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Pathways Recommended: PI3K/Akt/mTOR
Results for "

resting intracellular K concentration

" in MedChemExpress (MCE) Product Catalog:

3183

Inhibitors & Agonists

21

Screening Libraries

278

Fluorescent Dyes

188

Biochemical Assay Reagents

203

Peptides

33

MCE Kits

19

Inhibitory Antibodies

461

Natural
Products

13

Recombinant Proteins

148

Isotope-Labeled Compounds

18

Antibodies

30

Click Chemistry

65

Oligonucleotides

6

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0351
    Taurine
    Maximum Cited Publications
    17 Publications Verification

    2-Aminoethanesulfonic acid

    Autophagy Endogenous Metabolite Metabolic Disease Cancer
    Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes .
    Taurine
  • HY-U00451
    ATP-Red 1
    5+ Cited Publications

    Fluorescent Dye Others
    ATP-Red 1 is a multisite-binding switchable fluorescent probe, and can selectively and rapidly responds to intracellular concentrations of ATP in living cells (Ex/Em = 510/590 nm).
    ATP-Red 1
  • HY-100973A

    ADP ribose sodium

    TRP Channel Autophagy Metabolic Disease Endocrinology Cancer
    Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD +) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca 2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .
    Adenosine 5′-diphosphoribose sodium
  • HY-143589

    JAB-21822; KRAS G12C inhibitor 36

    Ras Cancer
    Glecirasib (Compound 1-2; JAB-21822) is an orally active and potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. Glecirasib has the potential for the research of KRAS G12C-mediated cancer .
    Glecirasib
  • HY-157646
    MZ-101
    2 Publications Verification

    GYS1-IN-2

    Glycosyltransferase Metabolic Disease
    MZ-101 (GYS1-IN-2) is an orally active, potent and selective small-molecule glycogen synthase 1 (GYS1) inhibitor with with an IC50 value of 0.041 µM. MZ-101 reduces glycogen concentrations in cells and in mice. MZ-101 can used to study GYS1 -mediated Pompe disease and other glycogen storage diseases .
    MZ-101
  • HY-D0722
    5(6)-CFDA
    5+ Cited Publications

    5-(6)-Carboxyfluorescein diacetate; CFDA

    Fluorescent Dye Others
    5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes .
    5(6)-CFDA
  • HY-109500

    meso-Nordihydroguaiaretic acid; meso-NDGA

    Lipoxygenase Metabolic Disease Cancer
    Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes .
    Masoprocol
  • HY-136151
    UNC10217938A
    1 Publications Verification

    Nucleoside Antimetabolite/Analog Others
    UNC10217938A is a 3-deazapteridine analog with strong oligonucleotide enhancing effects. UNC10217938A enhances oligonucleotides effects by modulating their intracellular trafficking and release from endosomes. UNC10217938A also enhances the effects of antisense and siRNA oligonucleotides .
    UNC10217938A
  • HY-100973
    Adenosine 5′-diphosphoribose
    5+ Cited Publications

    ADP ribose

    TRP Channel Autophagy Neurological Disease Metabolic Disease Cancer
    Adenosine 5′-diphosphoribose (ADP ribose) is a nicotinamide adenine nucleotide (NAD +) metabolite. Adenosine 5′-diphosphoribose is the most potent and primary intracellular Ca 2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose also can enhance autophagy .
    Adenosine 5′-diphosphoribose
  • HY-101898
    Indo-1 AM
    1 Publications Verification

    Indo-1 Acetoxymethyl ester

    Fluorescent Dye Others
    Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
    Indo-1 AM
  • HY-D0221

    NSC 112125; 2,4,6-Tipyidyl-s-tiazie

    MOFs Fluorescent Dye Others
    2,4,6-Tri-2-pyridinyl-1,3,5-triazine (NSC 112125) is a colorimetric reagent for detecting iron. 2,4,6-Tri-2-pyridinyl-1,3,5-triazine forms a complex with Fe (II) and can be quantified as a measure of iron concentration by colorimetric detection at 594 nm .
    2,4,6-Tri-2-pyridinyl-1,3,5-triazine
  • HY-W039315

    Biochemical Assay Reagents Metabolic Disease
    2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .
    2,5-Anhydro-D-mannitol, 97%
  • HY-DY1008

    Fluorescent Dye Others
    Nile Red (solution) is a lipophilic stain. Nile red has environment-sensitive fluorescence. Nile red is intensely fluorescent in a lipid-rich environment while it has minimal fluorescence in aqueous media. Nile red is an excellent vital stain for the detection of intracellular lipid droplets by fluorescence microscopy and flow cytof uorometry. Nile red stains intracellular lipid droplets red. The fluorescence wavelength is 559/635 nm .
    Solvent and concentration: DMSO: 1 mM
    Nile Red (solution)
  • HY-N0642

    Drug Derivative Calcium Channel Metabolic Disease
    α-L-Rhamnose monohydrate is a neutral sugar present in plants, animals, viruses and bacteria. α-L-Rhamnose monohydrate is a ligand for α-L-rhamnose-recognizing lectin sites, trigger intracellular signaling pathways. α-L-Rhamnose monohydrate induces rhaE and rhaA expression as a specific carbon source in Aspergillus nidulans, while glucose inhibits its cellular uptake. α-L-Rhamnose monohydrate induces rapid and transient increases in intracellular free Ca 2+ concentration in normal human dermal fibroblasts .
    α-L-Rhamnose monohydrate
  • HY-113285

    3-Ureidopropionic acid

    Oxidative Phosphorylation Reactive Oxygen Species (ROS) Metabolic Disease
    Ureidopropionic acid (3-Ureidopropionic acid) is a selective mitochondrial respiratory chain complex V inhibitor. Ureidopropionic acid induces the production of reactive oxygen species, delayed elevation of intracellular calcium concentration, secondary energy-dependent excitotoxicity and neurodegeneration in neurons. Ureidopropionic acid promotes neuropathological changes by impairing mitochondrial energy metabolism, oxidative stress and excitotoxicity pathways. Ureidopropionic acid can be used in studies related to 3-ureidopropionase deficiency and severe propionic aciduria .
    Ureidopropionic acid
  • HY-104015
    NecroX-5
    3 Publications Verification

    Calcium Channel Inflammation/Immunology Cancer
    NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity.
    NecroX-5
  • HY-136460

    ETH 1001

    Calcium Channel Others
    Calcium ionophore I (ETH 1001) is a selective Ca 2+ ionophore for biological membranes. Calcium ionophore I can be used in Ca2+-selective microelectrodes that can be used for quantitative intracellular measurements of resting Ca2+-activities and of slowly changing Ca2+-levels .
    Calcium ionophore I
  • HY-136833
    X5050
    4 Publications Verification

    DNA/RNA Synthesis Neurological Disease
    X5050 is a REST inhibitor, with an EC50 of 2.1 μM .
    X5050
  • HY-N0724
    Mesaconitine
    2 Publications Verification

    NO Synthase Neurological Disease
    Mesaconitine is a nitric oxide synthase activator. Mesaconitine drives extracellular Na + and Ca 2+ influx into endothelial cells, increases intracellular Na + and Ca 2+ concentrations, and triggers nitric oxide release. Mesaconitine is applicable for pain-related research .
    Mesaconitine
  • HY-D1078

    Fluorescent Dye Reactive Oxygen Species (ROS) P-glycoprotein Others
    5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC4 for MRP2 binding sites and inhibits MRP2-mediated LTC4 transport (Ex/Em = 496/525 nm) .
    5(6)-Carboxy-2',7'-dichlorofluorescein diacetate
  • HY-131131

    Fluorescent Dye Others
    5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein, which contains an additional negative charge and can be better retained in the cell. 5-CFDA-AM can be used to detect cell viability .
    5-CFDA-AM
  • HY-124416
    ML604086
    1 Publications Verification

    CCR Inflammation/Immunology Endocrinology
    ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca 2+ concentrations .
    ML604086
  • HY-161928

    Glutathione Peroxidase Ferroptosis Cancer
    GPX4 activator 1 (Compound A9) is a allosteric activator of GPX4 (Kd = 5.86 μM, EC50 = 19.19 μM). GPX4 activator 1 can selectively act on ferroptosis and prevent the accumulation of intracellular lipid peroxides caused by ferroptosis inducers .
    GPX4 activator 1
  • HY-135867E
    NHC-triphosphate tetraammonium
    5+ Cited Publications

    CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV Infection
    NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate tetraammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .
    NHC-triphosphate tetraammonium
  • HY-142682

    Phosphatase Neurological Disease Cancer
    SCP1-IN-1 is a Small CTD Phosphatase 1 (SCP1) inhibitor with a human IC50 of 10 μM. SCP1-IN-1 inactivates SCP1, promotes REST transcription factor degradation, and reduces REST transcriptional activity. SCP1-IN-1 can be used for the research of glioblastoma multiforme .
    SCP1-IN-1
  • HY-101810

    TO 188; Tazalest; Tazanol

    Calcium Channel PKC Inflammation/Immunology
    Tazanolast (TO 188) is an orally active selective mast cell stabilizer. Tazanolast prevents the elevation of intracellular calcium concentration, inhibits calcium uptake and Protein kinase C translocation, without directly inhibiting phospholipase C. Tazanolast inhibits ozone-induced airway hyperresponsiveness to Methacholine in guinea pigs, as well as passive cutaneous anaphylaxis, Schultz-Dale reaction, experimental asthma, passive cutaneous anaphylaxis in rats, and increased cutaneous vascular permeability in rats. Tazanolast does not alter airway responsiveness in sham-exposed guinea pigs, cell distribution in bronchoalveolar lavage fluid after ozone exposure, type II-IV allergic reactions, or histamine release from atopic leukocytes. Tazanolast can be used in research related to allergic diseases .
    Tazanolast
  • HY-DY1014

    Fluorescent Dye Others
    ATP-Red 1 (solution) is a multisite-binding switchable fluorescent probe, and can selectively and rapidly responds to intracellular concentrations of ATP in living cells (Ex/Em = 510/590 nm).
    Solvent and concentration: DMSO: 1 mM
    ATP-Red 1 (solution)
  • HY-P1492

    Neurokinin Receptor Neurological Disease Endocrinology
    Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.
    Substance P (7-11)
  • HY-D1261
    Naph-EA-mal
    1 Publications Verification

    Thiol-green 1

    Fluorescent Dye Others
    Naph-EA-mal (Thiol-green 1) is a rapid detect and ultrafast turn-on thiol fluorescence probe for protein labeling and bioimaging. Naph-EA-mal (Thiol-green 1) can be used to detect thiols in living cells, label the protein thiols, quantify the concentration of total thiols in cell lysate, and determine the reversible protein thiols oxidation in fixed cells . Ex: 488 nM; Em: 540 nM.
    Naph-EA-mal
  • HY-DY1048

    Fluorescent Dye Cancer
    DAF-FM DA (Diaminofluorescein-FM diacetate) (solution) is a fluorescent probe for the detection and bioimaging of nitric oxide (NO). DAF-FM DA spontaneously crosses the plasma membrane and is subsequently cleaved by esterases to generate intracellular DAF-FM (Ex/Em=495/515 nm) .
    Solvent and concentration: DMSO: 2 mM
    DAF-FM DA (solution)
  • HY-D2482

    APG-1 AM

    Fluorescent Dye Neurological Disease
    Asante potassium green-1 AM (APG-1 AM) is a cell-permeable K +-sensitive fluorescent indicator and potassium ion indicator that exhibits minimal interference from Na + and pH at physiologically relevant intracellular levels. Asante potassium green-1 AM enables non-invasive monitoring and quantitative analysis of intracellular potassium ion concentrations (Ex/Em = 522/547 nm) .
    Asante potassium green-1 AM
  • HY-D1436

    Fluorescent Dye Neurological Disease
    PBFI is the cell-impermeant fluorescent indicator that is widely used for the determination of concentrations of K + (Ex/Em = 340,380/500 nm) .
    PBFI
  • HY-158741

    APG-2 Acetoxymethyl ester

    Fluorescent Dye Potassium Channel Others
    IPG-2 AM (APG-2 Acetoxymethyl ester) is a membrane-permeant acetoxymethyl ester derivative and selective fluorescent potassium ion indicator. IPG-2 AM exhibits fluorescence increases proportional to extracellular potassium ion concentrations. IPG-2 AM enables real-time monitoring of cytosolic free potassium ion fluxes in human platelets and macrophages. IPG-2 AM can be used for the research of intracellular potassium concentration dynamics .
    IPG-2 AM
  • HY-77537

    7DX

    Thymidylate Synthase Cardiovascular Disease
    7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC50 value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect .
    7-Deazaxanthine
  • HY-RS11853

    Small Interfering RNA (siRNA) Others

    REST Human Pre-designed siRNA Set A contains three designed siRNAs for REST gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    REST Human Pre-designed siRNA Set A
    REST Human Pre-designed siRNA Set A
  • HY-138875

    p38 MAPK Apoptosis Cardiovascular Disease Cancer
    Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphingosine exerts its inhibitory action on angiogenesis through the inhibition of MAPK activation and intracellular calcium increase . Tetraacetylphytosphingosine induces apoptosis in HaCaT cells .
    Tetraacetylphytosphingosine
  • HY-N2452

    GLP Receptor Cardiovascular Disease Infection Metabolic Disease
    Cochinchinenin C is a GLP-1R agonist that binds to the extracellular domain of the receptor via hydrophobic interactions and hydrogen bonds, and promotes glucose-dependent insulin secretion from pancreatic β-cells. Cochinchinenin C also increases intracellular cAMP and ATP levels. At low concentrations, Cochinchinenin C binds to human serum albumin, alters its microenvironment, and induces dominant static fluorescence quenching. Cochinchinenin C shows almost no cytotoxicity to pancreatic β-cells, and exerts a synergistic effect with Loureirin A (HY-N1505) when binding to human serum albumin. Cochinchinenin C has been widely used in studies of type 2 diabetes, Helicobacter pylori infection, thrombotic diseases, and other conditions .
    Cochinchinenin C
  • HY-128536

    Fluorescent Dye Others
    KMG-104AM is a Mg 2+ fluorescent probe. KMG-104AM is a membrane-permeable ester-modified derivative of KMG-104, which serves as a reporter and imaging agent. KMG-104AM can track the increase in intracellular free magnesium ion concentration induced by mitochondrial uncoupling. KMG-104AM enables visualization of the three-dimensional distribution of intracellular magnesium ion concentration. KMG-104AM is applicable to research related to the functions of intracellular magnesium ions .
    KMG-104AM
  • HY-139407

    3-Dodecanoyl-NBD-cholesterol

    Fluorescent Dye Others
    3-C12-NBD-cholesterol is a fluorescent cholesterol analog that can be used for measuring membrane and intracellular trafficking dynamics .
    3-C12-NBD-cholesterol
  • HY-143603

    Ras Cancer
    KRAS G12D inhibitor 10 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 10 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 34) .
    KRAS G12D inhibitor 10
  • HY-143607

    Ras Cancer
    KRAS G12D inhibitor 13 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 13 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 142) .
    KRAS G12D inhibitor 13
  • HY-135867

    CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV Infection
    NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .
    NHC-triphosphate
  • HY-100973AR

    ADP ribose sodium (Standard)

    Reference Standards TRP Channel Autophagy Metabolic Disease Endocrinology Cancer
    Adenosine 5′-diphosphoribose (sodium) (Standard) is the analytical standard of Adenosine 5′-diphosphoribose (sodium). This product is intended for research and analytical applications. Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .
    Adenosine 5′-diphosphoribose sodium (Standard)
  • HY-142683

    Phosphatase Neurological Disease Cancer
    SCP1-IN-2 (Compound SH T-65) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-2 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-2 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity .
    SCP1-IN-2
  • HY-113285R

    3-Ureidopropionic acid (Standard)

    Reference Standards Oxidative Phosphorylation Reactive Oxygen Species (ROS) Others
    Ureidopropionic acid (Standard) is the analytical standard of Ureidopropionic acid. This product is intended for research and analytical applications. Ureidopropionic acid (3-Ureidopropionic acid) is a selective mitochondrial respiratory chain complex V inhibitor. Ureidopropionic acid induces the production of reactive oxygen species, delayed elevation of intracellular calcium concentration, secondary energy-dependent excitotoxicity and neurodegeneration in neurons. Ureidopropionic acid promotes neuropathological changes by impairing mitochondrial energy metabolism, oxidative stress and excitotoxicity pathways. Ureidopropionic acid can be used in studies related to 3-ureidopropionase deficiency and severe propionic aciduria .
    Ureidopropionic acid (Standard)
  • HY-137311

    Calcium Channel Phospholipase mAChR Neurological Disease
    (S)-Albuterol hydrochloride is a muscarinic receptor and phospholipase C activator. (S)-Albuterol hydrochloride increases intracellular free calcium in airway smooth muscle .
    (S)-Albuterol hydrochloride
  • HY-W099576

    EHDA bromide

    Environmental Pollutants Biochemical Assay Reagents Others
    Ethylhexadecyldimethylammonium (EHDA) bromide, a surfactant, has been used in a number of adsorptive separational methods, such as the removal of nickel, zinc and chromium ions. Ethylhexadecyldimethylammonium (EHDA) bromide also can be used to prepare dye of staining intracellular ions .
    Ethylhexadecyldimethylammonium bromide
  • HY-138648

    ERK Neurological Disease
    PB1 is a potent intracellular disulfide reducing agent with several advantages including good cell permeability, the ability to form a high intracellular concentration gradient, and stability. PB1 is a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 increases retinal ganglion cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB1 can be used for the research of neuroprotective .
    PB1
  • HY-143606

    Ras Cancer
    KRAS G12D inhibitor 12 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 12 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 134) .
    KRAS G12D inhibitor 12
  • HY-143604

    Ras Cancer
    KRAS G12D inhibitor 11 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 11 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 52) .
    KRAS G12D inhibitor 11

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