degrader-6 Degrader / Unkown
HY-149485 JNK2-IN-1 Inhibitor / Unkown
HY-149816 Anti-inflammatory agent 41 Inhibitor / Unkown
HY-149940 SIMR3030 Inhibitor / Unkown
HY-150740 ODN 21595 Inhibitor / Unkown
HY-150740A ODN 21595 sodium Inhibitor / Unkown
HY-150744 ODN 24888 Inhibitor 93.10% Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-152251 CB2R/FAAH modulator-1 / Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-153330 TNF-α-IN-10 Inhibitor / Unkown
HY-153579 Anti-inflammatory agent 42 Inhibitor ≥98.0% Unkown
HY-155027 DPP-4-IN-8 Inhibitor / Unkown
HY-15509 Semapimod Inhibitor / Unkown
HY-155160 COX-2/15-LOX-IN-3 Inhibitor / Unkown
HY-155161 COX-2/15-LOX-IN-4 Inhibitor / Unkown
HY-155199 PDE1-IN-5 Inhibitor / Unkown
HY-155243 12R-LOX-IN-1 Inhibitor / Unkown
HY-155335 FPR2 agonist 3 Agonist / Unkown
HY-155405 Anti-inflammatory agent 64 Inhibitor / Unkown
HY-155753 Anti-inflammatory agent 50 Inhibitor / Unkown
HY-155820 Anti-inflammatory agent 54 Inhibitor / Unkown
HY-155821 Anti-inflammatory agent 55 Inhibitor / Unkown
HY-156025 HCAR2 agonist 1 / Unkown
HY-156297 β5i-IN-1 Inhibitor / Unkown
HY-157546 VEGFR-2-IN-40 Inhibitor / Unkown
HY-157809 Anti-inflammatory agent 74 Inhibitor / Unkown
HY-157992 LM-021 Inhibitor / Unkown
HY-160026 IL-17 modulator 8 Modulator / Unkown
HY-160028 IL-17 modulator 9 Modulator / Unkown
HY-160052 IL-6 aptamer sodium Chemical / Unkown
HY-160231 ssRNA42 sodium Activator / Unkown
HY-161240 MAO-B-IN-30 Inhibitor / Unkown
HY-161396 Anti-inflammatory agent 76 Inhibitor / Unkown
HY-162122 PPARα/γ agonist 3 Agonist / Unkown
HY-162316 NF-κB-IN-15 Inhibitor / Unkown
HY-163458 Anti-inflammatory agent 77 Inhibitor / Unkown
HY-A0031S Bazedoxifene-d4 Modulator / Unkown
HY-A0031S2 Bazedoxifene-d4 acetate / Unkown
HY-B0141S4 Estradiol-13C6 Agonist / Unkown
HY-B0141S5 Estradiol-13C2 Agonist / Unkown
HY-B0141S6 Estradiol-d2-1 Agonist / Unkown
HY-B0260S Methylprednisolone-d3 / Unkown
HY-B0260S2 Methylprednisolone-d4 / Unkown
HY-B0260S4 Methylprednisolone-d2 / Unkown
HY-B0667S1 Balsalazide-d4 Inhibitor / Unkown
HY-N0569R Madecassic acid (Standard) Inhibitor / Unkown
HY-N0604R Ginsenoside Rh1 (Standard) Inhibitor / Unkown
HY-N0619A cis-Mulberroside A Inhibitor / Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin / Unkown
HY-N11768 4-Methoxylonchocarpin Inhibitor / Unkown
HY-N12042 Taxamairin B Inhibitor / Unkown
HY-N2007S Veratric acid-d6 Inhibitor / Unkown
HY-N3380 Linderaspirone A Inhibitor / Unkown
HY-N3421 Koaburaside Inhibitor / Unkown
HY-N3552 Catalposide Inhibitor ≥98.0% Unkown
HY-N4061 Hedycoronen A Inhibitor / Unkown
HY-N7630 Rehmapicrogenin Inhibitor / Unkown
HY-N8107 Matairesinol monoglucoside / Unkown
HY-N8413 Chlojaponilactone B Inhibitor / Unkown
HY-N8936 Narchinol B / Unkown
HY-N9891 12-Dehydrogingerdione Inhibitor / Unkown
HY-P1117 MMK1 / Unkown
HY-P1117A MMK1 TFA / Unkown
HY-P5836 Citrullinated LL-37 1cit Inhibitor / Unkown
HY-P5837 Citrullinated LL-37 2cit Inhibitor / Unkown
HY-RS06774 IL6 Human Pre-designed siRNA Set A / Unkown
HY-RS06775 Il6 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06776 Il6 Rat Pre-designed siRNA Set A / Unkown
HY-RS06777 IL6R Human Pre-designed siRNA Set A / Unkown
HY-RS06778 IL6ST Human Pre-designed siRNA Set A / Unkown
HY-U00460B 3,6-DMAD dihydrochloride Inhibitor / Unkown
HY-W505984 TPNA10168 Activator / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990008 Atrosab 96.93% Unkown
HY-P99287 Elsilimomab Inhibitor 95.00% Unkown
HY-P99336 Enlimomab Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il6 NCBI NCBI:3569
Macaca fascicularis Il6 NCBI NCBI:102138971
Mus musculus Il6 NCBI NCBI:16193
Macaca mulatta Il6 NCBI NCBI:705819