Search Result
Results for "Acid Inhibitors" in MCE Product Catalog:
1542
Inhibitors & Agonists
13
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
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- HY-U00439
-
-
- HY-76547
-
|
p-Toluic acid
4-Methylbenzoic Acid
|
Endogenous Metabolite
|
Others
|
|
p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
|
-
- HY-W011819
-
|
Tetradecanedioic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated drug-drug interactions .
|
-
- HY-131005
-
-
- HY-113478
-
|
3β-Ursodeoxycholic acid
Isoursodeoxycholic Acid
|
Others
|
Metabolic Disease
|
|
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) can be isomerized by intestinal and hepatic enzymes to yield UDCA.
|
-
- HY-30216
-
-
- HY-16007
-
|
(-)-Hydroxycitric acid
Garcinia Acid
|
ATP Citrate Lyase
|
Metabolic Disease
|
|
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss.
|
-
- HY-W005178
-
-
- HY-N7354
-
-
- HY-121879
-
-
- HY-133022
-
|
trans-2-Undecenoic acid
(E)-2-Undecenoic Acid; (E)-Undec-2-enoic Acid
|
Others
|
Metabolic Disease
|
|
trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O.
|
-
- HY-12597
-
|
Quisqualic acid
L-Quisqualic Acid
|
iGluR
mGluR
|
Neurological Disease
|
|
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis chinensis.
|
-
- HY-113130
-
-
- HY-124422
-
-
- HY-N6998
-
|
Paederosidic acid
|
Apoptosis
|
Cancer
|
|
Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis.
|
-
- HY-106579S
-
-
- HY-W015343
-
|
3-Methoxyphenylacetic acid
m-Methoxyphenylacetic Acid
|
Others
|
Infection
|
|
3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot.
|
-
- HY-W015495
-
-
- HY-W008097
-
-
- HY-A0143
-
-
- HY-126995
-
-
- HY-43470
-
-
- HY-129467
-
|
Minerval
2-Hydroxyoleic Acid; 2-OHOA
|
Apoptosis
|
Cancer
|
|
Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect.
|
-
- HY-N6877
-
|
Purpurogallin carboxylic acid
|
Others
|
Cancer
|
|
Purpurogallin carboxylic acid, isolated from Macleaya microcarpa (Maxim.) Fedde, is an oxidation product of gallic acid in fermented tea. Purpurogallin carboxylic acid has anti-cancer activity.
|
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- HY-133068
-
|
5-Hydroxyferulic acid
|
COMT
|
Others
|
|
5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate.
|
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- HY-W010062
-
-
- HY-19373
-
-
- HY-16787
-
|
ICA-121431
|
Sodium Channel
|
Cardiovascular Disease
|
|
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM).
|
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- HY-N7387
-
-
- HY-N7059
-
|
Lactobionic acid
|
Bacterial
|
Infection
|
|
Lactobionic acid is a bionic acid naturally found in the Caspian Sea yogurt and chemically constituted of a gluconic acid bonded to a galactose. Lactobionic acid has antioxidant, antimicrobial, chelating, stabilizer, acidulant, and moisturizing properties.
|
-
- HY-W018512
-
-
- HY-76199
-
-
- HY-W003445
-
|
4-Bromo-3-hydroxybenzoic acid
|
Endogenous Metabolite
|
Neurological Disease
|
|
4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes.
|
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- HY-U00439A
-
|
Protein kinase inhibitors 1 hydrochloride
(E)-5-((2-Oxo-6'-(piperazin-1-yl)-1,2-dihydro-[3,3'-bipyridin]-5-yl)methylene)thiazolidine-2,4-dione hydrochloride
|
DYRK
|
Cancer
|
|
Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC50s of 136 and 74 nM for HIPK1 and HIPK2, and a Kd of 9.5 nM for HIPK2.
|
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- HY-N0728
-
|
α-Linolenic acid
|
PI3K
Akt
|
Cancer
Cardiovascular Disease
|
|
α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.
|
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- HY-135772
-
-
- HY-14518
-
|
Aminopterin
4-Aminofolic Acid; APGA
|
Antifolate
|
Cancer
Inflammation/Immunology
|
|
Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia.
|
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- HY-W012037
-
|
8-Hydroxyquinoline hemisulfate
8-Quinolinol hemisulfate
|
Bacterial
Antibiotic
|
Infection
|
|
8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.
|
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- HY-135103
-
|
Tauro-β-muricholic acid sodium
T-βMCA sodium
|
FXR
|
Cancer
|
|
Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM.
|
-
- HY-135425
-
|
10,12-Tricosadiynoic acid
|
Acyltransferase
|
Metabolic Disease
|
|
10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism.
|
-
- HY-N6036
-
|
Ganoderic acid F
|
Others
|
Cancer
|
|
Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress.
|
-
- HY-125801
-
|
3-Oxo-5β-cholanoic acid
Dehydrolithocholic Acid; 3-oxoLCA
|
ROR
|
Inflammation/Immunology
|
|
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM).
|
-
- HY-135813
-
|
LtaS-IN-1
|
Bacterial
|
Infection
|
|
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of Lipoteichoic acid (LTA) synthesis in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely.
|
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- HY-125957
-
|
A-3 hydrochloride
|
PKA
Casein Kinase
CaMK
PKC
|
Others
|
|
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM) and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectively.
|
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- HY-N2027
-
-
- HY-101918
-
|
DS-1040 Tosylate
|
Others
|
Cardiovascular Disease
|
|
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases.
|
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- HY-18728
-
-
- HY-136066
-
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Tauro-ω-muricholic acid sodium
TωMCA sodium
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Others
|
Metabolic Disease
|
|
Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies
|
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- HY-Y1620
-
-
- HY-15583
-
-
- HY-N2581
-
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Phytic acid sodium salt
myo-Inositol, hexakis(dihydrogen phosphate) sodium salt; Inositol hexaphosphate sodium salt
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Others
|
Others
|
|
Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphat) is often present in legume seeds with antinutritional effects. Phytic acid sodium salt is a [PO4] 3- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant.
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- HY-122470
-
|
Stampidine
|
Reverse Transcriptase
HIV
|
Infection
|
|
Stampidine is a nucleoside reverse transcriptase inhibitor (NRTI) with potent and broad-spectrum anti-HIV activity. Stampidine inhibits the laboratory HIV-1 strain HTLVIIIB (B-envelope subtype) and primary clinical isolates with IC50s of 1 nM and 2 nM, respectively. Stampidine also inhibits NRTI-resistant primary clinical isolates and NNRTI-resistant clinical isolates with IC50s of 8.7 nM and 11.2 nM, respectively.
|
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- HY-112942A
-
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CMP-Sialic acid sodium salt
CMP-Neu5Ac sodium salt
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Others
|
Metabolic Disease
|
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CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase, the enzyme that initiates sialic acid synthesis. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases.
|
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- HY-N1429
-
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- HY-11007
-
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GNF-2
|
Bcr-Abl
SARS-CoV
|
Cancer
|
|
GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC50 of 138 nM .
|
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- HY-122207
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-
- HY-N1451
-
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Betulonic acid
Betunolic Acid; Liquidambaric Acid; (+)-Betulonic Acid
|
Others
|
Cancer
|
|
Betulonic acid belongs to the pentacyclic triterpenic derivative class, has antitumor activities.
|
-
- HY-N3894
-
-
- HY-14850
-
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Sograzepide
Netazepide; YF 476; YM-220
|
Cholecystokinin Receptor
|
Metabolic Disease
Endocrinology
|
|
Sograzepide (Netazepide; YF 476; YM-220) is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC50 of 502 nM. Sograzepide (Netazepide; YF 476; YM-220) replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine and cloned human Gastrin/CCK-B receptors, with Ki values of 0.068, 0.62 and 0.19 nM, respectively.
|
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- HY-Y1362
-
-
- HY-135298
-
-
- HY-W015410
-
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Disodium succinate
|
Others
|
Metabolic Disease
|
|
Disodium succinate is the disodium salt of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
|
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- HY-N3010
-
-
- HY-N0593
-
-
- HY-N0457
-
-
- HY-10529
-
-
- HY-N1984
-
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Artemisic acid
Qing Hao Acid; Artemisinic Acid; Arteannuic Acid
|
Bacterial
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Cancer
Infection
Metabolic Disease
Inflammation/Immunology
|
|
Artemisinic acid (Qing Hao acid), an amorphane sesquiterpene isolated from Artemisia annua L., possesses a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.
|
-
- HY-N2310
-
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Domoic acid
(-)-Domoic Acid; L-Domoic Acid
|
iGluR
|
Neurological Disease
|
|
Domoic acid ((-)-Domoic acid; L-Domoic acid) is an excitatory neurotransmitter isolated from a form of marine vegetation, Nitzschia pungens. Domoic acid produces neurotoxic effect through activating kainate receptor.
|
-
- HY-N0280
-
|
Corosolic acid
Colosolic Acid; Corsolic Acid; Glucosol
|
Autophagy
|
Cancer
|
|
Corosolic acid isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity.
|
-
- HY-N1118
-
-
- HY-B1053
-
-
- HY-N0060
-
-
- HY-N7080
-
|
Dihydroferulic acid
Hydroferulic Acid
|
Others
|
Metabolic Disease
|
|
Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid.
|
-
- HY-W009732
-
|
Sinapinic acid
Sinapic Acid
|
HDAC
Angiotensin-converting Enzyme (ACE)
Reactive Oxygen Species
Apoptosis
|
Cancer
Metabolic Disease
|
|
Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM, and also inhibits ACE-I activity. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells. Sinapinic acid shows antioxidant and antidiabetic activities. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats.
|
-
- HY-101416
-
-
- HY-N0420
-
-
- HY-N2020
-
-
- HY-W004260
-
|
Arachidic acid
Icosanoic Acid
|
Endogenous Metabolite
|
Others
|
|
Arachidonic acid (Icosanoic acid), a long-chain fatty acid, is present in all mammalian cells, typically esterified to membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids present in human tissue.
|
-
- HY-Y0262
-
-
- HY-N4104
-
|
Agaric acid
Agaricinic Acid
|
Mitochondrial Metabolism
|
Metabolic Disease
|
|
Agaric acid (Agaricinic Acid) is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca 2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism.
|
-
- HY-N0384
-
-
- HY-N7057
-
|
Nonanoic acid
Pelargonic Acid
|
Bacterial
|
Infection
|
|
Nonanoic acid is a naturally-occurring saturated fatty acid with nine carbon atoms. Nonanoic acid significantly reduces bacterial translocation, enhances antibacterial activity, and remarkably increases the secretion of porcine β-defensins 1 (pBD-1) and pBD-2.
|
-
- HY-N0529
-
-
- HY-Y0781
-
-
- HY-N4106
-
-
- HY-100806
-
-
- HY-B1415
-
-
- HY-N3558
-
|
Ceanothic acid
Emmolic Acid
|
Others
|
Cancer
|
|
Ceanothic acid (Emmolic acid) is a ring-A homologue of betulinic acid. Ceanothic acid inhibits OVCAR-3, HeLa, and FS-5 cells with the cell survival of 68%, 65%, and 81%, respectively.
|
-
- HY-N3625
-
-
- HY-W010255
-
-
- HY-B0704
-
-
- HY-B0760
-
|
Fenofibric acid
FNF Acid
|
PPAR
COX
|
Metabolic Disease
|
|
Fenofibric acid, an active metabolite of fenofibrate, is a PPAR activitor, with EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively; Fenofibric acid also inhibits COX-2 enzyme activity, with an IC50 of 48 nM.
|
-
- HY-N7129
-
-
- HY-N0823
-
|
Lithospermic acid
(+)-Lithospermic Acid
|
Others
|
Inflammation/Immunology
|
|
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo.
|
-
- HY-U00305
-
-
- HY-108309
-
|
Medronic acid
Methylenediphosphonic Acid
|
Others
|
Others
|
|
Medronic acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid has affinity for and adheres to the surface of hydroxyapatite crystals in the bone matrix. Medronic acid accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes in bone imaging.
|
-
- HY-N0077
-
|
Ginkgolic Acid
Ginkgolic Acid (15:1); Ginkgolic Acid I; Romanicardic Acid
|
E1/E2/E3 Enzyme
|
Cancer
|
|
Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC50 of 3.0 μM in in vitro assay.
|
-
- HY-N7076
-
|
Aleuritic acid
(±)-erythro-Aleuritic Acid; α-Aleuritic Acid
|
Others
|
Others
|
|
Aleuritic acid ((±)-erythro-Aleuritic acid) is a major ingredient in shellac and used in the perfumery industry.
|
-
- HY-N2815
-
|
Ursolic acid acetate
Acetylursolic Acid; 3-Acetylursolic Acid
|
Others
|
Cancer
|
|
Ursolic acid acetate (Acetylursolic acid), isolated from the aerial roots of Ficus microcarpa, exhibits cytotoxicity against KB cells with IC50 of 8.4 μM.
|
-
- HY-42068
-
-
- HY-B1259
-
-
- HY-113013
-
|
Hydroxypyruvic acid
β-Hydroxypyruvic Acid; 3-Hydroxypyruvic Acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Hydroxypyruvic acid (β-Hydroxypyruvic acid) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
|
-
- HY-N1394
-
-
- HY-N7079
-
|
Erythorbic acid
D-Isoascorbic Acid; D-Araboascorbic Acid
|
Others
|
Others
|
|
Erythorbic acid (D-Isoascorbic acid), produced from sugars derived from different sources, such as beets, sugar cane, and corn, is a food additive used predominantly in meats, poultry, and soft drinks.
|
-
- HY-N0457A
-
|
L-Chicoric Acid
(-)-Chicoric Acid; trans-Caffeoyltartaric Acid
|
HIV Integrase
HIV
|
Infection
Cancer
|
|
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture.
|
-
- HY-N2526
-
-
- HY-N0629
-
-
- HY-N0610A
-
|
Cinnamic acid
3-Phenylacrylic Acid; β-Phenylacrylic Acid
|
Endogenous Metabolite
|
Cancer
|
|
Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.
|
-
- HY-N2311
-
|
Ibotenic acid
(RS)-Ibotenic Acid; DL-Ibotenic Acid
|
iGluR
|
Neurological Disease
|
|
Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.
|
-
- HY-B1399
-
-
- HY-Y0839
-
|
Levulinic acid
4-Oxovaleric Acid; Laevulinic Acid; Levulic Acid; NSC 3716; β-Acetylpropionic Acid; γ-Ketovaleric Acid
|
Endogenous Metabolite
|
Others
|
|
Levulinic acid is a precursor for the synthesis of biofuels, such as ethyl levulinate.
|
-
- HY-N0492
-
-
- HY-Y1139
-
-
- HY-125686
-
|
Beesioside Q
|
Others
|
Others
|
|
Beesioside Q is a oleanolic acid triterpene saponin isolated from the rhizome of Beesia calthaefolia (Maxim.) Ulbr.
|
-
- HY-135801
-
|
Arachidonyl alcohol
|
Others
|
Metabolic Disease
|
|
Arachidonyl alcohol is a long-chain primary fatty alcohol. Arachidonyl alcohol is used as a substrate for the production of several ether lipids possessing beneficial functions.
|
-
- HY-129357
-
-
- HY-135652
-
|
Hexyl gallate
Hexyl 3,4,5-trihydroxybenzoate
|
Parasite
|
Infection
|
|
Hexylgallate (Hexyl 3,4,5-trihydroxybenzoate), a alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum, with IC50 of 0.11 mM.
|
-
- HY-107830
-
|
Methyl cholate
|
Others
|
Metabolic Disease
|
|
Methyl Cholate is methyl ester form of Cholic acid. Cholic acid is one of the major bile acids produced by the liver, where it is synthesized from cholesterol.
|
-
- HY-B0914
-
-
- HY-N0156
-
-
- HY-103395
-
-
- HY-N6601
-
|
Pomolic acid
Randialic Acid A
|
Apoptosis
|
Cancer
|
|
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC).
|
-
- HY-W041194
-
|
Tropic acid
DL-Tropic Acid
|
Others
|
Others
|
|
Tropic acid (DL-Tropic acid) is a laboratory reagent used in the chemical synthesis of Atropine and Hyoscyamine.
|
-
- HY-W040265
-
-
- HY-N1487
-
|
Oleanonic acid
3-Oxooleanolic Acid
|
HIV
|
Cancer
|
|
Oleanonic acid (3-Oxooleanolic acid) is a triterpenoid, inhibits infection by HIV-1 in in vitro infected PBMC, naturally infected PBMC and monocyte/macrophages with EC50 of 22.7 mM, 24.6 mM and 57.4 mM, respectively.
|
-
- HY-B2167
-
-
- HY-W004282
-
|
Undecanoic acid
Undecanoate; Hendecanoic Acid
|
Fungal
Endogenous Metabolite
|
Infection
|
|
Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
|
-
- HY-B0167
-
-
- HY-Y0095
-
|
Isethionic acid
2-Hydroxyethanesulfonic Acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Isethionic acid (2-Hydroxyethanesulfonic acid) is an organosulfur compound. Isethionic acid is widely distributed in animal species and in a few red algal species. Isethionic acid can be used as an anionic detergent and has anti-settlement activity against Balanus amphitrite.
|
-
- HY-N1486
-
-
- HY-N0342
-
-
- HY-113285
-
-
- HY-B0660
-
-
- HY-B0541
-
|
Cyclamic acid
Cyclohexylsulfamic Acid; Cyclamate
|
Others
|
Others
|
|
Cyclamic acid is one of the most widely used artificial sweeteners.
|
-
- HY-N0321
-
-
- HY-W015882
-
-
- HY-B1245
-
-
- HY-W016562
-
|
Hippuric acid
2-Benzamidoacetic Acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
|
-
- HY-113371
-
|
2-Methylcitric acid
Methylcitric Acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
|
-
- HY-B0926
-
-
- HY-Y0084
-
|
3,4,5-Trimethoxybenzoic acid
Eudesmic Acid; Trimethylgallic Acid
|
Others
|
Others
|
|
3,4,5-Trimethoxybenzoic acid (Eudesmic acid;Trimethylgallic Acid) is a benzoic acid derivative. A building block in medicine and organic synthesis.
|
-
- HY-N0787
-
-
- HY-18733
-
-
- HY-N2341
-
|
Palmitelaidic Acid
9-trans-Hexadecenoic Acid; trans-Palmitoleic Acid
|
AMPK
PPAR
Glucokinase
|
Metabolic Disease
|
|
Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
|
-
- HY-Y1088
-
-
- HY-N0078
-
|
Ginkgolic Acid C13:0
Ginkgolic Acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic Acid
|
Others
|
Infection
|
|
Ginkgolic Acid (C13:0) is a natural anticariogenic agent in that it exhibits antimicrobial activity against S.
|
-
- HY-N1446
-
-
- HY-79494
-
-
- HY-14649
-
|
Retinoic acid
Vitamin A Acid; all-trans-Retinoic Acid; ATRA
|
RAR/RXR
PPAR
Endogenous Metabolite
Autophagy
|
Cancer
|
|
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM.
|
-
- HY-B1306
-
-
- HY-W032915
-
-
- HY-113413
-
-
- HY-12769
-
-
- HY-W016814
-
|
(Z)-Aconitic acid
cis-Aconitic Acid
|
Endogenous Metabolite
|
Others
|
|
(Z)-Aconitic acid (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
|
-
- HY-W013636
-
|
2-Ketoglutaric acid
Alpha-Ketoglutaric Acid
|
Tyrosinase
Endogenous Metabolite
|
Others
|
|
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM).
|
-
- HY-100560
-
|
Abscisic acid
(S)-(+)-Abscisic Acid; ABA
|
Others
|
Metabolic Disease
|
|
Abscisic acid ((S)-(+)-Abscisic acid) is a plant hormone which is as a growth inhibitor. Abscisic acid has been shown to regulate many aspects of plant growth and development including embryo maturation, seed dormancy, germination, cell division and elongation, floral induction, and responses to environmental stresses such as drought, salinity, cold, pathogen attack and UV radiation.
|
-
- HY-N0611
-
-
- HY-Y0293
-
-
- HY-N0294
-
-
- HY-I0400
-
-
- HY-113381
-
-
- HY-N2007
-
|
Veratric acid
3,4-Dimethoxybenzoic Acid
|
COX
Reactive Oxygen Species
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.
|
-
- HY-N0060B
-
|
(E)-Ferulic acid
(E)-Coniferic Acid
|
β-catenin
Bcl-2 Family
Ferroptosis
Endogenous Metabolite
|
Cancer
|
|
(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.
|
-
- HY-10585
-
|
Valproic acid
VPA; 2-Propylpentanoic Acid
|
HDAC
Autophagy
Mitophagy
HIV
Notch
|
Cancer
|
|
Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
|
-
- HY-Y0069
-
|
N-Acetylglycine
Acetamidoacetic Acid; Aceturic Acid
|
Endogenous Metabolite
|
Others
|
|
N-Acetylglycine is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
|
-
- HY-N0060A
-
-
- HY-14608
-
-
- HY-N0067
-
-
- HY-41494
-
|
o-Toluic acid
2-Methylbenzoic Acid
|
Others
|
Others
|
|
o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
|
-
- HY-W053507
-
|
m-Tolylacetic acid
3-Methylbenzeneacetic Acid
|
Others
|
Others
|
|
m-Tolylacetic acid (3-Methylbenzeneacetic acid) is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid.
|
-
- HY-111807
-
-
- HY-100921
-
-
- HY-N0371
-
|
Pachymic acid
3-O-Acetyltumulosic Acid
|
Akt
ERK
|
Cancer
|
|
Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibits Akt and ERK signaling pathways.
|
-
- HY-100805
-
-
- HY-N1362
-
|
Salvianolic acid B
Lithospermic Acid B
|
Autophagy
|
Cardiovascular Disease
|
|
Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.
|
-
- HY-15464A
-
|
(R)-(-)-Gossypol acetic acid
AT-101 (acetic Acid); (-)-Gossypol acetic Acid; (R)-Gossypol acetic Acid
|
Bcl-2 Family
Autophagy
|
Cancer
|
|
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.
|
-
- HY-W007894
-
-
- HY-118651
-
|
Griseoluteic acid
|
Bacterial
|
Infection
|
|
Griseoluteic acid, a phenazine antibiotic, is originally isolated from S. griseoluteus. Griseoluteic acid is a breakdown product of griseolutein A and B.
|
-
- HY-121447
-
-
- HY-113301
-
-
- HY-N6929
-
|
Angelic acid
|
Others
|
Neurological Disease
|
|
Angelic Acid is a substance found in the essential oil of Anthemis nobilis, and it exists in an ester form. Angelic acid aids in wound healing and exhibits sedative and psychotropic properties.
|
-
- HY-N4137
-
-
- HY-W008820
-
-
- HY-N1469
-
-
- HY-N6871
-
-
- HY-N1479
-
|
Polygalic acid
|
Others
|
Others
|
|
Polygalic acid, a triterpenoid saponin, is considered one of the major active constituents of Polygala tenuifolia.
|
-
- HY-N2566
-
|
Euscaphic acid
|
DNA/RNA Synthesis
PI3K
Apoptosis
|
Cancer
|
|
Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM. Euscaphic acid induces apoptosis.
|
-
- HY-N1428
-
-
- HY-N0223
-
-
- HY-N0172
-
-
- HY-B1210
-
-
- HY-B1221
-
-
- HY-41404
-
|
Piperonylic acid
|
Cytochrome P450
|
Infection
|
|
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase.
|
-
- HY-N0656
-
|
Usnic acid
|
Bacterial
|
Cancer
Infection
|
|
Usnic acid, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid has excellent anticancer and antimicrobial properties. Usnic acid significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1.
|
-
- HY-N0481
-
|
Roburic acid
|
COX
|
Inflammation/Immunology
|
|
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC50s of 5 and 9 μM for COX-1 and COX-2, respectively.
|
-
- HY-N0644
-
-
- HY-135578
-
|
Artelinic acid
|
Parasite
|
Infection
|
|
Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes.
|
-
- HY-Y1373
-
-
- HY-Y0366
-
-
- HY-34740
-
-
- HY-B0398
-
|
Nalidixic acid
|
Bacterial
Antibiotic
Topoisomerase
|
Infection
|
|
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
|
-
- HY-W012241
-
-
- HY-N6869
-
-
- HY-113295
-
-
- HY-128744
-
-
- HY-128421
-
-
- HY-128483
-
-
- HY-W014666
-
-
- HY-131116
-
-
- HY-W020215
-
-
- HY-113227
-
-
- HY-N5024
-
|
Gambogenic acid
|
Histone Methyltransferase
|
Cancer
|
|
Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination.
|
-
- HY-125909
-
-
- HY-B0574
-
|
Mefenamic acid
|
COX
|
Inflammation/Immunology
|
|
Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
|
-
- HY-N7514
-
|
Strictosidinic acid
|
5-HT Receptor
|
Neurological Disease
|
|
Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice.
|
-
- HY-113008
-
-
- HY-113353
-
-
- HY-B1640
-
|
Ethacrynic acid
|
Gutathione S-transferase
NF-κB
Calcium Channel
|
Cancer
Inflammation/Immunology
|
|
Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.
|
-
- HY-N6070
-
|
Ricinoleic acid
|
Others
|
Others
|
|
Ricinoleic acid, from castor (Ricinus communis) seed oil, is a high-value hydroxy fatty acid with broad industrial applications. Ricinoleic acid is an attractive feedstock for the production of high-performance lubricants, cosmetics, polymers, surfactants, and coatings.
|
-
- HY-N7078
-
|
Spiculisporic acid
|
Others
|
Others
|
|
Spiculisporic acid is a γ-butenolide isolated from the cultue of Aspergillus sp. Spiculisporic acid is a microbial biosurfactant and has anti-oxidative stress actions.
|
-
- HY-N2546
-
-
- HY-113298
-
-
- HY-130187
-
|
Sapienic acid
|
Bacterial
|
Infection
|
|
Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively.
|
-
- HY-N6785
-
|
Okadaic acid
|
Phosphatase
Parasite
Apoptosis
|
Infection
|
|
Okadaic acid is extracted from black sponges of the genus Halichondria. Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A and PP3 inhibitor with IC50s of 10-15 nM, 0.5 nM and 4 nM, respectively. Okadaic acid eliminate metazoan symbionts/parasites by apoptosis.
|
-
- HY-N7109
-
|
Erucic acid
|
PI3K
Endogenous Metabolite
|
Neurological Disease
|
|
Erucic acid, a monounsaturated fatty acid (MUFA), is isolated from the seed of Raphanus sativus L. Erucic acid can readily cross the blood-brain barrier (BBB), it has been reported to normalize the accumulation of very long-chain fatty acids in the brain. Erucic acid can improve cognitive impairment and be effective against dementia
.
|
-
- HY-N0594
-
|
Deacetylasperulosidic Acid
|
Interleukin Related
|
Inflammation/Immunology
|
|
Deacetylasperulosidic acid (DAA) is a major phytochemical constituent of Morinda citrifolia fruit. Deacetylasperulosidic acidhas antioxidant activity by increasing superoxide dismutase activity. Deacetylasperulosidic acid has anticlastogenic activity, suppressing the induction of chromosome aberrations in hamster ovary cells and mice. Deacetylasperulosidic acid prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage in vitro, suppresses IL-2 production along with the activation of natural killer cells.
|
-
- HY-N2217
-
-
- HY-N6715
-
|
Tenuazonic acid
|
Influenza Virus
Bacterial
|
Infection
|
|
Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor.
|
-
- HY-W010098
-
-
- HY-141263
-
-
- HY-113756A
-
|
Latanoprost acid
|
Prostaglandin Receptor
|
Inflammation/Immunology
|
|
Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.
|
-
- HY-N2991
-
|
Dehydropachymic acid
|
Autophagy
|
Neurological Disease
|
|
Dehydropachymic acid is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid is more effective in autophagy-lysosome pathway (ALP) impaired cells rather than normal cells.
|
-
- HY-111604
-
-
- HY-W016349
-
|
Chelidamic acid
|
Others
|
Others
|
|
Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
|
-
- HY-N0729
-
-
- HY-N0513
-
|
Loganic acid
|
Others
|
Inflammation/Immunology
Cardiovascular Disease
|
|
Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity.
|
-
- HY-N0194
-
-
- HY-N3463
-
-
- HY-B0493
-
-
- HY-112052
-
|
Aminomalonic acid
|
Endogenous Metabolite
|
Cancer
|
|
Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis.
|
-
- HY-B0012
-
-
- HY-W015967
-
-
- HY-113099
-
-
- HY-41417
-
-
- HY-N2309
-
-
- HY-N3063
-
|
Pimaric acid
|
Others
|
|
|
Pimaric acid is a resin acid that has been found in A. cordata and various pines. Pimaric acid reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs).
|
-
- HY-B2136
-
-
- HY-N6909
-
-
- HY-N6908
-
|
Continentalic acid
|
Bacterial
|
Cancer
Infection
Inflammation/Immunology
|
|
Continentalic acid from Aralia continentalis has minimum inhibitory concentrations (MICs) of approximately 8-16 µg/mL against S. aureus, including the Methicillin susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA) standard strains.
|
-
- HY-N6087
-
-
- HY-N2896
-
|
Arjunolic acid
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
Arjunolic acid is a saponin isolated from Symplocos lancifolia and has various biologial activities, including antioxidant, antimicrobial, antibacterial and anti-inflammory activities. Arjunolic acid is also a potent antioxidant and plays an important role in the protection of cells and tissues against deleterious effects of reactive oxygen species.
|
-
- HY-W017522
-
|
Adipic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism.
|
-
- HY-19355
-
|
Rocagloic acid
|
Others
|
Cancer
|
|
Rocagloic acid is a racaglamide derivative isolated from the fruits of Amoora cucullata with potent cytotoxicity.
|
-
- HY-113079
-
-
- HY-N0339
-
-
- HY-N0626
-
-
- HY-N2490
-
|
Dehydrotrametenolic acid
|
Caspase
|
Cancer
Inflammation/Immunology
|
|
Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through caspase-3 pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects.
|
-
- HY-Y1009
-
-
- HY-W011873
-
-
- HY-B1406
-
-
- HY-118189
-
|
Misoprostol acid
|
Prostaglandin Receptor
|
Inflammation/Immunology
|
|
Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers. Misoprostol is an oral agent used to induce labor.
|
-
- HY-W041489
-
|
Chelidonic acid
|
NF-κB
Caspase
|
Inflammation/Immunology
Cancer
|
|
Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM.
|
-
- HY-N6705
-
|
Tropodithietic acid
|
Bacterial
|
Infection
|
|
Tropodithietic acid is a sulfur-containing antibiotic produced by the marine bacterium Phaeobacter inhibens. Tropodithietic acid exhibits a strong antibiotic activity against a broad spectrum of bacteria including alpha- and gammaproteobacteria, flavobacteria and actinobacteria.
|
-
- HY-N1996
-
-
- HY-N2033
-
-
- HY-N6246
-
|
Asperulosidic Acid
|
NF-κB
ERK
|
Cancer
Inflammation/Immunology
|
|
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities.
ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.
|
-
- HY-113071
-
-
- HY-113373
-
-
- HY-W006230
-
|
Anthraflavic acid
|
Others
|
Cancer
|
|
Anthraflavic acid, a flavonoid, is a potent IQ mutagenicity inhibitor by virtue of its ability to inhibit both its microsomal and cytosolic activation pathways. Anthraflavic acid is a potent and specific cytochrome P-448 inhibitor activity an enzyme system closely associated with the activation of many chemical carcinogens.
|
-
- HY-119358
-
|
Traumatic Acid
|
Others
|
Inflammation/Immunology
|
|
Traumatic Acid is a monounsaturated dicarboxylic acid isolated from Phaseolus vulgaris. Traumatic Acid can cause a decrease in membrane phospholipid peroxidation and show antioxidant and stimulatory effects on collagen biosynthesis. Traumatic Acid is a potential agent for the treatment of many skin diseases connected with collagen biosynthesis disorders and oxidative stress.
|
-
- HY-W012999
-
|
Tiglic acid
|
Endogenous Metabolite
|
Others
|
|
Tiglic acid is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. Tiglic aci has a role as a plant metabolite.
|
-
- HY-117275
-
|
Meclofenamic acid
|
Gap Junction Protein
|
Inflammation/Immunology
|
|
Meclofenamic Acid, a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
|
-
- HY-N6771
-
|
Cyclopiazonic acid
|
Calcium Channel
|
Others
|
|
Cyclopiazonic acid (CPA), a neurotoxic secondary metabolite (SM) made by A. flavus, is a nanomolar inhibitor of endoplasmic reticulum calcium ATPase (Ca 2+ATPase; SERCA) and a potent inducer of cell death in plants.
|
-
- HY-N2499
-
|
Dehydrotumulosic acid
|
Others
|
Metabolic Disease
|
|
Dehydrotumulosic acid, one of the effective constituents of Poria cocos, was isolated from the chloroform-soluble material of ethanol extract of the fungus. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body.
|
-
- HY-N3016
-
-
- HY-113267
-
-
- HY-W004284
-
-
- HY-113016
-
-
- HY-113094
-
-
- HY-N0656A
-
|
(+)-Usnic acid
|
mTOR
|
Cancer
|
|
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity.
|
-
- HY-N4095
-
-
- HY-113328
-
-
- HY-N6875
-
|
Oleuropeinic acid
|
Others
|
Metabolic Disease
|
|
oleuropeinic acid is present initially in olive tissues or formed by the thermal treatment, possibly by the oxidation of oleuropein. Oleuropeinic acid is an antioxidant-soluble fiber.
|
-
- HY-W018653
-
-
- HY-50730
-
|
Asparagusic acid
|
Others
|
Others
|
|
Asparagusic acid (1,2-dithiolane-4-carboxylic acid) is unique to asparagus.The compound is responsible for the odorous urine excreted after eating asparagus.Its derivatives ihydroasparagusic acid have anti-inflammatory effect.
|
-
- HY-W014787
-
-
- HY-N1423
-
-
- HY-N0569
-
-
- HY-W015300
-
-
- HY-100807
-
-
- HY-113362
-
-
- HY-W018161
-
|
Hexadecanedioic acid
|
Endogenous Metabolite
|
Others
|
|
Hexadecanedioic acid is covalently linked to Sepharose 4B, shows better performance in terms of specificity than dye-based resins and could be used for depletion of SA from plasma samples.
|
-
- HY-N6822
-
-
- HY-N0830
-
-
- HY-B2130
-
-
- HY-W015883
-
-
- HY-N4170
-
|
Chebulic acid
|
Others
|
Metabolic Disease
|
|
Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,
which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress and renal damage, supporting its beneficial effect in diabetic nephropathy.
|
-
- HY-N2041
-
-
- HY-N0216
-
-
- HY-N0130
-
-
- HY-W015309
-
-
- HY-I0508
-
|
Phthalic acid
|
Others
|
Others
|
|
Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers.
|
-
- HY-113212
-
|
Ursocholic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Ursocholic acid, a bile acid found predominantly in bile of mammals, is transformed into deoxycholic acid by the intestinal microflora in mice. Ursodeoxycholic acid is an inhibitor of 7α-hydroxysteroid dehydrogenase and hepatocyte nuclear factor 1α.
|
-
- HY-B0149
-
-
- HY-133105
-
-
- HY-106579
-
|
Tiaprofenic acid
|
COX
|
Inflammation/Immunology
|
|
Tiaprofenic acid is an orally active nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic potency. Tiaprofenic acid inhibits prostaglandin synthesis by suppressing cyclo-oxygenase (COX). Tiaprofenic acid can be used in the treatment of rheumatic diseases.
|
-
- HY-Y0669
-
-
- HY-W027555
-
-
- HY-122575
-
|
Aurintricarboxylic acid
|
P2X Receptor
Influenza Virus
Topoisomerase
|
Infection
Inflammation/Immunology
Neurological Disease
|
|
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway.
|
-
- HY-W013049
-
-
- HY-N0801
-
|
Polygalacic acid
|
MMP
AChE
|
Inflammation/Immunology
Neurological Disease
|
|
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment .
Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.
|
-
- HY-W009081
-
-
- HY-B0515A
-
|
Ibandronic acid
|
Others
|
Cancer
|
|
Ibandronic acid is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
|
-
- HY-122935
-
|
Nigranoic acid
|
HIV
Reverse Transcriptase
|
Infection
|
|
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
|
-
- HY-N0324
-
-
- HY-N0708
-
-
- HY-B0631
-
|
Alendronic acid
|
Others
|
Cancer
|
|
Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease.
|
-
- HY-B1043
-
-
- HY-42972
-
|
DBCO-acid
|
ADC Linker
|
Cancer
|
|
DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690).
|
-
- HY-W004261
-
|
Nonadecanoic acid
|
Others
|
Others
|
|
Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis to defence.
|
-
- HY-Y0367
-
-
- HY-N2058
-
|
Neogambogic acid
|
Bacterial
Apoptosis
|
Cancer
Infection
|
|
Neogambogic acid, an active ingredient in garcinia, induces apoptosis and has anticancer effect. Neogambogic acid has significant inhibitory activity toward methicillin-resistant Staphylococcus aureus (MRSA).
|
-
- HY-B2219
-
-
- HY-B1002
-
-
- HY-136406
-
|
Bongkrekic acid
|
ATP Synthase
|
Cancer
Infection
|
|
Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport.
|
-
- HY-W004283
-
-
- HY-N4304
-
-
- HY-N6777
-
|
Penicillic acid
|
Caspase
Bacterial
Apoptosis
Antibiotic
|
Cancer
Infection
|
|
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium, which exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8.
|
-
- HY-125731
-
-
- HY-Y0520
-
-
- HY-B1664
-
-
- HY-B1393
-
-
- HY-W050154
-
|
Kojic acid
|
Parasite
|
Infection
|
|
Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent.
|
-
- HY-N0010
-
-
- HY-N4094
-
-
- HY-N2318
-
-
- HY-122464
-
|
(±)-Jasmonic acid
|
Others
|
|
|
(±)-Jasmonic acid is a plant growth regulator and a derivative of α-linolenic acid. (±)-Jasmonic acid decreases chlorophyll levels in green and etiolated barley leaf segments and inhibits elongation of rice seedlings.
|
-
- HY-B0183
-
-
- HY-113162
-
-
- HY-N0271
-
-
- HY-N6055
-
|
Nuezhenidic acid
|
Others
|
Infection
|
|
Nuezhenidic acid, isolated from the fruits of Ligustrum lucidum, posseses inhibitory activities against influenza A virus.
|
-
- HY-N3977
-
|
Grifolic acid
|
GPR120
|
Inflammation/Immunology
|
|
Grifolic acid is a phenolic compound that is first extracted from the mushroom Albatrellus confluens. Grifolic acid acts as an agonist of the free fatty acid receptor (FFAR4/GPR120).
|
-
- HY-N6874
-
-
- HY-I0736
-
|
Isonicotinic acid
|
Drug Metabolite
Endogenous Metabolite
|
Others
|
|
Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C.
|
-
- HY-125934
-
|
Allocholic acid
|
Others
|
Cancer
|
|
Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis. Allocholic acid is also a potent and specific stimulant of the adult olfactory system.
|
-
- HY-Y0267
-
-
- HY-113219
-
-
- HY-W014125
-
-
- HY-N7262
-
|
Hydroxyvalerenic acid
|
Others
|
Cancer
|
|
Hydroxyvalerenic acid is isolated from Verbena officinalis, has a low toxicity with IC50 values of 123 and 165 μM against GLC4 and COLO 320 cells, respectively.
|
-
- HY-113283
-
-
- HY-P1340A
-
-
- HY-103355
-
|
YM022
|
CCR
|
Metabolic Disease
|
|
YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo.
|
-
- HY-113437
-
-
- HY-130803
-
|
5-Methyl-5,6-dihydrouridine
|
Others
|
Cancer
|
|
5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. 5-Methyl-5,6-dihydrouridine can be used for nucleic acid modification.
|
-
- HY-113437A
-
-
- HY-116100A
-
-
- HY-W009082
-
|
Methyl behenate
Methyl docosanoate
|
Others
|
Others
|
|
Methyl behenate (Methyl docosanoate) is a naturally fatty acid methyl ester isolated from the plant of Aspidopterys obcordata Lemsl.
|
-
- HY-P1340
-
-
- HY-112754A
-
|
DOTAP chloride
1,2-Dioleoyl-3-trimethylammonium-propane chloride
|
Others
|
Others
|
|
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.
|
-
- HY-113025A
-
|
L-hydroxylysine dihydrochloride
(2S,5R)-5-Hydroxylysine dihydrochloride
|
Endogenous Metabolite
|
Others
|
|
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues.
|
-
- HY-W002110
-
|
Isohomovanillic acid
3-Hydroxy-4-methoxyphenylacetic Acid; iso-HVA; Homoisovanillic Acid
|
Endogenous Metabolite
|
Cancer
|
|
Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is extracted from urine at pH 2 by ethyl acetate. Isohomovanillic acid is not found in appreciable values in many normal human urines.
|
-
- HY-B1258
-
-
- HY-W050031
-
|
(S)-3-Hydroxybutanoic acid
(S)-β-Hydroxybutanoic Acid; L-(+)-3-Hydroxybutyric Acid; L-β-Hydroxybutyric Acid
|
Endogenous Metabolite
|
Others
|
|
(S)-3-Hydroxybutanoic acid is a normal human metabolite, that has been found elevated in geriatric patients remitting from depression. In humans, 3-Hydroxybutyric acid is synthesized in the liver from acetyl-CoA, and can be used as an energy source by the brain when blood glucose is low.
|
-
- HY-107260
-
-
- HY-N2406
-
-
- HY-N7510
-
|
12-O-Methylcarnosic acid
12-Methoxycarnosic Acid
|
5 alpha Reductase
|
Cancer
Infection
|
|
12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity.
|
-
- HY-B1505
-
-
- HY-N0610
-
-
- HY-140589
-
-
- HY-N4125
-
-
- HY-N0057
-
-
- HY-N6864
-
|
Isovanillic acid
3-Hydroxy-4-methoxybenzoic Acid
|
Others
|
Inflammation/Immunology
|
|
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from S. frutescens, with Anti-inflammatory activity.
|
-
- HY-N0058
-
-
- HY-N1778
-
-
- HY-A0281
-
-
- HY-N0722
-
-
- HY-140113
-
-
- HY-111536
-
-
- HY-W012946
-
-
- HY-N0351
-
-
- HY-113371A
-
|
2-Methylcitric acid trisodium
Methylcitric Acid trisodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
|
-
- HY-111095
-
|
D-(-)-Lactic acid
(R)-2-Hydroxypropionic Acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-(-)-Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. D-(-)-Lactic acid is identified to be a competitive inhibitor of ProDH (proline dehydrogenase) in plants.
|
-
- HY-N0186
-
|
Indole-3-butyric acid
3-indolebutyric Acid
|
Endogenous Metabolite
|
Others
|
|
Indole-3-butyric acid (3-indolebutyric acid; IBA) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate.
|
-
- HY-30219
-
-
- HY-123672
-
-
- HY-14879
-
|
Avibactam free acid
NXL-104 free Acid
|
Bacterial
Antibiotic
|
Infection
|
|
Avibactam free acid (NXL-104 free acid) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
|
-
- HY-70002B
-
-
- HY-128425
-
-
- HY-140112
-
-
- HY-N0523
-
-
- HY-N2995
-
|
Poricoic acid A
Poricoic Acid A(F)
|
Others
|
Cancer
|
|
Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis.
|
-
- HY-101581
-
|
Bucloxic acid
804CB; Bucloxonic Acid; Esfar
|
Others
|
Inflammation/Immunology
|
|
Bucloxic acid is an anti-inflammatory pyrrazole derivative. Bucloxic acid can be used in the treatment of chronic glomerular nephropathies.
|
-
- HY-W012875
-
-
- HY-N0761
-
|
Isoferulic acid
3-Hydroxy-4-methoxycinnamic Acid
|
Adrenergic Receptor
Influenza Virus
|
Infection
Endocrinology
Metabolic Disease
|
|
Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use. Isoferulic acid also has anti-influenza virus activities.
|
-
- HY-W009776
-
|
Suberoyl bis-hydroxamic acid
Suberohydroxamic Acid; SBHA
|
HDAC
|
Cancer
|
|
Suberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively.Suberoyl bis-hydroxamic acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways.Suberoyl bis-hydroxamic acid can be used for the study of medullary thyroid carcinoma (MTC).
|
-
- HY-101401
-
-
- HY-B0711
-
|
Carglumic Acid
N-Carbamyl-L-glutamic Acid
|
Others
|
Cancer
|
|
Carglumic acid (N-Carbamyl-L-glutamic acid), a functional analogue of N-acetylglutamate (NAG) and a carbamoyl phosphate synthetase 1 (CPS1) activator, is used to treat acute and chronic hyperammonemia associated with NAG synthase (NAGS) deficiency.
|
-
- HY-Y0479
-
-
- HY-N1363
-
-
- HY-17510
-
|
Gossypol acetic acid
(±)-Gossypol-acetic Acid; BL 193 (acetic Acid)
|
Bcl-2 Family
|
Cancer
|
|
Gossypol acetic acid ((±)-Gossypol-acetic acid), a natural product isolated from cottonseeds and roots, binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.
|
-
- HY-14520
-
|
Tetrahydrofolic acid
L-5,6,7,8-Tetrahydrofolic Acid; L-Tetrahydrofolic Acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid.
|
-
- HY-B0236
-
|
6-Aminocaproic acid
EACA; Epsilon-Amino-n-caproic Acid; 6-Aminohexanoic Acid
|
Others
|
Metabolic Disease
|
|
6-Aminocaproic acid is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
|
-
- HY-122872
-
|
MKK7-COV-9
|
p38 MAPK
|
Cancer
|
|
MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC50 of 4.98 μM.
|
-
- HY-16743A
-
|
Ibiglustat L-Malic acid
Venglustat (L-Malic Acid); SAR402671 (L-Malic Acid); GZ402671 (L-Malic Acid)
|
Others
|
Metabolic Disease
|
|
Ibiglustat L-Malic acid (Venglustat L-Malic acid), a potential therapy for PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s, is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with ability to cross the blood-brain barrier.
|
-
- HY-Y1644
-
-
- HY-N1412
-
-
- HY-13212
-
|
(Z)-2-decenoic acid
cis-2-Decenoic Acid
|
Others
|
Cancer
|
|
(Z)-2-decenoic acid(cis-2-Decenoic acid) is an unsaturated short chain fatty acid that is secreted by P.
|
-
- HY-Y0202
-
-
- HY-14754
-
|
Salirasib
S-Farnesylthiosalicylic Acid; Farnesyl Thiosalicylic Acid; FTS
|
Ras
Autophagy
|
Cancer
|
|
Salirasib is a Ras inhibitor that inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth.
|
-
- HY-113008A
-
|
cis-Urocanic acid
(Z)-Urocanic Acid; cis-UCA
|
5-HT Receptor
|
Inflammation/Immunology
|
|
cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.
|
-
- HY-100511
-
|
Benzophenonetetracarboxylic acid
3,3',4,4'-Benzophenonetetracarboxylic Acid
|
Others
|
Others
|
|
Benzophenonetetracarboxylic acid (3,3',4,4'-Benzophenonetetracarboxylic acid) is particularly useful in the preparation of high performance polyimides and also useful as curing agents for epoxy resins.
|
-
- HY-107661
-
|
Arundic Acid
ONO-2506; (R)-2-Propyloctanoic Acid
|
Others
|
Neurological Disease
|
|
Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid (ONO-2506) has been developed as a therapeutic agent for stroke and Alzheimer’s disease.
|
-
- HY-17568
-
|
Nonivamide
Pelargonic Acid vanillylamide; Nonanoic Acid vanillylamide; Pseudocapsaicin
|
TRP Channel
|
Neurological Disease
|
|
Nonivamide is a agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.
|
-
- HY-W017100
-
|
2-Hydroxy-6-methoxybenzoic acid
6-Methoxysalicylic Acid
|
Others
|
Neurological Disease
|
|
2-Hydroxy-6-methoxybenzoic acid can be used for the determination of acetylsalicylic acid and its major metabolite, salicylic acid, in animal plasma. 2-Hydroxy-6-methoxybenzoic acid exhibits significant analgesic effects.
|
-
- HY-13211
-
|
(E)-2-Decenoic acid
trans-2-Decenoic Acid
|
Others
|
Cancer
|
|
(E)-2-Decenoic acid is an interesting fatty acid isolated from royal jelly secretions of honey bees.
|
-
- HY-113039
-
-
- HY-113038
-
-
- HY-W013636A
-
|
2-Ketoglutaric acid Sodium
Alpha-Ketoglutaric Acid Sodium
|
Tyrosinase
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM).
|
-
- HY-W004206
-
-
- HY-W007686
-
-
- HY-B1189
-
-
- HY-15599A
-
|
SSR128129E free acid
SSR free Acid
|
FGFR
|
Cancer
|
|
SSR128129E free acid is an orally available and allosteric FGFR inhibitor with an IC50 of 1.9 μM for FGFR1.
|
-
- HY-140114
-
-
- HY-15464D
-
|
(S)-Gossypol acetic acid
(S)-(+)-Gossypol acetic Acid
|
Bcl-2 Family
|
Cancer
|
|
(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
|
-
- HY-75625
-
-
- HY-117145
-
|
Thiophene-2
TP2
|
Bacterial
|
Infection
|
|
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity.
|
-
- HY-N7031
-
|
(±)-Vasicine
(±)-Peganine
|
Proton Pump
|
Inflammation/Immunology
|
|
(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine), isolated from Peganum harmala seeds, significantly inhibits H +-K +-ATPase activity in vitro with an IC50 of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect.
|
-
- HY-113972A
-
|
(E/Z)-Methyl mycophenolate
|
Others
|
Inflammation/Immunology
|
|
(E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl ester of mycophenolic acid. Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides.
|
-
- HY-W010832
-
-
- HY-W011688
-
|
Methyl palmitoleate
(Z)-Methyl hexadec-9-enoate; Methyl cis-9-Hexadecenoate
|
Others
|
Others
|
|
Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties.
|
-
- HY-W010820
-
-
- HY-Y0444
-
|
D-Tyrosine
|
Tyrosinase
|
Metabolic Disease
|
|
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth.
|
-
- HY-135795
-
|
1-Cyclohexyl-3-dodecyl urea
CDU; N-Cyclohexyl-N-dodecyl urea; NCND
|
Epoxide Hydrolase
|
Metabolic Disease
Cardiovascular Disease
|
|
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.
|
-
- HY-N4120
-
|
Valechlorine
|
Autophagy
|
Metabolic Disease
|
|
Valechlorine, a autophagy enhancer, breaks down lipid droplets. Valechlorine reduces oleic acid (OA)-induced lipid accumulation in an Atg5-dependent manner.
|
-
- HY-W001959
-
|
D-Allothreonine
|
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Allothreonine is the D type stereoisomer of Allothreonine. D-Allothreonine is a peptido-lipid derived from bacteria. D-Allothreonine, amide-linked to the D-galacturonic acid, is also a constituent in the polysaccharide.
|
-
- HY-N7132
-
|
Menthyl acetate
L-Menthyl acetate; (-)-Menthyl acetate
|
Others
|
Others
|
|
Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation.
|
-
- HY-N1424
-
-
- HY-131121
-
-
- HY-113004
-
-
- HY-140987
-
-
- HY-W010382
-
-
- HY-113410
-
-
- HY-130908
-
-
- HY-114771
-
-
- HY-W052234
-
|
4-Fluorophenoxyacetic acid
|
Others
|
Others
|
|
4-Fluorophenoxyacetic acid (4FPA) induces parthenocarpy. 4-Fluorophenoxyacetic acid (4FPA) protects cereals from piercing-sucking insects and thereby increases rice yield in the field.
|
-
- HY-W018059
-
-
- HY-113409
-
-
- HY-W009162
-
-
- HY-N0464
-
-
- HY-N0184
-
-
- HY-N2454
-
-
- HY-B0421
-
-
- HY-124480
-
-
- HY-N1447
-
-
- HY-N1515
-
|
Ganoderenic acid C
|
Others
|
Cancer
|
|
Ganoderenic acid C is a triterpenoid isolated from Ganoderma lingzhi. Ganoderenic acid C is abundant in fruit bodies at an early growth stage.
|
-
- HY-B0633A
-
-
- HY-B0494
-
-
- HY-N4096
-
|
Tsugaric acid A
|
Others
|
Inflammation/Immunology
|
|
Tsugaric acid A can significantly inhibit superoxide anion formation. Tsugaric acid A also protects human keratinocytes against damage induced by ultraviolet B (UV B) light. Tsugaric acid A can protect keratinocytes from photodamage.
|
-
- HY-N0198
-
-
- HY-N6916
-
-
- HY-W018678
-
|
8-Aminooctanoic acid
|
Others
|
Metabolic Disease
|
|
8-Aminooctanoic acid is an omega-amino fatty acid that is octanoic acid which carries an amino group at position 8. 8-aminooctanoic acid has a role as a human metabolite.
|
-
- HY-N1386
-
-
- HY-P1377
-
-
- HY-W010040
-
-
- HY-W017194
-
-
- HY-113098
-
-
- HY-B0183A
-
-
- HY-113427
-
-
- HY-N0319
-
|
Salvianolic acid C
|
Cytochrome P450
|
Cancer
|
|
Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.
|
-
- HY-N6867
-
-
- HY-N0318
-
-
- HY-135399
-
-
- HY-N1450
-
|
Aristolochic acid C
|
Phospholipase
|
Cancer
|
|
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis.
|
-
- HY-135400
-
-
- HY-101016
-
-
- HY-17556
-
-
- HY-131108
-
-
- HY-W016867
-
|
4-Chlorosalicylic acid
|
Fungal
Bacterial
|
Infection
|
|
4-Chlorosalicylic acid is a pharmaceutical intermediate. Inhibits monophenolase and diphenolase activity with IC50s of 1.89 mM and 1.10 mM. Potent antimicrobial activity. Against E. coli with the MIC of 250 μg/mL and with the MBC of 500 μg/mL.
|
-
- HY-113357
-
-
- HY-76082
-
|
L-Pyroglutamic acid
|
Endogenous Metabolite
|
Others
|
|
L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
|
-
- HY-135895
-
-
- HY-W017524
-
-
- HY-N2998
-
|
Ganoderenic acid A
|
Others
|
Metabolic Disease
|
|
Ganoderenic acid A is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury.
|
-
- HY-N1427A
-
-
- HY-W016813
-
|
trans-Aconitic acid
|
Endogenous Metabolite
|
Others
|
|
trans-Aconitic acid is present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aconitate 2-methyltransferase.
|
-
- HY-W015590
-
-
- HY-I0447
-
-
- HY-N1465
-
|
Aristolochic acid D
|
Others
|
Cancer
|
|
Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen.
|
-
- HY-113286
-
-
- HY-107265
-
-
- HY-75954
-
-
- HY-113491
-
-
- HY-76847
-
-
- HY-N6728
-
|
Helvolic acid
Fumigacin
|
Bacterial
|
Infection
|
|
Helvolic acid (Fumigacin) is an antibiotic isolated from Xylaria sp, active against the Gram-positive bacteria.
|
-
- HY-N6860
-
|
Lucidenic acid C
|
MMP
|
Cancer
|
|
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.
|
-
- HY-100804
-
|
L-Cysteinesulfinic acid
|
mGluR
Endogenous Metabolite
|
Neurological Disease
|
|
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
|
-
- HY-140329
-
-
- HY-W007926
-
-
- HY-W001996
-
-
- HY-122921
-
-
- HY-130187A
-
|
Sapienic acid sodium
|
Bacterial
|
Infection
|
|
Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid sodium is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively.
|
-
- HY-W015307
-
|
4-Ethyloctanoic acid
|
Others
|
Others
|
|
4-Ethyloctanoic acid is a natural compound first isolated from Saussurea lappa Clarke, widely used as a safe flavoring compound and acts as food additive.
|
-
- HY-N0324A
-
-
- HY-N5057
-
|
Przewalskinic acid A
|
Others
|
Cardiovascular Disease
|
|
Przewalskinic acid A is a rare, water-soluble phenolic acid thus far only found in the Salvia przewalskii Maxim herb. Phenolic acids show potent antioxidant activities and potential effects in protecting against brain and heart damage caused by ischemia reperfusion.
|
-
- HY-115433
-
-
- HY-W015924
-
-
- HY-W004049
-
-
- HY-125847
-
-
- HY-113027
-
-
- HY-N4290
-
-
- HY-N2006
-
|
Ganoderic acid B
|
HIV Protease
|
Infection
|
|
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease.
|
-
- HY-N4289
-
|
3-Epiursolic Acid
|
Cathepsin
|
Cancer
|
|
3-Epiursolic Acid is a triterpenoid isolated from Myrtaceae, acts as a competitive inhibitor of cathepsin L (ICIC50, 6.5 μM; Ki, 19.5 μM), with no obvious effect on cathepsin B.
|
-
- HY-113514
-
-
- HY-113493
-
-
- HY-W015229
-
-
- HY-30215
-
-
- HY-113107
-
-
- HY-113377
-
|
L-Glyceric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2.
|
-
- HY-136560
-
|
6-Azathymine acid
|
Drug Metabolite
|
Others
|
|
6-Azathymine acid is a metabolite of Pymetrozine. Pymetrozine is active against plant-sucking insects, such as aphids and whiteflies in vegetables, cotton, field crops and fruits and affects the nervous regulation of feeding behavior.
|
-
- HY-42145
-
-
- HY-N0169
-
-
- HY-128745
-
-
- HY-N0320
-
-
- HY-W010031
-
-
- HY-N1423B
-
-
- HY-I0177
-
-
- HY-W015326
-
-
- HY-113085
-
-
- HY-N7522
-
-
- HY-W016819
-
|
5-Fluoroorotic acid
|
Others
|
Cancer
Infection
|
|
5-Fluoroorotic is a selective agent in yeast molecular genetics. 5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects.
|
-
- HY-N0511
-
|
Aristolochic acid B
|
Others
|
Cancer
|
|
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo.
|
-
- HY-13595
-
|
Chrysophanol
Chrysophanic Acid
|
EGFR
|
Cancer
|
|
Chrysophanol (Chrysophanic acid) is a natural anthraquinone, which inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K.
|
-
- HY-W040304
-
-
- HY-128743
-
-
- HY-U00295
-
|
Melarsonyl
Melarsonic Acid
|
Parasite
|
Infection
|
|
Melarsonyl (Melarsonic acid) is an anthelmintic agent which can inhibit parasite potently.
|
-
- HY-113274
-
-
- HY-N0666
-
-
- HY-69220
-
|
7-Octynoic acid
|
PROTAC Linker
|
Cancer
|
|
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
|
-
- HY-Y0264
-
-
- HY-140335
-
-
- HY-B1350
-
-
- HY-21075
-
-
- HY-128734
-
-
- HY-N2993
-
|
Polyporenic acid C
|
Apoptosis
|
Cancer
|
|
Polyporenic acid C is a lanostane-type triterpenoid isolated from P. cocos. Polyporenic acid C induces cell apoptosis through the death receptor-mediated apoptotic pathway without the involvement of the mitochondria. Polyporenic acid C is promising agent for lung cancer therapy.
|
-
- HY-N6862
-
|
Lucideric acid A
|
MMP
|
Cancer
|
|
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells.
|
-
- HY-W010381
-
-
- HY-W012980
-
-
- HY-N0672
-
-
- HY-W021448
-
|
Glycocyamine
Guanidinoacetic Acid
|
Endogenous Metabolite
|
Others
|
|
Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird.
|
-
- HY-W014831
-
-
- HY-W015608
-
-
- HY-N6612
-
-
- HY-124108
-
|
Eicosatetraynoic acid
ETYA
|
COX
PPAR
|
Others
|
|
Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 µM.
|
-
- HY-130538
-
|
1-Naphthohydroxamic acid
|
HDAC
|
Cancer
|
|
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity.1-Naphthohydroxamic acid can induce tubulin acetylation.
|
-
- HY-W007752
-
-
- HY-W015302
-
-
- HY-Y0585
-
-
- HY-N1513
-
|
Ganoderic acid H
|
Others
|
Cancer
|
|
Ganoderic acid H is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderic acid H suppresses growth and invasive behavior of breast cancer cells through the inhibition of transcription factors AP-1 and NF-kappaB signaling.
|
-
- HY-129150
-
|
Ganoderic acid TR
|
Influenza Virus
|
Infection
|
|
Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H5N1 and H1N1 neuraminidases. The IC50 values of 10.9 and 4.6 μM, respectively.
|
-
- HY-N6939
-
-
- HY-W015664
-
-
- HY-N2472
-
|
Medicagenic acid
Castanogenin
|
Bacterial
|
Infection
|
|
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra L, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes. Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE.
|
-
- HY-107512
-
-
- HY-17528
-
|
Cyhalofop
Cyhalofop Acid
|
Others
|
Others
|
|
Cyhalofop(Cyhalofop acid) is a recently registered herbicide from the aryloxyphenoxy propionate group in India to control a wide range of grass weed species at various growth stages in rice crop.
|
-
- HY-115249
-
-
- HY-W004154
-
|
2-Ethylbutyric acid
|
Others
|
Others
|
|
2-Ethylbutyric acid acts as an internal standard (IS) in a standard addition calibration method for the VFA analysis of faeces.
|
-
- HY-77959
-
-
- HY-113411
-
-
- HY-N2334
-
|
Glycochenodeoxycholic acid
Chenodeoxycholylglycine
|
Endogenous Metabolite
Apoptosis
|
Cancer
|
|
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid (Chenodeoxycholylglycine) induces hepatocyte apoptosis.
|
-
- HY-N0157A
-
-
- HY-W001083
-
-
- HY-N7140
-
|
Gamma-Linolenic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Gamma-linolenic acid is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated fatty acid (PUFA) extracted from human milk and several botanical seed oils. Gamma-linolenic acid supplements could restore needed PUFAs and mitigate the disease.
|
-
- HY-Y0569
-
-
- HY-N2513
-
|
β-Boswellic acid
|
Lipoxygenase
DNA/RNA Synthesis
|
Cancer
|
|
β-Boswellic acid is isolated from the gum resin of Boswellia serrate.
β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells.
|
-
- HY-N2177
-
|
3-Dehydrotrametenolic acid
|
Lactate Dehydrogenase
Apoptosis
|
Cancer
|
|
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity.
|
-
- HY-113220
-
-
- HY-W001171
-
-
- HY-128700
-
|
Nicotinic acid mononucleotide
|
Others
|
Metabolic Disease
|
|
Nicotinic acid mononucleotide (NAMN) is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD +. Nicotinate mononucleotide is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase.
|
-
- HY-W014796
-
-
- HY-N4124
-
-
- HY-B0148
-
|
Risedronic acid
Risedronate
|
Others
|
Others
|
|
Risedronic acid (Risedronate ) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.
|
-
- HY-N2541
-
-
- HY-128371
-
-
- HY-Y1297
-
-
- HY-N1902
-
-
- HY-113101
-
-
- HY-N2458
-
-
- HY-113378
-
-
- HY-B1136
-
|
Menbutone
Genabilic Acid
|
Others
|
Inflammation/Immunology
|
|
Menbutone is an oxobutyric acid derivative, and is a choleretic.Menbutone has a rapid onset of action, reaching its maximum plasma level within 1 hour and lasting for roughly 10 hours.
|
-
- HY-113277
-
-
- HY-112732B
-
|
Sparfosic acid trisodium
|
Others
|
Cancer
Metabolic Disease
|
|
Sparfosic acid trisodium, is a potent inhibitor of aspartate transcarbamoyl transferase, with anti-tumor and antimetabolite activity. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis.
|
-
- HY-B1235
-
|
Acetohydroxamic acid
AHA
|
Bacterial
|
Infection
|
|
Acetohydroxamic acid is a potent and irreversible inhibitor of bacterial and plant urease and also used as adjunctive therapy in chronic urinary infection.
|
-
- HY-N0460
-
|
1-Caffeoylquinic acid
|
NF-κB
|
Cancer
|
|
1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with Ki of 0.002 μM and binding energy of 1.50 Kcal/mol. 1-Caffeoylquinic acid has anti-oxidative stress ability. 1-Caffeoylquinic acid inhibits PD-1/PD-L1 interact.
|
-
- HY-136327
-
-
- HY-140328
-
-
- HY-Y0624
-
-
- HY-N1516
-
|
Ganoderenic acid D
|
Apoptosis
|
Cancer
|
|
Ganoderenic acid D is a triterpene identified from the effective compounds of Ganoderma lucidum extract (GLE). Ganoderenic acid D inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
|
-
- HY-W017189
-
-
- HY-N1511
-
|
Ganoderic acid D
|
Sirtuin
Apoptosis
|
Cancer
|
|
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis.
|
-
- HY-W037355
-
-
- HY-N1387
-
-
- HY-N6917
-
-
- HY-113057
-
-
- HY-N2391
-
-
- HY-W015878
-
-
- HY-Y0181
-
-
- HY-W010178
-
|
4-Methyloctanoic acid
|
Others
|
Others
|
|
4-Methyloctanoic acid is a natural compound mainly responsible for the characteristic goaty sheepy flavour of sheep and goat milk.
|
-
- HY-N0673
-
|
Pseudolaric Acid A
|
Fungal
|
Infection
|
|
Pseudolaric Acid A is a diterpene acid isolated from Pseudolarix kaempferi, has antifungal, cytotoxic and antifertile activities.
|
-
- HY-107831
-
-
- HY-W015675
-
-
- HY-N6861
-
|
Lucidenic acid B
|
Apoptosis
|
Cancer
|
|
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells.
|
-
- HY-125713
-
|
Ganoderic acid Y
|
Glucosidase
Enterovirus
|
Infection
|
|
Ganoderic acid Y is a α-glucosidase inhibitor with an IC50 of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits enterovirus 71 (EV71) replication through blocking EV71 uncoating.
|
-
- HY-W015806
-
-
- HY-W010513
-
-
- HY-113013A
-
|
Hydroxypyruvic acid lithium hydrate
β-Hydroxypyruvic Acid lithium hydrate; 3-Hydroxypyruvic Acid lithium hydrate
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
|
-
- HY-N1393
-
|
2-Methoxybenzoic acid
NSC 3778; O-Methylsalicylic Acid; Salicylic Acid methyl ether
|
Endogenous Metabolite
|
Cancer
|
|
2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.
|
-
- HY-Y0760
-
|
3-Methoxybenzoic acid
3-Anisic Acid; 3-Methoxybenzoic Acid; NSC 27014; NSC 9264; m-Methoxybenzoic Acid
|
Endogenous Metabolite
|
Others
|
|
3-Methoxybenzoic acid can be used in the synthesis of 3-methoxybenzoates of europium (III) and gadolinium (III).
|
-
- HY-114760
-
|
Vanillic acid glucoside
Vanillic Acid 4-β-D-glucoside
|
Others
|
|
|
Vanillic acid glucoside is isolated from the fruits of C. annuum as well as the leaves of various additional plants. Vanillic acid glucoside belongs to a class of compounds known as hydrolyzable tannins and can be phytotoxic against different species.
|
-
- HY-17038B
-
|
Agomelatine (L(+)-Tartaric acid)
S-20098 L(+)-Tartaric Acid
|
Melatonin Receptor
5-HT Receptor
|
Neurological Disease
|
|
Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.
|
-
- HY-15284B
-
|
Prasugrel (Maleic acid)
PCR 4099 (Maleic Acid)
|
P2Y Receptor
|
Cardiovascular Disease
|
|
Prasugrel (PCR 4099) Maleic acid is a thienopyridine and prodrug, inhibits platelet function. Prasugrel Maleic acid is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
|
-
- HY-12222
-
|
Obeticholic acid
INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic Acid
|
FXR
Autophagy
|
Others
|
|
Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.
|
-
- HY-15461A
-
|
Ertugliflozin L-pyroglutamic acid
PF-04971729 L-pyroglutamic Acid
|
SGLT
|
Metabolic Disease
|
|
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2. Has the potential for the treatment of type 2 diabetes mellitus.
|
-
- HY-N0055
-
|
Chlorogenic acid
3-O-Caffeoylquinic Acid; Heriguard; NSC-407296
|
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species
Bacterial
Influenza Virus
Endogenous Metabolite
|
Cancer
Infection
Inflammation/Immunology
|
|
Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension.
|
-
- HY-W013215
-
-
- HY-18569
-
|
3-Indoleacetic acid
Indole-3-acetic Acid; 3-IAA
|
Endogenous Metabolite
|
Others
|
|
3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.
|
-
- HY-B0172
-
-
- HY-B0167S
-
-
- HY-141336
-
-
- HY-N7378
-
|
N-Hydroxypipecolic acid
1-Hydroxy-2-piperidinecarboxylic Acid; NHP
|
Others
|
Inflammation/Immunology
|
|
N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection.
|
-
- HY-W027968
-
|
Coumarin-3-carboxylic Acid
2-Oxochromene-3-carboxylic Acid
|
Others
|
Cancer
|
|
Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line.
|
-
- HY-124527
-
|
HET0016
|
Cytochrome P450
|
Cardiovascular Disease
|
|
HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth.
|
-
- HY-A0208
-
|
Rosoxacin
Acrosoxacin
|
Bacterial
Antibiotic
|
Infection
|
|
Rosoxacin (Acrosoxacin) is a potent and orally active quinolone antibiotic. Rosoxacin (Acrosoxacin) has antibacterial activities against a broad spectrum of Gram negative bacteria including Neisseria gonorrhoeae (MIC90=0.03mg/ml). Rosoxacin has the potential for urinary tract infections treatment.
|
-
- HY-B1132
-
|
Clidinium bromide
Ro 2-3773
|
mAChR
|
Neurological Disease
|
|
Clidinium bromide is a quaternary amine antimuscarinic agent. Clidinium bromide may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines in vivo.
|
-
- HY-W017443
-
-
- HY-W010629
-
|
2-Chloroacetamide
|
Bacterial
|
Infection
|
|
2-Chloroacetamide is a preservative and is a herbicide for both uplands and paddy fields. 2-Chloroacetamide is a biocide in agriculture, glues, paints and coatings. 2-Chloroacetamide inhibits very-long-chain fatty acid elongase.
|
-
- HY-109079A
-
|
Abeprazan hydrochloride
DWP14012 hydrochloride
|
Proton Pump
|
Metabolic Disease
|
|
Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H +, K +- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.
|
-
- HY-B0946
-
|
Sulfamonomethoxine
|
Bacterial
Antibiotic
|
Infection
|
|
Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.
|
-
- HY-P1202A
-
|
CYN 154806 TFA
|
Somatostatin Receptor
|
Endocrinology
|
|
CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
|
-
- HY-16100
-
-
- HY-W014502
-
|
D-Kynurenine
|
Aryl Hydrocarbon Receptor
Endogenous Metabolite
|
Cancer
|
|
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).
|
-
- HY-B0946S
-
|
Sulfamonomethoxine D4
|
Bacterial
|
Infection
|
|
Sulfamonomethoxine D4 is a deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.
|
-
- HY-P1202
-
|
CYN 154806
|
Somatostatin Receptor
|
Endocrinology
|
|
CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
|
-
- HY-N1272
-
|
Secaubryenol
|
Endogenous Metabolite
|
Others
|
|
Secaubryenol is a class of 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla. Secaubryenol does not display any cytotoxic effect at a dose of 10 µg/mL.
|
-
- HY-N2078
-
|
Yamogenin
Neodiosgenin
|
LXR
|
Metabolic Disease
|
|
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes.
|
-
- HY-109079
-
|
Abeprazan
DWP14012
|
Proton Pump
|
Metabolic Disease
|
|
Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H +, K +- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.
|
-
- HY-N2511
-
|
Trimyristin
|
AChE
Phosphatase
Endogenous Metabolite
|
Metabolic Disease
|
|
Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively.
|
-
- HY-Y1718
-
-
- HY-N7079A
-
|
Sodium erythorbate
D-Isoascorbic Acid sodium; D-Araboascorbic Acid sodium
|
Others
|
Cancer
|
|
Sodium erythorbate (D-Isoascorbic acid sodium), produced from sugars derived from different sources, such as beets, sugar cane, and corn, is a food additive used predominantly in meats, poultry, and soft drinks.
|
-
- HY-12771
-
-
- HY-W015114
-
|
L-2-Hydroxyglutaric acid disodium
(S)-2-Hydroxyglutaric Acid disodium
|
Histone Demethylase
Mitochondrial Metabolism
|
Cancer
|
|
L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.
|
-
- HY-101218
-
-
- HY-W012922
-
-
- HY-N2009
-
|
3-O-Methylgallic acid
3,4-Dihydroxy-5-methoxybenzoic Acid
|
Apoptosis
|
Cancer
|
|
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) is an anthocyanin metabolite and has potent antioxidant capacity. 3-O-methylgallic acid inhibits Caco-2 cell proliferation with an IC50 value of 24.1 μM. 3-O-methylgallic acid also induces cell apoptosis and has anti-cancer effects.
|
-
- HY-N0056
-
-
- HY-129554
-
|
cis-9,10-Epoxystearic acid
cis-9,10-Epoxyoctadecanoic Acid
|
Endogenous Metabolite
|
Others
|
|
cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) is an endogenous constituent in human blood and urine. cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) can be produced from oleic acid by enzymic and non-enzymic epoxidation.
|
-
- HY-103701
-
|
L-Ascorbic acid 2-phosphate
2-Phospho-L-ascorbic Acid
|
Phosphatase
|
Metabolic Disease
|
|
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
|
-
- HY-N2056
-
|
11-Keto-beta-boswellic acid
11-Keto-β-boswellic Acid
|
Lipoxygenase
Leukotriene Receptor
NF-κB
|
Cancer
|
|
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.
|
-
- HY-130426
-
|
Maleimido-tri(ethylene glycol)-propionic acid
Mal-PEG3-Acid
|
ADC Linker
|
Cancer
|
|
Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation.
|
-
- HY-N0510
-
|
Aristolochic acid A
Aristolochic Acid I; TR 1736
|
NF-κB
|
Cancer
|
|
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines.
|
-
- HY-126958
-
-
- HY-135820
-
-
- HY-Y0488A
-
-
- HY-131267
-
-
- HY-140179
-
-
- HY-136301
-
|
Acid secretion-IN-1
|
Others
|
Inflammation/Immunology
|
|
Acid secretion-IN-1 is a polycyclic compound extracted from patent WO2018024188A1, Compound Example 17.4. Acid secretion-IN-1 is synthesized and used in the IDO inhibitor synthetic experiment.
|
-
- HY-140496
-
-
- HY-118764
-
-
- HY-140501
-
|
m-PEG11-acid
|
ADC Linker
PROTAC Linker
|
Cancer
|
|
m-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-B1061
-
-
- HY-N7018
-
|
20-Hydroxyganoderic Acid G
|
Others
|
Inflammation/Immunology
|
|
20-Hydroxyganoderic Acid G is a lanostane triterpenoid obtained from the EtOH extract of fruiting bodies of the Ganoderma curtisii. 20-Hydroxyganoderic Acid G inhibits BV-2 microglia cells activated by LPS with an IC50 of 21.33 μM. 20-Hydroxyganoderic Acid G has therapeutic potential in the drug discovery of nerve inflammation diseases associated with microglia activated by LPS.
|
-
- HY-133050
-
-
- HY-130425
-
-
- HY-141026
-
-
- HY-W001963
-
-
- HY-N1517
-
|
Ganoderic acid C2
|
Others
|
Cancer
|
|
Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (RLAR) with an IC50 of 3.8 µM.
|
-
- HY-133386
-
-
- HY-140455
-
-
- HY-126318
-
|
Demethoxydeacetoxypseudolaric acid B analog
|
Others
|
Cancer
|
|
Demethoxydeacetoxypseudolaric acid B analog (Compound 13b) is semi-synthesized by efficient routines from Pseudolaric acid B. It has potent activities against HMEC-1, HL-60, A-549, MB-MDA-468, BEL-7402, HCT116, and Hela cells with IC50s ranging from 0.136 to 1.162 μM.
|
-
- HY-140020
-
-
- HY-141332
-
-
- HY-Y1069
-
-
- HY-W006371
-
-
- HY-141355
-
-
- HY-133334
-
-
- HY-130981
-
-
- HY-141267
-
-
- HY-140454
-
-
- HY-135153
-
-
- HY-126892
-
|
Bis-PEG7-acid
|
PROTAC Linker
ADC Linker
|
Cancer
|
|
Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
|
-
- HY-141021
-
-
- HY-126236
-
-
- HY-133054
-
-
- HY-133377
-
-
- HY-112540A
-
-
- HY-141354
-
-
- HY-16040
-
-
- HY-140962
-
-
- HY-108538
-
|
Ethacrynic acid D5
|
Gutathione S-transferase
NF-κB
Calcium Channel
|
Inflammation/Immunology
|
|
Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.
|
-
- HY-N0839
-
|
Quillaic acid
Quillaja sapogenin
|
Others
|
Others
|
|
Quillaic acid(Quillaja sapogenin) is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol; can elicit dose-dependent antinociceptive effects in two murine thermal models.
|
-
- HY-140183
-
-
- HY-120368
-
-
- HY-141027
-
-
- HY-B1827
-
-
- HY-133481
-
-
- HY-23166
-
-
- HY-W002105
-
-
- HY-140184
-
-
- HY-B0398A
-
|
Nalidixic acid sodium salt
|
Bacterial
Antibiotic
Topoisomerase
|
Infection
|
|
Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
|
-
- HY-130417
-
-
- HY-W015175
-
-
- HY-130442
-
|
Mal-PEG2-acid
|
ADC Linker
|
Cancer
|
|
Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule.
|
-
- HY-140100
-
-
- HY-113071A
-
-
- HY-116027
-
-
- HY-116655
-
-
- HY-141020
-
-
- HY-141159
-
-
- HY-141334
-
-
- HY-130857
-
-
- HY-B0989
-
|
Carzenide
4-Sulfamoylbenzoic Acid
|
Others
|
Others
|
|
Carzenide is an organic synthesis intermediate, for synthetic drug.
|
-
- HY-130595
-
-
- HY-18962A
-
|
AMI-1 free acid
|
Histone Methyltransferase
|
Cancer
|
|
AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding.
|
-
- HY-141022
-
-
- HY-128746
-
-
- HY-W014993
-
-
- HY-130334
-
-
- HY-130231
-
-
- HY-133006
-
-
- HY-112559
-
-
- HY-126959
-
-
- HY-141160
-
-
- HY-140499
-
-
- HY-140182
-
-
- HY-140176
-
-
- HY-130481
-
|
Propargyl-PEG4-acid
|
PROTAC Linker
|
Cancer
|
|
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells.
|
-
- HY-N2321
-
-
- HY-141264
-
-
- HY-141266
-
-
- HY-140265
-
-
- HY-140953
-
-
- HY-141363
-
-
- HY-140492
-
-
- HY-141161
-
-
- HY-126975
-
-
- HY-141382
-
|
Bromoacetamido-PEG4-acid
|
PROTAC Linker
ADC Linker
|
Cancer
|
|
Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
|
-
- HY-12769S
-
-
- HY-140268
-
-
- HY-B0302
-
|
Etidronic acid
HEDPA; HEDP
|
Apoptosis
|
Others
|
|
Etidronic acid (HEDPA) is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.
|
-
- HY-130504
-
|
Propargyl-PEG1-acid
|
PROTAC Linker
|
Cancer
|
|
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM.
|
-
- HY-W017230
-
|
L-Cysteinesulfinic acid monohydrate
|
mGluR
|
Neurological Disease
|
|
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
|
-
- HY-140185
-
-
- HY-140096
-
-
- HY-140018
-
-
- HY-141019
-
-
- HY-W013253
-
-
- HY-141352
-
-
- HY-B1788
-
-
- HY-W001179
-
-
- HY-W040195
-
-
- HY-W012575
-
-
- HY-N0867
-
-
- HY-124380
-
-
- HY-N3500
-
-
- HY-126894
-
|
Bis-PEG9-acid
|
PROTAC Linker
ADC Linker
|
Cancer
|
|
Bis-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
|
-
- HY-118189S
-
|
Misoprostol acid D5
|
Prostaglandin Receptor
|
Inflammation/Immunology
|
|
Misoprostol acid D5 is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers. Misoprostol is an oral agent used to induce labor.
|
-
- HY-117104
-
-
- HY-130572
-
-
- HY-122924
-
|
Theogallin
3-Galloylquinic Acid
|
Others
|
Neurological Disease
|
|
Theogallin (3-Galloylquinic acid) is an active ingredient in decaffeinated green tea extract. Theogallin has antidepressive and cognition enhancing effect.
|
-
- HY-N0180
-
-
- HY-B0641
-
-
- HY-78695
-
-
- HY-140267
-
-
- HY-113126
-
-
- HY-130542
-
-
- HY-130904
-
-
- HY-76504
-
-
- HY-140509
-
-
- HY-140153
-
-
- HY-133052
-
-
- HY-141023
-
-
- HY-133176
-
-
- HY-B0351
-
-
- HY-N0898A
-
|
(-)-Catechin
(-)-Cianidanol; (-)-Catechuic Acid
|
COX
|
Cancer
|
|
(-)-Catechin, isolated from green tea, is an isomer of Catechin having a trans 2S,3R configuration at the chiral center. Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
|
-
- HY-N7021
-
-
- HY-130475
-
-
- HY-126962
-
-
- HY-N7138
-
-
- HY-140178
-
-
- HY-140495
-
-
- HY-N6859
-
-
- HY-141024
-
-
- HY-141383
-
-
- HY-133385
-
-
- HY-140177
-
-
- HY-128749
-
-
- HY-140021
-
-
- HY-133384
-
-
- HY-W002011
-
-
- HY-141326
-
-
- HY-124009A
-
-
- HY-13771
-
|
Ursodiol
Ursodeoxycholic Acid; UDCA
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
Ursodiol (Ursodeoxycholic acid; UDCA) is a potent liver-specific fatty acid transport protein 5 (FATP5) inhibitor. Ursodiol inhibit LCFA uptake by primary hepatocytes in a FATP5-dependent manner. Ursodiol reduces cholesterol absorption and is used to dissolve gallstones and has the potential for obesity-associated fatty liver disease research.
|
-
- HY-16995
-
-
- HY-W015641
-
-
- HY-101157
-
|
Propargyl-PEG5-acid
|
ADC Linker
|
Cancer
|
|
Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3.
|
-
- HY-140394
-
-
- HY-W015560
-
-
- HY-Y0801
-
-
- HY-140269
-
-
- HY-113491A
-
-
- HY-140186
-
-
- HY-113274A
-
-
- HY-130909
-
-
- HY-133425
-
-
- HY-141164
-
-
- HY-B0574S
-
|
Mefenamic acid D4
|
COX
|
Inflammation/Immunology
|
|
Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
|
-
- HY-130198
-
-
- HY-140494
-
-
- HY-N0274
-
-
- HY-W001251
-
-
- HY-120587
-
-
- HY-100803
-
-
- HY-140457
-
-
- HY-133324
-
-
- HY-133323
-
-
- HY-140502
-
-
- HY-141333
-
-
- HY-126893
-
|
Bis-PEG8-acid
|
PROTAC Linker
ADC Linker
|
Cancer
|
|
Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
|
-
- HY-Y0127
-
-
- HY-W017162
-
-
- HY-N0087
-
|
Gambogic Acid
Beta-Guttiferrin
|
Bcl-2 Family
Autophagy
|
Cancer
|
|
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
|
-
- HY-W019358
-
-
- HY-75308
-
|
Azetidine-2-carboxylic acid
|
Others
|
Cancer
|
|
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent.
|
-
- HY-126961
-
-
- HY-126891
-
-
- HY-130938
-
-
- HY-N6910
-
|
Pseudolaric Acid C2
|
Others
|
Metabolic Disease
|
|
Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats.
|
-
- HY-140458
-
-
- HY-W001080
-
-
- HY-140500
-
|
m-PEG10-acid
|
ADC Linker
PROTAC Linker
|
Cancer
|
|
m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-112540B
-
|
Acetoacetic acid sodium salt
|
Others
|
Metabolic Disease
|
|
Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes.
|
-
- HY-140330
-
-
- HY-130166
-
-
- HY-W031757
-
-
- HY-113380
-
-
- HY-141335
-
-
- HY-16322
-
|
Minodronic acid
YM-529
|
P2X Receptor
Apoptosis
|
Cancer
|
|
Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain.
|
-
- HY-113379
-
-
- HY-Y0842
-
-
- HY-14654
-
-
- HY-130379
-
-
- HY-N7033
-
|
UDP-glucuronic acid trisodium
|
Others
|
Metabolic Disease
|
|
UDP-glucuronic acid trisodium is a critical precursor for essential glycoconjugates across biological kingdoms, ranging from mammalian glycosaminoglycans and plant cell wall polysaccharides to bacterial capsule glycoglycerolipids.
|
-
- HY-141353
-
-
- HY-N3501
-
-
- HY-140180
-
-
- HY-14781
-
-
- HY-141162
-
-
- HY-140395
-
-
- HY-133322
-
-
- HY-141265
-
-
- HY-N0566
-
-
- HY-I0096
-
-
- HY-141025
-
-
- HY-126666
-
|
PNU-159682 carboxylic acid
|
ADC Cytotoxin
|
Cancer
Inflammation/Immunology
|
|
PNU-159682 carboxylic acid (compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response.
|
-
- HY-W017434
-
-
- HY-N2433
-
|
Paederosidic acid methyl ester
|
Potassium Channel
|
Neurological Disease
|
|
Paederosidic acid methyl ester is a ATP‐sensitive K + channel activator, isolated from P. scandens. Paederosidic acid methyl ester exhibits significant central analgesic activity, and enhances the threshold of pain by activating ATP‐sensitive K + channel in the brain and spinal cord level.
|
-
- HY-130383
-
-
- HY-W015273A
-
-
- HY-140493
-
-
- HY-133231
-
-
- HY-141163
-
-
- HY-111498A
-
-
- HY-140000
-
-
- HY-113247
-
-
- HY-121805
-
|
DBCO-C6-acid
|
ADC Linker
|
Cancer
|
|
DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues.
|
-
- HY-100528A
-
|
Dianemycin
Nanchangmycin free Acid
|
Bacterial
Antibiotic
|
Infection
|
|
Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
|
-
- HY-140005
-
-
- HY-W051723
-
-
- HY-113108
-
|
(R)-3-Hydroxyisobutyric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-3-Hydroxyisobutyric acid is an intermediate in the pathways of l-valine and thymine and plays an important role in the diagnosis of the very rare inherited metabolic diseases 3-hydroxyisobutyric aciduria and methylmalonic semialdehyde dehydrogenase deficiency.
|
-
- HY-N7127
-
-
- HY-130213
-
-
- HY-140266
-
-
- HY-140022
-
-
- HY-140181
-
-
- HY-140453
-
-
- HY-113450
-
-
- HY-133291
-
-
- HY-126960
-
-
- HY-Y0771
-
-
- HY-B1768
-
|
Succimer
Dimercaptosuccinic Acid; DMSA
|
Others
|
Others
|
|
Succimer is a widely used chelating agent for the treatment of Pb poisoning.
|
-
- HY-W004945
-
-
- HY-136249
-
|
N-Acetylmuramic acid-alkyne
|
Bacterial
|
|
|
N-Acetylmuramic acid-alkyne is a derivative of N-acetylmuramic acid (NAM) component of bacterial peptidoglycans. N-Acetylmuramic acid-alkyne incorporates into bacterial peptidoglycans during biosynthesis. N-Acetylmuramic acid-alkyne can be used for fluorescent labeling of peptidoglycans when 'click'-conjugated to a fluorescent dye.
|
-
- HY-130386
-
-
- HY-126963
-
-
- HY-135971
-
-
- HY-W010184
-
-
- HY-131272
-
-
- HY-140456
-
-
- HY-140512
-
-
- HY-113474
-
-
- HY-113377A
-
|
L-Glyceric acid sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2.
|
-
- HY-N2618
-
|
3-O-Acetyloleanolic acid
|
Apoptosis
|
Cancer
|
|
3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity.
|
-
- HY-112038
-
|
GSK2983559 free acid
|
RIP kinase
|
Inflammation/Immunology
|
|
GSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.
|
-
- HY-133325
-
-
- HY-P1377A
-
-
- HY-40161
-
-
- HY-W019724
-
-
- HY-119429
-
-
- HY-140015
-
-
- HY-107494A
-
-
- HY-19992
-
|
3-Bromopyruvic acid
Bromopyruvic Acid; Hexokinase II Inhibitor II, 3-BP
|
Hexokinase
|
Cancer
|
|
3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells.
|
-
- HY-B0167A
-
-
- HY-70002BS
-
|
Enzalutamide carboxylic acid D6
MDV3100 carboxylic Acid D6
|
Others
|
Cancer
|
|
Enzalutamide carboxylic acid D6 is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide.
|
-
- HY-135747
-
|
Gut restricted-7
GR-7
|
Bacterial
|
Infection
|
|
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice.
|
-
- HY-W050026S
-
|
Phenylacetylglutamine-D5
NSC 203800-D5; Phenylacetyl-L-glutamine-D5
|
Others
|
Others
|
|
Phenylacetylglutamine-D5 (NSC 203800-D5;Phenylacetyl-L-glutamine-D5) is a deuterated form of Phenylacetylglutamine. Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.
|
-
- HY-107613
-
|
R 59-022
DKGI-I; Diacylglycerol kinase inhibitor I
|
PKC
5-HT Receptor
|
Inflammation/Immunology
|
|
R 59-022 (DKGI-I) is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 is a 5-HTR antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.
|
-
- HY-135283
-
|
ABT-546
A-216546
|
Endothelin Receptor
|
Endocrinology
Cardiovascular Disease
|
|
ABT-546 (A-216546) is a potent, highly selective and active endothelin ETA receptor antagonist with a Ki of 0.46 nM for [ 125I]endothelin-1 binding to cloned human endothelin ETA. ABT-546 is ＞25,000-fold more selective for the ETA receptor than for the ETB receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC50 of 0.59 nM and 3 nM, respectively.
|
-
- HY-P1125
-
|
4-CMTB
|
Others
|
Others
|
|
4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38).
|
-
- HY-119435
-
|
Triallate
|
Others
|
Others
|
|
Triallate is a selective preemergence herbicide for the control of wild oats in barley, spring wheat, Durum wheat, winter wheat, and sugar beets. Triallate inhibits fatty acid elongation and surface lipid (wax) biosynthesis.
|
-
- HY-N2920
-
|
β-Amyrenonol
11-Oxo-β-amyrin
|
Cytochrome P450
|
Cancer
Inflammation/Immunology
|
|
β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids.
|
-
- HY-108034
-
|
GET73
|
Others
|
Neurological Disease
|
|
GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus.
|
-
- HY-108529
-
|
BMS493
|
RAR/RXR
|
Metabolic Disease
|
|
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation.
|
-
- HY-14874
-
|
Topiroxostat
FYX-051
|
Xanthine Oxidase
Cytochrome P450
|
Metabolic Disease
|
|
Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.
|
-
- HY-136540
-
-
- HY-Y0123
-
|
DL-Tyrosine
|
Others
|
Neurological Disease
|
|
DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine).
|
-
- HY-101408
-
-
- HY-N7378A
-
|
N-Hydroxypipecolic acid potassium
1-Hydroxy-2-piperidinecarboxylic Acid potassium; NHP potassium
|
Others
|
Inflammation/Immunology
|
|
N-Hydroxypipecolic acid potassium (1-Hydroxy-2-piperidinecarboxylic acid potassium), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid potassium accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid potassium induces SAR to bacterial and oomycete infection.
|
-
- HY-W018035
-
-
- HY-N1969
-
|
3,3'-Di-O-methylellagic acid
3,8-Di-O-methylellagic Acid
|
Others
|
Infection
|
|
3,3'-Di-O-methylellagic acid obtained from Euphorbia adenochlora selectively inhibits the formation of acid-fastness in mycobacteria without retardation of their growth. 3,3'-di-O-methylellagic acid as a hepatoprotective compound is apparently due to its antioxidative effect.
|
-
- HY-107837
-
-
- HY-103701A
-
|
L-Ascorbic acid 2-phosphate magnesium
2-Phospho-L-ascorbic Acid magnesium
|
Phosphatase
|
Metabolic Disease
|
|
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
|
-
- HY-18569A
-
-
- HY-Y1311
-
|
Malic acid
E 296; FDA 2018; Hydroxybutanedioic Acid
|
Endogenous Metabolite
|
Others
|
|
Malic acid is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods.
|
-
- HY-140516
-
-
- HY-B1434
-
-
- HY-141298
-
-
- HY-141302
-
-
- HY-133049
-
-
- HY-127137
-
|
Adenylosuccinic acid
Adenylosuccinate; Aspartyl adenylate
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD).
|
-
- HY-Y1031
-
-
- HY-140115
-
-
- HY-W046906
-
-
- HY-100268
-
-
- HY-100233
-
|
IQ-1S free acid
|
JNK
|
Cancer
Inflammation/Immunology
|
|
IQ-1S free acid is a prospective inhibitor of NF-κB/activating protein 1 (AP-1) activity with an IC50 of 2.3±0.41 μM. IQ-1S free acid has binding affinity (Kd values) in the nanomolar range for all three JNKs with Kds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.
|
-
- HY-100811
-
|
7-Chlorokynurenic acid
7-CKA
|
iGluR
|
Neurological Disease
|
|
7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.
|
-
- HY-128695
-
-
- HY-140975
-
-
- HY-130554
-
-
- HY-W009216
-
-
- HY-133009
-
-
- HY-140601
-
-
- HY-W015874
-
-
- HY-B1320
-
|
Meclofenamate sodium
Meclofenamic Acid sodium
|
Gap Junction Protein
|
Inflammation/Immunology
|
|
Meclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.
|
-
- HY-140165
-
-
- HY-W000450
-
-
- HY-W017523
-
-
- HY-140973
-
-
- HY-119695A
-
|
Simvastatin acid ammonium
Tenivastatin ammonium
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
|
-
- HY-133061
-
-
- HY-140463
-
-
- HY-W008150
-
-
- HY-140171
-
-
- HY-140440
-
-
- HY-N2116
-
|
Ginkgolic acid C17:1
|
PTEN
Phosphatase
|
Cancer
|
|
Ginkgolic acid C17:1, extracted from Ginkgo biloba Leaves, suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase. Ginkgolic acid C17:1 has anticancer effects.
|
-
- HY-W015060
-
-
- HY-135974
-
-
- HY-B0271
-
-
- HY-140065
-
-
- HY-W007856
-
|
5-Methoxysalicylic acid
5-MeOSA
|
Others
|
Others
|
|
5-Methoxysalicylic acid (5-MeOSA) is a natural compound, used as a useful matrix in the MALDI MS analysis of oligonucleotides when combined with spermine.
|
-
- HY-W014217
-
-
- HY-141096
-
-
- HY-118844
-
-
- HY-109025A
-
|
Baloxavir
Baloxavir Acid; S-033447
|
Influenza Virus
|
Infection
|
|
Baloxavir (Baloxavir acid) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity.
|
-
- HY-141159A
-
-
- HY-W015061
-
-
- HY-140175
-
-
- HY-140326
-
-
- HY-B0150
-
|
Nicotinamide
Niacinamide; Nicotinic Acid amide
|
Endogenous Metabolite
Sirtuin
|
Neurological Disease
Cancer
|
|
Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
|
-
- HY-N3502
-
-
- HY-W010448
-
-
- HY-W067705
-
-
- HY-140511
-
-
- HY-W010611
-
-
- HY-W011704A
-
-
- HY-130399
-
-
- HY-140464
-
-
- HY-107994
-
-
- HY-15127
-
-
- HY-14839
-
-
- HY-140460
-
-
- HY-141308
-
-
- HY-A0213A
-
|
Tiludronate disodium
Tiludronic Acid disodium
|
Others
|
Inflammation/Immunology
|
|
Tiludronate disodium (Tiludronic Acid disodium) is a new bisphosphonate, which prevents postmenopausal bone loss. Tiludronate disodium (Tiludronic Acid disodium) presents antiresorptive and anti-inflammatory properties.
|
-
- HY-140461
-
-
- HY-130414
-
-
- HY-141318
-
-
- HY-D0885
-
|
Phosphocreatine
Creatine phosphate; Creatinephosphoric Acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Phosphocreatine, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction..
|
-
- HY-140412
-
-
- HY-140097
-
-
- HY-133008
-
-
- HY-140174
-
-
- HY-130737
-
-
- HY-140490
-
-
- HY-140515
-
-
- HY-141294
-
-
- HY-141097
-
-
- HY-141307
-
-
- HY-W016103
-
-
- HY-140974
-
-
- HY-U00242
-
|
Indacrinone
MK-196; Indacrynic Acid
|
Others
|
Metabolic Disease
|
|
Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.
|
-
- HY-130907
-
-
- HY-141306
-
-
- HY-140066
-
-
- HY-B0119
-
|
Risedronate sodium
Risedronic Acid Sodium
|
Others
|
Others
|
|
Risedronate sodium is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption.
|
-
- HY-N7347
-
|
(-)-Hydroxycitric acid lactone
Garcinia lactone
|
ATP Citrate Lyase
|
Metabolic Disease
|
|
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis.
|
-
- HY-135964
-
-
- HY-141098
-
-
- HY-140170
-
-
- HY-W019798
-
-
- HY-130496
-
-
- HY-B1056
-
|
Procodazole
Propazol; 2-Benzimidazolepropionic Acid
|
Bacterial
|
Infection
|
|
Procodazole is a non-specific active immunoprotective agent against viral and bacterial infections, used as a potentiator.
|
-
- HY-N7384
-
-
- HY-140462
-
-
- HY-W007566
-
-
- HY-141034
-
-
- HY-30004
-
-
- HY-N1964
-
|
Gibberellic acid
Gibberellin A3
|
Others
|
Others
|
|
Gibberellic Acid is named after a fungus Gibberella fujikuroi . Gibberellic Acid regulates processes of plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time.
|
-
- HY-133370
-
-
- HY-128467
-
-
- HY-W013674
-
-
- HY-133369
-
-
- HY-113063
-
-
- HY-N0140
-
-
- HY-W016993
-
-
- HY-B0633
-
|
Hyaluronic acid sodium
Sodium hyaluronate
|
Others
|
Cancer
|
|
Hyaluronic acid sodium (Sodium hyaluronate) is a biopolymer composed of repeating units of disaccharides with various applications.
|
-
- HY-B1182
-
-
- HY-W014099
-
|
Boc-NH-C4-acid
|
PROTAC Linker
|
Cancer
|
|
Boc-NH-C4-acid is a PROTAC linker, which belongs to a Alkyl/ether linker. Boc-NH-C4-acid can be used in the synthesis of the compound PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
|
-
- HY-N6926
-
-
- HY-140169
-
-
- HY-N0626A
-
-
- HY-130930
-
-
- HY-130157
-
-
- HY-W013549
-
|
6-Aminopenicillanic acid
6-APA
|
Bacterial
|
Infection
|
|
6-Aminopenicillanic acid (6-APA) is an important precursor for the synthesis of -lactam antibiotics. 6-Aminopenicillanic acid is the main product of Penicillin G (PenG) hydrolyzed by penicillin acylase (PA).
|
-
- HY-109590
-
-
- HY-140350
-
-
- HY-U00295A
-
-
- HY-W050044
-
-
- HY-B1211
-
-
- HY-113304
-
-
- HY-140443
-
-
- HY-W015591
-
-
- HY-W015240
-
-
- HY-140413
-
-
- HY-W016482
-
-
- HY-136158
-
-
- HY-101363
-
|
1-BCP
Piperonylic Acid piperidide
|
iGluR
|
Neurological Disease
|
|
1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents. 1-BCP is a memory-enhancing agent.
|
-
- HY-114818
-
|
4-(tert-Butyl)-benzhydroxamic Acid
|
Bacterial
|
Infection
|
|
4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4-(tert-Butyl)-benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM.
|
-
- HY-136159
-
-
- HY-W005255
-
-
- HY-140270
-
-
- HY-W012530
-
-
- HY-113159
-
-
- HY-W010510
-
-
- HY-76210
-
-
- HY-N2075
-
-
- HY-140047
-
-
- HY-126304
-
-
- HY-130557
-
-
- HY-W012974
-
-
- HY-101737
-
-
- HY-N0898
-
-
- HY-W012708
-
-
- HY-140173
-
-
- HY-113524
-
-
- HY-N0157S
-
-
- HY-141297
-
-
- HY-10221
-
|
Vorinostat
SAHA; Suberoylanilide hydroxamic Acid
|
HDAC
Autophagy
Mitophagy
Filovirus
|
Cancer
Infection
|
|
Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.
|
-
- HY-W017158
-
-
- HY-W010224
-
-
- HY-W012123
-
|
3,4,5-Trimethoxycinnamic acid
|
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia
WILLD, with anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits.
|
-
- HY-140441
-
-
- HY-W040245
-
-
- HY-141033
-
-
- HY-W008253
-
-
- HY-W006057
-
-
- HY-128965
-
-
- HY-W075674
-
-
- HY-140990
-
-
- HY-W012722
-
-
- HY-109008
-
|
Nacubactam
OP0595 free Acid
|
Bacterial
|
Infection
|
|
Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs.
|
-
- HY-101417
-
-
- HY-140168
-
-
- HY-140469
-
-
- HY-140166
-
-
- HY-W016734
-
-
- HY-125541
-
-
- HY-U00141
-
|
ABTL-0812
α-Hydroxylinoleic Acid
|
Autophagy
|
Metabolic Disease
|
|
ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity.
|
-
- HY-W014225
-
-
- HY-W005241
-
-
- HY-140167
-
-
- HY-W002587
-
-
- HY-W013673
-
-
- HY-140504
-
-
- HY-15654
-
|
Sodium 4-phenylbutyrate
4-Phenylbutyric Acid sodium; 4-PBA sodium; Benzenebutyric Acid sodium
|
HDAC
Autophagy
Apoptosis
|
Cancer
|
|
Sodium 4-phenylbutyrate (4-Phenylbutyric acid sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
|
-
- HY-B0987
-
-
- HY-136593
-
|
(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid
(S)-3-(4-Hydroxyphenyl)lactic Acid
|
Others
|
Others
|
|
(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid (compound 1) is a metabolite isolated from the culture medium of Leuconostoc mesenteroides. (S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid has high DPPH radical-scavenging activities and antioxidative activities.
|
-
- HY-113259
-
|
7α-Hydroxy-4-cholesten-3-one
|
Endogenous Metabolite
|
Metabolic Disease
|
|
7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1.
|
-
- HY-15209
-
-
- HY-103138A
-
|
(Rac)-WAY-161503
|
5-HT Receptor
|
Metabolic Disease
Neurological Disease
|
|
(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects.
|
-
- HY-Y0445A
-
|
Sodium dichloroacetate
|
PDHK
Reactive Oxygen Species
NKCC
Apoptosis
|
Cancer
|
|
Sodium dichloroacetate is a metabolic regulator in cancer cells' mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. Sodium dichloroacetate also works as NKCC inhibitor.
|
-
- HY-121450
-
|
Lavoltidine
Loxtidine; AH-234844
|
Histamine Receptor
|
Cancer
|
|
Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia.
|
-
- HY-W018555
-
|
D-Cysteine
|
Endogenous Metabolite
Bacterial
|
Infection
Neurological Disease
|
|
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of Escherichia coli growth. D-cysteine is mediated by D-amino acid oxidase to produce H2S and is a neuroprotectant against cerebellar ataxias. D-Cysteine could inhibit the growth and cariogenic virulence of dual-species biofilms formed by S. mutans and S. sanguinis.
|
-
- HY-N0121
-
|
Sesamin
|
Others
|
Neurological Disease
|
|
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia.
|
-
- HY-N7062
-
|
JNJ-1661010
Takeda-25
|
FAAH
|
Neurological Disease
|
|
JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics.
|
-
- HY-135808
-
|
BIZ 114
|
NF-κB
|
Inflammation/Immunology
|
|
BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases.
|
-
- HY-126327
-
|
UNC4976
|
Histone Methyltransferase
|
Cancer
|
|
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA.
|
-
- HY-107443
-
-
- HY-B2236
-
|
DL-Lysine
(±)-2,6-Diaminocaproic Acid
|
Others
|
Others
|
|
DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-14664
-
-
- HY-30220
-
-
- HY-140491
-
-
- HY-140481
-
-
- HY-W002304
-
-
- HY-B0335
-
|
Tolfenamic Acid
GEA 6414
|
COX
|
Inflammation/Immunology
Cancer
|
|
Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
|
-
- HY-B0935
-
-
- HY-18005
-
-
- HY-13213
-
-
- HY-140485
-
-
- HY-N0666B
-
|
Aspartic acid calcium
Calcium L-aspartate
|
Others
|
Cardiovascular Disease
|
|
Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic acid is an amino acid and serves as a building block for proteins in the body.
|
-
- HY-101981
-
|
Uridine 5'-monophosphate
5'-Uridylic Acid
|
Endogenous Metabolite
|
Others
|
|
Uridine 5'-monophosphate (5'-Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk.
|
-
- HY-130489
-
-
- HY-140116
-
-
- HY-140482
-
-
- HY-140024
-
-
- HY-140479
-
-
- HY-B0143
-
-
- HY-W040165
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- HY-15598
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- HY-140452
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- HY-141305
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- HY-N1750
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- HY-140541
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- HY-B0958
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Mupirocin
BRL-4910A; Pseudomonic Acid
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Bacterial
Antibiotic
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Infection
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Mupirocin (BRL-4910A) is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin (BRL-4910A) apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis.
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- HY-W040168
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- HY-113315
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- HY-136166
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- HY-B0486
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Lonidamine
AF-1890; Diclondazolic Acid; DICA
|
Hexokinase
Mitochondrial Metabolism
Apoptosis
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Cancer
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Lonidamine (AF-1890), an antitumor agent, is a hexokinase, mitochondrial pyruvate carrier (Ki 2.5 μM in isolated rat liver mitochondria) and plasma membrane monocarboxylate transporters inhibitor, which also inhibits mitochondrial complex II.
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-
- HY-136575
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4-Hydroxy-2-methylbenzenesulfonic acid ammonium
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Virus Protease
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Infection
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4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC50 of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC50 of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability.
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- HY-130653
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- HY-N0229
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- HY-N0105
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- HY-140468
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- HY-W014815
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BPBA
2-Bromopyridine-5-boronic Acid
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Others
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Others
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BPBA (2-Bromopyridine-5-boronic acid) is a new labeling reagent to derivatize brassinosteroids (BRs).
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- HY-18003
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- HY-B0350A
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- HY-141001
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- HY-23167
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- HY-118628
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- HY-W009390A
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- HY-140118
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