Pathogen Effectors Regulate Host Calcium Signaling Pathways

Calcium Homeostasis

Pathogen regulation of host calcium signaling describes the capacity of microbial virulence factors and effector proteins to reshape Ca²⁺ influx, intracellular Ca²⁺ release, calcium sensors, and downstream calcium-dependent signaling during infection. Ca²⁺ signaling has long been linked to bacterial adhesion, invasion, cytoskeletal remodeling, inflammatory responses, and intracellular pathogen control, while plant studies establish rapid cytosolic Ca²⁺ elevation as an essential early immune response. Calcium signatures are generated through regulated calcium channels and decoded by sensors including calmodulin (CaM), calmodulin-like proteins (CMLs), and calcium-dependent protein kinases, connecting pathogen recognition to transcriptional, reactive oxygen species (ROS), and cell-death responses. The field has therefore progressed from describing infection-associated Ca²⁺ transients to identifying individual pathogen effectors and their host calcium-signaling targets^[1]^[2]^[3].

Mechanistic studies reveal several distinct strategies for pathogen-driven calcium rewiring. Shigella OspC1 and OspC3 bind the Ca²⁺ sensor CaM, inhibit CaM kinase II, and consequently suppress downstream JAK/STAT interferon signaling; loss of these effectors attenuates bacterial growth in epithelial cells and mice, demonstrating a direct connection between calcium-sensor targeting and virulence. In plants, the Phytophthora infestans effector AVRblb2 uses CaM/CML proteins as cofactors to associate with cyclic nucleotide-gated channels and prevents CaM/CML release from NbCNGC18, thereby inhibiting channel activation and Ca²⁺ influx during pattern-triggered immunity. The RXLR effector PlAvh222 from Peronophythora litchii likewise targets host calmodulins, increases their accumulation, lowers cytosolic Ca²⁺, and suppresses Ca²⁺-associated programmed cell death and ROS responses. These mechanisms intersect with a host defense network in which TCH3/CaM proteins cooperate with CPKs and CPK5 directly phosphorylates CBP60g to promote immune transcriptional activity^[4]^[5]^[6]^[7].

Calcium manipulation also extends beyond direct CaM targeting. Neisseria meningitidis PilC1 induces host cytosolic Ca²⁺ elevation through release from intracellular stores in a phospholipase-C-dependent process, and intracellular Ca²⁺ chelation impairs bacterial adherence and invasion. During Shigella invasion, bacterially induced actin reorganization restricts molecular diffusion at entry sites, permitting local InsP3 accumulation and sustained local Ca²⁺ responses. In phagocytes, Ca²⁺ contributes to actin rearrangement, NADPH oxidase and protein kinase C activity during phagosome maturation, whereas intracellular pathogens can manipulate Ca²⁺-associated pathways to interfere with phagosome-lysosome fusion. Together, these findings identify calcium channels, CaM/CML sensors, CaMKII, CPKs, phospholipase C, InsP3 signaling, cytoskeletal responses, ROS production, interferon signaling, and programmed cell death as interconnected infection-control nodes. The strongest translational opportunities are therefore host-directed anti-infective strategies and engineering pathogen-resistant crops, but important gaps remain in defining effector-specific Ca²⁺ signatures, resolving how multiple calcium sensors and channels cooperate during infection, and determining which pathogen-calcium interactions provide selective therapeutic targets without disrupting essential host Ca²⁺ homeostasis^[4]^[5]^[6]^[8]^[9]^[10].

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Cat. No.	Product Name	Information	Application	Publication
HY-10219	Rapamycin	Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant. Source: Streptomyces hygroscopicus	mTOR FKBP Molecular Glues Fungal Autophagy Endogenous Metabolite Antibiotic Bacterial Breast Cancer Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Viral Infection Bacterial Infection Fungal Infection Pain Non-Small Cell Lung Cancer Lung Adenocarcinoma SARS-CoV-2 Infection Obesity Lung Fibrosis	1540
HY-100558	Bafilomycin A1	Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis. Source: Streptomyces griseus strains	Proton Pump Autophagy Antibiotic Bacterial Apoptosis Colorectal Cancer Liver Cancer Ovarian Cancer Viral Infection Parasitic Infection SARS-CoV-2 Infection HIV-1 Infection	981
HY-18739	Phorbol 12-myristate 13-acetate	Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress).	PKC SphK NF-κB Prostate Cancer Thyroid Cancer Pancreatic Cancer Pain Nonalcoholic Steatohepatitis	917
HY-15142	Doxorubicin hydrochloride	Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy. Source: Streptomyces peucetius var. Caesius	Topoisomerase ADC Payloads AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye Non-Small Cell Lung Cancer HER-2 Positive Breast Cancer Triple-Negative Breast Cancer Metastatic Breast Cancer	744
HY-10071	Y-27632	Y-27632 is a ROCK inhibitor with K_i values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade.	ROCK Reactive Oxygen Species (ROS) Akt Ras mTOR Apoptosis PAK NADPH Oxidase NF-κB Autophagy Ovarian Cancer Nonalcoholic Steatohepatitis Lung Fibrosis Hepatic Fibrosis	642
HY-14648	Dexamethasone	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research.	Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payloads Metabolic or Endocrine Disease Prostate Cancer Pancreatic Cancer Viral Infection Bacterial Infection Fungal Infection Pain Autoimmune Disease Cardiovascular Disease Non-Small Cell Lung Cancer Lung Squamous Cell Carcinoma Metastatic Breast Cancer SARS-CoV-2 Infection Nonalcoholic Steatohepatitis Lung Fibrosis	426
HY-Y0320	Dimethyl sulfoxide, meets analytical specification of Ch.P.	Dimethyl sulfoxide (DMSO), meets analytical specification of Ch.P. is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties. MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition). Amicrobic, low endotoxin, can be used in various biochemical experiments such as drug dissolution.	Environmental Pollutants Cholinesterase (ChE) Bacterial Bacterial Infection Heart Failure	415
HY-13818	Stattic	Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727). Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice.	STAT Apoptosis Lung Cancer Breast Cancer Prostate Cancer Liver Cancer Cervical Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Obesity	340
HY-10201	Sorafenib	Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.	Raf VEGFR FLT3 Autophagy Apoptosis STAT Akt MMP Cadherin p38 MAPK ERK MEK PI3K PARP Bcl-2 Family Ephrin Receptor PDGFR c-Kit Gastric Cancer Liver Cancer Ovarian Cancer Small Cell Lung Cancer Non-Small Cell Lung Cancer Metastatic Breast Cancer Metastatic Colorectal Cancer Metastatic Prostate Cancer Multiple Myeloma Metastatic Pancreatic Cancer SARS-CoV-2 Infection Alzheimer's Disease Parkinson's Disease Nonalcoholic Steatohepatitis Obesity Lung Fibrosis	328
HY-50858	Ruxolitinib phosphate	Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC₅₀s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3.	JAK Autophagy Mitophagy Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Non-Small Cell Lung Cancer HER-2 Positive Breast Cancer Metastatic Breast Cancer SARS-CoV-2 Infection Nonalcoholic Steatohepatitis Rheumatoid Arthritis	293
HY-50856	Ruxolitinib	Ruxolitinib (INCB18424) is an orally active and selective JAK1/2 inhibitor with IC₅₀s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy.	JAK Autophagy Mitophagy Apoptosis Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Non-Small Cell Lung Cancer HER-2 Positive Breast Cancer Metastatic Breast Cancer SARS-CoV-2 Infection Rheumatoid Arthritis	293
HY-19363	GW4869	GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC₅₀ of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release.	Exosomes Phospholipase Inflammation or Immune System Disease Breast Cancer Prostate Cancer Cardiovascular Disease	277
HY-15141	Staurosporine	Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer. Source: Streptomyces staurosporeus	PKC PKA Apoptosis Bacterial Fungal Antibiotic Prostate Cancer Bacterial Infection Fungal Infection Neurodegenerative Disease	253
HY-15371	Forskolin	Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.	Organoid Adenylate Cyclase FXR Autophagy PKC Glucose Metabolism Non-Small Cell Lung Cancer Hypertension	248
HY-K0208	Streptavidin Magnetic Beads	MCE Streptavidin Magnetic Beads provide a fast and convenient method for numerous applications, including purification of proteins and nucleic acids, protein interaction studies, immunoprecipitation, immunoassays, pull-down and cell isolation. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.	Protein Biology Protein Purification Magnetic Beads	244
HY-13629	Etoposide	Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Non-Small Cell Lung Cancer Lung Squamous Cell Carcinoma Large Cell Lung Carcinoma Triple-Negative Breast Cancer Metastatic Breast Cancer	202
HY-B2176	ATP	ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice. Source: widespread	Endogenous Metabolite NOD-like Receptor (NLR) Interleukin Related Bacterial Inflammation or Immune System Disease Metabolic or Endocrine Disease Bacterial Infection	184
HY-16592	Brefeldin A	Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A inhibits HSV-1 and has anti-cancer activity. Source: Penicillium	Autophagy Mitophagy HSV Antibiotic Bacterial Breast Cancer Viral Infection Nonalcoholic Steatohepatitis	180
HY-12000	AG490	AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.	EGFR STAT JAK Autophagy Lung Cancer Breast Cancer Colorectal Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Glucose Metabolism Hepatitis C Virus Infection Rheumatoid Arthritis	179
HY-L001	Bioactive Compound Library	Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. MCE owns a unique collection of 27,560 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. These can also be used for signal pathway research, drug discovery and drug repurposing, etc.	General Bioactive Screening Libraries	150
HY-13434A	Ionomycin calcium	Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC). Source: Streptomyces conglobatus	Calcium Channel PKC Bacterial Apoptosis Antibiotic Colorectal Cancer Bladder Cancer Bacterial Infection Nonalcoholic Steatohepatitis	146
HY-13434	Ionomycin	Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC). The product specifications provided below refer solely to the active content of Ionomycin. Source: Streptomyces conglobatus	Calcium Channel PKC Bacterial Apoptosis Antibiotic Bladder Cancer Clostridium Difficile Infection	146
HY-B0069	Fludarabine	Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes.	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis STAT Apoptosis Prostate Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Viral Infection Non-Small Cell Lung Cancer Lung Adenocarcinoma Lung Squamous Cell Carcinoma Triple-Negative Breast Cancer SARS-CoV-2 Infection Obesity	124
HY-13419	U-73122	U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC₅₀of 1-2.1 µM for PLC.	Phospholipase Lipoxygenase Ferroptosis Inflammation or Immune System Disease Prostate Cancer	117
HY-15465B	KN-93 phosphate	KN-93 phosphate is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM.	CaMK Autophagy Cancer	112
HY-15465	KN-93	KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a K_i of 370 nM.	CaMK Autophagy Prostate Cancer Glucose Metabolism Retinopathy	112
HY-L006	GPCR/G Protein Compound Library	GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery. MCE provides a unique collection of 3,570 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.	Signaling Pathway Targeting Libraries	110
HY-L003	Apoptosis Compound Library	Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease. MCE designs a unique collection of 3,746 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.	Signaling Pathway Targeting Libraries	107
HY-L007	Immunology/Inflammation Compound Library	The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. MCE designs a unique collection of 8,843 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.	Signaling Pathway Targeting Libraries	107
HY-L011	Membrane Transporter/Ion Channel Compound Library	Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development. MCE designs a unique collection of 2,332 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.	Signaling Pathway Targeting Libraries	107
HY-L089	Mitochondria-Targeted Compound Library	Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. MCE supplies a unique collection of 1,223 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.	Signaling Pathway Targeting Libraries	107
HY-40354	Tofacitinib	Tofacitinib (Tasocitinib) is an orally active, blood-brain barrier permeable selective inhibitor of JAK1/JAK3. Tofacitinib blocks the JAK-STAT/NF-κB signaling pathway, inhibits cytokine signal transduction, phosphorylation of STAT1/STAT5, and suppresses innate and adaptive immune responses. Tofacitinib can be used in research related to major depressive disorder, rheumatoid arthritis, pulmonary diseases, systemic lupus erythematosus, and immune-mediated liver injury.	JAK STAT NF-κB Depression Pulmonary Disease Systemic Lupus Erythematosus Liver Injury Rheumatoid Arthritis	105
HY-L010	MAPK Compound Library	MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers. MCE designs a unique collection of 1,198 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.	Signaling Pathway Targeting Libraries	105
HY-L031	Small Molecule Immuno-Oncology Compound Library	Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines. MCE Small Molecule Immuno-Oncology Compound Library offers 851 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.	Disease Focused Libraries	105
HY-L008	JAK/STAT Compound Library	The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 753 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.	Signaling Pathway Targeting Libraries	103
HY-L017	Stem Cell Signaling Compound Library	Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy. MCE owns a unique collection of 3,007 compounds that can be used for stem cell regulatory and signaling pathway research.	Signaling Pathway Targeting Libraries	103
HY-L109	Protein-protein Interaction Inhibitor Library	Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures. With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 842 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.	Signaling Pathway Targeting Libraries	103
HY-L014	NF-κB Signaling Compound Library	Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 1,873 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.	Signaling Pathway Targeting Libraries	102
HY-L013	Neuronal Signaling Compound Library	Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders. MCE designs a unique collection of 4,027 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.	Signaling Pathway Targeting Libraries	101
HY-L033	Peptidomimetic Library	Peptidomimetics are compounds whose essential elements (pharmacophore) mimic a natural peptide or protein in 3D space and which retain the ability to interact with the biological target and produce the same biological effect. Peptidomimetics are designed to circumvent some of the problems associated with a natural peptide: e.g. stability against proteolysis (duration of activity) and poor bioavailability. Certain other properties, such as receptor selectivity or potency, often can be substantially improved. The design and synthesis of peptidomimetics are most important because of the dominant position peptide and protein-protein interactions play in molecular recognition and signaling, especially in living systems. Hence mimics have great potential in drug discovery. MCE Peptidomimetic Library contains 371 compounds including peptoid, α-helix mimetics, β-turn/sheets mimetics, etc. This library is an indispensable tool of structure-activity relationships in drug discovery.	Structure Classified Libraries	101
HY-L046	Anti-Cardiovascular Disease Compound Library	Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk. MCE supplies a unique collection of 2,509 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.	Disease Focused Libraries	101
HY-L051	Ferroptosis Compound Library	Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc. MCE carefully collected a unique collection of 1,283 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.	Signaling Pathway Targeting Libraries	101
HY-L059	Pyroptosis Compound Library	Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 2,110 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.	Signaling Pathway Targeting Libraries	101
HY-L070	Neuroprotective Compound Library	Neurodegenerative diseases are characterised by progressive dysfunction and death of neurons, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (MS). Neuroprotection is an approach to preserve neurons so that neurons cannot be hurt by different pathological factors in neurodegenerative diseases. Neuroprotectors are some agonists and antagonists targeting some key targets in neuroprotactive signal pathways, such as calcium and sodium channel blockers, GABA receptor agonists, NMDA receptor Antagonists, etc. Current neuroprotectors cannot reverse existing damage, but they may protect against further nerve damage and slow down any degeneration of the central nervous system (CNS) and still play important roles in the treatment of neurodegenerative diseases. MCE offers a unique collection of 1,893 compounds with potential neuroprotective activities. These compounds mainly act on some key targets in neuroprotetive signal pathways, such as calcium channel, sodium channel, adenosine A1 receptor, etc. MCE Neuroprotective Compopund Library is a useful tool in neuroprotective drug discovery.	Compound Characteristic Classified Libraries	101
HY-L075	Anti-Lung Cancer Compound Library	Lung cancer is a major global health problem, as it is the leading cause of cancer-related deaths worldwide. Lung cancer is divided into two categories: small cell lung cancer and non-small cell lung cancer (NSCLC). Non-small cell lung cancer accounts for about 85 percent of lung cancers. As with all cancers, lung cancer may be treated with surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy or a combination thereof. Targeted therapy is one of the most exciting developments in lung cancer medicine, especially for NSCLC. Extensive genomic characterization of NSCLC has led to the identification of molecular subtypes of NSCLC that are oncogene addicted and exquisitely sensitive to targeted therapies. These include activating mutations in epidermal growth factor receptor (EGFR) and BRAF or echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusions and ROS1 receptor tyrosine kinase fusions. These are important targets for target therapy. MCE offers a unique collection of 3,150 compounds with identified and potential anti-lung cancer activity. These compounds target lung cancer’s major targets and signaling pathways. MCE anti-lung cancer compound library is a useful tool for anti-lung cancer drugs screening and other related research.	Disease Focused Libraries	101
HY-L166	Ion Channel Compound Library	Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important. MCE designs a unique collection of 1,782 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.	Signaling Pathway Targeting Libraries	101
HY-L0104V	UORSY New Generation Screening Library	UORSY New Generation Screening Library contains about 1,900,000 compounds. The library is a revolutionary collection of lead-like molecules with outstanding structural quality and diversity—New Generation Screening Library (NGSL). Its core is decorated with interesting building blocks, including important medicinal fragments such as peptide bonds, amino groups and hydroxyl groups. and designed for discovery of new Voltage-gated calcium channel blockers.		100
HY-L0119V	Asinex PPI Pre-Plated Library	Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures. The PPI Library comprises molecules of various sizes, frameworks, and shapes ranging from fragment-like entities to macrocyclic derivatives designed as secondary structure mimetics or as epitope mimetics. The designs cover β-turn / loop mimetics and α-helix mimetics. Since helices present at the interface in 62% of all protein-protein interactions. This library focused on designs including mimics with the substitution geometry of an a-helices, as well as designs that mimic the location of “hot-spot” side chains in helix-mediated PPIs.		100
HY-L041	Macrocyclic Compound Library	Macrocycles, molecules containing 12-membered or larger rings, are receiving increased attention in small-molecule drug discovery. The reasons are several, including providing access to novel chemical space, challenging new protein targets, showing favorable ADME- and PK-properties. Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small-molecule drug discovery, especially in modulating macromolecular processes such as protein–protein interactions (PPI). Otherwise, the size and complexity of macrocyclic compounds make possible to ensure numerous and spatially distributed binding interactions, thereby increasing both binding affinity and selectivity. MCE offers a unique collection of 469 macrocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE Macrocyclic Compound Library is a useful tool for discovering new drugs, especially for “undruggable” targets and protein–protein interactions.	Structure Classified Libraries	100
HY-L045	Oxygen Sensing Compound Library	Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival. HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation. MCE offers a unique collection of 4,431 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.	Signaling Pathway Targeting Libraries	100
HY-L074	Anti-Breast Cancer Compound Library	Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC). Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer. MCE supplies a unique collection of 3,492 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.	Disease Focused Libraries	100
HY-L088	Angiogenesis-Related Compound Library	Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer). MCE offers a unique collection of 3,776 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.	Signaling Pathway Targeting Libraries	100
HY-L117	Calcium Channel Blocker Library	Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat. MCE supplies a unique collection of 228 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.	Signaling Pathway Targeting Libraries	100
HY-L119	Potassium Channel Compound Library	Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. There are four major classes of K channels: voltage-gated potassium channel, calcium-activated potassium channel, inwardly rectifying potassium channel and tandem pore domain potassium channel. There is growing evidence that dysfunction in potassium channels correlates with several diseases, such as chronic hypertension, diabetes, hypercholesterolemia and atherosclerosis, etc. MCE Potassium Channel Compound Library consists of 340 potassium channel inhibitor and activators, which is a useful tool to discover drugs for cardiovascular diseases and potassium channel research.	Signaling Pathway Targeting Libraries	100
HY-L145	Antihypertensive Compound Library	The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death. Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs). MCE offers a unique collection of 931 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.	Disease Focused Libraries	100
HY-L156	Autoimmune Disease Compound Library	Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A). MCE designs a unique collection of 1,089 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.	Disease Focused Libraries	100
HY-L161	Cytokine Inhibitors Library	Cytokines are a kind of low molecular soluble proteins synthesized and secreted by immunogen, mitogen or other factors. They have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The process of releasing a large number of cytokines is also called “Cytokine storm”, which can cause damage to many tissues and organs in the body. Cytokine is involved in the pathogenesis of many human diseases, including cancer, diabetes, chronic inflammatory diseases and so on. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. Cytokine inhibitors are important compounds for the study of tumor and autoimmune diseases. MCE designs a unique collection of 1,461 cytokine inhibitors, mainly targeting the receptor interleukin (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), growth factor (GF) and chemokine, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases and anti-autoimmune diseases compounds.	Signaling Pathway Targeting Libraries	100
HY-L162	Cell Death Library	Cell death plays a crucial role in the development of the body and the maintenance of internal balance to prevent the development of diseases. According to the regulation of the involved processes, cell death can be defined as programmed and non-programmed death. Programmed cell death (PCD) can be divided into lytic cell death and nonlytic cell death, mainly including apoptosis, necrotic apoptosis and Pyroptosis. Non-Programmed cell death (Non-PCD) generally refers to necrosis. In stark contrast to Accidental Cell Death (ACD), Regulatory Cell Death (RCD) relies on specialized molecular mechanisms. Cell death includes internal apoptosis, external apoptosis, necrotic apoptosis, ferroptosis, pyroptosis, lysosome-dependent cell death, etc. MCE designs a unique collection of 3,939 cell death compounds, covering multiple targets, such as Apoptosis, Ferroptosis, Pyroptosis, Necroptosis, etc. It is a useful tool for screening cell death drugs.	Compound Characteristic Classified Libraries	100
HY-L162M	Cell Death Inhibitor Library Mini	Cell death is a core biological process that maintains homeostasis in multicellular organisms, playing a dual role in life activities. On one hand, cell death participates in physiological processes such as cell renewal and damage repair through precise regulation; on the other hand, it actively eliminates damaged, infected, or cancerous cells, thereby blocking pathological progression and preserving organism health. Cell death not only ensures the normal development and growth regulation of organisms but is also closely associated with the occurrence and development of various diseases. Numerous studies have shown that specific types of programmed cell death play critical roles in disease progression, providing an important theoretical basis for developing novel therapeutic strategies by regulating cell death pathways. MCE offers 23 types of commonly used cell death inhibitors, such as apoptosis, ferroptosis, pyroptosis, and cuproptosis, suitable for use as positive controls in the study of novel cell death mechanisms.	Signaling Pathway Targeting Libraries	100
HY-L168	Extracellular Vesicles (EVs) Compound Library	Extracellular vesicles (EVs) are small membrane binding structures that are released from cells into the surrounding environment and play a crucial role in mediating and regulating intercellular communication related to physiological and pathological processes. EVs are lipid membrane vesicles composed of proteins, lipids, and nucleic acids. EVs can be divided into several types based on their source, such as extracellular vesicles, microcapsules, and apoptotic vesicles. The size range of exosomes is 30-150nm, which are endocrine in multi vesicular endosomes (MVEs); microvesicles (50-1000nm) are secreted directly through extracellular interactions, thereby releasing plasma membrane vesicles. In contrast, apoptotic bodies are usually larger, ranging in size from 1 to 5 μ m. This is generated during programmed cell death. EV plays a crucial role in transmitting information between cells and influencing the behavior and function of receptor cells. MCE designs a unique collection of 722 small molecules related to extracellular vesicles (EVs). It is a good tool to be used for research on metabolize, cancer and other diseases.	Signaling Pathway Targeting Libraries	100
HY-L172	Immunopotentiator Compound Library	Immunity refers to the ability of the body to resist the invasion of pathogenic microorganisms and resist a variety of diseases. Immunocompromised will inevitably lead to a series of diseases. Immunopotentiator are a class of compounds that enhance immune function and induce immune response. Immunopotentiator can activate the proliferation and differentiation of one or more kinds of immune active cells in the body, promote the secretion of lymphocytes, and then enhance the immune function of the body. Immunopotentiator are mainly used in the treatment of tumors, infectious diseases and immunodeficiency diseases. In addition, immunopotentiator are often used as adjuvants in combination with vaccine antigens to enhance the immunogenicity of vaccines. MCE designs a unique collection of 152 compounds with definite or potential Immunopotentiating effect, mainly targeting the NOD-like Receptor (NLR), Toll-like Receptor (TLR), NF-κB, etc. It is an effective tool for development and research of anti-cancer, anti-infectious diseases and anti-immunodeficiency diseases compounds.	Compound Characteristic Classified Libraries	100
HY-L174	Macrophage Related Compound Library	Macrophages are effector cells of the innate immune system, engulfing bacteria and secreting pro-inflammatory and antibacterial mediators. They are an important component of the first line defense against pathogens and tumor cells. In addition, macrophages play an important role in eliminating damaged cells through programmed cell death. Like all immune cells, macrophages originate from pluripotent hematopoietic stem cells in the bone marrow. Macrophages play key functions in many physiological processes beyond homeostasis and innate immunity, including metabolic function, cell debris clearance, tissue repair, and remodeling. In order to fulfill their different functional roles, macrophages can polarize into a series of phenotypes, including classic (pro inflammatory, M1) and alternative (anti-inflammatory, healing promoting, M2) activation states, as well as a wide range of regulatory phenotypes and subtypes. Macrophages exist in all vertebrate tissues and have a dual function in host protection and tissue damage, maintaining a good balance. MCE designs a unique collection of 289 macrophage related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.	Compound Characteristic Classified Libraries	100
HY-L177	Antibody Inhibitor Library	Antibody inhibitors are compounds with the same activity as the original therapeutic antibodies, which can be used as positive controls for drug efficacy evaluation and other studies. Antibody inhibitors can also assist in verifying the functional activity of the target protein. These antibody inhibitors are active in vivo and can achieve certain physiological functions by blocking or neutralizing target proteins, such as CD20, HER2, EGFR, VEGFR, TNF-α, etc. In drug screening, antibody inhibitor-based screening can be carried out to identify active compounds targeting target proteins and target diseases. MCE can provide 2,001 antibody inhibitors that can be used for drug development in cancer, immunity, infection and other hot research areas.	Compound Characteristic Classified Libraries	100
HY-L178	Radioprotector Library	Radiation sickness is a general term for various types and degrees of damage (or disease) occurring in the human body after exposure to ionizing radiation. Although small amounts of ionizing radiation can also cause the body to produce free radicals and ROS, causing oxidative stress, resulting in DNA damage and chromosomal aberration. Radioprotector are compounds with radiation protection that can be used to prevent/protect non-tumor cells from the harmful effects of radiation. Radioprotective compounds can prevent the damage of radioactive substances to the human body and reduce the clinical symptoms of various radioactive diseases. In addition, radioprotectors can protect normal cells from damage during radiation therapy. The ideal anti-radiation drug should not affect the sensitivity of tumor cells to radiation therapy while protecting normal cells. MCE designs a unique collection of 3,165 radioprotectors. Radioprotector Library is an effective tool for acute Radiation Syndrome, drug combination research with radiation drugs.	Compound Characteristic Classified Libraries	100
HY-L194	Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library	Heat-clearing and detoxification is a specific treatment method in the research of traditional Chinese medicine (TCM), which is clinically used to treat infectious diseases with remarkable effect. Over the past decades, the research of heat-clearing and detoxification treatment has been one of the most active fields of combining traditional Chinese and western medicines, and has made remarkable achievements. Nowadays, the application field of heat-clearing and detoxification traditional Chinese medicine is not only limited to antibacterial and antiviral, but also has made progress in the research fields of anti-inflammatory reaction, anti-endotoxin, anti-peroxidative damage, anti-inflammatory cytokines, enhancement of immune function, protection of cellular organelles, and maintenance of calcium homeostasis. In addition to this, clearing heat and removing toxins has also made significant research progress in non-infectious diseases, for example, in tumors, cardiovascular diseases, renal diseases, blood diseases, geriatrics, and diabetes, all of which have shown good curative effect. MCE can supply 1,286 monomer component from more than a hundred sources of heat-clearing and detoxification TCM, which can be used in TCM studies, drug development and mechanism-based studies.		100
HY-L219	Antimicrobial Peptides Library	Antimicrobial Peptides (AMPs), also known as antimicrobial peptides or antibiotic peptides, are a class of polypeptides encoded by specific genes in various biological cells and induced by external stimuli. They exhibit broad-spectrum bioactivity against bacteria, fungi, viruses, protozoa, and even tumor cells. AMPs serve as crucial effector molecules in the host's innate immune system.Due to their wide antimicrobial spectrum, low toxicity to normal cells of higher animals, high safety profile, low tendency to induce resistance, and additional benefits such as immune enhancement and antioxidant effects, antimicrobial peptides hold significant promise in new drug development. MCE offers 57 types of antimicrobial peptides, which can be applied in high-throughput screening for research in anti-infection therapies, immunotherapy, anticancer drug development, and agricultural disease control.		100
HY-L222	PROTAC Linkers Library	Linkers play a necessary role in the physicochemical properties and biological activity of the bifunctional molecule. These linkers are not a simply connection of two functional modules together, but its design and nature directly affect the stability, activity, selectivity, pharmacokinetics, and ultimately the therapeutic efficacy of the entire molecule. The length of the linker determines the extent of interaction between the two ligands and thus the maximum activity of the PROTAC molecule. MCE has collected 1,240 PROTAC Linkers can be used for the design and synthesis of bifunctional molecules.		100
HY-L226	Posttranslational Modification Library	Post-translational modifications (PTMs) refer to chemical modifications that occur on amino acid residues of proteins after translation, involving the addition or removal of specific functional groups. These modifications regulate protein activity, localization, folding, and interactions with other biomolecules. By influencing protein function, PTMs play a crucial role in various pathophysiological processes. Common types of PTMs include protein phosphorylation, methylation, acetylation, ubiquitination, glycosylation, and more. MCE offers 3,687 PTM-targeting compounds, which can be used for drug screening in cancer, neurodegenerative diseases, metabolic disorders, etc.		100
HY-L227	Amino Acid Metabolite Compound Library	Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism. MCE can provide 193 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases	Metabolism Focused Libraries	100
HY-L234	Nucleotide Metabolite Compound Library	Nucleotide metabolism is central to cancer aggressiveness, underpinning uncontrolled proliferation, chemotherapy resistance, immune evasion, and metastasis. It is transcriptionally regulated by oncogenes (e.g., MYC) and tumor suppressors (e.g., pRb). Nucleotide imbalance and nucleoside degradation further regulate cell state transitions, especially following replication stress. Additionally, secretion of nucleotides/nucleosides into the tumor microenvironment modulates immune responses and influences treatment efficacy. Therefore, nucleotide metabolites have roles in disease response and indication in cancer research, and can be utilized to develop cancer-related mechanisms and drugs. MCE can provide 83 metabolites produced by nucleotide metabolic pathways, which can be used for disease mechanism research and drug research.	Metabolism Focused Libraries	100
HY-L237	Pattern Recognition Receptors Library	Pattern Recognition Receptors (PRRs) are a crucial class of protein molecules expressed in cells of the innate immune system. The core function of Pattern Recognition Receptors is to recognize Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs). Upon recognizing and binding to PAMPs or DAMPs, PRRs rapidly initiate intracellular signaling pathways (such as the NF-κB, IRF, and inflammasome pathways). This triggers the production of inflammatory factors, chemokines, and type I interferons, thereby initiating inflammatory responses to eliminate pathogens or repair damage. PRRs represent the body's first line of defense against infection, and the rapidity and broad specificity of their response are crucial for host survival. However, aberrant activation of PRR signaling is also a cause of many chronic inflammatory diseases, autoimmune disorders, and neurodegenerative diseases. Therefore, precisely regulating PRR activity has become a key therapeutic strategy for these conditions. MCE has cataloged 349 inhibitors targeting key PRRs, such as NLRs, TLRs, C-type Lectin Receptors (CLRs), and cGAS, to support drug discovery efforts for chronic inflammatory diseases.		100
HY-L266	PD-1 Compound Library	PD-1/PD-L1 signaling is a central negative regulatory axis that maintains immune homeostasis. It involves the specific binding of PD-1 to its ligands PD-L1/PD-L2 and the subsequent transduction of inhibitory signals, which suppress T cell activation and proliferation, drive T cell exhaustion, and contribute to tumor immune evasion. Dysregulation of this pathway is closely linked to major diseases including cancer, chronic viral infections, autoimmune disorders, and transplant rejection. Immune checkpoint blockade targeting PD-1/PD-L1 has emerged as a leading frontier in cancer therapy and mechanistic research. The MCE PD-1 Compound Library contains 104 structurally defined small molecules, covering modulators related to the PD-1/PD-L1 signaling pathway. It can be used for cancer immunotherapy research, studies of immune resistance mechanisms, and candidate compound screening, providing chemical tools for immune checkpoint mechanism research, drug discovery, and high-throughput screening.		100
HY-L267	Protein Synthesis Regulatory Compound Library	Protein synthesis is a fundamental process that converts genetic information into functional proteins and is essential for maintaining cellular growth, proliferation, differentiation, and metabolic homeostasis. Protein synthesis is precisely regulated by a complex network of signaling pathways, including mTOR, PI3K/Akt, MAPK/ERK, and eIF (eukaryotic translation initiation factor)-mediated signaling. These pathways finely control cellular protein synthesis by regulating translation initiation, ribosomal activity, and the expression and phosphorylation status of key translation factors. Dysregulation of protein synthesis is closely associated with the development and progression of various diseases, including cancer, metabolic disorders, neurodegenerative diseases, and immune-related disorders. Therefore, key proteins, kinases, and translation regulators within these pathways are of significant value for research and drug development. MCE offers 1,252 small-molecule compounds targeting key components of protein synthesis signaling pathways, covering multiple targets involved in protein synthesis and translational regulation, as well as diverse modes of target modulation and functions. By selectively modulating the activity or function of different pathway components, these compounds can be used to investigate protein synthesis and translational regulatory networks, elucidate the roles of specific targets in cellular physiology and disease processes, and support disease mechanism studies, potential drug target validation, candidate drug evaluation, and the exploration of therapeutic strategies.		100
HY-L268	Optogenetics Compound Library	Optogenetics and photopharmacology are emerging technologies that enable precise spatiotemporal control of biological processes. Optogenetics primarily employs genetically encoded light-sensitive proteins to modulate cellular activity in response to specific wavelengths of light, whereas photopharmacology utilizes photoswitchable compounds and photocaged molecules to achieve light-dependent control of molecular activity. These approaches provide valuable tools for investigating ion channel function, calcium signaling, downstream kinase cascades, neuronal excitability, and intracellular signal transduction. They have broad applications in neuroscience, synthetic biology, and the investigation of disease-associated mechanisms in neurological and psychiatric disorders. The MCE Optogenetics Compound Library comprises 927 structurally defined small molecules, including modulators targeting ion channels, calcium signaling, and associated downstream neuronal signaling pathways. The library supports mechanistic studies of neuronal signaling, investigations of neuronal excitability and calcium dynamics, and preliminary screening of candidate compounds, providing chemical tools for optogenetics-related neuroscience research.		100
HY-L907	MCE Kinase Hinge Binder Fragment Library	The most prominent mechanism of action of kinase inhibitors is their competition with ATP by binding to the hinge region of the kinase protein. Once the kinase is blocked by an inhibitor, it loses the ability to transfer phosphate groups from ATP to other molecules, resulting in the loss of kinase activity. The hinge-binding region of kinase inhibitors mimics the interaction pattern between the ATP nucleobase and the kinase. MCE extracted thousands of kinase inhibitors from the ChEMBL database and isolated their molecular fragments. In certain cases, the amino and amide groups on the molecular fragments are crucial for binding in the hinge region. Therefore, we enhanced the diversity of the collected results by adding these two groups to unoccupied positions on the ring system. Subsequently, the fragments were assessed for their hinge region binding ability via docking at distinct kinases, we also applied pharmacophore constraints to ensure interactions with key amino acids in the kinase hinge region, ultimately obtaining kinase-related molecular fragments. MCE provides over 12,364 kinase fragment molecules that meet the above requirements and are available off the shelf, serving as an effective tool for screening and developing drugs targeting kinases.	Functional Fragment Libraries	100
HY-L917	RNA Binding Library	RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs. MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.	Focused and target libraries	100
HY-L924	Boronic acid/boronic ester fragment library	Boronic acid and boronic ester represent a relatively novel and promising chemical structure in drug design. Boronic acid exists in an sp²-hybridized state, possessing an empty p-orbital that can act as a Lewis acid to accept lone pairs from heteroatoms (O, N, or S). This Lewis acidity enables it to form reversible covalent bonds with amino acid residues such as lysine, serine, threonine, and histidine. Currently, five FDA-approved drugs containing boronic acid or boronic ester predominantly involve such covalent binding mechanisms in their interactions with target proteins. Furthermore, boronic acid can serve as a bioisostere for carboxylic acids, phosphates, and phenolic groups, utilized to improve pharmacokinetic properties and enhance drug efficacy. To date, five boron-containing drugs have been approved by the FDA. The unique properties of boronic acids and boronic esters confer significant potential in drug design, with applications spanning cancer therapy (e.g., multiple myeloma), anti-infectives (e.g., fungal infections, tuberculosis), anti-inflammatory treatments (e.g., atopic dermatitis), antibacterial agents (e.g., carbapenem-resistant bacterial infections), and Reactive Oxygen Species (ROS)-responsive prodrugs, among others. The MCE Boronic Acid/Boronic Ester Fragment Library, which contains 1,486 compounds, serves as a valuable tool for the development of boron-containing drugs.	According to Fragment Structures	100
HY-L926	Cysteine Protease Focused Covalent Library	Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors. This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.	Focused and target libraries	100
HY-L935	Molecular Glue POI binding Fragment library	POI (Protein of Interest) refers to the target protein, namely the disease-causing protein or key functional protein that undergoes degradation or functional modulation in molecular glue-mediated processes. The Molecular Glue POI Library consists of a series of fragments that can specifically bind to different types of POIs. As key components of molecular glues, these ligands form stable interactions with target proteins, laying the foundation for molecular glues to induce the interaction between POIs and E3 ubiquitin ligases. The covered POIs include various types such as cancer-associated GSPT1, androgen receptors, and abnormally aggregated proteins linked to neurodegenerative diseases. This fragment library can be applied to the screening and optimization of targeted protein degraders. By screening ligands with high affinity and strong selectivity for specific POIs from the library, core structures can be identified to develop novel molecular glues. For instance, optimization of ligands targeting GSPT1 has yielded molecular glue degraders with enhanced degradation activity. Since many POIs are difficult to drug due to the lack of traditional small-molecule binding pockets, some ligands in the POI Ligand Library can modulate such POIs by inducing protein-protein interactions, thereby further expanding the scope of drug discovery for undruggable targets. MCE has compiled a POI Fragment Library comprising thousands of POI fragments with molecular weights ranging from 150 to 400. This compound library can be widely applied in Molecular Glue research and development.	Featured Fragment Libraries	100
HY-13689	Go 6983	Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC₅₀ of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.	PKC Breast Cancer	94
HY-18258	Berberine chloride	Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.	Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite Bacterial Infection Parasitic Infection Schizophrenia Lung Adenocarcinoma SARS-CoV-2 Infection Type 1 Diabetes Type 2 Diabetes Ulcerative Colitis	88
HY-15315	Baricitinib	Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC₅₀s of 5.9 nM and 5.7 nM, respectively.	JAK Acute Myeloid Leukemia SARS-CoV-2 Infection Obesity Rheumatoid Arthritis	87
HY-B0470	Neomycin sulfate	Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca²⁺ release, MgATP-dependent Ca²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer. Source: Micromonospora species	Environmental Pollutants Bacterial Phospholipase Antibiotic Cancer Bacterial Infection SARS-CoV-2 Infection Obesity	86
HY-18950	GSK2795039	GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC₅₀ of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis.	NADPH Oxidase Reactive Oxygen Species (ROS) Apoptosis Lung Cancer Colorectal Cancer	82
HY-16141	Cilengitide	Cilengitide (EMD 121974) is an integrin (integrin) inhibitor with blood-brain barrier permeability, with IC₅₀ values against human targets as follows: 0.61 nM for αvβ3, 8.4 nM for αvβ5, 14.9 nM for α5β1, 5400 nM for αIIbβ3, 2050 nM for αvβ6, 2350 nM for αvβ8. Cilengitide inhibits the binding of integrins to vitronectin, fibronectin, fibrinogen and LAP (TGF-β), and serves as an internal standard for solid-phase integrin binding assays. Cilengitide inhibits tumor cell viability, induces apoptosis, reduces the phosphorylation levels of STAT3, AKT and mTOR, downregulates the expression of PD-L1, inhibits cell viability and angiogenesis, regulates anti-tumor immune responses and slows tumor growth. Cilengitide can be used in research related to glioblastoma, melanoma, advanced solid tumors and refractory brain tumors.	Integrin TGF-β Receptor Apoptosis PD-1/PD-L1 STAT Akt mTOR Melanoma Glioblastoma	78
HY-100965	Diphenyleneiodonium chloride	Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC₅₀ of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.	TRP Channel NADPH Oxidase Reactive Oxygen Species (ROS) Inflammation or Immune System Disease Pain Lung Fibrosis	73
HY-Y0320C	Dimethyl sulfoxide	Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Low endotoxin, can be used in various biochemical experiments such as drug dissolution.	Environmental Pollutants Cholinesterase (ChE) Bacterial Cancer Inflammation or Immune System Disease	73
HY-100111	GLX351322	GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC₅₀ of 5 μM.	NADPH Oxidase Metabolic or Endocrine Disease	57
HY-10409	Fedratinib	Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC₅₀s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research.	JAK Apoptosis Leukemia/Lymphoma/Myeloma Pancreatic Cancer Pain Non-Small Cell Lung Cancer Triple-Negative Breast Cancer	57
HY-13502	Mitoxantrone	Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.	Topoisomerase PKC Orthopoxvirus Apoptosis Lung Cancer Pancreatic Cancer Metastatic Breast Cancer Castration-Resistant Prostate Cancer Acute Myeloid Leukemia Orthopoxvirus Infection SARS-CoV-2 Infection Nonalcoholic Steatohepatitis	53
HY-13867	Bisindolylmaleimide I	Bisindolylmaleimide I (GF109203X) is a cell-permeable and reversible PKC inhibitor (IC₅₀ of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I is also a GSK-3 inhibitor.	PKC GSK-3 Alzheimer's Disease	46
HY-N0193	Artesunate	Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).	STAT Ferroptosis Parasite Virus Protease Glutathione Peroxidase Ligands for Target Protein for PROTAC Inflammation or Immune System Disease Lung Cancer Breast Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Parasitic Infection SARS-CoV-2 Infection Obesity	43
HY-14944	Homoharringtonine	Homoharringtonine (Omacetaxine mepesuccinate;HHT) is a cytotoxic alkaloid with antitumor properties which acts by inhibiting translation elongation.	STAT Breast Cancer Prostate Cancer Liver Cancer Pancreatic Cancer Autoimmune Disease Non-Small Cell Lung Cancer Acute Myeloid Leukemia Obesity	42
HY-19805	STO-609	STO-609 is a selective and cell-permeable inhibitor of the Ca²⁺/calmodulin-dependent protein kinase kinase (CaM-KK), with K_i values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC₅₀ ~0.02 g/ml.	CaMK AMPK Autophagy Gastric Cancer Ovarian Cancer Nonalcoholic Steatohepatitis	41
HY-10230	Midostaurin	Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects.	PKC VEGFR c-Kit NO Synthase Apoptosis Lung Cancer Colorectal Cancer Ovarian Cancer Triple-Negative Breast Cancer Acute Myeloid Leukemia Alzheimer's Disease Nonalcoholic Steatohepatitis Lung Fibrosis Hepatic Fibrosis	41
HY-100168	BAPTA	BAPTA is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.	Phospholipase Pancreatitis	41
HY-117287	Deucravacitinib	Deucravacitinib (BMS-986165) is an orally active allosteric inhibitor of tyrosine kinase 2 (TYK2), with an IC₅₀ of 0.2 nM and a K_i of 0.02 nM against the JH2 domain of TYK2, and it exhibits selectivity over other JAK subtypes and most of the kinome. Deucravacitinib blocks IL-23, IL-12, p-STAT1/3 and Type I IFN signaling, and inhibits Th17/Th1-mediated psoriasis inflammation. Deucravacitinib can be used in research related to moderate-to-severe plaque psoriasis, inflammatory bowel disease and systemic lupus erythematosus.	JAK STAT Interleukin Related IFNAR Systemic Lupus Erythematosus Psoriasis Inflammatory Bowel Disease	39
HY-16954	ARV-825	ARV-825 is a BET protein PROTAC degrader that recruits cereblon, and it targets BRD2, BRD3, and BRD4 for degradation via the ubiquitin-proteasome pathway. ARV-825 downregulates c-MYC, PLK1, MYCN, CDK4/6, JAK2, pSTAT3/5, PIM1, and Bcl-xL, upregulates p21 and p27, and modulates H3K27Ac-mediated transcription, the G2/M checkpoint, the Wnt/β-catenin pathway, and amino acid transport pathways. ARV-825 induces G1 phase cell cycle arrest, caspase 3/PARP-mediated apoptosis, DNA damage, and reactive oxygen species (ROS) production, reduces mitochondrial respiration, and simultaneously inhibits cell proliferation, clonogenic growth, and cell migration. ARV-825 is used in research on gastric cancer, leukemia, neuroblastoma, and cholangiocarcinoma.	PROTACs Epigenetic Reader Domain c-Myc Polo-like Kinase (PLK) CDK JAK STAT Pim Bcl-2 Family PAK Wnt β-catenin Caspase PARP Reactive Oxygen Species (ROS) Apoptosis Gastric Cancer Leukemia/Lymphoma/Myeloma Neuroblastoma	37
HY-P9902	Pembrolizumab	Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy. Species: Human	PD-1/PD-L1 Non-Small Cell Lung Cancer Lung Adenocarcinoma HER-2 Positive Breast Cancer Triple-Negative Breast Cancer Metastatic Breast Cancer	37
HY-N0088	Apocynin	Apocynin is a selective NADPH-oxidase inhibitor with an IC₅₀ of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.	NADPH Oxidase Cancer Inflammation or Immune System Disease Metabolic or Endocrine Disease	36
HY-19569	Upadacitinib	Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC₅₀=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research.	JAK Pain Rheumatoid Arthritis	36
HY-12298	Setanaxib	Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with K_is of 140 and 110 nM, respectively.	NADPH Oxidase Ferroptosis Cardiovascular Disease SARS-CoV-2 Infection Type 2 Diabetes Lung Fibrosis	34
HY-110385A	cGAMP diammonium	cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.	STING Endogenous Metabolite Cancer Inflammation or Immune System Disease	33
HY-110385	cGAMP disodium	cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.	STING Endogenous Metabolite Inflammation or Immune System Disease	33
HY-B1511A	Cyclic AMP sodium	Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes.	Biochemical Assay Reagents Cancer Anxiety or Fear-Related Disease	31
HY-10341	Fasudil Hydrochloride	Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca²⁺ channel antagonist and vasodilator.	ROCK Calcium Channel Autophagy PKA PKC HIV Prostate Cancer Epilepsy Parkinson's Disease Amyotrophic Lateral Sclerosis Experimental Autoimmune Encephalomyelitis Hypertension	31
HY-100001	SKF-96365 (hydrochloride)	SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac I_Na/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G₂/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice. SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia.	TRP Channel CRAC Channel Autophagy CaMK Akt Apoptosis Na+/Ca2+ Exchanger Calcium Channel Colorectal Cancer Nonalcoholic Steatohepatitis	29
HY-K1047	AntiFade Mounting Medium (with DAPI)	Anti-Fade Mounting Medium (with DAPI) is a mounting reagent designed to retard fluorescence photobleaching and preserve signal intensity during long-term imaging. For immediate observation of samples, please select HY-K1048, a non-solidifying anti-fade mounting medium with DAPI. The 5 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.	Cell Biology Cell Analysis AntiFade Mounting Medium	29
HY-N6732	K-252a	K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. Source: Nocardiopsis sp.	Autophagy Trk Receptor PKC PKA CaMK Neurological, Eye or Ear Disease	28
HY-W010342	6-Aminonicotinamide	6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP⁺-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells.	NADPH Oxidase Breast Cancer Ovarian Cancer	25
HY-P9903	Nivolumab	Nivolumab is a programmed death receptor-1 (PD-1) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer. Species: Human	PD-1/PD-L1 Non-Small Cell Lung Cancer Lung Adenocarcinoma Triple-Negative Breast Cancer Metastatic Breast Cancer SARS-CoV-2 Infection	24
HY-12804	VAS2870	VAS2870 is a NADPH oxidase (NOX) inhibitor.	NADPH Oxidase Liver Cancer Lipid Metabolism Lung Fibrosis	21
HY-P0233	Melittin	Melittin is a PLA₂ activator, stimulates the activity of the low molecular weight PLA₂, while it does not the increase activity of the high molecular weight PLA₂.	Phospholipase Inflammation or Immune System Disease Breast Cancer Bacterial Infection	18
HY-N0527	Pentagalloylglucose	Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities.	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species (ROS) E1/E2/E3 Enzyme Lung Cancer Breast Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Obesity Rheumatoid Arthritis	18
HY-K0320	ROS Assay Kit	MCE ROS Assay Kit utilizes the fluorescent probe DCFH-DA to detect ROS.	Cell Biology Cell Analysis Metabolism Assay Kit	18
HY-17567	Heparin	Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.	Exosomes Thrombin Autophagy Endogenous Metabolite Bacterial Cancer Blood or Cardio-cerebrovascular Disease Bacterial Infection SARS-CoV-2 Infection	15
HY-13290	KN-62	KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a K_i of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X₇ receptors in HEK293 cells, with an IC₅₀ value of approximately 15 nM.	CaMK P2X Receptor Liver Cancer Depression	14
HY-N0390S1	L-Glutamine-13C5	L-Glutamine-¹³C₅ is the ¹³C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na⁺-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.	Isotope-Labeled Compounds mGluR Ferroptosis Environmental Pollutants Endogenous Metabolite HIF/HIF Prolyl-Hydroxylase mTOR STAT NF-κB Neurological, Eye or Ear Disease Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	14
HY-P2565	Pepinh-TRIF TFA	Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction.	Toll-like Receptor (TLR) Inflammation or Immune System Disease	12
HY-N0678	Icaritin	Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornuMaxim. and potently inhibits proliferation of K562 cells (IC₅₀ of 8 µM) and primary CML cells (IC₅₀ of 13.4 µM for CML-CP and 18 µM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis.	JAK Autophagy Apoptosis Lung Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Autoimmune Disease Metastatic Breast Cancer Nonalcoholic Steatohepatitis	12
HY-100736	ML348	ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC₅₀ of 210 nM, and barely inhibits LYPLA2.	Phospholipase Mutant Melanoma	12
HY-113355	NADH	NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.	Endogenous Metabolite Apoptosis Neurodegenerative Disease Autoimmune Disease Renal Disease Spinal Cord Injury Ischemia-Reperfusion Injury	11
HY-W250154	β-Nicotinamide adenine dinucleotide reduced dipotassium	β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally effective reduced coenzyme. β-Nicotinamide adenine dinucleotide reduced dipotassium plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. β-Nicotinamide adenine dinucleotide reduced dipotassium regulates calcium homeostasis by promoting the opening of IP3-gated Ca²⁺ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. β-Nicotinamide adenine dinucleotide reduced dipotassium is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction.	Endogenous Metabolite Calcium Channel VDAC Neurodegenerative Disease Cerebrovascular Disease Cellular Senescence	11
HY-123962	G6PD activator AG1	G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes.	NADPH Oxidase Metabolic or Endocrine Disease	11
HY-111382	Diphenylterazine	Diphenylterazine (DTZ) is a bioluminescence agent. Diphenylterazine alone yielded very little background, leading to excellent signal-to-background ratios.	Fluorescent Dye	11
HY-100912	W-7 hydrochloride	W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca²⁺-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC₅₀ values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias.	Phosphodiesterase (PDE) Myosin Apoptosis Calmodulin Potassium Channel Leukemia/Lymphoma/Myeloma Cardiovascular Disease Alzheimer's Disease	11
HY-F0001	NADH disodium salt	NADH disodium salt (Disodium NADH) is an orally effective reduced coenzyme. NADH disodium salt plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. NADH disodium salt regulates calcium homeostasis by promoting the opening of IP3-gated Ca²⁺ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. NADH disodium salt is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction.	Endogenous Metabolite Calcium Channel VDAC Neurodegenerative Disease Cerebrovascular Disease Cellular Senescence	11
HY-B0532A	Trifluoperazine dihydrochloride	Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis.	Dopamine Receptor Adrenergic Receptor CaMK P-glycoprotein Influenza Virus Autophagy Schizophrenia Influenza Virus Infection	10
HY-N1447	Ganoderic acid A	Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.	Free Radical Scavengers Apoptosis Autophagy Endogenous Metabolite MDM-2/p53 Nonalcoholic Steatohepatitis	10
HY-130592	Compound 48/80 trihydrochloride	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .	Phospholipase Neurological, Eye or Ear Disease Inflammation or Immune System Disease	10
HY-115768	Compound 48/80	Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways.	Phospholipase Cancer Neurological, Eye or Ear Disease	10
HY-16952A	Bepridil hydrochloride hydrate	Bepridil hydrochloride hydrate (CERM 1978 hydrate; Org 5730 hydrochloride hydrate) is an orally active non-selective calcium channel antagonist with multi-ion channel blocking activity. Bepridil hydrochloride hydrate modulates Calmodulin, the 20S proteasome, T-type/L-type calcium channels, cardiac sodium channels, multiple potassium channels, γ-secretase, β-secretase, and mitoK_ATP/sarcK_ATP channels. Bepridil hydrochloride hydrate acts as a hydroxyl radical scavenger, regulates mitochondrial and intracellular calcium handling, and exerts antiarrhythmic, antianginal, and cardioprotective effects. Bepridil hydrochloride hydrate alters amyloid precursor protein processing, reduces β-amyloid and thalamic calcium levels, restores seladin-1/DHCR24 expression, and improves sensorimotor recovery after cerebral ischemia. Bepridil hydrochloride hydrate also exhibits potent inhibitory effects on SARS-CoV-2 replication. Bepridil hydrochloride hydrate is used in studies related to stable angina, arrhythmias, cerebral ischemia, Alzheimer's disease, and SARS-CoV-2 infection.	Calcium Channel Sodium Channel Potassium Channel SARS-CoV Beta-secretase Amyloid-β Proteasome γ-secretase Calmodulin Cerebrovascular Disease SARS-CoV-2 Infection Alzheimer's Disease Angina Arrhythmias	9
HY-103315	Bepridil hydrochloride	Bepridil hydrochloride (CERM 1978; Org 5730 hydrochloride) is an orally active non-selective calcium channel antagonist with multi-ion channel blocking activity. Bepridil hydrochloride modulates Calmodulin, the 20S proteasome, T-type/L-type calcium channels, cardiac sodium channels, multiple potassium channels, γ-secretase, β-secretase, and mitoK_ATP/sarcK_ATP channels. Bepridil hydrochloride acts as a hydroxyl radical scavenger, regulates mitochondrial and intracellular calcium handling, and exerts antiarrhythmic, antianginal, and cardioprotective effects. Bepridil hydrochloride alters amyloid precursor protein processing, reduces β-amyloid and thalamic calcium levels, restores seladin-1/DHCR24 expression, and improves sensorimotor recovery after cerebral ischemia. Bepridil hydrochloride also exhibits potent inhibitory effects on SARS-CoV-2 replication. Bepridil hydrochloride is used in studies related to stable angina, arrhythmias, cerebral ischemia, Alzheimer's disease, and SARS-CoV-2 infection.	Calcium Channel Sodium Channel Potassium Channel SARS-CoV Beta-secretase Amyloid-β Proteasome γ-secretase Calmodulin Cerebrovascular Disease SARS-CoV-2 Infection Alzheimer's Disease Angina Arrhythmias	9
HY-108599	DCP-LA	DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(²⁺)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis.	PKC CaMK Phosphatase Apoptosis Neurological, Eye or Ear Disease	9
HY-110096	A-484954	A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC₅₀ of 280 nM.	CaMK Autophagy Pulmonary Hypertension	9
HY-D1839	Biotin TSA（200×）	Biotin TSA (200×) (Biotin Tyramide) is a biotin derivative used for tyramide signal amplification (TSA), as a reagent to amplify both immunohistochemical signals and in situ hybridization protocols. Biotinyl tyramide can be used for the research of tyramide signal amplification.	Fluorescent Dye	8
HY-W127530	α-Tocopherol phosphate disodium	α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity.	Apoptosis Reactive Oxygen Species (ROS) Pancreatic Cancer Viral Infection Cardiovascular Disease Glucose Metabolism Non-Small Cell Lung Cancer Nonalcoholic Steatohepatitis	8
HY-P1934	Cyclo(Phe-Pro)	Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance.	HCV Bacterial Antibiotic Reactive Oxygen Species (ROS) Infection	8
HY-N0587	Demethylzeylasteral	Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation .	Apoptosis TGF-beta/Smad Estrogen Receptor/ERR NF-κB FAK Colorectal Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Cardiovascular Disease Triple-Negative Breast Cancer Obesity Lung Fibrosis	8
HY-19870	Setmelanotide	Setmelanotide (RM-493) is a blood-brain barrier-permeable, selective MC4R agonist with a K_i value of 2.1 nM for hMC4R. Setmelanotide activates the CaMKK2/AMPK signaling pathway. Setmelanotide mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression.	Melanocortin Receptor Calmodulin AMPK Blood or Cardio-cerebrovascular Disease Respiratory Disease Obesity Fatty Liver Disease	8
HY-100737	ML349	ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a K_i of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC₅₀ of 144 nM.	Phospholipase Cancer	8
HY-10521	Darapladib	Darapladib (SB-480848) is an orally active, selective and reversible Lp-PLA2 inhibitor (IC₅₀=0.25 nM). Darapladib can trigger irreversible actions on glioma cell apoptosis and induce cycle arrest. Darapladib can be used in the study of atherosclerosis and cancer.	Phospholipase Apoptosis Cancer Cardiovascular Disease SARS-CoV-2 Infection	8
HY-107632	GYY4137	GY4137 is a sustained-release H2S donor possessing vasodilatory, antihypertensive, and anti-inflammatory activities. GY4137 can inhibit cell growth, induce apoptosis, and cause cell cycle arrest by blocking the STAT3 pathway, demonstrating potent anticancer activity.	Apoptosis STAT NF-κB NO Synthase COX TNF Receptor Interleukin Related Breast Cancer Colorectal Cancer Parkinson's Disease Acute Lung Injury Hypertension	8
HY-32343	Secalciferol	Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC₅₀ value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders.	Endogenous Metabolite VD/VDR Autoimmune Disease Hypercalcemia	7
HY-108537	L 012 sodium salt	L 012 sodium salt is a luminal-based chemiluminescent probe. L 012 sodium salt can detect NADPH oxidase (Nox)-derived superoxide and nitrogen species (reactive oxygen species (ROS) and reactive nitrogen species (RNS)).	Reactive Oxygen Species (ROS) Inflammation or Immune System Disease	7
HY-P1029	MLCK inhibitor peptide 18	MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC₅₀ of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.	Myosin CaMK Autophagy	6
HY-113308A	Taurolithocholic acid sodium salt	Taurolithocholic acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis. Source: animals	Calcium Channel Ferroptosis PI3K Reactive Oxygen Species (ROS) Akt HBV Cancer Metabolic or Endocrine Disease Viral Infection Neurodegenerative Disease	6
HY-P0091	Thymalfasin	Thymalfasin is an immunomodulating agent able to enhance the Thl immune response.	Influenza Virus Non-Small Cell Lung Cancer	5
HY-103319	Calmidazolium chloride	Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC₅₀s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to calmodulin with a K_d of 3 nM.	Autophagy Calmodulin	5
HY-K0353	Human CD3/CD28 T Cell Activation Magnetic Beads	MCE Human CD3/CD28 T Cell Activation Magnetic Beads are based on the two important co-stimulatory signals, without relying on feeder cells (antigen-presenting cells) or antigens, CD3 and CD28, without relying on feeder cells (antigen-presenting cells) or antigens, enabling simple and rapid T cell activation.	Cell Biology Cell Isolation	5
HY-N0596	Panaxadiol	Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities.	PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT Inflammation or Immune System Disease Lung Cancer Breast Cancer Colorectal Cancer Prostate Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Obesity	4
HY-116522	AR420626	AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3) (IC₅₀=117 nM). AR420626 has anti-inflammatory, anticancer and antidiabetic activities. AR420626 improves neurogenic diarrhea by inhibiting nAChR mediated neural pathways. AR420626 inhibits the growth of HepG2 xenografts and inhibits the proliferation of hepatoma cells by inducing apoptosis. AR420626 also suppresses allergic asthma and eczema and has the ability to activate GPR41 to increase Ca²⁺ signal-mediated glucose uptake and improve diabetes.	Free Fatty Acid Receptor Histone Methyltransferase HDAC mTOR CaMK p38 MAPK Epigenetic Reader Domain GLUT nAChR TNF Receptor Liver Cancer Depression Glucose Metabolism Parkinson's Disease Allergic Asthma Atopic Dermatitis	4
HY-B2123	Lactose	Lactose is a β-galactoside consisting of galactose and glucose residues, the main carbohydrate in mammalian breast milk. Lactose, a macronutrient and an inducer of host innate immune responses, possesses immune modulatory functions.	Environmental Pollutants ERK Interleukin Related Endogenous Metabolite NF-κB Chronic Obstructive Pulmonary Disease Pancreatitis Type 2 Diabetes Obesity	4
HY-P99156	Relatlimab	Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC₅₀ value of 0.67 nM and LAG-3/FGL1 interaction with an IC₅₀ value of 0.019 nM. Relatlimab can be used in research of cancer. Species: Human	LAG-3 Non-Small Cell Lung Cancer	4
HY-P81169A	PD-1 Antibody(YA3401)	PD-1 Antibody(YA3401) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PD-1. Host: Mouse; Reactivity: Human, Mouse	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	4
HY-P0214	Autocamtide-2-related inhibitory peptide	Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.	CaMK Autophagy Neurological, Eye or Ear Disease	3
HY-D2907	Cyanine 5 DBCO	Cyanine5 DBCO (DBCO-Cy5) is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm).	Fluorescent Dye	3
HY-P1077	CALP1	CALP1 is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca²⁺-binding site. CALP1 blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity.	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin Depression Parkinson's Disease Nonalcoholic Steatohepatitis	3
HY-N0385	Gomisin J	Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc.	NO Synthase NF-κB CaMK AMPK Keap1-Nrf2 Breast Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Depression Pain Spinal Cord Injury Ischemia-Reperfusion Injury Nonalcoholic Steatohepatitis Hypertension Obesity Lung Fibrosis	3
HY-P1077A	CALP1 TFA	CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity.	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin Depression Parkinson's Disease Nonalcoholic Steatohepatitis	3
HY-P0214A	Autocamtide-2-related inhibitory peptide TFA	Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.	CaMK Autophagy Neurological, Eye or Ear Disease	3
HY-N1951	Miltirone	Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC₅₀ of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; K_i = 0.04 μM) and SARS-CoV main protease (Mpro).	GABA Receptor Apoptosis Carboxylesterase (CES) SARS-CoV Colorectal Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma	3
HY-32350	Ercalcitriol	Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases.	VD/VDR Drug Metabolite Endogenous Metabolite Periodontal Disease	3
HY-W015346	Desaminotyrosine	Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling. Source: Saccharomyces cerevisiae	Influenza Virus Endogenous Metabolite Viral Infection	3
HY-111377	Amine-PEG3-Biotin	Amine-PEG3-Biotin is a signal amplification label containing a biotin group and a terminal primary amine group.	Fluorescent Dye	3
HY-P9993	Peresolimab	Peresolimab is a humanized IgG1-κ antibody targeting to PD-1. Peresolimab potentially stimulates physiological immune inhibitory pathways to restore immune homeostasis. Peresolimab can be used in research of rheumatoid arthritis. Species: Human	PD-1/PD-L1 Multiple Sclerosis	3
HY-D1583	Cyanine5 DBCO hexafluorophosphate	Cyanine5 DBCO (DBCO-Cy5) hexafluorophosphate is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO hexafluorophosphate has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO hexafluorophosphate can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm).	Fluorescent Dye	3
HY-P99201	Zilovertamab	Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling. Species: Human	ROR Wnt Non-Small Cell Lung Cancer Triple-Negative Breast Cancer	3
HY-125859	Peroxidase, Horseradish	Peroxidase, Horseradish actively involves in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases.	Reactive Oxygen Species (ROS) Inflammation or Immune System Disease Metabolic or Endocrine Disease	3
HY-P7395	PD-1 Protein, Human (CHO, Fc)	PD-1 Protein is an important immune regulatory molecule expressed on the surface of activated immune cells. By binding to its ligands (PD-L1/PD-L2), the PD-1 Protein exerts immunosuppressive effects. PD-1 Protein can be used in the research of tumors, autoimmune diseases, and other conditions. PD-1 protein, Human (CHO, Fc) is a recombinant PD-1 protein expressed by CHO cells and carries a C-hFc tag. Species: Human; Source: CHO	Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins PD-1	3
HY-P0271	Syntide 2	Syntide 2, a Ca²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected.	CaMK Autophagy Neurological, Eye or Ear Disease	2
HY-P4744	LL-37 amide	LL-37 amide is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED₉₉=8.5-8.7 μg/mL). LL-37 amide exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing.	Formyl Peptide Receptor (FPR) Bacterial Cancer Infection	2
HY-P0271A	Syntide 2 TFA	Syntide 2 (TFA), a Ca²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected.	CaMK Neurological, Eye or Ear Disease	2
HY-P4744A	LL-37 amide TFA	LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1, effectively inhibiting periodontal pathogens (ED₉₉=8.5-8.7 μg/mL). LL-37 amide TFA exerts its bactericidal effect by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It can also regulate inflammatory responses (inhibiting the release of factors such as TNF-α) and promote angiogenesis. Amidation modification reduces its sensitivity to serum inhibition and improves its stability. LL-37 amide TFA possesses key activities in bactericidal action, immunomodulation, and wound healing, and is mainly used in research on infection-related diseases such as periodontal disease and deep tissue injuries (pressure ulcers), and wound healing.	Formyl Peptide Receptor (FPR) Bacterial Cancer Infection	2
HY-N1990	Gypenoside XLIX	Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a K_a value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation.	PPAR Sirtuin Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis Pyroptosis Autophagy Neurological, Eye or Ear Disease Atherosclerosis and Inflammation Acute Lung Injury Cardiomyopathy Liver Injury	2
HY-N0852	Benzoylpaeoniflorin	Benzoylpaeoniflorin is an orally active monoterpene glycoside compound. Benzoylpaeoniflorin exerts anti-inflammatory, anti-allergic, psoriasis-improving and sepsis-improving effects by inhibiting signaling pathways such as TNF/NF-κB and MAPK, as well as regulating immune homeostasis. Benzoylpaeoniflorin can be used in research related to immune, allergic and inflammatory diseases.	p38 MAPK NF-κB Interleukin Related JNK PERK CXCR Cardiovascular Disease Nonalcoholic Steatohepatitis	2
HY-P2322	Iturin A	Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity.	Fungal Reactive Oxygen Species (ROS) Apoptosis Autophagy Cancer Infection	2
HY-P99171	Gevokizumab	Gevokizumab is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II). Species: Human	Interleukin Related Inflammation or Immune System Disease Colorectal Cancer	2
HY-129960	L-Selenocystine	L-Selenocystine is a selenium-containing amino acid. L-Selenocystine has redox properties. L-Selenocystine is cytotoxic to various tumor cells and can induce the production of ROS and apoptosis. L-Selenocystine can block the Nrf2 and autophagy pathways. L-Selenocystine has anti-tumor activity.	Keap1-Nrf2 Autophagy p62 Apoptosis Reactive Oxygen Species (ROS) Caspase Bcl-2 Family Inflammation or Immune System Disease Liver Cancer	2
HY-D1744	ICG Maleimide	ICG Maleimide is thiol reactive near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging (Ex/Em = 789/813 nm).	Fluorescent Dye	2
HY-P99044	Sabatolimab	Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells. Species: Human	Tim3 Inflammation or Immune System Disease Leukemia/Lymphoma/Myeloma Non-Small Cell Lung Cancer	2
HY-P99434	Amlitelimab	Amlitelimab () is an anti-OX40 Ligand (OX40L) monoclonal antibody (mAb). Amlitelimab inhibits OX40-OX40L interaction, and can be used in the research of atopic dermatitis. Species: Human	Others Atopic Dermatitis	2
HY-P7396	PD-1 Protein, Human (HEK293, His)	PD-1 Protein, Human (HEK293, His) suppress activating signals from the T cell receptor when bound by either of its ligands, programmed death-ligand 1 (PD-L1) or PD-L2. Species: Human; Source: HEK293	Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins PD-1	2
HY-P82082	Calmodulin Antibody (YA1827)	Calmodulin Antibody (YA1827) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Calmodulin. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	2
HY-P80445	CaMKII alpha Antibody (YA569)	CaMKII alpha Antibody (YA569) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII alpha. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	2
HY-113308AS	Taurolithocholic acid-d4 sodium	Taurolithocholic acid-d₄ (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.	Isotope-Labeled Compounds Calcium Channel Ferroptosis PI3K Reactive Oxygen Species (ROS) Akt HBV Metabolic or Endocrine Disease	1
HY-W720917	Junicedric acid	Junicedric acid is a diterpenoid compound that can be isolated from the resin of the Araucaria araucana tree. Junicedric acid exerts neuroprotective activity by increasing intracellular calcium levels in hippocampal neurons, activating PKC and calcium/calmodulin-dependent protein kinase (CaMKII), and preventing Amyloid-β oligomer-induced synaptic protein loss, apoptosis, and long-term potentiation (LTP) inhibition. Junicedric acid can be used in the study of the pathological mechanisms of neurodegenerative diseases such as Alzheimer's disease.	CaMK Apoptosis Amyloid-β PKC Alzheimer's Disease	1
HY-W094477D	Magnesium sulfate heptahydrate, for molecular biology	Magnesium sulfate heptahydrate (for molecular biology) is a molecular biology-grade form of Magnesium sulfate (HY-Y1267). Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a uterine contraction inhibitor. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in research on diseases such as preeclampsia/eclampsia.	Environmental Pollutants Interleukin Related Phospholipase COX Calcium Channel Biochemical Assay Reagents NO Synthase NF-κB Inflammation or Immune System Disease Traumatic Brain Injury Spinal Cord Injury Arrhythmias	1
HY-W094475D	Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC	Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC (Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC) is a hydrate of Magnesium sulfate (HY-Y1267) suitable for cell culture. Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a uterine contraction inhibitor. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in research on diseases such as preeclampsia/eclampsia.	COX Calcium Channel NO Synthase NF-κB Interleukin Related Phospholipase Inflammation or Immune System Disease Traumatic Brain Injury Spinal Cord Injury Arrhythmias	1
HY-W094475E	Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard	Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard (Epsom salts (Pharmaceutical primary standard, USP)) is a reference standard for Magnesium sulfate (HY-Y1267). Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia.	Environmental Pollutants Interleukin Related Phospholipase COX Calcium Channel Biochemical Assay Reagents NO Synthase NF-κB Inflammation or Immune System Disease Traumatic Brain Injury Spinal Cord Injury Arrhythmias	1
HY-141567	Pseudouridine 5'-triphosphate	Pseudouridine 5'-triphosphate (Pseudo-UTP) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate can be used for the research of vaccinia virus infection.	DNA/RNA Synthesis Viral Infection	1
HY-N5101	Kobusin	Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel.	CFTR Chloride Channel Neurological, Eye or Ear Disease Inflammation or Immune System Disease	1
HY-122921	5-Galloylquinic acid	5-Galloylquinic acid, an main scavenger of the reactive oxygen species (ROS) in green tea.	Reactive Oxygen Species (ROS) Cancer	1
HY-P9801	Anti-Spike-RBD mAb	Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment.	SARS-CoV SARS-CoV-2 Infection	1
HY-B0469S	Medroxyprogesterone acetate-d3	Medroxyprogesterone acetate-d₃ is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Cancer Metabolic or Endocrine Disease	1
HY-P10387A	RSM3 TFA	RSM3 TFA is a METTL3-METTL14 complex inhibitor with a K_d of 3.10 μM for the METTL3-METTL14 complex. RSM3 TFA reduces the m⁶A modification level of SLC31A1 and the global RNA methylation level. RSM3 TFA upregulates programmed cell death-related genes, enhances cell apoptosis, inhibits pro-cancer signals and suppresses tumor growth. RSM3 TFA is applicable to the research of preeclampsia and cancer.	METTL3 Apoptosis Cancer	1
HY-N6689	Destruxin A	Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections. Source: Metarhizium anisopliae	Insecticide Bacterial Cancer Infection Inflammation or Immune System Disease	1
HY-W250307	Diphenyliodonium iodide	Diphenyliodonium iodide is an inhibitor of reactive oxygen species (ROS). Diphenyliodonium iodide can inhibit the accumulation of bisdemethoxycurcumin in fresh-cut yam by inhibiting the phenylpropanoid pathway and the biosynthesis of bisdemethoxycurcumin, thereby preventing the yellowing of fresh-cut yam. Diphenyliodonium iodide can be used in medicine and fruit preservation.	Reactive Oxygen Species (ROS)	1
HY-N9929	Docosane	Docosane is a plant resistance inducer found in Frullania probosciphora. Docosane induces activation of the salicylic acid signaling pathway. Docosane induces activation of the jasmonic acid signaling pathway. Docosane induces activation of the ethylene signaling pathway. Docosane can be used in research on tomato bacterial wilt and apple fire blight.	Biochemical Assay Reagents Plant Growth Regulators Bacterial	1
HY-P3496	Pep19-2.5	Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis.	Pyroptosis Inflammation or Immune System Disease	1
HY-D1327	Cyanine3 azide chloride	Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λ_ex=684 nm, λ_em=710 nm). Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.	Fluorescent Dye	1
HY-N1471	Liquiritin apioside	Liquiritin apioside is an orally active inhibitor of TRPV1 receptor. Liquiritin apioside selectively inhibits laryngeal chemoreflex (LCR) and has no significant effect on mechanoreflex (LMR). Liquiritin apioside inhibits LCR by inhibiting reactive oxygen species (ROS) and NADPH oxidase, weakening the interaction between ROS and TRPV1. Liquiritin apioside can be used in the research of respiratory-related diseases.	Others Inflammation or Immune System Disease	1
HY-P10387	RSM3	RSM3 is a METTL3-METTL14 complex inhibitor with a K_d of 3.10 μM for the METTL3-METTL14 complex. RSM3 reduces the m⁶A modification level of SLC31A1 and the global RNA methylation level. RSM3 upregulates programmed cell death-related genes, enhances cell apoptosis, inhibits pro-cancer signals and suppresses tumor growth. RSM3 is applicable to the research of preeclampsia and cancer.	METTL3 Apoptosis MDM-2/p53 NF-κB Caspase Cancer	1
HY-N3980	Guaiol	Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC₅₀ of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions^[4]	Autophagy RAD51 Inflammation or Immune System Disease Respiratory Disease Parasitic Infection Cardiovascular Disease Non-Small Cell Lung Cancer	1
HY-Z0478	(-)-Limonene	(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca²⁺) and Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture.	Bacterial Antibiotic CaMK Metabolic or Endocrine Disease Bacterial Infection Cardiovascular Disease Parkinson's Disease	1
HY-B0469R	Medroxyprogesterone acetate (Standard)	Medroxyprogesterone acetate (Standard) is the analytical standard of Medroxyprogesterone acetate. This product is intended for research and analytical applications. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.	Reference Standards Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite Cancer Metabolic or Endocrine Disease	1
HY-D1056H	Lipopolysaccharides, from S. marcescens	Lipopolysaccharides, from S. marcescens (Serratia marcescens) are lipopolysaccharide endotoxins and TLR-4 activators derived from Serratia marcescens, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. marcescens exhibit a typical three-part structure: O-antigen (O-antigen), core oligosaccharide (core oligosaccharide), and lipid A (Lipid A). Lipopolysaccharides, from S. marcescens induce NF-κB activation in mouse cells via Toll-like receptor (TLR4)/MD-2. The lipopolysaccharides of S. marcescens can induce apoptosis in host immune cells, thereby suppressing the host's innate immunity. It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.	Toll-like Receptor (TLR) Inflammation or Immune System Disease	1
HY-162009	CaMKK2-IN-1	CaMKK2-IN-1 is a selective, ligand-efficient inhibitor of CaMKK2, with IC₅₀ of 7 nM.	Calmodulin Cancer	1
HY-Y1267D	Magnesium sulfate, for cell culture	Magnesium sulfate, for cell culture is a bioreagent. Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia.	Environmental Pollutants Interleukin Related Phospholipase COX Calcium Channel Biochemical Assay Reagents NO Synthase NF-κB Neurological, Eye or Ear Disease Inflammation or Immune System Disease Cardiovascular Disease	1
HY-W094475C	Magnesium sulfate heptahydrate, for cell culture	Magnesium sulfate heptahydrate, for cell culture (Epsom salts, for cell culture) is a hydrate of magnesium sulfate (HY-Y1267) suitable for cell culture applications. Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia.	Biochemical Assay Reagents NO Synthase NF-κB Interleukin Related Phospholipase COX Calcium Channel Inflammation or Immune System Disease Traumatic Brain Injury Spinal Cord Injury Arrhythmias	1
HY-W032013	1-Octanol	1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents. 1-Octanol is a highly attractive biofuel with diesel-like properties. Source: Escherichia coli	Endogenous Metabolite Calcium Channel Metabolic or Endocrine Disease Pain Hypertension	1
HY-W286743	Nε-(Carboxymethyl)-L-lysine	Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties.	Polo-like Kinase (PLK) ERK NF-κB Liver Cancer	1
HY-N0229S12	L-Alanine-d3	L-Alanine-d₃ is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.	Endogenous Metabolite Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	1
HY-129434A	4aα,7α,7aα-Nepetalactone	4aα,7α,7aα-Nepetalactone is an iridoid compound, a TRPA1 agonist, a repellent, and an attractant. 4aα,7α,7aα-Nepetalactone can be isolated from the oil of N. crispa. 4aα,7α,7aα-Nepetalactone induces repellent responses in three sap-sucking pests (Chinese psyllid, Asian citrus psyllid, and western flower thrips) via PKCα. Nepetalactone attracts two predatory lady beetles (Harmonia axyridis and Propylea japonica) through CaMKII. 4aα,7α,7aα-Nepetalactone causes mortality in Pogonomyrmex sp. ants. 4aα,7α,7aα-Nepetalactone can be used in studies related to bacterial infections and mandibulate pest infestations.	Insecticide TRP Channel PKC CaMK Bacterial Infection Parasitic Infection	1
HY-P2847	Urocortin II, mouse	Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow.	CRFR Hypertension Heart Failure Obesity	1
HY-N1916	Coniferyl ferulate	Coniferyl ferulate is an orally active phenolic acid compound. Coniferyl ferulate is a potent inhibitor of glutathione S-transferase (GST) (IC₅₀ = 0.3 μM), which downregulates P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance. Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice. Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2. Coniferyl ferulate exhibits antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus.	Glutathione S-transferase P-glycoprotein Apoptosis iGluR CaMK p38 MAPK Reactive Oxygen Species (ROS) Bacterial Lung Cancer Gastric Cancer Depression Cardiovascular Disease Staphylococcus Aureus Infection Bacillus Subtilis Infection Alzheimer's Disease Nonalcoholic Steatohepatitis Lung Fibrosis Ulcerative Colitis Rheumatoid Arthritis	1
HY-P99533	Urabrelimab	Urabrelimab (SRF231) is a fully human anti-CD47 monoclonal antibody that blocks the CD47-SIRP interaction. Species: Human	CD47 Interleukin Related Diffuse Large B-cell Lymphoma Multiple Myeloma	1
HY-F0001R	NADH disodium salt (Standard)	NADH disodium salt (Disodium NADH) Standard is the analytical standard of NADH disodium salt (HY-F0001). This product is intended for research and analytical applications. NADH disodium salt (Disodium NADH) is an orally effective reduced coenzyme. NADH disodium salt plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. NADH disodium salt regulates calcium homeostasis by promoting the opening of IP3-gated Ca²⁺ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. NADH disodium salt is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction.	Reference Standards Endogenous Metabolite Neurodegenerative Disease Cerebrovascular Disease Cellular Senescence	1
HY-B1204S	Histamine-α,α,β,β-d4 dihydrochloride	Histamine-α,α,β,β-d₄ (dihydrochloride) is the deuterium labeled Histamine. Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.	Histamine Receptor Endogenous Metabolite Cancer Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	1
HY-N0704	Agrimol B	Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27.	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial Colorectal Cancer Liver Cancer Bacterial Infection Obesity	1
HY-P99494	Carotuximab	Carotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions. Species: Human	TGF-beta/Smad Prostate Cancer Non-Small Cell Lung Cancer Metastatic Breast Cancer	1
HY-Y0537E	Potassium chloride, for cell culture	Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells.	Environmental Pollutants Biochemical Assay Reagents Potassium Channel Calcium Channel Neurological, Eye or Ear Disease	1
HY-W041892	Dimethyl itaconate	Dimethyl itaconate induces innate immune memory (trained immunity), and exhibits immunomodulatory property. Dimethyl itaconate inhibits the activation of microglia, reduces the neuroinflammation and synaptic structural damage. Dimethyl itaconate regulates the composition of intestinal flora.	Reactive Oxygen Species (ROS) Infection Neurological, Eye or Ear Disease Inflammation or Immune System Disease	1
HY-W250111	Carboxymethyl chitosan	Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma.	Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family Caspase Biochemical Assay Reagents Liver Cancer	1
HY-125771	1-Stearoyl-sn-glycero-3-phosphocholine	1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells. Source: Hirudo nipponica	Endogenous Metabolite HDAC STAT Apoptosis Leukemia/Lymphoma/Myeloma	1
HY-D1840	Tyramide Amplification Buffer	Tyramide Amplification Buffer is a ready-to-use buffer primarily intended for immunostaining of cells and tissues by the technique of tyramide signal amplification (TSA). Tyramide Amplification Buffer enables the reaction between tyramide-labeled antibodies and fluorescently labeled tyramide substitutes (tyramide) using peroxidase, resulting in a highly amplified fluorescent signal. Tyramide Amplification Buffer can be used for signal enhancement in detection methods such as immunofluorescence (IF), immunohistochemistry (IHC), or in situ hybridization (FISH).	Biochemical Assay Reagents	1
HY-P7710	Calmodulin Protein, Human	Calmodulin Protein, Human is a recombinant human Calmodulin expressed in E. coli. Calmodulin is a low molecular weight, acidic, calcium binding protein which mediates the Ca²⁺ regulation of a wide range of physiological processes throughout eukaryotic organisms. Species: Human; Source: E. coli		1
HY-P70639	PD-1 Protein, Mouse (HEK293, Fc)	The PD-1 protein is expressed on antigen-activated T cells and can induce and maintain immune tolerance to itself.PD-1 binds to CD274/PDCD1L1 and CD273/PDCD1LG2, transmits inhibitory signals, inhibits T cell activation and regulates immune responses.PD-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag. Species: Mouse; Source: HEK293	Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins PD-1	1
HY-P73634	SNAP25 Protein, Human (His)	SNAP25 is a key t-SNARE in neurotransmitter release, regulating synaptic function and plasma membrane recycling. It cooperates with CENPF to affect vesicle docking and membrane fusion. SNAP25 Protein, Human (His) is the recombinant human-derived SNAP25 protein, expressed by E. coli , with N-His labeled tag. Species: Human; Source: E. coli		1
HY-P704204	CDKN1A Protein, Mouse (His)	CDKN1A Protein, Mouse (His) is the recombinant mouse-derived CDKN1A protein, expressed by E. coli, with C-6His tag. Species: Mouse; Source: E. coli*	Enzymes & Regulators Cyclin-Dependent Kinase Inhibitor Proteins Cyclin Dependent Kinase Inhibitor 1A (CDKN1A)	1
HY-P73344A	PD-1 Protein, Human (HEK293, hFc)	PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1, Human (HEK293, hFc) is the recombinant human-derived PD-1 protein, expressed by HEK293, with Tag Free labeled tag. Species: Human; Source: HEK293	Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins PD-1	1
HY-P73724	PD-1 Protein, Mouse (HEK293, His-Fc)	PD-1 (programmed cell death 1) protein negatively regulates immune responses and affects processes such as apoptosis and tolerance induction. It is a transmembrane protein found on the outside of the plasma membrane and expressed in the retina. PD-1 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived PD-1 protein, expressed by HEK293 , with C-hFc, C-8His labeled tag. Species: Mouse; Source: HEK293*	Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins PD-1	1
HY-P84930	CaMKII Antibody (YA4627)	CaMKII Antibody (YA4627) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII. Host: Rabbit; Reactivity: Human, Mouse, Rat, Monkey, Pig	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	1
HY-P80006	AIF Antibody (YA636)	AIF Antibody (YA636) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AIF. Host: Rabbit; Reactivity: Human, Mouse	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	1
HY-P84551	CaMKII gamma Antibody (YA4248)	CaMKII gamma Antibody (YA4248) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CAMK2 gamma. Host: Mouse; Reactivity: Human, Mouse, Rat, Monkey, Rabbit	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	1
HY-B0317BS	Amlodipine-d4 besylate	Amlodipine-d₄ (besylate) is the deuterium labeled Amlodipine besylate. Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer.	Isotope-Labeled Compounds Calcium Channel Cancer Blood or Cardio-cerebrovascular Disease	/
HY-P99698	Lesabelimab	Lesabelimab (LDP) is an immunoglobulin G1-kappa anti-CD274 monoclonal antibody. CD274 is an immune checkpoint ligand, represses antitumour immunity through the interaction with PDCD1 receptor. Species: Human	PD-1/PD-L1 Cancer Inflammation or Immune System Disease	/
HY-P99949	Etigilimab	Etigilimab (OMP-313M32), a humanized IgG1 monoclonal antibody, blocks TIGIT interaction with PVR (CD155; poliovirus receptor) and inhibits downstream signalling with target cell killing. Species: Human	Others Cancer	/
HY-132001S1	Ziftomenib-d4	Ziftomenib-d₄ (KO-539-d₄) is the deuterium labeled Ziftomenib (HY-132001). Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities.	Isotope-Labeled Compounds Epigenetic Reader Domain Cancer	/
HY-P4583	Suc-Val-Pro-Phe-SBzl	Suc-Val-Pro-Phe-SBzl (succinyl-valine-proline-phenylalanine thiobenzyl ester) is an inhibitor of CatG enzymes with IC₅₀ values of 111-225 mM.	Cathepsin	/
HY-NP106	Highly purified Type XI collagen, from bovine articular cartilage	Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.	MMP Inflammation or Immune System Disease	/
HY-D0838S1	Dodecyltrimethylammonium-d34bromide	Dodecyltrimethylammonium-d₃₄ (bromide) is the deuterium labeled Dodecyltrimethylammonium (bromide). Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction.	Isotope-Labeled Compounds	/
HY-B1511G	Cyclic AMP (GMP)	Cyclic AMP (GMP) (Cyclic adenosine monophosphate (GMP)) is Cyclic AMP (HY-B1511) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes.	Endogenous Metabolite Cancer Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	/
HY-N0596R	Panaxadiol (Standard)	Panaxadiol (Standard) is the analytical standard of Panaxadiol. This product is intended for research and analytical applications. Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities.	Reference Standards PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT Cancer	/
HY-158104	LPPM-8	LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology.	ATF6	/
HY-P5317	MAQAAEYYR	MAQAAEYYR is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MAQAAEYYR has high DPPH, ABTS radical and ROS-scavenging ability. MAQAAEYYR protects zebrafish larvae from H₂O₂-induced oxidative damage.	Reactive Oxygen Species (ROS) Free Radical Scavengers Inflammation or Immune System Disease	/
HY-N3980R	Guaiol (Standard)	Guaiol (Standard) is the analytical standard of Guaiol. This product is intended for research and analytical applications. Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions[4]	Reference Standards Autophagy RAD51 Infection Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Respiratory Disease Non-Small Cell Lung Cancer	/
HY-N0678R	Icaritin (Standard)	Icaritin (Standard) is the analytical standard of Icaritin. This product is intended for research and analytical applications. Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornuMaxim. and potently inhibits proliferation of K562 cells (IC₅₀ of 8 μM) and primary CML cells (IC₅₀ of 13.4 μM for CML-CP and 18 μM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis[3.	Reference Standards JAK Autophagy Apoptosis Cancer	/
HY-167815	myo-Inositol hexasulfate hexapotassium	Myo-Inositol hexasulfate hexapotassium is a sulfated derivative of inositol that has the activity of mimicking highly sulfated polysaccharides such as heparin, affecting many cell signaling pathways.	Biochemical Assay Reagents	/
HY-W750451	Reptoside	Reptoside, an iridoid glucoside, is a DNA damaging active agent. Reptoside has strong interactions with Trp352 and Tyr335 in AKT1.	Akt Cancer	/
HY-P1614	ZEP-3	ZEP-3 is a tetrapeptide derivative with anti-aging activity for the skin. ZEP-3 can inhibit ROS production and alleviate oxidative stress.	Reactive Oxygen Species (ROS) Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-P5179	Huwentoxin I	Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC₅₀ values of 66.1 and 4.80 nM, respectively.	Calcium Channel Sodium Channel Neurological, Eye or Ear Disease	/
HY-N8859	Isoiridogermanal	Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against MCF-7 and C32 cell lines.	Others	/
HY-P992436	PAS-003	PAS-003 is a humanized monoclonal antibody targerting α5β1 integrin. PAS-003 modulates immune cell migration, immune cell adhesion, improves behavior, and improves survival in ALS mouse models. PAS-003 can be used for the research of amyotrophic lateral sclerosis. Species: Human	Integrin Amyotrophic Lateral Sclerosis	/
HY-P11116	Periplanetasin-2	Periplanetasin-2 is an antifungal peptide that induces oxidative stress through the production of reactive oxygen species (ROS) and lipid peroxidation. Periplanetasin-2 can also induce apoptosis.	Bacterial Apoptosis Reactive Oxygen Species (ROS) Infection	/
HY-B1090S	Cinnarizine-d8	Cinnarizine-d₈ is a deuterium labeled Cinnarizine. Cinnarizine is an antihistamine and a calcium channel blocker.	Calcium Channel Histamine Receptor Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	/
HY-P10316	CaMKI(299-320)	CaMKI (299-320) refers to a peptide consisting of residues 299-320 of Calcium/calmodulin-dependent protein kinase I (CaMKI). CaMKI (299-320), as a protein kinase, has a high affinity interaction with Ca²⁺-CAM (K_d≤1 nM≤1 nM), which can phosphorylate specific substrate proteins, thereby regulating their activity. CaMKI (299-320) contains the CAM-binding domain and the self-inhibition domain, and CaMKI (299-320) can be used to study cell physiological processes, including cell proliferation, differentiation, and apoptosis.	CaMK	/
HY-P10066	Menin-MLL inhibitor 31	Menin-MLL inhibitor 31 (compound 18) is a potent inhibitor of the menin MLL interaction with an IC₅₀ value of 4.6 nM.	Epigenetic Reader Domain Cancer	/
HY-D3000	NIR-RED ROS-H2O2 Probe	NIR-RED ROS-H2O2 Probe is a near-infrared fluorescent probe used for detecting hydrogen peroxide (H₂O₂) and featuring dual-modal fluorescence/photoacoustic imaging capabilities. NIR-RED ROS-H2O2 Probe successfully detects the upregulated fluorescence signal of H₂O₂ in HepG2 cells and a mouse liver injury model. NIR-RED ROS-H2O2 Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI).	Fluorescent Dye Liver Injury	/
HY-50878AS	Crizotinib-d9 hydrochloride	Crizotinib-d₉ hydrochloride is deuterated labeled Crizotinib hydrochloride (HY-50878A). Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition.	c-Met/HGFR ROS Kinase Anaplastic lymphoma kinase (ALK) Autophagy Isotope-Labeled Compounds Cancer	/
HY-B0532AS	Trifluoperazine-d3 dihydrochloride	Trifluoperazine-d₃ (dihydrochloride) is deuterium labeled Trifluoperazine (dihydrochloride). Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis.	Isotope-Labeled Compounds Dopamine Receptor Adrenergic Receptor CaMK P-glycoprotein Influenza Virus Autophagy Cancer Neurological, Eye or Ear Disease	/
HY-P6013	wt hMLN	wt hMLN is a microprotein that inhibits of SR Ca²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis.	Calcium Channel	/
HY-P3065	Calcicludine	Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated calcium channel, especially L-type calcium channel. Source: Ceratogyrus cornuatus	Calcium Channel Neurological, Eye or Ear Disease	/
HY-W717950	Pseudomonas quinolone signal-d4	Pseudomonas quinolone signal-d4 is a stable isotope internal standard.	Isotope-Labeled Compounds	/
HY-P10779	flg22Pst	flg22Pst is a peptide that can be derived Pseudomonas syringae pv. tabaci and serves as an effective elicitor for the plant immune system. flg22Pst can induce callose deposition in plants, trigger plant immune responses, and thereby assist plants in defending against pathogen invasion.	Bacterial Inflammation or Immune System Disease	/
HY-P992369	HMBD-002	HMBD-002 is an Fc-independent, non-depleting IgG4 subclass antibody that targets VISTA and VSIG3. It is widely used in research related to various solid tumors, including colon cancer, triple-negative breast cancer, and non-small cell lung cancer. HMBD-002 blocks the interactions of VISTA with VSIG3 and LRIG1, relieves immunosuppression without depleting VISTA-positive cells, activates the cytotoxic program of CD8⁺ T cells, and drives the type I interferon signaling pathway. HMBD-002 reprograms tumor-associated macrophages to the M1 phenotype, reduces tumor infiltration of inhibitory myeloid cells, thereby significantly inhibiting tumor growth and improving survival. HMBD-002 is well tolerated in rodent and non-human primate animal models. Species: Human	VISTA Cancer	/
HY-P5436	SK-MLCK M13	SK-MLCK M13 is a biological active peptide. (M-13 is a peptide that represents CAM-binding domain of Calmodulin (CaM) target proteins. CaM is an ubiquitous Ca2+ binding protein.)	Others	/
HY-N18018	Tetrahydroswertianolin	Tetrahydroswertianolin (Compound 1) is a tetrahydroxyxanthone glycoside that can be isolated from the whole plant of Swertia japonica Makino. Tetrahydroswertianolin reduces the elevated blood ALT levels in mice with immune-induced liver injury and exhibits protective activity against liver injury. Tetrahydroswertianolin can be used in studies related to anthelmintic, antipyretic and immune-induced liver injury.	Drug Derivative Inflammation or Immune System Disease Liver Injury	/
HY-N9826	Icterogenin	Icterogenin is a selective inhibitor targeting the Bcl-XL/Bak BH3 domain peptide interaction and exhibits anti-leukemic activity. Icterogenin regulates protein interactions and affects tumor cell survival. Icterogenin is an oleanane-type triterpenoid compound that can be isolated from Lantana camara and is useful in the field of anti-tumor drug development.	Bcl-2 Family Leukemia/Lymphoma/Myeloma	/
HY-170424	D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium	D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium increases the extracellular Ca²⁺ entry through upregulation of voltage-gated calcium channels.	Biochemical Assay Reagents	/
HY-P5813	Cd1a	Cd1a is a β-toxin derived from the African spider Ceratogyrus darlingi. Cd1a can regulate calcium ion channels. Cd1a inhibits human calcium ion channels (Ca_v2.2)(IC₅₀2.6 μM) and mouse sodium ion channels (Na_v1.7). Cd1a can be used in the development of peripheral pain treatment drugs .	Calcium Channel Neurological, Eye or Ear Disease	/
HY-NP111	Highly purified Type V collagen, from mouse intestine	Highly purified Type V collagen, from mouse intestine (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse intestine, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.	MMP Inflammation or Immune System Disease	/
HY-P992253	Anti-L1-CAM Antibody	Anti-L1-CAM Antibody is a monoclonal antibody that targets L1-CAM. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-L1-CAM Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001). Species: Human	Transmembrane Glycoprotein Inflammation or Immune System Disease	/
HY-N21842	Vincapusine	Vincapusine is an inhibitor of CaV3.1 calcium channel, with a IC₅₀ of 11.83 μM against the human target. Vincapusine suppresses the functional activity of the CaV3.1 calcium channel. Vincapusine exerts antihypertensive activity by inhibiting the CaV3.1 calcium channel. Vincapusine is used in hypertension-related research.	Calcium Channel Hypertension	/
HY-P5109	Minigastrin	Minigastrin is an acidic peptide. Minigastrin can be used to study peptidepeptide interaction.	Cholecystokinin Receptor	/
HY-P10496	MAGE-A1-derived peptide	MAGE-A1-derived peptide is a short peptide sequence derived from MAGE-A1 protein. As a tumor-specific antigen, MAGE-A1-derived peptide can be recognized and activated by cytotoxic T lymphocytes (CTLs), thereby generating an immune response to tumor cells expressing MAGE-A1. This immune response can lead to the lysis and death of tumor cells. MAGE-A1-derived peptide can be used in the study of tumor immunity.	Others Cancer	/
HY-N12106	Neosartoricin	Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri. Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC₅₀ of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence. Source: Aspergillus fumigatus	Endogenous Metabolite Fungal Infection	/
HY-136513S	Bifenox-d3	Bifenox-d₃ is the deuterium labeled Bifenox. Bifenox (MC-4379) is a nitrophenyl ether herbicide. Bifenox disrupts cellular membrane, inhibits photosynthesis and inhibits the protoporphyrinogen oxidase. Bifenox increases the ROS production in the microalgae Chlamydomonas reinhardtii.	Isotope-Labeled Compounds Herbicide Protoporphyrinogen IX oxidase Reactive Oxygen Species (ROS)	/
HY-NP0230	Bovine calmodulin	Bovine calmodulin can be used for the in vitro phosphorylation assay of recombinant retinoic acid-induced gene I protein. Bovine calmodulin has also been used in studies of the hydrolysis and deamidation of the endopeptide Glu-C protein.	Calmodulin	/
HY-P1184	HNGF6A	HNGF6A is a humanin analogue. HNGF6A increases glucose-stimulated insulin secretion and glucose metabolism, and has the potential for diabetes research. HNGF6A inhibits of ROS production during oxidative stress. HNGF6A can prevent endothelial dysfunction and atherosclerosis in vivo.	Reactive Oxygen Species (ROS) Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	/
HY-170220	PacFA Ceramide	PacFA Ceramide is a 15-carbon long photoactivatable and clickable fatty acid. PacFA Ceramide can be used for the analysis of protein-lipid interactions in living cells.	Biochemical Assay Reagents Metabolic or Endocrine Disease	/
HY-P991541	HGS101	HGS101 is a fully human CCR5 monoclonal antibody with high affinity to CCR5. HGS101 binds to the 2nd extracellular loop (ECL-2) and acts as a signal antagonist. HGS101 restores Maraviroc (HY-13004) inhibition of Maraviroc-resistant HIV-1 infection of PBMCs. HGS101 shows anti-HIV activity by inhibiting CCR5 signaling in simian immunodeficiency virus-uninfected RMs models. Species: Human	CCR HIV Infection	/
HY-B1214S	Prednisolone acetate-d8	Prednisolone acetate-d₈ is the deuterium labeled Prednisolone acetate. Prednisolone acetate (Prednisolone 21-acetate) is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.	Isotope-Labeled Compounds Glucocorticoid Receptor Cancer Inflammation or Immune System Disease	/
HY-P10950	PD-L1 inhibitory peptide	PD-L1 inhibitory peptide is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide is promising for research of cancers.	PD-1/PD-L1 Cancer Inflammation or Immune System Disease	/
HY-P2005	Malformin C	Malformin C is an algicidal peptide can be isolated from Aspergillus and exhibits dose-dependent algicidal activity. Malformin C induces a significant increase in ROS levels in algal cells, resulting in impaired SOD activity and high production of MDA content. Source: Aspergillus sp	Reactive Oxygen Species (ROS) SOD	/
HY-W777002	Famotidine-13C3	Famotidine-¹³C₃ (MK-208-¹³C₃) is the ¹³C₃-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.	Isotope-Labeled Compounds Histamine Receptor MMP Toll-like Receptor (TLR) ERK Coronavirus Infection Pneumonia Gastric Ulcer Liver Injury	/
HY-N21835	Partricin	Partricin is an aromatic heptaene macrolide antibiotic complex consisting of partricin A and B, an antifungal agent found in Streptomyces aureofaciens. Partricin exhibits antifungal activity. Partricin has poor selective toxicity in the pathogen/host system. Partricin can be used for the research of fungal infections. Source: Streptomyces aureofaciens	Antibiotic Fungal Fungal Infection	/
HY-D1595	BODIPY FL Cholesterol	BODIPY FL Cholesterol is a green fluorescent, lipophilic probe. BODIPY FL Cholesterol can be used for the research of lipid transport processes and lipid-protein interactions.	Fluorescent Dye	/
HY-N20550	Haliotidis concha extract	Haliotidis concha extract (Abalone shell extract) is an extract of the shell of Haliotis concha that can regulate ion calcium channels and calcium-ATPase.	Calcium Channel	/
HY-P10469	NBD-2	NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc.	NF-κB Cancer Inflammation or Immune System Disease	/
HY-N21624	Pleioside A	Pleioside A is a flavonoid glycoside with immunomodulatory activity that is found in the leaves of Pleioblastus amarus. Pleioside A exerts differential regulatory effects on adaptive immune lymphocyte proliferation by inhibiting mouse T cell proliferation and promoting B lymphocyte proliferation. Pleioside A can be used for research on adaptive immunity and immunomodulation.	Biochemical Assay Reagents Immunomodulation	/
HY-13764A	dl-Tetrandrine	dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca²⁺ influx with an IC₅₀ value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal.	Calcium Channel Cancer Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease	/
HY-W707517	Famotidine-d4	Famotidine-d₄ (MK-208-d₄) is the deuterated-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.	Isotope-Labeled Compounds Histamine Receptor MMP Toll-like Receptor (TLR) ERK Coronavirus Infection Pneumonia Gastric Ulcer Liver Injury	/
HY-W728503S	N-Nitroso Vonoprazan-13C,d3	N-Nitroso Vonoprazan-sup>13C,d₃ is the sup>13C- and deuterium labeled N-Nitroso Vonoprazan. N-Nitroso Vonoprazan is an impurity of Vonoprazan.	Isotope-Labeled Compounds Infection	/
HY-N10198	Acremonidin A	Acremonidin A is a potent calmodulin (CaM) inhibitor found in Purpureocillium lilacinum. Acremonidin A binds to the human calmodulin (hCaM) biosensor hCaM M124C-mBBr, with K_d of 19.40 nM. Source: filamentous fungi	Endogenous Metabolite Calmodulin Blood or Cardio-cerebrovascular Disease	/
HY-D2925	dTCOBG	dTCOBG (dTCO-SNAP) is a SNAP-tag reactive benzylguanine (BG) analogue specifically designed for the specific labeling of immune cells. dTCOBG forms a stable thioether bond through the cysteine at the active site of SNAP-tag and O6-benzylguanine, resulting in a covalent linkage. dTCOBG demonstrates unique advantages in the labeling of macrophages derived from ER-HoxB8: it only labels SNAP-tag + macrophages, with no background signal in the control group. dTCOBG can be used for click chemistry labeling.	Biochemical Assay Reagents	/
HY-B0166E	L-Ascorbic acid magnesium	L-Ascorbic acid (L-Ascorbate) magnesium, an electron donor, is an endogenous antioxidant. L-Ascorbic acid selectively inhibits Cav3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition promoter and elastin production inhibitor. L-Ascorbic acid exhibits anticancer effects by generating reactive oxygen species (ROS) and selectively damaging cancer cells.	Reactive Oxygen Species (ROS) Calcium Channel Apoptosis Endogenous Metabolite Cancer Neurological, Eye or Ear Disease	/
HY-P1479	Calmodulin-Dependent Protein Kinase II (290-309)	Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC₅₀ of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.	Autophagy CaMK Neurological, Eye or Ear Disease	/
HY-P991305	AGEN-1571	AGEN-1571 is a human IgG1 monoclonal antibody (mAb) targeting ILT2. AGEN-1571 promotes adaptive and innate immune responses. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) Species: Human	Transmembrane Glycoprotein Cancer	/
HY-16129A	CBP-501 acetate	CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser²¹⁶-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer.	Calmodulin MAP3K MAPKAPK2 (MK2) Checkpoint Kinase (Chk) Cancer	/
HY-P2291	Beta-defensin 103 isoform X1, pig	Beta-defensin 103 isoform X1, pig is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens.	Bacterial Inflammation or Immune System Disease	/
HY-178411S	Dodecyltrimethylammonium-d9 bromide	Dodecyltrimethylammonium-d₉ bromide is the deuterium labeled Dodecyltrimethylammonium bromide (HY-D0838). Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction.	Isotope-Labeled Compounds Biochemical Assay Reagents	/
HY-157926	Nitroso-PSAP	Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe²⁺), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe²⁺) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >).	Biochemical Assay Reagents	/
HY-N8824	Maackiaflavanone	Maackiaflavanone (compound 4) is a kind of prenylated flavanone. Maackia can be isolated from M. amurensi.	Others	/
HY-B0162S	Ivabradine-d6	Ivabradine-d₆ is the deuterium labeled Ivabradine. Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity.	Isotope-Labeled Compounds HCN Channel Blood or Cardio-cerebrovascular Disease	/
HY-N21792	4-Hydroxy-3,3',5-trimethoxybibenzyl	4-Hydroxy-3,3',5-trimethoxybibenzyl is a synthetic bibenzyl analog with spasmolytic activity. It inhibits spontaneous contractions of isolated guinea pig ileum. In the presence of Ca²⁺, 4-Hydroxy-3,3',5-trimethoxybibenzyl also alters the electrophoretic mobility of bovine brain calmodulin (calmodulin), supporting its interaction with CaM. It can be used in studies of smooth muscle contraction and calmodulin-related processes.	Calmodulin	/
HY-N8724	Lamalbid	Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation.	ROS Kinase	/
HY-W874904	C.I. Solvent Yellow 33	C.I. Solvent Yellow 33 is a nontoxic yellow dye that can be used in industrial and several Navy signaling devices.	Biochemical Assay Reagents	/
HY-12515AS2	Nicardipine-d4 hydrochloride	Nicardipine-d₄ hydrochloride is deuterated labeled Nicardipine hydrochloride (HY-12515A). Nicardipine hydrochloride (YC-93) is a calcium channel blocker with an IC₅₀ of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure.	Autophagy Calcium Channel Isotope-Labeled Compounds Cancer Neurological, Eye or Ear Disease	/
HY-P3151A	Gliadin p31-43 TFA	Gliadin p31-43 TFA is an undigested gliadin peptide. Gliadin p31-43 TFA induces an innate immune response in the intestine and interferes with endocytic trafficking. Gliadin p31-43 TFA can be used for celiac disease research.	Biochemical Assay Reagents Inflammation or Immune System Disease	/
HY-P992451	RLYB331	RLYB331 (KY1066) is a is a monoclonal antibody targeting Matriptase-2 (TMPRSS6). RLYB331 binds to the serine protease active site of matriptase-2, blocking protease activity to increase hepcidin expression. RLYB331 reduces iron overload, inhibits α-aggregates, reduces ROS, inhibits apoptosis, and enhances erythroid differentiation. RLYB331 ameliorates ineffective erythropoiesis in β-thalassemic mouse models. RLYB331 can be used for the research of β-thalassemia. Species: Human	Ser/Thr Protease Hepcidin Reactive Oxygen Species (ROS) Apoptosis Anemia	/
HY-N20679	Aequinetin	Aequinetin is a tyrosinase inhibitor, and docking results show that it forms hydrogen bonds and hydrophobic interactions with key protein residues of NF-κB p65, MAPK10 and ERK1.	Drug Derivative Tyrosinase	/
HY-NP124	Highly purified Type III collagen, from porcine skin	Highly purified Type III collagen, from porcine skin (Porcine Type III collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.	MMP Inflammation or Immune System Disease	/
HY-B0469S1	Medroxyprogesterone acetate-d7	Medroxyprogesterone acetate-d₇ (Medroxyprogesterone 17-acetate-d₇) is the deuterium labeled Medroxyprogesterone acetate (HY-B0469) . Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.	Isotope-Labeled Compounds Progesterone Receptor Glucocorticoid Receptor Androgen Receptor Endogenous Metabolite Cancer Metabolic or Endocrine Disease	/
HY-P1363S1	β-Amyloid (1-42), human, Ala(13C3,15N) TFA	β-Amyloid (1-42), human, Ala(¹³C₃,¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death.	Isotope-Labeled Compounds Amyloid-β Neurological, Eye or Ear Disease	/
HY-N0465S	Olaquindox-d4	Olaquindox-d₄ is the deuterium labeled Olaquindox (HY-N0465). Olaquindox, a quinoxalin derivative, is an orally active antibiotic. Olaquindox stimulates growth and decreases intestinal mucosal immunity of piglets.	Isotope-Labeled Compounds Antibiotic Bacterial	/
HY-P10370	d-(KLAKLAK)2, Proapoptotic Peptide	d-(KLAKLAK)2, as an antibacterial and anti-tumor polypeptide, is a representative of the antimicrobial peptide group, and also has good anticancer properties. d-(KLAKLAK)2 is able to kill bacteria by damaging their cell membranes, causing cell contents to leak out. d-(KLAKLAK)2 can also inhibit tumor cell proliferation by causing mitochondrial swelling and mitochondrial membrane destruction, triggering apoptosis (programmed cell death).	Bacterial Apoptosis Cancer	/
HY-B2221S4	U-13C Cellulose high DP from maize (high purity)	U-sup>13C Cellulose high DP from maize (high purity) is the ¹³C labeled Cellulose.	Endogenous Metabolite Isotope-Labeled Compounds	/
HY-W014531S	2,6-Dichloro-4-nitrophenol-13C6	2,6-Dichloro-4-nitrophenol-sup>13C₆ is the ¹³C-labeled 2,6-Dichloro-4-nitrophenol.	Isotope-Labeled Compounds	/
HY-P1281	Kaliotoxin	Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability.	Potassium Channel Neurological, Eye or Ear Disease	/
HY-D2266	FluoBar1	FluoBar1 is an imaging fluorescence probe modified by a barbiturate ligand with fluorescent coumarin. FluoBar1 can monitor L-type voltage-gated calcium channels (LTCC) in living cells in real time for the study of neurological diseases .	Fluorescent Dye Neurological, Eye or Ear Disease	/
HY-112526	Thiofluor 623	Thiofluor 623 (Compound 3) is a fluorescent turn-on probe that can be used for the selective sensing and bioimaging of thiols. Thiofluor 623 displays excellent immunity to interference from nitrogen and oxygen nucleophiles. Thiofluor 623 is essentially nonfluorescent in the absence of thiols, which cleave the probe and release the red-emissive donor-acceptor fluorophore (Ex=563 nm, Em=623 nm).	Fluorescent Dye	/
HY-113308AS2	Taurolithocholic acid-d4-1 sodium	Taurolithocholic acid-d₄-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.	Isotope-Labeled Compounds Calcium Channel Ferroptosis PI3K Reactive Oxygen Species (ROS) Akt HBV Metabolic or Endocrine Disease	/
HY-D0330	Mordant black 17	Mordant black 17 (Sunchromine blue black R) is a versatile chelating agent, demonstrating significant adsorptive properties through its interaction with metal ions, enhancing the efficiency of polymeric materials in various applications.	Biochemical Assay Reagents	/
HY-P5525	AC3-I, myristoylated	AC3-I, myristoylated is a biological active peptide. (This is a myristoylated form of Autocamtide-3-Derived Inhibitory Peptide (AC3-I), a highly specific inhibitor of Calmodulin-Dependent Protein Kinase ll (CaMKII) that is resistant to proteolysis. AC3-I is derived from Autocamtide-3, a substrate for CaMKII, with the Thr-9 phosphorylation site substituted with Ala.)	CaMK	/
HY-W778179	Benoxaprofen-13C,d3	Benoxaprofen-¹³C, d₃ is the ¹³C-labeled Benoxaprofen (HY-13568). Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms.	Isotope-Labeled Compounds COX Cytochrome P450 Lipoxygenase PGE synthase Inflammation or Immune System Disease	/
HY-142087	Beauverolide Ja	Beauverolide Ja, a cyclotetradepsipeptide, is a potent calmodulin (CaM) inhibitor with a K_d of 0.078 μM and a K_i of 0.39 μM for Ca²⁺-CaM. Beauverolide Ja is a secondary metabolite of Isaria fumosorosea. Source: Beauveria sp.	Calmodulin Endogenous Metabolite Neurological, Eye or Ear Disease	/
HY-W015346S	Desaminotyrosine-d8	Desaminotyrosine-d₈ (3-(4-Hydroxyphenyl)propionic acid-d₈) is the deuterium labeled Desaminotyrosine (HY-W015346). Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.	Isotope-Labeled Compounds Endogenous Metabolite Influenza Virus Influenza Virus Infection	/
HY-126675G	AS2863619 (GMP)	AS2863619 GMP is AS2863619 (HY-126675) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS2863619 is an orally active CDK8/19 inhibitor that also inhibits BMP2, MDA5 and RIG-I receptors. AS2863619 targets Stat5a-CDK8/19 to promote the differentiation of CD4⁺ T cells into regulatory T cells and induce FOXP3 expression, thereby restoring immune homeostasis and establishing transplant immune tolerance. AS2863619 also enhances the BMP2/SMAD signaling pathway to promote osteogenic differentiation and inhibit adipogenic differentiation. AS2863619 exerts osteoprotective effects by alleviating inflammation-induced impairment of osteogenic function and inducing neutrophil apoptosis (apoptosis). AS2863619 can be applied to research in related fields such as periodontitis-induced bone defects.	CDK Apoptosis TGF-beta/Smad STAT Periodontal Disease	/
HY-P10071	CaMKII inhibitory peptide KIIN	CaMKII inhibitory peptide KIIN is a potent inhibitor of CaMKII.	CaMK	/
HY-N12411	(S)-O-Methylencecalinol	(S)-O-Methylencecalinol (compound 10) is a calmodulin-targeting molecule isolated from the aerial parts of Ageratina grandifolia.	Calmodulin	/
HY-D0838S	Dodecyltrimethylammonium-d25 bromide	Dodecyltrimethylammonium-d₂₅ (bromide) is the deuterium labeled Dodecyltrimethylammonium (bromide). Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction.	Isotope-Labeled Compounds	/
HY-P10682	PuroA	PuroA is a tryptophan-rich domain of Puroindoline a that exerts antibacterial activity through interaction with bacterial membranes.	Bacterial Infection	/
HY-167814	Trimethylsilyl-D-(+)-mannitol	Trimethylsilyl-D-(+)-mannitol is a compound with osmoprotective activity that can effectively scavenge reactive oxygen species (ROS) and provide protection for plants and microorganisms.	Biochemical Assay Reagents	/
HY-143712S1	Allolithocholic Acid-d4	Allolithocholic Acid-d₄ (3α-hydoxy-5α-Cholaoic Acid-d₄, allo-LCA-d₄) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC₅₀ = 2.7 μM) and RORγt inverse agonist (IC₅₀ = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease.	Isotope-Labeled Compounds Drug Metabolite G protein-coupled Bile Acid Receptor 1 ROR Cancer Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-113308S	Taurolithocholic acid-d5	Taurolithocholic acid-d₅ is deuterium labeled Taurolithocholic acid. Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.	Isotope-Labeled Compounds Calcium Channel Ferroptosis PI3K Reactive Oxygen Species (ROS) Akt HBV	/
HY-B1978S	Iprodione-d5	Iprodione-d₅ is the deuterium labeled Iprodione. Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective.	Fungal Reactive Oxygen Species (ROS) Infection	/
HY-P11226	TI-16	TI-16 is a peptide that targets β-amyloid (Aβ) protein. TI-16 can cross the blood-brain barrier. TI-16 can increase the concentration of intracellular free CaM, thereby restoring calcium ion homeostasis and reducing Aβ toxicity. TI-16 can reduce the deposition of Aβ in the brain, improve neuronal pathology, inhibit cell apoptosis, and improve cognitive function in mice. TI-16 is commonly used in the study of Alzheimer's disease.	Amyloid-β CaMK Apoptosis Neurological, Eye or Ear Disease	/
HY-E70178	Protein O-Glucosyltransferase 1	Protein O-Glucosyltransferase 1 is a glucosyltransferase. Protein O-Glucosyltransferase 1 modifies Notch signaling by adding glucose to serine residues in Notch.	Glucosylceramide Synthase (GCS)	/
HY-N12405	Encecalinol	Encecalinol, extracted from aerial parts of Ageratina grandifolia, is a potent inhibitor of calmodulin inhibitor.	Calmodulin	/
HY-N20375	Cockroach extract	Cockroach extract (Black beetle extract) is a cockroach extract used for allergy diagnosis and cockroach-specific immunity research.	Others Inflammation or Immune System Disease	/
HY-W011683S2	2'-Deoxyadenosine monohydrate-3′-13C	2'-Deoxyadenosine monohydrate-3′-¹³C is the ¹³C labeled 2'-Deoxyadenosine monohydrate (HY-W011683)^{adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer>}	Isotope-Labeled Compounds Endogenous Metabolite Nucleoside Antimetabolite/Analog Caspase Apoptosis Metabolic or Endocrine Disease	/
HY-N0486S13	L-Leucine-15N,d10	L-Leucine-¹⁵N,d₁₀ is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.	mTOR Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-Y1754	2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid	2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid (TOAC) is a compound with the ability to probe conformational changes, folding processes and interactions of peptides and proteins. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid is often used in relevant biological research to gain a deeper understanding of the behavior and function of biomacromolecules. 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid plays an important role in analyzing the interactions and dynamic responses of biological systems.	Biochemical Assay Reagents	/
HY-W286743S1	CML-d3	CML-d₃ is the deuterium labeled CML.	Isotope-Labeled Compounds	/
HY-P1078	Huwentoxin XVI	Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC₅₀ of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels.	Calcium Channel Neurological, Eye or Ear Disease	/
HY-NP107	Highly purified Type I collagen, from rat skin	Highly purified Type I collagen, from rat skin (Rat Type I collagen, immunization grade) is an immune grade collagen derived from rat skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.	MMP Inflammation or Immune System Disease	/
HY-W769991	Lactate sodium-13C2	Lactic acid-¹³C₂ (DL-Lactic acid-¹³C₂) sodium is the ¹³C-labeled Lactic acid sodium . Lactic acid (DL-Lactic acid) sodium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity. Lactic acid sodium also has antimicrobial activity, which can be used as a food preservative.	Isotope-Labeled Compounds Bacterial Hydroxycarboxylic Acid Receptor (HCAR) Endogenous Metabolite Cancer	/
HY-P2710	Noxiustoxin	Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC₅₀ = 360 nM), and calcium-activated potassium channel. Noxiustoxin plays an important role in neuroinflammatory disease.	Potassium Channel Neurological, Eye or Ear Disease Inflammation or Immune System Disease	/
HY-DY1068	Cyanine5 DBCO hexafluorophosphate (solution)	Cyanine5 DBCO (DBCO-Cy5) hexafluorophosphate (solution) is a low-toxicity azide reactive probe (NIR fluorescent dye) , for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO hexafluorophosphate has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO hexafluorophosphate can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) . Solvent and concentration: DMSO: 10 mM	Fluorescent Dye	/
HY-P991590	1D09C3	1D09C3 is a fully human anti-HLA-DR monoclonal antibody. 1D09C3 induces apoptosis and cell death involving a cascade of events, including ROS generation, JNK activation, mitochondrial membrane depolarization, and AIF release from mitochondria. 1D09C3 shows potent anti-tumor activity and increases overall survival and median survival in JVM-2 cells and GRANTA-519 cells xenograft mice models. 1D09C3 can be used for the researches of cancer, such as chronic lymphocytic leukemia (CLL). Species: Human	MHC Apoptosis JNK Reactive Oxygen Species (ROS) Cancer	/
HY-W074977S	2,6-Dibromo-4-nitrophenol-13C6	2,6-Dibromo-4-nitrophenol-sup>13C₆ is the ¹³C-labeled 2,6-Dibromo-4-nitrophenol.	Isotope-Labeled Compounds	/
HY-D3181	CyGbPF	CyGbPF is a granzyme B-specific near-infrared fluorescent probe. CyGbPF can be cleaved by granzyme B to remove the peptide cage group, restoring near-infrared fluorescence. CyGbPF passively accumulates in mouse tumors, and its activated fluorescence correlates with granzyme B expression, CD8⁺cytotoxic T lymphocyte populations, and CD4⁺helper T lymphocyte populations in tumor tissues. CyGbPF is efficiently cleared by the kidneys, enabling the assessment of immune activation via optical urine analysis. CyGbPF allows real-time non-invasive evaluation of cancer immunotherapeutic efficacy in living animals. CyGbPF can be used in research on cancers such as breast cancer. Excitation wavelength/emission wavelength: approximately 658 nm/approximately 717 nm.	Fluorescent Dye Caspase Breast Cancer	/
HY-P2269	MAIT-203	MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a K_i of 0.015 μM and a K_d of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.	Drug Derivative Cancer	/
HY-N8930	Eupatorin-5-methyl ether	Eupatorin-5-methyl ether (TMF) can be isolated from Orthosiphon stamineus. Eupatorin-5-methyl ether is a kind of flavonoid compound. Eupatorin-5-methyl ether inhibits NO production (IC50 5.5 μM).	Others	/
HY-W777434	Mitiglinide calcium hydrate-d8	Mitiglinide (calcium hydrate)-d₈ is the deuterium labeled Mitiglinide (calcium hydrate) (HY-B0682A). Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes.	Isotope-Labeled Compounds Potassium Channel Metabolic or Endocrine Disease	/
HY-P2061	Leualacin	Leualacin, a calcium channel blocker, can be isolated from the fungus Hapsidospora irregularis.	Calcium Channel Blood or Cardio-cerebrovascular Disease	/
HY-P991432	VTX-0811	VTX-0811 is a human IgG4 monoclonal antibody (mAb) targeting PSGL1/CD162. VTX-0811 up-regulates TNF-α/NF-κB and chemokine-mediated signaling and down-regulates oxidative phosphorylation, fatty acid metabolism, and Myc signaling pathways. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells. VTX-0811 has antitumor activity in a humanized mouse PDX model of melanoma. Species: Human	TNF Receptor NF-κB c-Myc Cancer	/
HY-B0317AS1	Amlodipine-d9 maleate	Amlodipine-d₉ maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.	Calcium Channel Isotope-Labeled Compounds Cancer Blood or Cardio-cerebrovascular Disease	/
HY-W127485	cis-9,10-Methyleneoctadecanoic Acid	cis-9,10-Methyleneoctadecanoic acid is a cyclopropane fatty acid that has been found in bacteria and in the digestive glands of P. globosa. It is a component of the cell membrane of Staphylococcus aureus, and levels were reduced after treatment with carvacrol. cis-9,10-Methyleneoctadecanoic acid is secreted by H. pylori and enhances histamine- and dibutyryl cAMP-stimulated acid secretion in isolated guinea pig parietal cells. It also activates protein kinase C (PKC) in a calcium-dependent manner.	Biochemical Assay Reagents Helicobacter Pylori Infection	/
HY-P5319	MCaE12A	MCaE12A is a high-affinity modulator of RyR2 and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell.	Calcium Channel	/
HY-D1740	Dihydrotetramethylrosamine	Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.	Fluorescent Dye	/
HY-D2204	SHP1-IN-1	SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe³⁺ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM).	Phosphatase SHP1 Fluorescent Dye Cancer	/
HY-P5340	Amyloid-Forming peptide GNNQQNY	Amyloid-Forming peptide GNNQQNY is a biological active peptide. (This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.)	Others	/
HY-D3168	PCL-2	PCL-2 is a reactive oxygen species (ROS)-responsive fluorescent probe. PCL-2 reacts with ROS to release 6-hydroxy-2-cyanobenzothiazole (HCBT), which then reacts with D-cysteine to form firefly luciferin in situ. PCL-2 must be used in conjunction with IETDC (HY-D3169) to detect the co-existence of hydrogen peroxide and caspase 8. PCL-2 is applicable to studies related to acute inflammation.	Fluorescent Dye Reactive Oxygen Species (ROS) Inflammation or Immune System Disease	/
HY-P10178	Myristoylated ARF6 (2-13)	Myristoylated ARF6 (2-13) blocks MyD88–ARNO–ARF6–signaling axis by deactivating ARF6.	Arf Family GTPase MyD88 Inflammation or Immune System Disease	/
HY-NP208	Myelin Basic Protein (Porcine)	Myelin Basic Protein (Porcine), the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. Myelin Basic Protein (Porcine) mediates interactions with actin and tubulin and effect of post-translational modifications.	Arp2/3 Complex Microtubule/Tubulin Neurological, Eye or Ear Disease	/
HY-42360G	SMCC (GMP)	SMCC (GMP) is the GMP level of SMCC (HY-42360). GMP guidelines are used to produce SMCC (HY-42360) (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. SMCC (GMP) is a protein crosslinker. SMCC (GMP) contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.	ADC Linkers Cancer Inflammation or Immune System Disease	/
HY-N20519	Kelp extract	Kelp extract is a kelp (Laminariales) extract that can inhibit the production of reactive oxygen species (ROS).	Others Antioxidant Agent	/
HY-P992351	ELB021	ELB021 is an antibody inhibitor targeting the CD160 checkpoint. ELB021 specifically binds to CD160 on the cell surface and blocks its immune checkpoint pathway, thereby stimulating innate and adaptive anti-tumor immune responses. ELB021 effectively eliminates CD160-expressing cancer cells by enhancing T cell proliferation and CD8⁺ T cell-mediated cytotoxicity. Independent of PD-1 regulation, ELB021 is applicable to research related to B-cell leukemia and HIV-1 infection. Species: Human	Others Leukemia/Lymphoma/Myeloma HIV-1 Infection	/
HY-P1078A	Huwentoxin XVI TFA	Huwentoxin XVI TFA, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC₅₀ of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI TFA has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels.	Calcium Channel Neurological, Eye or Ear Disease	/
HY-E70172	Heparan Sulfate 3-O-Sulfotransferase 4	Heparan Sulfate 3-O-Sulfotransferase 4 is a sulfotransferase. Heparan Sulfate 3-O-Sulfotransferase 4 regulates Notch signaling.	Notch Neurological, Eye or Ear Disease	/
HY-B0377S	Famotidine-13C,d3	Famotidine-¹³C,d₃ (MK-208-¹³C,d₃) is the deuterated, ¹³C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.	Isotope-Labeled Compounds Histamine Receptor MMP Toll-like Receptor (TLR) ERK Coronavirus Infection Pneumonia Gastric Ulcer Liver Injury	/
HY-P4628	TPNQRQNVC	TPNQRQNVC is a nonapeptide and is the epitope of HLA-B0702. TPNQRQNVC induces a CD8+ T cell immune response.	Others Inflammation or Immune System Disease	/
HY-P992448	RC98	RC98 is a monoclonal antibody targeting programmed cell death ligand 1 (PD-L1) and acts as a selective PD-L1 inhibitor. RC98 binds specifically to human and cynomolgus monkey PD-L1. RC98 blocks the interaction between PD-L1 and its receptor PD-1 to reverse T-cell inactivation mediated by PD-1/PD-L1 signaling. RC98 enhances the cytotoxic T-lymphocyte-mediated anti-tumor immune response against PD-L1-expressing tumor cells. RC98 can be used for the research of tumor immunity and solid tumors. Species: Human	PD-1/PD-L1 Cancer	/
HY-W015346R	Desaminotyrosine (Standard)	Desaminotyrosine (Standard) (3-(4-Hydroxyphenyl)propionic acid (Standard)) is the analytical standard of Desaminotyrosine (HY-W015346). This product is intended for research and analytical applications. Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.	Reference Standards Influenza Virus Endogenous Metabolite Infection	/
HY-N21759	Dendroside D	Dendroside D is a sesquiterpenoid compound. Dendroside D binds to the RNA site of RNA-dependent RNA polymerase and the active site of SARS-CoV-2 main protease through hydrogen bonds, electrostatic interactions, and hydrophobic interactions, thereby blocking viral replication. Dendroside D stimulates the proliferation of mouse T and B lymphocytes, promotes T and B lymphocyte proliferation, and exhibits immunomodulatory activity. Dendroside D can be used for viral infection and immune-related research.	Endogenous Metabolite DNA/RNA Synthesis Inflammation or Immune System Disease Viral Infection	/
HY-P992089	Telimomab	Telimomab is an anti-human monoclonal antibody targeting-CD5. Telimomab can be used for the research of immune disease. Species: Human	Transmembrane Glycoprotein Inflammation or Immune System Disease	/
HY-P991996	SM201	SM201 is a monoclonal antibody that targets FcγRIIB. SM201 specifically binds to FcγRIIB, enhances ITIM phosphorylation of FcγRIIB in an immune complex-dependent manner, and acts synergistically with immune complexes to amplify inhibitory signals. SM201 does not induce apoptosis, activate NK cells, or deplete B cells. SM201 can be used for the research of autoimmune diseases. Species: Human	Fc Receptor (FcR) Inflammation or Immune System Disease	/
HY-P2291A	Beta-defensin 103 isoform X1, pig TFA	Beta-defensin 103 isoform X1, pig TFA is an antimicrobial peptide found in different living organisms, involved in the first line of defense in their innate immune response against pathogens.	Bacterial Inflammation or Immune System Disease	/
HY-132001S	Ziftomenib-d3	Ziftomenib-d₃ (KO-539-d₃) is the deuterium labeled Ziftomenib (HY-132001). Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities.	Isotope-Labeled Compounds Epigenetic Reader Domain Cancer	/
HY-N12231	Carbazomycin B	Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC₅₀ Of 1.5 µMsup>[2]sup>[3]sup>[4]. Source: Streptoverticillium ehimense	Antibiotic Bacterial Lipoxygenase Cancer Bacterial Infection	/
HY-E70176	N-Deacetylase/N-Sulfotransferase 1	N-Deacetylase/N-Sulfotransferase 1 is a sulfotransferase. N-Deacetylase/N-Sulfotransferase 1 modifies heparan sulfate-dependent growth factor and morphogen signalling.	Others Metabolic or Endocrine Disease	/
HY-P10543	SMRT peptide	SMRT peptide is one of the co-repressors of BCL6 BTB domain interaction. SMRT peptide binds to the BTB domain of BCL6 and enhances the transcriptional repression function of BCL6. SMRT peptide can be used to study protein-protein interactions.	BCL6 Cancer	/
HY-N11122	7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol	7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol is a cuminol glycoside. 7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol can be isolated from Rhodiola rosea sup>[1].	Others	/
HY-N6714R	Alternariol (Standard)	Alternariol (Standard) is the analytical standard of Alternariol. This product is intended for research and analytical applications. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.	Reference Standards Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis Cancer Infection	/
HY-114773	N-Undecanoyl-L-homoserine lactone	Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.	Biochemical Assay Reagents Pseudomonas Aeruginosa Infection	/
HY-B0141S7	rel-Estradiol-13C6	rel-Estradiol-¹³C₆ is the sup>13C-labeled rel-Estradiol.	Isotope-Labeled Compounds	/
HY-P2457	rCRAMP (rat)	rCRAMP (rat) is the rat cathelin-related antimicrobial peptide. rCRAMP (rat) contributes to the antibacterial activity in rat brain peptide/protein extracts. rCRAMP (rat) is a potential key player in the innate immune system of rat CNS.	Bacterial Inflammation or Immune System Disease Bacterial Infection	/
HY-N12410	3,5-Diprenyl-4-hydroxyacetophenone	3,5-Diprenyl-4-hydroxyacetophenone (compound 8) is a calmodulin-targeting molecule compound isolated from the aerial parts of Ageratina grandifolia.	Others	/
HY-P11902	IRS1	IRS1 is an integrin-targeted, ROS-responsive self-assembling peptide prodrug molecule with selective anti-cancer activity against integrin-overexpressing tumor cells. IRS1 contains an RGD motif for integrin binding, can covalently bind to DR4/DR5, and promotes DR4/DR5 aggregation. After oxidation by ROS, IRS1 undergoes a morphological transition from nanoparticles to nanofibers, exposes the pharmacophore of Chlorambucil (HY-13593), disrupts cell membrane integrity, activates the extrinsic apoptosis pathway, and can penetrate and inhibit the three-dimensional uveal melanoma spheroid model. IRS1 can be used for the research of uveal melanoma.	Drug Intermediate Caspase PARP Apoptosis Melanoma	/
HY-W770183	Uric acid-13C3	Uric acid-¹³C₃ is ¹³C-labeled Uric acid (HY-B2130). Uric acid is the end product of purine metabolism in the human body. Uric acid can scavenge reactive oxygen species (ROS), such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation.	Isotope-Labeled Compounds	/
HY-N12905	Celastramycin A (isomer)	Celastramycin A isomer is an isomer of Celastramycin A (HY-122292), an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 μg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-α pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL. Source: Streptomyces strains	Antibiotic Bacterial Mycobacterium Tuberculosis Infection	/
HY-N11934	Piperkadsin A	Piperkadsin A is a potent inhibitor of ROS. Piperkadsin inhibits PMA-induced ROS production in human polymorphonuclear neutrophils with an IC₅₀ of 4.3 μM.	Reactive Oxygen Species (ROS) Cancer Inflammation or Immune System Disease	/
HY-P5553	cPcAMP1/26	cPcAMP1/26 is an antimicrobial peptide. cPcAMP1/26 effectively kills A.hydrophila and S. aureus. cPcAMP1/26 induces depolarization of the bacterial plasma membrane, and increases intracellular ROS levels.	Bacterial Infection	/
HY-P991309	ZM-008	ZM-008 is an anti-LLT1 monoclonal antibody. ZM-008 blocks the interaction between LLT1 and CD161 on the surface of NK cells and T cells. ZM-008 restores anti-tumor immune activity, shifts the tumor microenvironment to an immune-responsive state, and recovers NK cell-mediated cytotoxicity against tumor cells, thereby reversing immunosuppression in immune-resistant "cold" tumors. ZM-008 is applicable to the research of immune-resistant solid tumors. Species: Human	C-type Lectin-like Receptors (CTLRs) Cancer	/
HY-W096997S	Sodium octyl sulfate (SOS)-d17	Sodium octyl sulfate (SOS)-d₁₇ (Sodium capryl sulfate-d₁₇) is the deuterated analogue of Sodium octyl sulfate (SOS). Sodium octyl sulfate (Sodium capryl sulfate; SOS) is a medium‑chain anionic surfactant. Sodium octyl sulfate (SOS) can undergo strong hydrophobic interactions with serum albumins (such as human serum albumin (HSA) and bovine serum albumin (BSA)), while exhibiting weak interactions with other proteins including myoglobin and hemoglobin. As an environmental pollutant in freshwater ecosystems, Sodium octyl sulfate (SOS) can mimic interspecific pheromones released by Daphnia magna and induce the formation of multicellular colonies in green algae.	Isotope-Labeled Compounds	/
HY-N7733	Fasciculic acid A	Fasciculic acid A is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity. Source: Naematoloma fasciculare	Calmodulin Inflammation or Immune System Disease	/
HY-100168R	BAPTA (Standard)	BAPTA (Standard) is the analytical standard of BAPTA. This product is intended for research and analytical applications. BBAPTA is a selective and cell-impermeant chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca²⁺ release from intracellular stores or influx via Ca²⁺-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.	Reference Standards Phospholipase	/
HY-D0584	Reactive orange 86	Reactive orange 86 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.	Fluorescent Dye	/
HY-W750858	DIBOA-Glucoside	DIBOA-Glucoside is a glycoside derivative that can be found in cereal crops like rye, wheat, and maize. DIBOA-Glucoside is a stable, less toxic glucoside form of DIBOA. DIBOA-Glucoside, upon pest or pathogen attack, is hydrolyzed by an enzyme, releasing the toxic aglycone DIBOA and glucose, thereby deterring insects and suppressing weeds through an allelopathic effect.	Drug Derivative Herbicide	/
HY-D0668	Reactive orange 13	Reactive orange 13 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.	Fluorescent Dye	/
HY-B0317S	Amlodipine-1,1,2,2-d4 maleate	Amlodipine-1,1,2,2-d₄ (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer.	Isotope-Labeled Compounds Calcium Channel Cancer Blood or Cardio-cerebrovascular Disease	/
HY-W927359	Fluorescein hydrazide (3,6-Dihydroxyxanthane)	Fluorescein hydrazide (3,6-Dihydroxyxanthane) is a fluorescein dye that can be used for the fluorophotometric determination of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS).	Fluorescent Dye	/
HY-121125	Aucubigenin	Aucubigenin, the aglycone of the iridoid glycoside aucubin, has been characterized through X-ray diffraction analysis. Its crystal structure reveals monoclinic symmetry with specific conformations adopted by its cyclopentane and pyran rings. The study also determined the absolute configurations of both aucubin and aucubigenin. Significant O-H O hydrogen bonding interactions were observed in the crystal lattices of both compounds, highlighting their structural stability and potential for intermolecular interactions.	Others	/
HY-P5407	HD5	HD5 is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer.	SARS-CoV Angiotensin-converting Enzyme (ACE) Colorectal Cancer Small Cell Lung Cancer Epithelial Ovarian Cancer SARS-CoV-2 Infection HPV Infection	/
HY-N1951R	Miltirone (Standard)	Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro).	Reference Standards GABA Receptor Apoptosis Carboxylesterase (CES) SARS-CoV Cancer Neurological, Eye or Ear Disease	/
HY-D0653	Reactive orange 35	Reactive orange 35 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.	Fluorescent Dye	/
HY-N16463	QS-S2	QS-S2 is the impurity of QS-21 (HY-101092A). QS-21 is an innate immune system-targeted adjuvant.	Drug Intermediate	/
HY-N14889	Ophiobolin D	Ophiobolin D is a terpenoid antibiotic found in Cochliobulus miyabeanus and has four components A, B, C and D. A, B, C have anti-Gram-positive bacteria, mycobacteria and fungi, and have a strong inhibitory effect on some plant pathogens. D has a weak inhibitory effect on Staphylococcus aureus.	Antibiotic Bacterial Infection	/
HY-111582G	BBIQ (GMP)	BBIQ (GMP) is BBIQ (HY-111582) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BBIQ is a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC₅₀ of  59.1 nM. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses.	Toll-like Receptor (TLR) Inflammation or Immune System Disease	/
HY-B0377S1	Famotidine-13C	Famotidine-¹³C (MK-208-¹³C) is the ¹³C-labeled Famotidine (HY-B0377). Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer.	Isotope-Labeled Compounds Histamine Receptor MMP Toll-like Receptor (TLR) ERK Coronavirus Infection Pneumonia Gastric Ulcer Liver Injury	/
HY-D0622	Reactive Green 19	Reactive Green 19 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.	Fluorescent Dye	/
HY-W286743S	CML-d4	CML-d₄ is the deuterium labeled Fmoc-L-Lys (Boc)-OH.	Isotope-Labeled Compounds	/
HY-17405S	Alarelin-(Leu-13C6,15N) TFA	Alarelin-(Leu-sup>13C₁₀,¹⁵N) TFA is the ¹³C- and ¹⁵N-labeled Alarelin TFA.	Isotope-Labeled Compounds	/
HY-N3872R	Ethyl β-D-glucopyranoside (Standard)	Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS	Others Reference Standards	/
HY-D0514	Reactive blue 5	Reactive blue 5 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.	Fluorescent Dye	/
HY-P991582	BI-1607	BI-1607 is a humanized monoclonal antibody targeting FcγRIIB/CD32b. BI-1607 selectively blocks inhibitory FcγRIIB signaling, abrogates its inhibitory function, redirects tumor cell-bound antibodies to activating FcγRs, and its modified Fc region prevents the binding of its own Fc segment to FcγRs. BI-1607 reduces αPD-1 trogocytosis, enhances the effector functions of anti-tumor antibodies (including ADCP and ADCC, promotes intratumoral regulatory T cell (Treg) depletion, myeloid cell reprogramming, induction of interferon-γ (IFN-γ) and CXCL10, and increases the number of activated effector CD8⁺ T cells. BI-1607 can be used in research related to colorectal cancer, HER2-positive advanced solid tumors, HER2-positive locally advanced or metastatic breast cancer, and HER2-positive metastatic gastric cancer. Species: Human	Fc Receptor (FcR) IFNAR PD-1/PD-L1 CXCR Breast Cancer Colorectal Cancer Gastric Cancer	/
HY-D0522	Reactive orange 16	Reactive orange 16 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.	Fluorescent Dye	/
HY-N7503R	Psoralenoside (Standard)	Psoralenoside is a benzofuran glycoside from Psoralea corylifolia. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol). Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.	Reference Standards Histamine Receptor Calcium Channel Calmodulin Cancer Metabolic or Endocrine Disease Bacterial Infection	/
HY-D0639	Reactive Brown 23	Reactive Brown 23 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.	Fluorescent Dye	/
HY-D0661	Reactive red 45	Reactive red 45 is common textile dyes that can be adsorbed onto single-walled carbon nanotubes (SWCNTs) through electrostatic interactions, allowing the separation of residual dyes.	Fluorescent Dye	/
HY-P6696S	β-CL, Ala(13C3,15N) TFA	β-CL, Ala(sup>13C₃,¹⁵N) TFA is the ¹³C- and ¹⁵N-labeled β-CL TFA.	Isotope-Labeled Compounds	/
HY-B0682S	Mitiglinide-d8 calcium hydrate	Mitiglinide-d₈ calcium hydrate (KAD-1229-d₈) is the deuterium labeled Mitiglinide calcium hydrate. Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes.	Potassium Channel Metabolic or Endocrine Disease	/
HY-D2227	IR-58	IR-58, a mitochondria-targeting near-infrared (NIR) fluorophore, is an autophagy enhancer. IR-58 kills tumour cells and induces apoptosis via inducing excessive autophagy, which is mediated through the reactive oxygen species (ROS)-Akt-mTOR pathway.	Autophagy Apoptosis Cancer	/
HY-32350S1	Ercalcitriol-d3	Ercalcitriol-d₃ (1α,25-Dihydroxy Vitamin D2-d₃) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases.	Isotope-Labeled Compounds VD/VDR Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-W776847	3-(2-Iodoacetamido)-proxyl	3-(2-Iodoacetamido)-proxyl serves as a free radical spin probe employed in spin labeling techniques, which facilitate the exploration of the dynamic interactions among molecules, proteins, lipids, and cell membranes.	Fluorescent Dye	/
HY-100168BR	BAPTA tetrapotassium (Standard)	BAPTA tetrapotassium (Standard) is the analytical standard of BAPTA tetrapotassium (HY-100168B). This product is intended for research and analytical applications. BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA tetrapotassium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca²⁺ release from intracellular stores or influx via Ca²⁺-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca²⁺ chelators.	Reference Standards Phospholipase	/
HY-W096997A	Sodium octyl sulfate (SOS), 95%	Sodium octyl sulfate (Sodium capryl sulfate; SOS), 95% is a medium-chain anionic surfactant. Sodium octyl sulfate (SOS), 95% exhibits strong hydrophobic interactions with serum albumins (such as human serum albumin HSA and bovine serum albumin BSA), but only weak interactions with other proteins including myoglobin and hemoglobin. Sodium octyl sulfate (SOS), 95% acts as an environmental pollutant in freshwater ecosystems, mimicking the interspecific pheromones released by Daphnia magna to induce the formation of multicellular colonies in green algae.	Biochemical Assay Reagents Environmental Pollutants	/
HY-W653896	Alternariol-d2	Alternariol-d₂ is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.	Isotope-Labeled Compounds Topoisomerase Apoptosis Androgen Receptor Estrogen Receptor/ERR Infection	/
HY-N6610	Protoanemonin	Protoanemonin is a natural unsaturated γ-lactone small molecule derived from plants of the Ranunculaceae family, possessing various activities such as plant growth regulation, antibacterial, and antifungal effects. Protoanemonin is a quorum sensing inhibitor that inhibits Pseudomonas aeruginosa quorum sensing, downregulates virulence factor expression, and activates the iron starvation response pathway. Protoanemonin possesses broad-spectrum antibacterial and antifungal activities, and also has antimutagenic activity. Protoanemonin exhibits bidirectional plant growth regulatory effects, promoting plant tissue elongation at low concentrations and inhibiting plant tissue elongation at high concentrations. Protoanemonin can be used in research related to bacterial quorum sensing, microbial metabolism, antibacterial and antifungal activity, antimutagenesis, and plant growth regulation.	Bacterial Fungal Drug Derivative Metabolic or Endocrine Disease Bacterial Infection Fungal Infection	/
HY-W011086R	Tri-O-tolyl phosphate (Standard)	Tri-O-tolyl phosphate (Tri-O-cresyl phosphate; TOTP) (Standard) is an analytical standard of Tri-O-tolyl phosphate (HY-W011086). This product is intended for research and analytical applications. Tri-O-tolyl phosphate is an aryl phosphate compounds commonly utilized as flame retardants and lubricant additives across various industrie. Tri-O-tolyl phosphate has neurotoxicity and reproductive toxicity, decreasing cell viability, inhibiting cell proliferation, triggering cell cycle arrest, induceing apoptosis, causing mitochondrial dysfunction, disrupts calcium homeostasis.	Biochemical Assay Reagents Reference Standards Apoptosis Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	/
HY-173091S	pyroE-QEAVEGGC(Cam)SHLGQSYADR-(Arg-13C6,15N4) TFA	pyroE-QEAVEGGC(Cam)SHLGQSYADR-(Arg-¹³C₆,¹⁵N₄) TFA is the ¹³C- and ¹⁵N-labeled pyroE-QEAVEGGC(Cam)SHLGQSYADR-(Arg) TFA.	Isotope-Labeled Compounds	/
HY-113308AS1	Taurolithocholic Acid-d5 sodium salt	Taurolithocholic Acid-d₅ (sodium) is the deuterium labeled Taurolithocholic acid sodium salt. Taurolithocholic Acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic Acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic Acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic Acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic Acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic Acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.	Isotope-Labeled Compounds Calcium Channel Ferroptosis PI3K Reactive Oxygen Species (ROS) Akt HBV Metabolic or Endocrine Disease	/
HY-122292	Celastramycin A	Celastramycin A is a potent innate immune suppressor and Antibacterial agent. Celastramycin A inhibits TNF-α-stimulated IL-8 production and reduces IL-6 in a ZFC3H1-independent manner. Celastramycin A inhibits the growth of Pasteurella multocida and Mannheimia haemolytica and modulates the immune system. Celastramycin A can be used for research on bovine respiratory disease (BRD). Source: Drosophila	Bacterial Interleukin Related TNF Receptor Inflammation or Immune System Disease Digestive System Disease Bacterial Infection	/
HY-P10425	T2857W	T2857W is a mutant peptide that has inhibitory effect on KIX-MLL interaction (IC₅₀=5.67 μM). T2857W can be used for protein-protein interaction (PPI) and for the study of diseases related to KIX-MLL interaction, such as leukemia, cancer, etc.	Histone Methyltransferase Cancer	/
HY-P2076A	Dusquetide TFA	Dusquetide (SGX942) TFA is a first-in-class innate defense regulator (IDR). Dusquetide TFA modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide TFA shows activity in both reducing inflammation and increasing clearance of bacterial infection. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns	p62 Bacterial Cancer Infection	/
HY-18258S	Berberine-d6 chloride	Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.	Isotope-Labeled Compounds Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Cancer	/
HY-NP126	Highly purified Type XI collagen, from porcine articular cartilage	Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.	MMP Inflammation or Immune System Disease	/
HY-N10772	Albanin A	Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca²⁺/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity.	Calcium Channel Calmodulin Adenylate Cyclase Neurological, Eye or Ear Disease Inflammation or Immune System Disease	/
HY-P5834	Boc-AEVD-CHO	Boc-AEVD-CHO is a Caspase 8 inhibitor useful in the study of apoptosis and immune and inflammatory diseases.	Caspase Apoptosis Nonalcoholic Steatohepatitis	/
HY-144002	RIBI-529	RIBI-529 (RC-529) is a fully synthetic, low-toxicity TLR4 agonist vaccine adjuvant. RIBI-529 upregulates cell surface co-stimulatory molecules, receptors, cytokines and chemokines, and activates the innate immune system. RIBI-529 enhances short-term CD4⁺ T cell clonal expansion, division, and ex vivo survival under growth factor withdrawal conditions. RIBI-529 enhances humoral and cell-mediated adaptive immune responses, induces non-specific resistance against viral and bacterial pathogens, and skews responses toward a Th1 type, accompanied by Th2 responses.	Toll-like Receptor (TLR) Interleukin Related Inflammation or Immune System Disease	/
HY-126712	ROS tracer precursor	ROS tracer precursor is the precursor of [¹⁸F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis.	Biochemical Assay Reagents Neurological, Eye or Ear Disease	/
HY-P6013A	wt hMLN TFA	wt hMLN (TFA) is a microprotein that inhibits of SR Ca²⁺ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis.	Calcium Channel	/
HY-N0587R	Demethylzeylasteral (Standard)	Demethylzeylasteral (Standard) is the analytical standard of Demethylzeylasteral. This product is intended for research and analytical applications. Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation .	Reference Standards Apoptosis TGF-beta/Smad Estrogen Receptor/ERR NF-κB FAK Cancer Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease	/
HY-P2266	SAH-EZH2	SAH-EZH2, a stable EZH2 α-helical peptide, is an EZH2/EED interaction inhibitor. SAH-EZH2 targets native embryonic ectoderm development (EED), disturbs its interactions with EZH1 and EZH2, and selectively decreases trimethylation of H3K27.	Histone Methyltransferase Cancer	/
HY-W015954R	(2R,3R)-Butane-2,3-diol (Standard)	(2R,3R)-Butane-2,3-diol (Standard) is the analytical standard of (2R,3R)-Butane-2,3-diol (HY-W015954). This product is intended for research and analytical applications. (2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La³⁺)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC₅₀ of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases.	Reference Standards Endogenous Metabolite Calcium Channel Bacterial Infection Metabolic or Endocrine Disease	/
HY-P991160	Suvonstobart	Suvonstobart is a monoclonal antibody targeting human CD24 (signal transducer CD24). Suvonstobart specifically binds to CD24, activating relevant immune cell signaling pathways and exerting immunostimulatory and antitumor activities. Species: Human	Others Cancer Inflammation or Immune System Disease	/
HY-N7875	Celangulin	Celangulin is an insecticidal component isolated from Celastrus angulatus. Celangulin activates the calcium channel on the plasma membrane with increasing the intracellular Ca²⁺ after influx from the external. Celangulin activates the calcium channel in the ER.	Others	/
HY-N10588	Nardoguaianone K	Nardoguaianone K, a guaiane-type compound, can be isolated from Nardostachys chinensis roots. Nardoguaianone K cam be used in the research of pancreatic cancer.	Others Cancer	/
HY-147889	BBR-BODIPY	BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins.	Apoptosis Caspase Bcl-2 Family	/
HY-D1056A5	Lipopolysaccharides, from E. coli K-235	Lipopolysaccharides, from E. coli (Escherichia coli) K-235 are lipopolysaccharide endotoxins and TLR-4 activators derived from E. coli, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from E. coli K-235 exhibit a typical three-part structure: O-antigen (O-antigen), core oligosaccharide (core oligosaccharide), and lipid A (Lipid A). Lipopolysaccharides, from E. coli K-235 have a mitogenic effect on C57BL/10ScN spleen cells. Additionally, LPS purified using butanol and deoxycholic acid methods stimulates spleen cells in C57BL/10ScCR and C3H/HeJ mice. It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.	Toll-like Receptor (TLR) Inflammation or Immune System Disease	/
HY-P10496A	MAGE-A1-derived peptide acetate	MAGE-A1-derived peptide acetate is a short peptide sequence derived from MAGE-A1 protein. As a tumor-specific antigen, MAGE-A1-derived peptide acetate can be recognized and activated by cytotoxic T lymphocytes (CTLs), thereby generating an immune response to tumor cells expressing MAGE-A1. This immune response can lead to the lysis and death of tumor cells. MAGE-A1-derived peptide acetate can be used in the study of tumor immunity.	Others Cancer	/
HY-P10813	ZLIRTLHEWY	ZLIRTLHEWY is a potent peptide CD47/SIRPα interaction inhibitor. ZLIRTLHEWY is promising for research of cancers.	CD47 Cancer Inflammation or Immune System Disease	/
HY-P991113	Abazistobart	Abazistobart is an immunostimulant and antineoplastic agent targeting the programmed cell death protein 1 (PDCD1). Abazistobart is a chimeric and humanized monoclonal antibody that specifically binds to PDCD1 to block the relevant signaling pathway, thereby activating the immune system and exerting antineoplastic activity. Abazistobart is promising for research of cancers. Species: Human	PD-1/PD-L1 Cancer Inflammation or Immune System Disease	/
HY-W654078	Bisphenol AF-13C12	Bisphenol AF-¹³C₁₂ is an isotopic label of Bisphenol AF. Bisphenol AF is used in polycarbonate plastic and epoxy resin manufacturing. Bisphenol AF can significantly increase intracellular ROS levels.	Isotope-Labeled Compounds	/
HY-W015913R	Pyruvic acid sodium (Standard)	Sodium 2-oxopropanoate (Standard) is the analytical standard of Sodium 2-oxopropanoate. This product is intended for research and analytical applications. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Metabolic or Endocrine Disease	/
HY-N2077	Heteroclitin D	Heteroclitin D is a lignin from Kadsura medicinal plants with anti-liqid peroxidation. Heteroclitin D inhibits L-type calcium channels.	Calcium Channel Neurological, Eye or Ear Disease Metabolic or Endocrine Disease Hypertension	/
HY-NP103	Highly purified Type III collagen, from bovine skin	Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.	MMP Inflammation or Immune System Disease	/
HY-157922	Trehalose C12	Trehalose C12 (α-D-Glucopyranosyl-α-D-glucopyranoside monododecanoate) is a nonreducing disaccharide with amphiphilic property, which is used as emulsifier, surfactant, encapsulating materials, and in the biochemical researches of cellular processes and membrane interactions.	Biochemical Assay Reagents	/
HY-P99709	Lodapolimab	Lodapolimab (LY3300054) is a fully human IgG1λ anti-PD-L1 monoclonal antibody, with an EC₅₀ of 0.075 nM against hPD-L1 and an EC₅₀ of 0.085 nM against cynomolgus monkey PD-L1. Lodapolimab induces naive T cell activation, enhances the T cell activation effect of anti-CTLA4 antibodies, promotes anti-tumor alloreactivity, regulates innate immune pathways, and induces characteristics of adaptive immune activation. Lodapolimab can be used in research related to high-grade serous ovarian cancer and other solid tumors. Species: Human	PD-1/PD-L1 Inflammation or Immune System Disease Ovarian Cancer Triple-Negative Breast Cancer	/
HY-P1463A	Calcitonin, eel TFA	Calcitonin, eel TFA is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.	Thyroid Hormone Receptor	/
HY-W141788	N-Butyryl-DL-homocysteine thiolactone	N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity.	Bacterial Infection	/
HY-16129	CBP-501	CBP-501, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser²¹⁶-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 is used for various types of cancer.	Calmodulin Checkpoint Kinase (Chk) MAPKAPK2 (MK2) MAP3K Cancer	/
HY-12515AS	Nicardipine-d3 hydrochloride	Nicardipine-d₃ hydrochloride (YC-93 D₃) is the deuterium labeled Nicardipine hydrochloride. Nicardipine hydrochloride is a calcium channel blocker with an IC₅₀ of 1 μM for blocking cardiac calcium channels. Nicardipine hydrochloride acts as an agent for chronic stable angina and for controlling blood pressure.	Calcium Channel Neurological, Eye or Ear Disease	/
HY-P1463	Calcitonin, eel	Calcitonin, eel is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.	Thyroid Hormone Receptor Metabolic or Endocrine Disease	/
HY-123533S	Resorufin-d6	Resorufin-d₆ is the deuterium labeled Resorufin. Resorufin (NSC 12097) is a highly fluorescent pink dye for the detection of ROS/RNS and a second analyte.	Reactive Oxygen Species (ROS)	/
HY-W585926	Disperse polyester dark blue	Disperse Polyester Dark Blue is a chemical compound extensively employed in scientific research. It serves as a redox-active agent and functions as a probe for identifying reactive oxygen species (ROS) in cells and tissues. By accepting electrons from ROS and undergoing oxidation, Disperse Polyester Dark Blue demonstrates its redox activity. Consequently, a chemiluminescent signal is generated, which can be measured using a luminometer. The intensity of the signal directly correlates with the quantity of ROS detected within the sample.	Reactive Oxygen Species (ROS)	/
HY-126474S	MitoB-d15 bromide	MitoB-d₁₅ (bromide) is deuterium labeled MitoB (bromide). MitoB bromide is an exomarker of mitochondrial hydrogen peroxide. MitoB bromide is a mitochondria-targeted ratiometric probe, and can be used to measure levels of one major ROS, hydrogen peroxide, within living animals.	Isotope-Labeled Compounds Reactive Oxygen Species (ROS) Inflammation or Immune System Disease	/
HY-B0317AS	Amlodipine-d4 maleate	Amlodipine-d₄ (maleate) is the deuterium labeled Amlodipine maleate. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.	Isotope-Labeled Compounds Calcium Channel Cancer Blood or Cardio-cerebrovascular Disease	/
HY-P5304A	RTQLLWTPAAPTAMA TFA	RTQLLWTPAAPTAMA TFA is a peptide antigen，used for drug delivery in immune response.	Others Inflammation or Immune System Disease	/
HY-113308AR	Taurolithocholic acid sodium salt (Standard)	Taurolithocholic acid (sodium salt) (Standard) is the analytical standard of Taurolithocholic acid (sodium salt). This product is intended for research and analytical applications. Taurolithocholic acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.	Reference Standards Calcium Channel Ferroptosis PI3K Reactive Oxygen Species (ROS) Akt HBV Metabolic or Endocrine Disease	/
HY-W015913S3	Pyruvic acid-13C-1 sodium	Sodium 2-oxopropanoate-¹³C is the ¹³C labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.	Free Radical Scavengers Endogenous Metabolite Reactive Oxygen Species (ROS) Metabolic or Endocrine Disease	/
HY-P3811A	Autocamtide-3 acetate	Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca²⁺/calmodulin-dependent kinase II) (CaMK) substrate.	CaMK Neurological, Eye or Ear Disease	/
HY-W008907	5'-O-Tritylthymidine	5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis. 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.	Apoptosis Cancer Nonalcoholic Steatohepatitis	/
HY-P11023	E16-uPA24	E16-uPA24 is a chimeric peptide targeting urokinase-type plasminogen activator receptor (uPAR). E16-uPA24 modifies senescent cells surface with polyglutamic acid, promoting immune cell-mediated responses through glutamate recognition. E16-uPA24 induces immune clearance of senescent cells and restores tissue homeostasis by enhancing immune cells recruitment and directly coupling senescent cells and immune cells. E16-uPA24 can be used for tissue degeneration, chronic inflammatory disease and age-related tumorigenesis research.	Others Cancer Inflammation or Immune System Disease Metabolic or Endocrine Disease	/
HY-W145481A	D-Galacto-D-mannan	D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease.	C-type Lectin-like Receptors (CTLRs) Sirtuin Inflammation or Immune System Disease	/
HY-P2320	IDR-1	IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release.	Bacterial Infection Inflammation or Immune System Disease	/
HY-P10638A	TAT-CN21 (scrambled)	TAT-CN21 (scrambled) is a nonsense sequence control peptide fused with the TAT cell-penetrating sequence. It exerts no inhibitory effect on CaMKII activity and serves as a negative control for TatCN21 (HY-P10638).	CaMK Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease	/
HY-P99525	Varisacumab	Varisacumab (R 84; GNR-011) is a fully humanized IgG1 monoclonal antibody targeting VEGF. Varisacumab specifically blocks the interaction between VEGF and VEGFR2, but does not interfere with the interaction between VEGF and VEGFR1. Varisacumab achieves effective anti-tumor and anti-angiogenic effects and can be used in the research of non-small cell lung cancer and pancreatic cancer. Species: Human	VEGFR Pancreatic Cancer Non-Small Cell Lung Cancer	/
HY-B0317S1	Amlodipine-d4	Amlodipine-d₄ is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer.	Isotope-Labeled Compounds Calcium Channel Cancer	/
HY-P991842	Anti-CD3 Antibody (UCHT-1)	Anti-CD3 Antibody (UCHT-1) is an antibody targeting CD3. Anti-CD3 Antibody (UCHT-1) activates the phospholipase C and phosphatidylinositol 3-kinase (PI3K) signaling pathways, elevates intracellular calcium levels, regulates the T3 epitope, and triggers T lymphocyte proliferation. Anti-CD3 Antibody (UCHT-1) also inhibits lymphocyte proliferation, abolishes IL-2 production, and blocks the expression of IL-2 receptors. Anti-CD3 Antibody (UCHT-1) is applicable to research related to graft-versus-host disease, acute myeloid leukemia, and B-cell acute lymphoblastic leukemia. Species: Human	CD3 Phospholipase PI3K Interleukin Related Inflammation or Immune System Disease Acute Myeloid Leukemia Acute Lymphoblastic Leukemia	/
HY-N9517	QS 7	QS 7 (QS 7 Api) is a triterpene saponin found in the bark of Quillaja saponaria and immune adjuvant with immune response potentiator activity. QS 7 can be used as vaccine adjuvant for the research of antitumor and antiviral vaccine development.	Others Cancer Inflammation or Immune System Disease	/
HY-B1847S	Terbuthylazine-d9	Terbuthylazine-d₉ is the deuterium labeled Terbuthylazine (HY-B1847). Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein.	Isotope-Labeled Compounds Herbicide Acetolactate Synthase (ALS)	/
HY-W015913S1	Pyruvic acid-d3 sodium	Sodium 2-oxopropanoate-d₃ is the deuterium labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.	Free Radical Scavengers Endogenous Metabolite Reactive Oxygen Species (ROS) Metabolic or Endocrine Disease	/
HY-P99346	Regdanvimab	Regdanvimab (CT-P59) is a human monoclonal antibody that targets the receptor-binding domain of SARS-CoV-2 spike protein, blocking interaction with ACE2 for viral entry. Regdanvimab can be used for the research of COVID-19. Species: Virus	SARS-CoV Angiotensin-converting Enzyme (ACE) Coronavirus Infection	/
HY-P990018	Boserolimab	Boserolimab (MK-5890) is a humanized agonist monoclonal antibody that binds to CD27 to provide a costimulatory signal that enhances T-cell–mediated responses. Species: Human	TNF Receptor NF-κB Cancer Inflammation or Immune System Disease	/
HY-P99938	Pucotenlimab	Pucotenlimab (HX008) is a humanized immunoglobulin G4 (IgG4) anti programmed cell death protein 1 (anti-PD-1) monoclonal antibody. Pucotenlimab can be used for the research of tumor. Species: Human	PD-1/PD-L1 Cancer	/
HY-120234	Z-LLNle-CHO	Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia.	γ-secretase Proteasome Apoptosis Breast Cancer Leukemia/Lymphoma/Myeloma Neurodegenerative Disease Nonalcoholic Steatohepatitis	/
HY-P1805	Calmodulin Binding Peptide 1	Calmodulin Binding Peptide 1 is a high-affinity (pM) CaM-binding peptide derived from smooth muscle myosin light chain kinase (MLCK peptide). The interface of the complex formed by Calmodulin Binding Peptide 1 and Ca²⁺-CaM can be specifically bound by small-molecule inhibitors, serving as a key target for selective regulation of smooth muscle contraction and development of anti-CaM drugs.	Calmodulin Neurological, Eye or Ear Disease	/
HY-125771S	1-Stearoyl-sn-glycero-3-phosphocholine-d35	1-Stearoyl-sn-glycero-3-phosphocholine-d₃₅ is deuterium labeled 1-Stearoyl-sn-glycero-3-phosphocholine (HY-125771). 1-Stearoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine that inhibits HDAC3 activity and phosphorylation of STAT3 in K562 cells. 1-Stearoyl-sn-glycero-3-phosphocholine induces apoptosis and exhibits anticancer activity in chronic myelogenous leukemia (CML) K562 cells.	Isotope-Labeled Compounds Endogenous Metabolite HDAC STAT Apoptosis Cancer	/
HY-P991570	Zaptuzumab	Zaptuzumab (AD5-10) is a DR5-specific humanized monoclonal antibody that selectively binds to DR5 with high affinity. Zaptuzumab specifically induces cancer cell death by both caspase-apoptosis and autophagic cell death (ACD). Zaptuzumab activates both ADCC and CDC. Zaptuzumab induces ROS generation and GSH level reduction. Zaptuzumab shows a significant suppression of the tumor growth and good safety in various xenografts mice tumor models. Species: Human	TNF Receptor Apoptosis Caspase Atg8/LC3 Akt Beclin1 JNK Cancer	/
HY-NP109	Highly purified type I collagen, from mouse skin	Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.	MMP Inflammation or Immune System Disease	/
HY-P990782	Efzofitimod	Efzofitimod is a splice variant of the aminoacyl-tRNA synthetase HARS1, which is fused with the Fc segment of a human antibody. Efzofitimod targets the neuronal phospholipid NRP2 (neuropilin-2) and has anti-inflammatory and immunomodulatory activities. Efzofitimod can downregulate the innate and adaptive immune responses in inflammatory disease states, suppressing indirect lung disease (ILD). Species: Human	Aminoacyl-tRNA Synthetase Inflammation or Immune System Disease	/
HY-B2123R	Lactose (Standard)	Lactose (Standard) is the analytical standard of Lactose. This product is intended for research and analytical applications. Lactose is a β-galactoside consisting of galactose and glucose residues, the main carbohydrate in mammalian breast milk. Lactose, a macronutrient and an inducer of host innate immune responses, possesses immune modulatory functions.	Reference Standards Endogenous Metabolite Interleukin Related ERK NF-κB Inflammation or Immune System Disease	/
HY-B1111S1	Amitraz-d3	Amitraz-d₃ is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.	Isotope-Labeled Compounds Adrenergic Receptor Monoamine Oxidase Parasite Infection Metabolic or Endocrine Disease	/
HY-P991023	Safimestomig	Safimestomig (6MW3211) is an CD47/PD-L1-targeting bispecific antibody. Safimestomig blocks CD47-mediated 'don't eat me' signaling and selectively binds to CD47 on tumor cells. Safimestomig blocks PD-L1-mediated immune checkpoint signaling. Safimestomig can be used for the research of cancer. Species: Human	CD47 PD-1/PD-L1 Cancer	/
HY-P990233	Anti-Mouse IFNγR/CD119 Antibody (GR-20)	Anti-Mouse IFNγR/CD119 Antibody (GR-20) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IFNγR/CD119.Anti-Mouse IFNγR/CD119 Antibody (GR-20) reacts with the mouse IFNγR (interferon gamma receptor) α chain also known as CD119 and IFNγ receptor 1. Anti-Mouse IFNγR/CD119 Antibody (GR-20) blocks the binding of IFNγ to CD119 therefore inhibiting IFNγ signaling. Anti-Mouse IFNγR/CD119 Antibody (GR-20) can be used for the researches of cancer, infection, inflammation and immunology, such as melanoma and C. trachomatis infected genital tract inflammation. Species: Mouse	IFNAR Cancer Infection Inflammation or Immune System Disease	/
HY-P991646	ING-1	ING-1 (heMab) is a high-affinity humanized monoclonal antibody against epithelial cell adhesion molecule (Ep-CAM). ING-1 is a transmembrane glycoprotein mediating Ca²⁺. ING-1 binds to Ep-CAM on tumor cells and exhibits potent in vitro activity, targeting and inhibiting tumor growth and metastasis in mouse cancer models. ING-1 is useful in the research of breast, colorectal, and lung cancers, among other cancers. Species: Human	Transmembrane Glycoprotein Cancer	/
HY-165607S	MCB-22-174	MCB-22-174 is a deuterated Piezo1 agonist, with an EC₅₀ value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca²⁺ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP).	Piezo Channel Isotope-Labeled Compounds ERK CaMK Metabolic or Endocrine Disease	/
HY-P99941	Retifanlimab	Retifanlimab is an anti-programmed cell death protein 1 (anti-PD-1) monoclonal antibody (mAb). Retifanlimab can be used for the research of gastroesophageal adenocarcinoma (GEA). Species: Human	PD-1/PD-L1 Non-Small Cell Lung Cancer Triple-Negative Breast Cancer Metastatic Breast Cancer	/
HY-N0229S13	L-Alanine-d7	L-Alanine-d₇ is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.	Isotope-Labeled Compounds Endogenous Metabolite Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	/
HY-P990757	Ragistomig	Ragistomig can simultaneously target programmed death-ligand 1 (PD-L1) and the 4-1BB receptor. Ragistomig elicits potent anti-tumor T-cell responses without inducing significant toxicity. Ragistomig is applicable for tumor research. Species: Human	PD-1/PD-L1 Inflammation or Immune System Disease	/
HY-N3463	Isopimaric acid	Isopimaric acid is a coniferous tree defense compound. Isopimaric acid binds to AKT and inhibits mTOR phosphorylation, thereby regulating the AKT/mTOR pathway. Isopimaric acid inhibits oxidative stress, inflammation, microglial migration, apoptosis, autophagic flux, ornithine decarboxylase activity, breast cancer proliferation and metastasis, and fungal spore germination. Isopimaric acid also induces M2 microglial polarization, mitochondrial damage, ROS accumulation, starvation-induced colon cancer cell apoptosis, and breast cancer cell cycle arrest. Isopimaric acid activates potassium channels, regulates sodium channels and calcium channels, reduces myocardial excitability, and improves arrhythmia. Isopimaric acid acts as an oxidative substrate for CYP6BW1/3, down-regulates PINK1/Parkin, and regulates calcium homeostasis, oxidative phosphorylation, EMT, and the Wnt pathway. Isopimaric acid exhibits activity against drug-resistant Staphylococcus aureus, repels feeding, and promotes the growth of rice seedlings. Isopimaric acid is suitable for research related to epilepsy, tumors, drug-resistant bacterial infections, atrial fibrillation, hypertension, hyperlipidemia, pulmonary tuberculosis, etc.	Akt mTOR Apoptosis Autophagy Reactive Oxygen Species (ROS) Potassium Channel Sodium Channel Calcium Channel PINK1/Parkin Oxidative Phosphorylation Wnt Bacterial Breast Cancer Colorectal Cancer Bacterial Infection Epilepsy Tuberculosis Hypertension Atrial Fibrillation Hypercholesterolemia	/
HY-N8418	Cearoin	Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.	Autophagy Reactive Oxygen Species (ROS) ERK Apoptosis Cancer	/
HY-N3872	Ethyl β-D-glucopyranoside	Ethyl β-D-glucopyranoside (compound 10) is an ethyl derivative. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellata LS.	Others	/
HY-129330	Sapintoxin D	Sapintoxin D is a fluorescent phorbol ester that can be used to study the activation of protein kinase C (PKC). Sapintoxin D is a calcium-dependent PKC activator.	PKC	/
HY-P991381	JST-TfR09	JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992). Species: Human	Transferrin Receptor Reactive Oxygen Species (ROS) Ferroptosis Leukemia/Lymphoma/Myeloma	/
HY-101092B	QS-21-Xyl	QS-21-Xyl is a active component of QS-21 (HY-101092A). QS-21 is a natural vaccine adjuvant and induces a balanced Th1/Th2 immune response, particularly cellular immunity.	Drug Intermediate Cancer Inflammation or Immune System Disease	/
HY-N6781	Ophiobolin A	Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC₅₀ value of 9 μM. Ophiobolin A antimicrobial and anticancer activity. Source: fungus Bipolaris sp.	Phosphodiesterase (PDE) Cancer Infection	/
HY-P5275	Tripeptide-41	Tripeptide-41 (CG-Lipoxyn) is a signal peptide. Tripeptide-41 activates the NF-kB signaling pathway, inhibits the expression of C/EBP and increases cAMP. Tripeptide-41 is an important intracellular signaling factor that causes lipolysis by promoting the hydrolysis of lipids into triglycerides. Tripeptide-41 can be used in cosmetics that targets fat accumulation.	NF-κB Histone Demethylase Obesity	/
HY-P5314	OK2	OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 can be used for kidney fibrosis and chronic kidney disease research.	EGFR STAT Lung Cancer Breast Cancer Colorectal Cancer Prostate Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Pancreatic Cancer Ovarian Cancer Hepatitis C Virus Infection Obesity	/
HY-P990189	Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243)	Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to monkey/human MHC class II. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can inhibits tumor cells proliferation and induce apoptosis. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) increases cellular reactive oxygen species (ROS) and loss of mitochondrial membrane potential in human endothelial cells. Anti-Monkey/Human MHC class II (HLA-DR) Antibody (L243) can be used for the researches of cancer and infection, such as lymphoma. Species: Human/Monkey	MHC Apoptosis Reactive Oxygen Species (ROS) Cancer Infection	/
HY-P990009	Nisevokitug	Nisevokitug (NIS-793) is a humanized IgG2λ monoclonal antibody and an inhibitor of the TGF-β signaling pathway. Nisevokitug blocks the binding of TGF-β to the membrane-bound TGF-βR1/TGF-βR2 receptors, inhibits both Smad-dependent and Smad-independent downstream cascade signaling, downregulates fibrosis-related genes, and reverses the TGF-β-mediated immunosuppressive microenvironment. Nisevokitug can be used in the research of diseases such as pancreatic ductal adenocarcinoma, colorectal cancer, myelofibrosis, and myelodysplastic syndrome. Species: Human	TGF-beta/Smad TGF-β Receptor Colorectal Cancer Pancreatic Cancer	/
HY-P1076A	CALP2 TFA	CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages.	Calmodulin Inflammation or Immune System Disease	/
HY-P10045	Integrin signaling inhibitor, mP13	Integrin signaling inhibitor, mP13 is an inhibitor of integrin signaling. Integrin signaling inhibitor, mP13 inhibits inside-out and outside-in signaling, including fibrinogen binding, platelet adhesion, and clot retraction.	Integrin Blood or Cardio-cerebrovascular Disease	/
HY-N0229S2	L-Alanine-15N	L-Alanine-¹⁵N is the ¹⁵N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.	Endogenous Metabolite Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	/
HY-100911	W-5 hydrochloride	W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC₅₀ value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912).	Calmodulin Neurological, Eye or Ear Disease	/
HY-N0229S8	L-Alanine-13C3	L-Alanine-¹³C₃ is the ¹³C-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.	Endogenous Metabolite Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	/
HY-N2060	Evocarpine	Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity.	Apoptosis Bacterial Cancer Bacterial Infection Nonalcoholic Steatohepatitis	/
HY-101092A	QS-21	QS-21 is a mixture of QS-21-Xyl (HY-101092B) and QS-21-Api (HY-101092), with a ratio of 35:65. QS-21 is an innate immune system-targeted adjuvant. QS-21 is promising for research of oncology vaccines (e.g., melanoma) and infectious disease vaccines (e.g., HIV, malaria).	Toll-like Receptor (TLR) Cancer Vaccine and Immunization	/
HY-W010410	Oct-1-en-3-ol	Oct-1-en-3-ol, a fatty acid fragrant, is a self-stimulating oxylipin messenger. Oct-1-en-3-ol serves as a signaling molecule in plant cellular responses, plant-herbivore interactions, and plant-plant interactions. Oct-1-en-3-ol causes dopamine neuron degeneration through disruption of dopamine handling.	Environmental Pollutants Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	/
HY-P11303	PADRE peptide	PADRE peptide is a pan-HLA-DR binding epitope and immunostimulant. PADRE peptide binds to the peptide-binding groove of MHC class II molecules for presentation to CD4⁺ T cells, thereby effectively stimulating specific immune responses. PADRE peptide not only enhances anti-tumor immune responses, inhibits tumor growth and prolongs survival; it also significantly increases the frequency of E7-specific CD8⁺ T cells and improves therapeutic efficacy against TC-1 tumors when used in combination with E7 peptide-based vaccines and poly (I:C). The intensity of the immune response induced by PADRE peptide is lower than that of the Ii-PADRE DNA vaccine, and it fails to enhance the immune effect of CRT-E7 DNA. PADRE peptide is widely applicable to research on related tumors such as melanoma, glioblastoma and cervical cancer.	CD74 MHC Cervical Cancer Neuroblastoma Glioblastoma	/
HY-P99292	Fontolizumab	Fontolizumab (HuZAF) is a human monoclonal antibody targeting interferon γ (IFN-γ). Fontolizumab binds specifically and with high affinity to secreted IFN-γ, neutralizes its activity, blocks receptor binding, and inhibits downstream signal transduction and the expression of IFNγ-responsive genes. Fontolizumab reduces serum C-reactive protein levels, inhibits the expression of IL-1α, IL-1β and IL-12Rβ2, and decreases the number of IFNγ-producing T cells in activated peripheral blood mononuclear cells. Fontolizumab can be used in research related to Crohn's disease. Species: Human	IFNAR Crohn's Disease	/
HY-159114	Whole Glucan Particles	Whole Glucan Particles is a Dectin-1a agonist. Whole Glucan Particles activates the innate immune system to improve the function of macrophages, monocytes and other immune cells.	C-type Lectin-like Receptors (CTLRs) Biochemical Assay Reagents Inflammation or Immune System Disease	/
HY-NP113	Highly purified Type II collagen, from chick sternal cartilage	Highly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.	MMP Inflammation or Immune System Disease	/
HY-P99114	Sugemalimab	Sugemalimab is a fully human, full length, anti-programmed death ligand 1 (PD-L1) immunoglobulin G4 (IgG4) monoclonal antibody (mAb). Sugemalimab shows anticancer activities and can be used for non-small cell lung cancer research. Species: Human	PD-1/PD-L1 Respiratory Disease Non-Small Cell Lung Cancer	/
HY-P0225	Autocamtide 2	Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay.	CaMK Autophagy Cancer Neurological, Eye or Ear Disease	/
HY-W015954	(2R,3R)-Butane-2,3-diol	(2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La³⁺)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC₅₀ of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases.	Endogenous Metabolite Calcium Channel Bacterial Metabolic or Endocrine Disease Bacterial Infection	/
HY-P0215	Autocamtide-2-related inhibitory peptide, myristoylated	Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.	CaMK Autophagy Neurological, Eye or Ear Disease	/
HY-P990961	Palverafusp alfa	Palverafusp alfa (IMM-2510; SYN-2510) is a PD-L1/VEGF-targeting IgG1κ type humanized antibody. Palverafusp alfa blocks PD-1/PD-L1 binding, relieves immune suppression, mediates PD-L1-directed antibody-dependent cellular cytotoxicity (ADCC). Palverafusp alfa blocks VEGF/VEGFR binding, inhibits angiogenic signaling, relieves VEGF-induced immune suppression. Palverafusp alfa reduces endothelial cell proliferation, enhances ADCC and antibody-dependent cellular phagocytosis (ADCP), inhibits tumor growth, reverses T cell immune suppression. Palverafusp alfa exhibits immune stimulatory, antiangiogenic, and anti-tumor activity in the tumor microenvironment. Palverafusp alfa can be used for the research of cancer, such as solid tumors, non-small cell lung cancer. Species: Human	VEGFR PD-1/PD-L1 Cancer Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease	/
HY-W000357	4-(Imidazol-1-yl)phenol	4-(Imidazol-1-yl)phenol is a highly potent signal enhancer in a horseradish peroxidase (HRP)-luminol chemiluminescence (CL) immunoassay.	Biochemical Assay Reagents	/
HY-N2524	Camelliaside A	Camelliaside A is a phytochemical and also a HER2 ligand. Camelliaside A shows no inhibitory effect on mycelial growth of Rhizoctonia solani, indicating no antifungal activity against this pathogen. Camelliaside A is applicable to breast cancer-related research.	EGFR Breast Cancer	/
HY-P99795	Otilimab	Otilimab (GSK 3196165) is an anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) human monoclonal antibody. Otilimab neutralises the biological function of GM-CSF by blocking the interaction of GM-CSF with its cell surface receptor. Species: Human	c-Fms Inflammation or Immune System Disease	/
HY-P3136A	TRV055 hydrochloride	TRV055 (TRV120055) hydrochloride is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV055 hydrochloride induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. RV055 hydrochloride activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. RV055 hydrochloride induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. RV055 hydrochloride can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses^[1]	Angiotensin Receptor Cardiovascular Disease	/
HY-P10439	CVRARTR	CVRARTR is a programmed cell death ligand-1 (PD-L1) antagonist with a K_D of 281 nM. CVRARTR induces the internalization of PD-L1 and downregulates PD-L1 on the cell surface. CVRARTR restores cytokine secretion and T cell proliferation in cell CT26. CVRARTR exhibits antitumor efficacy against in CT26 homograft mouse model. CVRARTR can be used in melanoma research.	PD-1/PD-L1 Cancer Inflammation or Immune System Disease	/
HY-P990294	Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)	Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis. Species: Mouse	Transmembrane Glycoprotein STAT Collagen Reactive Oxygen Species (ROS) Interleukin Related Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease	/
HY-W001952	6-Bromo-2-naphthol	6-Bromo-2-naphthol is an RTP (real-time polymerase chain reaction) probe that forms a 1:1 or 2:1 complex with β-cyclodextrin (β-CD). 6-Bromo-2-naphthol is capable of real-time monitoring of PCR reactions and quantification of specific nucleic acid sequences. RTP probes are a class of small DNA or RNA sequences labeled with fluorescent dyes and quencher molecules, which can be widely used in gene expression analysis, SNP genotyping, and pathogen detection. 6-Bromo-2-naphthol embeds into the cyclodextrin cavity through hydrophobic interactions, inhibits the oxygen quenching effect, and emits a phosphorescent signal at room temperature. 6-Bromo-2-naphthol can also be used as an intermediate for the synthesis of antibacterial azo dyes, and its derivatives show antibacterial activity against Staphylococcus aureus, Escherichia coli and other bacteria.	Fluorescent Dye Drug Intermediate Escherichia Coli Infection	/
HY-NP0196	Mouse immunoglobulin G	Mouse Immunoglobulin G (Mouse IgG) is the most abundant glycoprotein in mouse serum, which bridges innate and adaptive immune responses. A conserved asparagine-297 residue on each heavy chain contains an N-linked glycosylation site. Mouse Immunoglobulin G shares many glycosylation features with human IgG, but contains N-Glycolylneuraminic acid (HY-128965) instead of N-acetylneuraminic acid (HY-I0400). Mouse Immunoglobulin G is widely used as a negative isotype control, immunoassay coating protein and research standard in the life sciences.	Biochemical Assay Reagents Inflammation or Immune System Disease	/
HY-N6714	Alternariol	Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects. Source: fungi of the genus Alternaria	Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis Breast Cancer	/
HY-N1434	Methyl p-coumarate	Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens.	Fungal Cancer Fungal Infection	/
HY-N4285	Negletein	Negletein (5,6-Dihydroxy-7-methoxyflavone) is a flavone found in Scutellaria. Negletein shows anti-inflammatory activity via inhibiting TNF-α and IL-1β with IC₅₀ values of 16.4 and 6.4 μM, respectively. Negletein can activate Nrf2 and inhibit ROS production. Negletein can enhance the neuroprotective effect of nerve growth factor. Negletein can inhibit amyloid beta-peptide release and accumulation. Negletein can inhibit pathogens biofilms formation. Negletein can be used for the researches of cancer, infection, inflammation and neurological disease, such as colon cancer and Alzheimer's disease.	TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Keap1-Nrf2 Amyloid-β Infection Colorectal Cancer Prostate Cancer Depression Pain Alzheimer's Disease Nonalcoholic Steatohepatitis Obesity Lung Fibrosis Rheumatoid Arthritis	/
HY-W145486	Calcium gluconate	Calcium gluconate is an orally effective calcium salt supplement. Calcium gluconate reduces elevated serum potassium, decreased serum calcium, and postoperative myalgia associated with succinylcholine administration. Calcium gluconate restores calcium homeostasis, skeletal integrity, bone mineralization and bone density, and maintains levels of parathyroid hormone, bone resorption markers and osteoclasts. Calcium gluconate reverses LPS (HY-D1056)-induced ERK phosphorylation, inflammatory cytokine release and acute lung injury, alleviates airway inflammatory damage and suppresses immune responses. Calcium gluconate can be used in research related to postoperative myalgia, osteoporosis/osteomalacia and acute lung injury.	Environmental Pollutants Biochemical Assay Reagents Postoperative Pain Acute Lung Injury Osteoporosis	/
HY-P99833	Cosibelimab	Cosibelimab (CK-301) is a high-affinity, fully human PD-L1-blocking monoclonal antibody that binds PD-L1 and blocks its interaction with PD-1. Cosibelimab exhibits antitumor efficacy. Species: Human	PD-1/PD-L1 Cancer	/
HY-P3151	Gliadin p31-43	Gliadin p31-43 is an undigested gliadin peptide. Gliadin p31-43 induces an innate immune response in the intestine and interferes with endocytic trafficking. Gliadin p31-43 can be used for celiac disease research.	Others Inflammation or Immune System Disease	/
HY-P99791	Orilanolimab	Orilanolimab (SYNT001) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity. Species: Human	Others Inflammation or Immune System Disease	/
HY-P99759	Nogapendekin alfa (his tag)	Nogapendekin alfa his tag is an immunostimulant that binds to the IL-2RβγC complex on immune cells. Nogapendekin alfa his tag stimulates the proliferation and activation of natural killer cells and CD8⁺ T cells, upregulates the expression of granzyme B and perforin, and activates the innate and adaptive immune branches. Nogapendekin alfa his tag forms ALT-803 with IL-15RαSuFc; this complex has an extended biological half-life, improved biodistribution and retention in lymphoid tissues, enhances natural killer cell-mediated rituximab-dependent cellular cytotoxicity, and reduces tumor burden and improves survival when combined with anti-CD20 monoclonal antibody therapy. Nogapendekin alfa his tag can be used in the research of non-Hodgkin's lymphoma. Species: Human	Interleukin Related Inflammation or Immune System Disease Non-Hodgkin Lymphoma	/
HY-P2076	Dusquetide	Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns	p62 Bacterial	/
HY-121310	Phthalocyanine	Phthalocyanine is a type of pigment and Photosensitizer. Upon irradiation, Phthalocyanine generates ROS or converts light energy into heat, inducing oxidative damage, cytotoxicity, and photodynamic killing of bacterial biofilms. Phthalocyanine produces chemiluminescence when oxidized. It can be used in studies related to cancer, bacterial infections, and photodynamic approaches.	Bacterial Photosensitizer Reactive Oxygen Species (ROS) Biochemical Assay Reagents Cancer Bacterial Infection	/
HY-123533A	Resorufin sodium salt	Resorufin sodium salt (NSC 12097) is a highly fluorescent pink dye. Resorufin sodium salt shows favorable properties such as water solubility, red-shifted absorption/emission signals. Resorufin sodium salt is used for the detection of ROS/RNS and a second analyte.	Reactive Oxygen Species (ROS)	/
HY-P4821	pTH (1-34) amide (human)	PTH (1-34) amide human is a type 1 PTH/PTHrP receptor agonist. PTH (1-34) amide human activates adenylate cyclase and phospholipase C pathways, thereby mediating mineral ion homeostasis and bone metabolism regulation. PTH (1-34) amide human increases serum calcium, decreases serum phosphorus, regulates renal excretion, while inducing the inhibition of endogenous PTH (1-84) and the increase of 1,25-dihydroxyvitamin D2 and bone resorption. PTH (1-34) amide human stimulates phosphatidylcholine hydrolysis via phospholipase D mediation, and its hypercalcemic effect is inhibited by human PTH-(7-84). PTH (1-34) amide human can be used in the research of diseases related to humoral hypercalcemia of malignancy.	PTHR Adenylate Cyclase Phospholipase Cancer Hypercalcemia	/
HY-W145665	Amylose	Amylose is not a typical small-molecule ligand with a specific traditional receptor-binding target. It is a polysaccharide. In food science and biological systems, amylose can interact with proteins and free fatty acids through non-covalent forces like hydrophobic interactions and electrostatic interactions. For example, it can form a ternary complex with them, which is related to the structure and digestion of starch. It is widely studied in the fields of food science, carbohydrate metabolism, and is also relevant in research on controlling glycemic responses, as it affects starch digestion rate.	Biochemical Assay Reagents Endogenous Metabolite	/
HY-P10396	Elf18	Elf18 is a peptide fragment of bacterial translation elongation factor Tu (EF-Tu). Elf18 can be recognized by plant pattern recognition receptors, thereby inducing an immune response. Elf18 can enhance plants' resistance to pathogens and can be used in research related to plant immune responses.	Bacterial Inflammation or Immune System Disease Bacterial Infection	/
HY-D0307A	Amaranth	Amaranth is an organic azo dye. Amaranth inhibits cellular immune response. Amaranth can be used as a food additive.	Environmental Pollutants Biochemical Assay Reagents Inflammation or Immune System Disease	/
HY-107202GL	Polyinosinic-polycytidylic acid (GMP Like)	Polyinosinic-polycytidylic acid (Poly(I:C)) (GMP Like) is the GMP Like class Polyinosinic-polycytidylic acid (HY-107202), and can be used as pharmaceutical excipients. Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.	Toll-like Receptor (TLR) PKD HSP Bcl-2 Family Interleukin Related Apoptosis Cancer Infection Inflammation or Immune System Disease	/
HY-P3136	TRV055	TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses^[1]	Angiotensin Receptor ERK Cardiovascular Disease	/
HY-D1078	5(6)-Carboxy-2',7'-dichlorofluorescein diacetate	5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC₄ for MRP2 binding sites and inhibits MRP2-mediated LTC₄ transport (Ex/Em = 496/525 nm).	Fluorescent Dye Reactive Oxygen Species (ROS) P-glycoprotein	/
HY-W002879	4-Hydroxyphenylboronic acid pinacol ester	4-Hydroxyphenylboronic acid pinacol ester is a ROS-responsive component. 4-Hydroxyphenylboronic acid pinacol ester can structurally modify hyaluronic acid to prepare ROS-responsive intelligent nanocarriers and compound delivery systems. 4-Hydroxyphenylboronic acid pinacol ester endows hyaluronic acid-based nanocarriers with ROS responsiveness, enabling them to rapidly release the encapsulated Curcumin (HY-N0005) in the presence of reactive oxygen species. 4-Hydroxyphenylboronic acid pinacol ester is applicable to research related to periodontitis. 4-Hydroxyphenylboronic acid pinacol ester can also be used for the synthesis of boronic acid-modified resins.	Reactive Oxygen Species (ROS) Periodontal Disease	/
HY-12557	γ-Glutamylvaline	γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation.	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin Inflammation or Immune System Disease	/
HY-P99480	Bintrafusp alfa	Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer.	TGF-β Receptor Non-Small Cell Lung Cancer HER-2 Positive Breast Cancer Triple-Negative Breast Cancer Metastatic Breast Cancer	/
HY-P99031	Mavrilimumab	Mavrilimumab (CAM 3001) is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophage colony stimulating factor (GM-CSF) receptor and blocks intracellular signalling downstream of GM-CSF. GM-CSF might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death. Species: Human	c-Fms SARS-CoV-2 Infection Rheumatoid Arthritis	/
HY-P990016	Temtokibart	Temtokibart (ARGX-112) is a monoclonal antibody and also an IL-22RA1 inhibitor. Temtokibart inhibits the signal transduction of IL-22, IL-20 and IL-24. Temtokibart reduces the expression levels of inflammatory proteins, chemokines, immune cell migration and markers of activated immune pathways. Temtokibart improves the expression of genes related to immunity and epidermal barrier function. Temtokibart is applicable to research on moderate-to-severe atopic dermatitis. Species: Human	Interleukin Related Atopic Dermatitis	/
HY-W040143	2',7'-Dichlorofluorescein	2',7'-Dichlorofluorescein is an important fluorescent product in the detection of oxidative stress and can be used to measure reactive oxygen species (ROS) (Ex=503 nm and Em=523 nm).	Reactive Oxygen Species (ROS) Fluorescent Dye Inflammation or Immune System Disease	/
HY-P99139	Anti-Mouse IL-1b Antibody (B122)	Anti-Mouse IL-1b Antibody (B122) is an anti-mouse IL-1b IgG monoclonal antibody. Anti-Mouse IL-1b Antibody (B122) enhances ferroptosis and increases levels of reactive oxygen species (ROS) combined with Sulfasalazine (SAS) (HY-14655). Anti-Mouse IL-1b Antibody (B122) can reduce monocyte infiltration and alleviate T cell exhaustion by blocking IL-1β signaling. Anti-Mouse IL-1b Antibody (B122) can be used for researches on cancer and cardiovascular conditions such as oral squamous cell carcinoma (OSCC), glioblastoma (GBM) and heart failure. Species: Mouse	Interleukin Related Reactive Oxygen Species (ROS) Ferroptosis Blood or Cardio-cerebrovascular Disease Glioma	/
HY-D0987	Stains-All	Stains-All, a cationic carbocyanine dye, is a convenient probe to study the structural features of the individual calcium-binding sites of calmodulin (CaM) and related calcium-binding proteins (CaBP).	Calmodulin	/
HY-N0229S3	L-Alanine-d4	L-Alanine-d₄ is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.	Endogenous Metabolite Neurological, Eye or Ear Disease Metabolic or Endocrine Disease	/
HY-P9916	Sarilumab	Sarilumab is a monoclonal antibody targeting IL6 that binds to IL6R and blocks the binding of IL6, thereby inhibiting the activation of the downstream STAT3 phosphorylation signaling pathway. In tumor cells with active IL6/STAT3 signaling pathways, Sarilumab induces Apoptosis and inhibits cell growth. Sarilumab is applicable to research related to prostate cancer, lung cancer and rheumatoid arthritis. Species: Human	Interleukin Related STAT Apoptosis Lung Cancer Prostate Cancer Rheumatoid Arthritis	/
HY-P9990	Litifilimab	Litifilimab (BIIB059) is a humanized IgG1 monoclonal antibody targeting BDCA2. Litifilimab induces internalization of BDCA2 receptors on the membrane of plasmacytoid dendritic cells, inhibits the TLR7/TLR9 signaling pathway, and suppresses the production of type I interferons. Litifilimab can be used in the research of systemic and cutaneous lupus erythematosus. Species: Human	C-type Lectin-like Receptors (CTLRs) Toll-like Receptor (TLR) Systemic Lupus Erythematosus	/
HY-123533	Resorufin	Resorufin (NSC 12097) is a highly fluorescent pink dye. Resorufin shows favorable properties such as water solubility, red-shifted absorption/emission signals. Resorufin is used for the detection of ROS/RNS and a second analyte.	Reactive Oxygen Species (ROS) Fluorescent Dye Cancer	/
HY-D0838	Dodecyltrimethylammonium bromide	Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction.	Biochemical Assay Reagents	/
HY-113449	Ubiquinone-1	Ubiquinone-1 is an intermediate in the synthesis of Coenzyme Q. Ubiquinone-1 can be reduced by NADPH oxidase, hepatoma cells, Ascorbic acid (HY-B0166). The product specifications provided below refer solely to the active content of Ubiquinone-1.	Endogenous Metabolite NADPH Oxidase Metabolic or Endocrine Disease	/
HY-P70640	PD-1 Protein, Mouse (HEK293, His)	PD-1 Protein is an important immune regulatory molecule expressed on the surface of activated immune cells. By binding to its ligands (PD-L1/PD-L2), the PD-1 Protein exerts immunosuppressive effects. PD-1 Protein can be used in the research of tumors, autoimmune diseases, and other conditions. PD-1 Protein, Mouse (HEK293, His) is a recombinant PD-1 protein expressed by HEK293 cells and carries a C-6His tag and glycosylation modification. Species: Mouse; Source: HEK293*	Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins PD-1	/
HY-P70118	CLEC4E Protein, Human (HEK293, His)	The CLEC4E protein is a calcium-dependent lectin that functions as a pattern recognition receptor in the immune system.It detects and binds DAMPs and PAMPs, including α-mannose residues on mycobacterial TDM and fungi.CLEC4E Protein, Human (HEK293, His) is the recombinant human-derived CLEC4E protein, expressed by HEK293 , with C-6His labeled tag. Species: Human; Source: HEK293*	Receptor Proteins Pattern Recognition Receptors C-type Lectin Receptors Macrophage-inducible C-type Lectin/CLEC4E	/
HY-P76761	CaMKII alpha/CAMK2A Protein, Human (Active, sf9, GST)	CaMKII α/CAMK2A protein functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. CaMKII alpha/CAMK2A Protein, Human (sf9, GST) is the recombinant human-derived CaMKII alpha/CAMK2A protein, expressed by Sf9 insect cells , with N-GST labeled tag. Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK2 CAMK2A/CaMKII alpha	/
HY-P70676	PD-1 Protein, Cynomolgus (HEK293, His)	PD-1 is a cell surface receptor on T and B cells that binds to PD-L1 and PD-L2. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells). The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PD-1 protein, expressed by HEK293 , with C-6His labeled tag. Species: Cynomolgus; Source: HEK293*	Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins PD-1	/
HY-P74536	STIM1 Protein, Human (HEK293, His)	STIM1 (stromal interacting molecule 1) coordinates store-operated Ca(2+) entry (SOCE) and acts as a Ca(2+) sensor in the endoplasmic reticulum. Upon Ca(2+) depletion, STIM1 translocates to the plasma membrane and activates the Ca(2+)-releasing activated Ca(2+) (CRAC) channel subunit ORAI1. STIM1 Protein, Human (HEK293, His) is the recombinant human-derived STIM1 protein, expressed by HEK293 , with C-His labeled tag. Species: Human; Source: HEK293		/
HY-P70525	PD-1 Protein, Human (HEK293, mFc)	PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (HEK293, mFc) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-mFc labeled tag. Species: Human; Source: HEK293	Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins PD-1	/
HY-P701720	CaMKII delta/CAMK2D Protein, Human (Active, sf9, GST)	CAMK2D protein regulates calcium levels and excitation-contraction coupling in the heart. CaMKII delta/CAMK2D Protein, Human (sf9, GST) is the recombinant human-derived CAMK2D protein, expressed by sf9 insect cells , with N-GST labeled tag. Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK2 CAMK2D/CaMKII Delta	/
HY-P703082	MAVS Protein, Human (His-SUMO)	MAVS Protein, Human (His-SUMO) is the recombinant human-derived MAVS, expressed by E. coli , with N-6His, N-SUMO labeled tag. , Species: Human; Source: E. coli*		/
HY-P76760	CALML5 Protein, Human (His)	The CALML5 protein is known for its calcium-binding ability and may be involved in terminal differentiation of keratinocytes, suggesting a role in skin cell maturation. Its association with transglutaminase 3 suggests cooperation in skin development function. CALML5 Protein, Human (His-GST) is the recombinant human-derived CALML5 protein, expressed by E. coli , with N-His, N-GST labeled tag. Species: Human; Source: E. coli		/
HY-P70766	PD-1 Protein, Human (147a.a, HEK293, His)	PD-1 protein is an inhibitory receptor on T cells that maintains immune tolerance by binding to CD274/PDCD1L1 and CD273/PDCD1LG2. It blocks T cell activation by binding to CD3-TCR and recruiting PTPN11/SHP-2 to dephosphorylate key signaling molecules. PD-1 Protein, Human (147a.a, HEK293, His) is the recombinant human-derived PD-1 protein, expressed by HEK293 , with C-6His labeled tag. Species: Human; Source: HEK293*	Immune Checkpoint Proteins CD Antigens Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins PD-1	/
HY-P71140A	S100A4 Protein, Human (C/N-His)	The S100A4 protein is a calcium-binding protein involved in angiogenesis, cell differentiation, apoptosis, and autophagy. S100A4 protein interacts with MYH9 to enhance cell motility and invasion. S100A4 also inhibits the pro-apoptotic function of TP53 by reducing its protein levels. S100A4 Protein, Human (C/N-His) is the recombinant human-derived S100A4 protein, expressed by E. coli , with N-6His, C-6His labeled tag. Species: Human; Source: E. coli		/
HY-P700570	CDKN1A Protein, Human (GST)	The CDKN1A protein critically controls cell cycle progression and mediates DNA damage-induced G2 arrest through p53/TP53-dependent and CREB3L1-mediated p53-independent pathways. It inhibits cyclin-dependent kinase activity, blocking cell cycle progression by preventing phosphorylation of key substrates. CDKN1A Protein, Human (GST) is the recombinant human-derived CDKN1A protein, expressed by E. coli , with N-GST labeled tag. Species: Human; Source: E. coli	Enzymes & Regulators Cyclin-Dependent Kinase Inhibitor Proteins Cyclin Dependent Kinase Inhibitor 1A (CDKN1A)	/
HY-P71202	PHLDA2 Protein, Human (His)	PHLDA2 protein regulates placenta growth, potentially through its PH domain, which competes with other PH domain-containing proteins, hindering their binding to membrane lipids. PHLDA2 Protein, Human (His) is the recombinant human-derived PHLDA2 protein, expressed by E. coli , with C-6His labeled tag. Species: Human; Source: E. coli*		/
HY-P75461	CALM2 Protein, Human (His)	The CALM2 protein is an important component of calcium signaling, controlling enzymes, ion channels, and aquaporins through calcium binding. CALM2 Protein, Human (His) is the recombinant human-derived CALM2 protein, expressed by E. coli , with N-His labeled tag. Species: Human; Source: E. coli		/
HY-P7714	CAMKI alpha/CAMK1 Protein, Human (Active, HEK293, His)	CAMKI alpha/CAMK1 Protein, Human (HEK293, His), a recombinant human CAMK1 produced in HEK293 cells, has a His tag at the N-terminus. CAMK1 is involved in multiple cell functions, including calmodulin binding, ATP binding, signal transduction, development and cell differentiation. Species: Human; Source: HEK293	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK1 CaMK1a/CAMK1	/
HY-P702714	ROS1 Protein, Human (Active, sf9, His)	ROS1 Protein, Human (sf9, His) is the recombinant human-derived ROS1, expressed by Sf9 insect cells , with His labeled tag. , Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) Protein Tyrosine Kinases TK Sev ROS1/ROS	/
HY-P71191	PDCD4 Protein, Human (His)	PDCD4 inhibits translation initiation by disrupting the EIF4A1-EIF4G interaction and inhibiting EIF4A helicase activity. It regulates JUN kinase activation and downregulates MAP4K1, inhibiting invasion and tumorigenesis. PDCD4 Protein, Human (His) is the recombinant human-derived PDCD4 protein, expressed by E. coli , with C-6His labeled tag. Species: Human; Source: E. coli*		/
HY-P705867	PTK2B Protein, Human (Active, Biotinylated, sf9, Avi)	Species: Human; Source: sf9 insect cells	Enzymes & Regulators Kinases Biotinylated Proteins Transferases (EC 2) TK FAK PTK2B/PYK2	/
HY-P77336	CLEC4E Protein, Rhesus Macaque (HEK293, hFc, solution)	CLEC4E Protein is a calcium-dependent lectin displaying mannose-binding specificity, and induces the formation of Birbeck granules (BGs). CLEC4E Protein is a potent regulator of membrane superimposition and zippering, and binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. CLEC4E Protein, Rhesus Macaque (HEK293, hFc, solution) is the recombinant Rhesus Macaque-derived CLEC4E protein, expressed by HEK293 , with N-hFc labeled tag. Species: Rhesus Macaque; Source: HEK293	Receptor Proteins Pattern Recognition Receptors C-type Lectin Receptors Macrophage-inducible C-type Lectin/CLEC4E	/
HY-P72110	CALML3 Protein, Human (GST)	The CALML3 protein has a dual role, acting as a specific light chain of unconventional myosin 10 (MYO10) and enhancing MYO10 translation. CALML3 has a potential molecular chaperone role and contributes to the synthesis of the emerging MYO10 heavy chain protein. CALML3 Protein, Human (GST) is the recombinant human-derived CALML3 protein, expressed by E. coli , with N-GST labeled tag. Species: Human; Source: E. coli		/
HY-P76311	ECSIT Protein, Human (His)	ECSIT protein is an adapter protein in Toll-like receptors, IL-1, and antiviral signaling that crucially activates NF-kappa-B by complexing with TRAF6 and TAK1/MAP3K7, leading to TAK1/MAP3K7 activation and subsequent IKK activation. Ubiquitinated ECSIT interacts with RELA and NFKB1 and translocates to induce NF-kappa-B-dependent gene expression. ECSIT Protein, Human (His) is the recombinant human-derived ECSIT protein, expressed by E. coli , with N-His labeled tag. Species: Human; Source: E. coli		/
HY-P76700	VTI1A Protein, Human (HEK293, His)	VTI1A protein is a V-SNARE that mediates vesicle trafficking and promotes lipid bilayer fusion by interacting with t-SNARE on target membranes. It plays a role in vesicle trafficking from late endosomes to the trans-Golgi network. VTI1A Protein, Human (HEK293, His) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-His labeled tag. Species: Human; Source: HEK293		/
HY-P76701	VTI1A Protein, Human (HEK293, Fc)	VTI1A protein is a V-SNARE that mediates vesicle trafficking and promotes lipid bilayer fusion by interacting with t-SNARE on target membranes. It plays a role in vesicle trafficking from late endosomes to the trans-Golgi network. VTI1A Protein, Human (HEK293, Fc) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-mFc labeled tag. Species: Human; Source: HEK293		/
HY-P76762	CaMKII beta/CAMK2B Protein, Human (Active, sf9, His-GST)	CaMKII beta/CAMK2B is a calcium/calmodulin-dependent protein kinase that functions autonomously upon Ca(2+)/calmodulin binding and autophosphorylation. It plays an important role in dendritic spine and synapse formation, neuronal plasticity, and the regulation of skeletal muscle sarcoplasmic reticulum Ca(2+) transport. CaMKII beta/CAMK2B Protein, Human (sf9, His-GST) is the recombinant human-derived CaMKII beta/CAMK2B protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK2 CAMK2B/CaMKII beta	/
HY-P7715	CAMKI delta/CAMK1D Protein, Human (GST)	CAMKI delta/CAMK1D Protein, Human (GST), a recombinant human CAMK1D expressed in E. coli, has a GST tag at the N-terminus. CAMK1D acts as a key modulator of tumor-intrinsic immune resistance. Species: Human; Source: E. coli	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK1 CAMK1D	/
HY-P705662	CAMKI alpha/CAMK1 Protein, Human (Active)	CAMKI alpha/CAMK1 Protein, Human, a recombinant human CAMK1 produced in HEK293 cells. CAMK1 is involved in multiple cell functions, including calmodulin binding, ATP binding, signal transduction, development and cell differentiation. Species: Human; Source: E. coli	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK1 CaMK1a/CAMK1	/
HY-P701398	RGS14 Protein, Human	The RGS14 protein complexly regulates G protein-coupled receptor signaling by enhancing the GTPase activity of specific α subunits and acting as a GDP dissociation inhibitor (GDI). It exhibits GDI activity on GNAI1 and GNAI3 but not on GNAI2 and GNAO1. RGS14 Protein, Human is the recombinant human-derived RGS14 protein, expressed by E. coli , with tag free. Species: Human; Source: E. coli	Enzymes & Regulators	/
HY-P701757	PNCK Protein, Human (Active, sf9, His, GST)	The PNCK protein is a calcium/calmodulin-dependent protein kinase and a key component of the calcium-triggered signaling cascade. In vitro, PNCK exhibits the ability to phosphorylate CREB1 and SYN1/synapsin I, emphasizing its involvement in regulating cellular processes associated with these substrates. PNCK Protein, Human (sf9, His, GST) is the recombinant human-derived PNCK protein, expressed by sf9 insect cells , with N-8His, N-GST labeled tag. Species: Human; Source: Sf9 insect cells*	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK1 CaMK1b/PNCK	/
HY-P702652	CAMKIV/CAMK4 Protein, Human (Active, sf9, GST)	CAMKIV/CAMK4 Protein, Human (sf9, GST) is the recombinant human-derived CAMKIV/CAMK4, expressed by Sf9 insect cells , with GST labeled tag. Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK1 CAMK4/CAMKIV	/
HY-P702653	CAMK1 delta Protein, Human (Active, sf9, GST)	CAMK1 delta Protein, Human (sf9, GST) is the recombinant human-derived CAMK1 delta, expressed by Sf9 insect cells , with GST labeled tag. Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK1 CAMK1D	/
HY-P702654	CAMK1 alpha/CAMK1 Protein, Human (Active, sf9, His, GST)	CAMK1 alpha/CAMK1 Protein, Human (sf9, His, GST) is the recombinant human-derived CAMK1 alpha, expressed by Sf9 insect cells , with His, GST labeled tag. Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) Serine/Threonine Kinase Proteins CAMK CAMK1 CaMK1a/CAMK1	/
HY-P702942	ERF1 protein, Human (sf9, GST)	ERF1 protein, Human (sf9, GST) is the recombinant human-derived ERF1, expressed by Sf9 insect cells , with GST labeled tag. Species: Human; Source: Sf9 insect cells	Enzymes & Regulators	/
HY-P703113	DLG4 Protein, Human (Biotinylated, HEK293)	DLG4 Protein, Human (Biotinylated, HEK293) is the recombinant human-derived DLG4, expressed by HEK293 , with tag Free labeled tag. Species: Human; Source: HEK293		/
HY-P703114	DLG4 Protein, Human (Biotinylated, Avi)	DLG4 Protein, Human (Biotinylated, Avi) is the recombinant human-derived DLG4, expressed by E. coli , with Avi labeled tag. Species: Human; Source: E. coli		/
HY-P703476	CALM3 Protein, Tetronarce californica	CALM3 Protein, Tetronarce californica is the recombinant CALM3, expressed by E. coli , with tag Free labeled tag. Species: Others; Source: E. coli		/
HY-P703566	ETF1 Protein, Human	ETF1 Protein, Human is the recombinant human-derived ETF1, expressed by E. coli , with tag Free labeled tag. Species: Human; Source: E. coli		/
HY-P71010	PSD95 Protein, Rat (His)	PSD95 protein plays a crucial role in PDZ domain binding, enzyme binding and signaling receptor binding. It is a structural component of the postsynaptic density and is involved in the regulation of synaptic transmission and cellular organization. PSD95 Protein, Rat (His) is the recombinant rat-derived PSD95 protein, expressed by E. coli , with N-6His labeled tag. Species: Rat; Source: E. coli*		/
HY-P701399	RGS14 Protein, Human (His)	The RGS14 protein complexly regulates G protein-coupled receptor signaling by enhancing the GTPase activity of specific α subunits and acting as a GDP dissociation inhibitor (GDI). It exhibits GDI activity on GNAI1 and GNAI3 but not on GNAI2 and GNAO1. RGS14 Protein, Human (His) is the recombinant human-derived RGS14 protein, expressed by E. coli , with N-6His labeled tag. Species: Human; Source: E. coli*	Enzymes & Regulators	/
HY-P705135	GUCY2D Protein, Human (Biotinylated, HEK293, His-Avi)	Species: Human; Source: HEK293	Biotinylated Proteins	/
HY-P705752	CAMKV Protein, Human (sf9, His-GST)	Although the CAMKV protein is classified as a kinase, it does not exhibit detectable kinase activity. This feature distinguishes CAMKV from classical kinases, which typically phosphorylate substrates as an essential aspect of their enzymatic function. CAMKV, Human (sf9, His-GST) is the recombinant human-derived CAMKV protein, expressed by sf9 insect cells, with N-Avi labeled tag. Species: Human; Source: sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) CAMK CAMK-Unique CAMKV/VACAMKL	/
HY-P705753	CASK Protein, Human (sf9, His-GST)	CASK protein is a Mg(2+)-independent multidomain scaffold kinase that catalyzes phosphate transfer to proteins, including NRXN1, thereby contributing to synaptic transmembrane protein anchoring and ion channel trafficking. It plays a critical role in neural development, regulation of gene expression through TBR1 interactions, and mediates connections between the extracellular matrix, multiligands, and the actin cytoskeleton. CASK, Human (sf9, His-GST) is the recombinant human-derived CASK protein, expressed by sf9 insect cells, with N-Avi labeled tag. Species: Human; Source: sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) CAMK CASK	/
HY-P705866	PTK2B Protein, Human (277a.a, sf9)	Species: Human; Source: sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) TK FAK PTK2B/PYK2	/
HY-P705880	ROS1 Protein, Human (G2101A, sf9, His-Strep)	Species: Human; Source: sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) TK Sev ROS1/ROS	/
HY-P706023	CAMKK2 Protein, Human (Active, sf9, His-GST)	Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) Other Kinases CAMKK CaMKK2	/
HY-P706095	ROS1 Protein, Human (Active, G2032R, sf9, His-GST)	Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) TK Sev ROS1/ROS	/
HY-P706096	ROS1 Protein, Human (Active, L2086F, sf9, His-GST)	Species: Human; Source: Sf9 insect cells	Enzymes & Regulators Kinases Transferases (EC 2) TK Sev ROS1/ROS	/
HY-P81205	CAMKK2 Antibody	CAMKK2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CAMKK2. Host: Rabbit; Reactivity: Human, Mouse, Rat, Sheep	Polyclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P86955	MAVS Antibody (YA6648)	MAVS Antibody (YA6648) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAVS. Host: Rabbit; Reactivity: Human, Mouse	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P83404	L1CAM Antibody (YA3149)	L1CAM Antibody (YA3149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to L1CAM. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P86066	Phospho-CaMKIIβ/γ/δ Antibody (YA5758)	Phospho-CaMKIIβ/γ/δ Antibody (YA5758) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Phospho-CaMKIIβ/γ/δ. Host: Mouse; Reactivity: Human, Rat, Mouse	Monoclonal Antibodies Modification Specific Antibodies Primary Antibodies	/
HY-P81569	CBP Tag Antibody (YA1314)	CBP Tag Antibody (YA1314) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CBP Tag. Host: Mouse; Reactivity: Species independent	Monoclonal Antibodies Primary Antibodies	/
HY-P84582	PD-1 Antibody (YA4279)	PD-1 Antibody (YA4279) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PD-1. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P80290	PYK2 Antibody (YA115)	PYK2 Antibody (YA115) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PYK2. Host: Rabbit; Reactivity: Human, Mouse	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P86230	AIF Antibody (YA5922)	AIF Antibody (YA5922) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AIF. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P86365	CaMKII alpha Antibody (YA6057)	CaMKII alpha Antibody (YA6057) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII alpha. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P80534	AIF Antibody (YA835)	AIF Antibody (YA835) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AIF. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P80580	CaMK1 Antibody (YA570)	CaMK1 Antibody (YA570) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMK1. Host: Rabbit; Reactivity: Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P82592	CaMKII delta Antibody (YA2337)	CaMKII delta Antibody (YA2337) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII delta. Host: Rabbit; Reactivity: Human, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P85443	L1CAM Antibody (YA5135)	L1CAM Antibody (YA5135) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to L1CAM. Host: Mouse; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P85341	PYK2 Antibody (YA5033)	PYK2 Antibody (YA5033) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to PYK2. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P86140	PYK2 Antibody (YA5832)	PYK2 Antibody (YA5832) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PYK2. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P80877	PYK2 Antibody (YA682)	PYK2 Antibody (YA682) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PYK2. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P80877A	PYK2 Antibody (YA682)(PBS only)	PYK2 Antibody (YA682) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PYK2. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P84568	PYK2 Antibody (YA4265)	PYK2 Antibody (YA4265) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PYK2. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P84568A	PYK2 Antibody (YA4265)(PBS only)	PYK2 Antibody (YA4265) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PYK2. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P85462	PYK2 Antibody (YA5154)	PYK2 Antibody (YA5154) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PYK2. Host: Mouse; Reactivity: Human, Mouse, Dog, Pig, Rabbit	Monoclonal Antibodies Primary Antibodies	/
HY-P88028	CAMKK2 Antibody (YA7713)	CAMKK2 Antibody (YA7713) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to CAMKK2. Host: Mouse; Reactivity: Human, Mouse	Monoclonal Antibodies Primary Antibodies	/
HY-P811322	Stim2 Antibody	Stim2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Stim2. Host: Rabbit; Reactivity: Human, Mouse	Polyclonal Antibodies Primary Antibodies	/
HY-P84428	RF1 Antibody (YA4125)	RF1 Antibody (YA4125) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RF1. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P88128	RGS5 Antibody (YA7812)	RGS5 Antibody (YA7812) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RGS5. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P88670A	ROMO1 Antibody (YA8354)(PBS only)	ROMO1 Antibody (YA8354) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ROMO1. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P80534A	AIF Antibody (YA835)(PBS only)	AIF Antibody (YA835) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AIF. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P80580A	CaMK1 Antibody (YA570)(PBS only)	CaMK1 Antibody (YA570) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMK1. Host: Rabbit; Reactivity: Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P810461	POLDIP2 Antibody (YA9760)	POLDIP2 Antibody (YA9760) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to POLDIP2. Host: Rabbit; Reactivity: Human, mouse, rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P810753	Calmodulin Antibody (YA9996)	Calmodulin Antibody (YA9996) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Calmodulin. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P810790	Phospho-CaMK2 alpha (Thr286) Antibody (YA10033)	Phospho-CaMK2 alpha (Thr286) Antibody (YA10033) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Phospho-CaMK2 alpha (Thr286). Host: Rabbit; Reactivity: Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P811720	RGS9 Antibody (YA10191)	RGS9 Antibody (YA10191) is a Rabbit-derived and non-conjugated IgG recombinant monoclonal antibody, targeting to RGS9. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P81263	CaMKIV Antibody (YA942)	CaMKIV Antibody (YA942) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CaMKIV. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P81625	L1CAM Antibody (YA1370)	L1CAM Antibody (YA1370) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to L1CAM. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P81667	SNAP25 Antibody (YA1412)	SNAP25 Antibody (YA1412) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SNAP25. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P81667A	SNAP25 Antibody (YA1412)(PBS only)	SNAP25 Antibody (YA1412) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SNAP25. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P81935	POLDIP2 Antibody (YA1680)	POLDIP2 Antibody (YA1680) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to POLDIP2. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P81935A	POLDIP2 Antibody (YA1680)(PBS only)	POLDIP2 Antibody (YA1680) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to POLDIP2. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P82347	Stromal Interaction Molecule 1 Antibody (YA2092)	Stromal Interaction Molecule 1 Antibody (YA2092) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Stromal Interaction Molecule 1. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P82347A	Stromal Interaction Molecule 1 Antibody (YA2092)(PBS only)	Stromal Interaction Molecule 1 Antibody (YA2092) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Stromal Interaction Molecule 1. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P82592A	CaMKII delta Antibody (YA2337)(PBS only)	CaMKII delta Antibody (YA2337) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII delta. Host: Rabbit; Reactivity: Human, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P82599	CaMKII beta Antibody (YA2344)	CaMKII beta Antibody (YA2344) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII beta. Host: Rabbit; Reactivity: Mouse	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P82599A	CaMKII beta Antibody (YA2344)(PBS only)	CaMKII beta Antibody (YA2344) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII beta. Host: Rabbit; Reactivity: Mouse	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P82609	RGS18 Antibody (YA2354)	RGS18 Antibody (YA2354) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RGS18. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P83402	KRIT1 Antibody (YA3147)	KRIT1 Antibody (YA3147) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KRIT1. Host: Rabbit; Reactivity: Human, Mouse	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P83402A	KRIT1 Antibody (YA3147)(PBS only)	KRIT1 Antibody (YA3147) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KRIT1. Host: Rabbit; Reactivity: Human, Mouse	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P83404A	L1CAM Antibody (YA3149)(PBS only)	L1CAM Antibody (YA3149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to L1CAM. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P83466	RGS6 Antibody (YA3211)	RGS6 Antibody (YA3211) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RGS6. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P84428A	RF1 Antibody (YA4125)(PBS only)	RF1 Antibody (YA4125) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RF1. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P84551A	CaMKII gamma Antibody (YA4248)(PBS only)	CaMKII gamma Antibody (YA4248) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CAMK2 gamma. Host: Mouse; Reactivity: Human, Mouse, Rat, Monkey, Rabbit	Monoclonal Antibodies Primary Antibodies	/
HY-P86423	CaMKII beta Antibody (YA6115)	CaMKII beta Antibody (YA6115) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII beta. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P86530	Stromal Interaction Molecule 1 Antibody (YA6222)	Stromal Interaction Molecule 1 Antibody (YA6222) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Stromal Interaction Molecule 1. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P86956	MAVS Antibody (YA6649)	MAVS Antibody (YA6649) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAVS. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P87054	ROS1 Antibody (YA6747)	ROS1 Antibody (YA6747) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROS1. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P87346	PDCD7 Antibody (YA7029)	PDCD7 Antibody (YA7029) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDCD7. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P87355	AIDA Antibody (YA7038)	AIDA Antibody (YA7038) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AIDA. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P87588	PDCD7 Antibody (YA7272)	PDCD7 Antibody (YA7272) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDCD7. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P87599	CaMKII delta Antibody (YA7283)	CaMKII delta Antibody (YA7283) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKII delta. Host: Rabbit; Reactivity: Human	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-P88018	ROS1 Antibody (YA7703)	ROS1 Antibody (YA7703) is a Mouse-derived and non-conjugated IgG1, monoclonal antibody, targeting to ROS1. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P88346	C1orf106 Antibody (YA8030)	C1orf106 Antibody (YA8030) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1orf106. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P88346A	C1orf106 Antibody (YA8030)(PBS only)	C1orf106 Antibody (YA8030) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1orf106. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P88488	RGS10 Antibody (YA8172)	RGS10 Antibody (YA8172) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to RGS10. Host: Mouse; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Primary Antibodies	/
HY-P88670	ROMO1 Antibody (YA8354)	ROMO1 Antibody (YA8354) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ROMO1. Host: Mouse; Reactivity: Human, Mouse, Rat, Monkey, Dog	Monoclonal Antibodies Primary Antibodies	/
HY-P88797	GIMAP4 Antibody (YA8481)	GIMAP4 Antibody (YA8481) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GIMAP4. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P88797A	GIMAP4 Antibody (YA8481)(PBS only)	GIMAP4 Antibody (YA8481) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GIMAP4. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P89099	RGS13 Antibody (YA8783)	RGS13 Antibody (YA8783) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RGS13. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P84581	PD-1 Antibody (YA4278)	PD-1 Antibody (YA4278) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PD-1. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Flow Cytometry Antibodies Primary Antibodies	/
HY-P85925	PD-1 Antibody (YA5617)	PD-1 Antibody (YA5617) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PD-1. Host: Mouse; Reactivity: Human	Monoclonal Antibodies Primary Antibodies	/
HY-P87597	CaMKI Antibody (YA7281)	CaMKI Antibody (YA7281) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CaMKI. Host: Rabbit; Reactivity: Human, Mouse, Rat	Monoclonal Antibodies Recombinant Antibodies Primary Antibodies	/
HY-K0354	Mouse CD3/CD28 T Cell Activation Magnetic Beads	MCE Mouse CD3/CD28 T Cell Activation Magnetic Beads are based on the two important co-stimulatory signals, without relying on feeder cells (antigen-presenting cells) or antigens, CD3 and CD28, without relying on feeder cells (antigen-presenting cells) or antigens, enabling simple and rapid T cell activation.	Cell Biology Cell Isolation	/
HY-K0703	Avi-Tagged Protein Biotinylation Kit (BirA Enzymatic Method)	MCE Avi-Tagged Protein Biotinylation Kit (BirA Enzymatic Method) uses the biotin ligase BirA to rapidly and efficiently achieve site-specific biotinylation of Avi-tagged fusion proteins. The resulting biotinylated proteins can be captured, detected, and purified using streptavidin or avidin, making the kit suitable for a variety of protein analysis and molecular interaction studies.	Protein Biology Labeling Kit	/
HY-K1106	DAB Peroxidase Substrate Kit (Brown)	MCE DAB Peroxidase Substrate Kit (Brown) is a chromogenic reagent kit based on the HRP-catalyzed oxidation of DAB. It is suitable for staining and chromogenic detection in immunohistochemistry, immunocytochemistry, in situ hybridization, Western blotting, and other applications using cell or tissue samples. The resulting insoluble brown precipitate provides clear localization and stable visualization of target signals, facilitating direct observation and analysis. Following DAB development, counterstaining can be performed according to experimental requirements. For example, ethanol-soluble dyes can be used for subsequent counterstaining to facilitate the visualization and analysis of cellular or tissue morphology.	Cell Biology Cell Analysis Staining Kit	/
HY-K1202	Western Blot Antibody Stripping Solution (Acidic)	MCE Western Blot Membrane Stripping Solution (Acidic) is a mild antibody stripping buffer. It removes primary and secondary antibodies bound to the membrane after Western blot detection by disrupting antigen–antibody interactions under acidic conditions.	Protein Biology Protein Electrophoresis & WB Membrane Regeneration Solution	/
HY-K2020	OptiLNP RNA Transfection Reagent (Primary Immune Cells)	MCE OptiLNP RNA Transfection Reagent (Primary Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into primary immune cells.	Cell Biology Cell Culture Cell Transfection	/
HY-K2021	OptiLNP RNA Transfection Reagent (Immune Cells)	MCE OptiLNP RNA Transfection Reagent (Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient transfection of various RNA types into immune cells.	Cell Biology Cell Culture Cell Transfection	/
HY-K2028	OptiLNP Gene Editing Kit (Immune Cells)	MCE OptiLNP Gene Editing Kit (Immune Cells) is a ready-to-use transfection reagent based on LNP technology. It is designed for the efficient co-transfection of Cas9 mRNA and sgRNA during gene editing inimmune cells.	Cell Biology Cell Culture Cell Transfection	/
HY-K2033	OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells)	MCE OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells) utilizes antibody-conjugated cell-targeted lipid nanoparticle (Cell-targeted Lipid Nanoparticle, ctLNP) technology to achieve highly efficient nucleic acid(eg. pDNA、mRNA、sgRNA、siRNA) delivery into Jurkat cells. It is designed for in vitro transfection of Jurkat cells and is well suited for applications in immunotherapy, tumor immunology, and other immune cell-related research.	Cell Biology Cell Culture Cell Transfection	/
HY-K2034	OptiLNP Antibody-ctLNP RNA Transfection Reagent (Human Primary T Cells)	MCE OptiLNP Antibody-ctLNP pDNA Transfection Reagent (Jurkat Cells) utilizes antibody-conjugated cell-targeted lipid nanoparticle (Cell-targeted Lipid Nanoparticle, ctLNP) technology and is specifically optimized for human primary T cells. It enables efficient and targeted RNA delivery, improving transfection efficiency in difficult-to-transfect primary T cells. The kit is ideally suited for applications including CAR-T and TCR-T cell engineering, cancer immunology research, immune cell engineering, and in vitro T cell functional studies.	Cell Biology Cell Culture Cell Transfection	/
HY-K3120	Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads)	MCE Serum/Plasma Exosome Isolation and Purification Kit (Magnetic Beads) utilizes a magnetic bead-based method for the isolation and purification of exosomes. The underlying principle is based on the charge-dependent interaction between exosomes and functional polymers on the surface of the magnetic beads under an optimized buffer system, enabling selective adsorption of exosomes. Subsequent adjustment of the ionic strength and pH of the buffer promotes the gentle dissociation of exosomes from the magnetic beads, thereby enabling efficient exosome isolation and purification while maintaining high vesicle integrity and low impurity carryover.	Cell Biology Cell Analysis Exosome Isolation, Purification and Detection	/
HY-K6009	Basement Membrane Matrix GFR&HC	MCE Basement Membrane Matrix GFR&HC (Growth Factor Reduced, High Concentration) is primarily composed of natural basement membrane matrix extracted from mouse tumors, is suitable for cell cultures that need to reduce growth factor induction and studies related to growth factors, signaling pathways, etc.	Cell Biology 3D Cell Culture Basement Membrane Matrix	/
HY-K6119P	Mouse Intestinal Organoid Plus Kit	MCE Mouse Intestinal Organoid Plus Kit is an upgraded serum-free culture system developed based on the Mouse Small Intestinal Organoid Culture Kit (HY-K6119), designed for the establishment, expansion, and long-term maintenance of mouse small intestinal organoids. The kit contains basal culture medium and multiple essential supplements, and an optional Wnt ligand supplement is provided to enable modulation of Wnt signaling activity in the culture system.	Cell Biology 3D Cell Culture Normal Tissue Organoid Culture Medium	/
HY-K6301	Human iPSC/ESC Cortical Brain Organoid Induction Differentiation Kit	MCE Human iPSC/ESC Cortical Brain Organoid Induction Differentiation Kit is a standardized culture system specifically designed to recapitulate the developmental processes and functional features of the human cerebral cortex through forebrain ventralization-based signaling regulation. By sequentially activating the Wnt/β-catenin pathway and gradually inhibiting BMP/Smad signaling, this system efficiently drives human pluripotent stem cells (PSC) to differentiate into high-purity glutamatergic neurons (VGLUT1/2⁺ > 85%), while simultaneously promoting the formation of Pax6⁺/BLBP⁺ radial glial cells that establish a biomimetic ventricular-zone–like structure.	Cell Biology 3D Cell Culture PSC Induction Product Series	/
HY-K6303	Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit	MCE Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit is based on the classical GiWi system. By precisely modulating the Wnt/β-catenin signaling pathway in a temporally controlled manner (sequential activation and inhibition), the kit enables highly efficient directed differentiation of human pluripotent stem cells into cardiomyocytes. It is suitable for cardiac disease modeling, drug cardiotoxicity assessment, and mechanistic studies.	Cell Biology 3D Cell Culture PSC Induction Product Series	/
HY-KD1004A	Vari Fluor 4-colour Multiple Fluorescent Staining Kit-1 (For all samples)	Multiplex immunohistochemistry is also known as Tyramide Signal Amplification (TSA, Tyramide dignal amplification). It has been used for more than 20 years as an enzymatic assay for high-density in situ labelling of target proteins or nucleic acids by horseradish peroxidase (HRP). The method is based on multiple cis-immunostaining with tyramide signal amplification, which allows the detection of multiple target sites in cell or tissue samples in situ, and elucidation of their interaction mechanism through the study of the combination and positional relationship of these target sites.	Protein Biology Multiple Fluorescent Staining	/