CALY - calcyon neuron specific vesicular protein Gene

Also Known as NSG3; DRD1IP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 50632

About CALY

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,324,072-133,336,896 (from NCBI)

This gene has 5 transcripts (splice variants), 169 orthologues and 2 paralogues. Biased expression in brain (RPKM 10.6), adrenal (RPKM 3.4) and 1 other tissue.

Summary

The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 Dopamine Receptor and may interact with Other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]

CALY Products (2)

mRNA Protein Name
NM_001321617.2 NP_001308546.1 neuron-specific vesicular protein calcyon isoform 2
NM_015722.4 NP_056537.1 neuron-specific vesicular protein calcyon isoform 1
Molecular Function GO Annotation Evidence 参考文献 由来
enables clathrin light chain binding IDA
IDA: Inferred from direct assay
16595675 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16595675 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in clathrin coat assembly IDA
IDA: Inferred from direct assay
16595675 GOA
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
16595675 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
14534309 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
14534309 GOA
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
16595675 GOA
is active in postsynaptic endocytic zone IMP
IMP: Inferred from mutant phenotype
16595675 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALY Protein Structure

Calcyon

Calcyon: D1 dopamine receptor-interacting protein (calcyon) (1 - 197)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

neuron-specific vesicular protein calcyon

  • D1 dopamine receptor-interacting protein

CALY Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CALY Q9NYX4 CLTA Homo sapiens P09496 16595675
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Childhood Pilocytic Astrocytoma
  • Pediatric Pilocytic Astrocytoma

Glutaric Aciduria Iii
  • Glutaryl-Coa Oxidase Deficiency

  • Ga Iii

  • Glutaric Acidemia Type 3

  • GA3

  • Glutaric Aciduria Type 3

  • Glutaric Aciduria 3

  • Glutaric Acidemia Type Iii

  • Glutaric Aciduria Type Iii

Malignant Essential Hypertension
  • Accelerated Essential Hypertension

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus CALY VGNC VGNC:26718
Macaca mulatta CALY VGNC VGNC:70575
Rattus norvegicus CALY RGD RGD:621719
Canis familiaris CALY VGNC VGNC:38676
Mus musculus CALY MGD MGI:1915816
Others CALY NCBI