PI3 - peptidase inhibitor 3 Gene

Also Known as ESI; WAP3; SKALP; WFDC14; cementoin

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5266

About PI3

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,174,902-45,176,544 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues and 9 paralogues. Biased expression in esophagus (RPKM 578.7), colon (RPKM 50.5) and 1 other tissue.

Summary

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and Fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by Bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]

PI3 Products (1)

mRNA Protein Name
NM_002638.4 NP_002629.1 elafin preproprotein
Molecular Function GO Annotation Evidence References Source
enables structural constituent of skin epidermis IDA
IDA: Inferred from direct assay
7543090 GOA
Biological Process GO Annotation Evidence References Source
involved in peptide cross-linking IDA
IDA: Inferred from direct assay
7543090 GOA
Cellular Component GO Annotation Evidence References Source
located in cornified envelope IDA
IDA: Inferred from direct assay
7543090 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PI3 Protein Structure

Cementoin

Cementoin: Trappin protein transglutaminase binding domain (31 - 47)

Cementoin

Cementoin: Trappin protein transglutaminase binding domain (55 - 71)

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (72 - 116)

  • 0
  • 100
  • 117 a.a.
Protein Preferred Names Protein Names

elafin

  • PI-3

Recombinant PI3 Proteins

Cat. No. Product Name Accession Purity
HY-P70316 Elafin/Trappin-2 Protein, Human (HEK293, His) P19957 (A23-Q117) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pustular Psoriasis
Farmer'S Lung
  • Farmer Lung

  • Farmers Lung

  • Farmer'S Lung Disease

  • Farmers' Lung

  • Farmers' Lung Disease

  • Mouldy Hay Disease

  • Moldy Hay Disorder

  • Fibrosis Of Lung With Farmers' Lung

  • Harvesters' Hypersensitivity Pneumonitis

  • Moldy Hay Pneumoconiosis

  • Haymakers' Hypersensitivity Pneumonitis

  • Threshers' Lung

  • Harvester Lung

  • Haymaker Lung

Extrinsic Allergic Alveolitis
  • Hypersensitivity Pneumonitis

  • Alveolitis, Extrinsic Allergic

  • Alveolitis

  • Allergic Interstitial Pneumonitis

  • Allergic Pneumonitis

  • Extrinsic Allergic Pneumonia Hypersensitivity Pneumonitis

  • Hp

  • Pneumonitis Hypersensitivity

  • Allergic Alveolitis

  • Extrinsic Allergic Alveolitis Nos

  • Airway Obstruction With Allergic Alveolitis

  • Unspecified Allergic Alveolitis And Pneumonitis

  • Extrinsic Allergic Bronchiolo-Alveolitis

  • Hypersensitivity Pneumonia

  • Hypersensitivity Pneumonitis Nos

  • Obstructive Lung Disease With Allergic Alveolitis

  • Obstructive Lung Disorder With Hypersensitivity Pneumonitis

  • Obstructive Lung Disorder With Allergic Alveolitis

  • Obstructive Lung Disease With Hypersensitivity Pneumonitis

Erysipelas
Adult Respiratory Distress Syndrome
  • Acute Respiratory Distress Syndrome

  • Ards

  • Non-Cardiogenic Pulmonary Edema

  • Acute Lung Injury

  • Respiratory Distress Syndrome, Adult

  • Shock Lung

  • Acute Respiratory Distress

  • Respiratory Distress Syndrome

  • Adult Rds

  • Ali

  • Increased-Permeability Pulmonary Edema

  • Stiff Lung

  • Respiratory Distress Syndrome Adult

Impetigo
Netherton Syndrome
  • NETH

  • Ns

  • Netherton Disease

  • Comel-Netherton Syndrome

  • Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

  • Bamboo Hair Syndrome

  • Ichthyosis Linearis Circumflexa

  • Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

  • Ilc

  • Nts

  • N Syndrome

Allergic Contact Dermatitis
  • Dermatitis, Allergic Contact

  • Contact Dermatitis, Allergic

  • Dermatitis Allergic Contact

  • Allergic Contact Eczema

  • Acd - [Allergic Contact Dermatitis]

  • Allergic Contact Dermatitis, Unspecified Cause

  • Allergic Dermatitis

  • Allergic Eczema

  • Allergy Dermatitis

  • Allergy Eczema

  • Allergic Contact Eczema Due To Clothing Or Footwear

  • Perfume Allergic Contact Dermatitis

  • Allergic Contact Dermatitis Due To Cosmetics

  • Allergic Contact Eczema Due To Cosmetics Or Fragrances

  • Allergic Contact Eczema Due To Dental Materials

  • Allergic Contact Eczema Due To Food Flavours Or Additives

  • Allergic Contact Eczema Due To Hairdressing Products

  • Allergic Contact Eczema Due To Metals Or Metal Salts

  • Allergic Contact Eczema Due To Proteins

  • Allergic Contact Eczema Due To Plastics Or Resin Systems

  • Allergic Contact Eczema Due To Preservatives Or Biocides

  • Allergic Contact Eczema Due To Rubber Chemicals

  • Rubber Dermatitis

  • Allergic Contact Eczema Due To Systemic Medicaments

  • Allergic Contact Eczema Due To Topical Medicaments

  • Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Lung Disease
  • Lung Diseases

  • Disorder Of Lung

  • Abnormality Of The Lung

Psoriasis
Corneal Abscess
Double Pterygium
Pasteurellosis
  • Pasteurella Infection

  • Pasteurella Infections

  • Pasteurella Infectious Disease

  • Shipping Fever

  • Transport Fever

Skin Disease
  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders

Cystic Fibrosis
  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis

Familiar Ovarian Carcinoma
Bacterial Infectious Disease
  • Bacterial Infections

  • Bacterial Infection Nos

  • Disease Caused By Bacteria

  • Bacterial Disease Or Disorder

Type 1 Diabetes Mellitus 8
  • Diabetes Mellitus, Insulin-Dependent, 8

  • Iddm8

  • Insulin-Dependent Diabetes Mellitus 8

  • T1D8

  • Insulin-Dependent Diabetes Mellitus-8

Preterm Premature Rupture Of The Membranes
  • Preterm Premature Rupture Of Membranes

  • PPROM

  • Preterm Premature Rupture Of The Membranes, Susceptibility To

  • Pprom - [Preterm Premature Rupture Of Membranes]

  • Preterm Rupture Of Membranes

Pulmonary Disease, Chronic Obstructive
  • Chronic Obstructive Pulmonary Disease

  • COPD

  • Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

  • Chronic Obstructive Lung Disease

  • Chronic Obstructive Airway Disease

  • Pulmonary Disease, Chronic Obstructive, Susceptibility To

  • Cold

  • Severe Early-Onset Chronic Obstructive Pulmonary Disease

  • Pulmonary Disease Chronic Obstructive

  • Pulmonary Disease, Obstructive, Chronic, Susceptibility To

  • Chronic Obstructive Pulmonary Disease Of Horses

  • Common Cold

  • Upper Respiratory Infections

  • Copd - [Chronic Obstructive Pulmonary Disease]

  • Coad - [Chronic Obstructive Airways Disease]

  • Cold - [Chronic Obstructive Lung Disease]

  • Chronic Airway Disease Nos

  • Chronic Airways Limitation, Unspecified

  • Chronic Obstructed Airway, Unspecified

  • Chronic Obstructive Airway Disease, Unspecified

  • Chronic Obstructive Airway, Unspecified

  • Obstructive Lung Disease Nos

  • Chronic Obstructive Lung Disease Nos

  • Chronic Obstructive Lung Nos

  • Obstructive Pulmonary Disease Nos

  • Exacerbation Copd Nos

  • Acute Exacerbation Copd

Parotid Gland Adenoid Cystic Carcinoma
  • Adenoid Cystic Carcinoma Of Parotid Gland

Joubert Syndrome 7
  • JBTS7

  • Cerebello-Oculo-Renal Syndrome 3

  • Cors3

  • Joubert Syndrome, Type 7

Inflammatory Bowel Disease
  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory

Basal Cell Carcinoma
  • Basal Cell Cancer

  • Basal Cell Neoplasm

  • Basal Cell Carcinoma Of Skin

  • Malignant Basal Cell Tumor

  • Basal Cell Tumor

  • Epithelioma Basal Cell

  • Malignant Basal Cell Neoplasm

  • Rodent Ulcer

  • Carcinoma Basal Cell

  • Neoplasms, Basal Cell

  • Basal Cell Carcinomas

  • Experimental Organism Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Basalioma

  • Basal Cell Epithelioma Of Skin

  • Bcc - [Basal Cell Carcinoma] Of Skin

  • Rodent Ulcer Of Skin

  • Rodent Ulcer Of Unspecified Site

  • Basal Cell Epithelioma Of Unspecified Site

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma