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Results for "

Aldolase b Inhibitors

" in MedChemExpress (MCE) Product Catalog:

7948

Inhibitors & Agonists

14

Screening Libraries

80

Fluorescent Dye

152

Biochemical Assay Reagents

393

Peptides

30

MCE Kits

212

Inhibitory Antibodies

1390

Natural
Products

1518

Recombinant Proteins

431

Isotope-Labeled Compounds

430

Antibodies

48

Click Chemistry

2019

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2726
    Aldolase, Rabbit muscle

    Fructose-diphosphate Aldolase

    		 Endogenous Metabolite Metabolic Disease
    Aldolase, Rabbit muscle is a glycolytic enzyme and a component of the VATPase complex. Aldolase causes fructose 1, 6-diphosphate to decompose into dihydroxyacetone and glyceraldehyde 3-phosphate .
    Aldolase, Rabbit muscle
  • HY-147061
    2-Deoxyribose 5-phosphate disodium

    		Endogenous Metabolite Others
    2-Deoxyribose 5-phosphate disodium is a substrate of 2-deoxyribose-5-phosphate aldolase (DERA). DERA belongs to the class I aldolases and catalyzes the reversible aldol condensation reaction without any cofactors .
    2-Deoxyribose 5-phosphate disodium
  • HY-148077
    Phosphoglycolohydroxamic acid

    		Bacterial Fungal Infection
    Phosphoglycolohydroxamic acid is a potent aldolase and triose-phosphate isomerase inhibitor. Phosphoglycolohydroxamic acid can be used in the research of antibacterial and antifungal area .
    Phosphoglycolohydroxamic acid
  • HY-143899
    FBA-IN-1

    		Fungal Infection
    FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL .
    FBA-IN-1
  • HY-P2977
    N-Acetylneuraminate lyase (CgNal)

    Sialic acid Aldolase (CgNal)

    		 Endogenous Metabolite Others
    N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .
    N-Acetylneuraminate lyase (CgNal)
  • HY-147064
    DL-4-Hydroxy-2-ketoglutarate lithium

    		Others Others
    DL-4-Hydroxy-2-ketoglutarate lithium is the substrate of 4-hydroxy-2-oxoglutarate aldolase (HOGA). DL-4-Hydroxy-2-ketoglutarate lithium can be cleaved by HOGA to produce pyruvate and glyoxylate .
    DL-4-Hydroxy-2-ketoglutarate lithium
  • HY-160498
    Amoitone B

    		Nuclear Hormone Receptor 4A/NR4A Cancer
    Amoitone B, a derivative of cystosporone B, is an agonist of NR4A1. Amoitone B has anticancer activity .
    Amoitone B
  • HY-N10694
    Rehmannioside B

    		Others Others
    Rehmannioside B is a desacyl derivative of Picrorhizaoside B, which can be isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae) .
    Rehmannioside B
  • HY-142013
    Blestriarene B

    (-)-Blestriarene B

    		 Others Others
    Blestriarene B ((-)-Blestriarene B) a stilbenoid isolated by the guidance of inhibitory effect of tubulin polymerization from the tubers of Bletilla striata (Orchidaceae) .
    Blestriarene B
  • HY-P5733
    Tryglysin B

    		Bacterial Infection
    Tryglysin B is an antimicrobial peptide inhibits the growth of other streptococci .
    Tryglysin B
  • HY-158174
    Cbl-b-IN-20

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-20 (Example 50) is a casitas proto-oncogene-B ( CPL-B ) inhibitor with IC50 <100 nM .
    Cbl-b-IN-20
  • HY-N2961
    Broussonin B

    		Others Others
    Broussonin B is a phenolic compound isolated from the stem barks of Broussonetia kanzinoki (Moraceae). Broussonin B inhibits adipocyte differentiation in 3T3-L1 cells .
    Broussonin B
  • HY-136887
    Arphamenine B hemisulfate

    		Others Others
    Arphamenine B (hemisulfate) is a Zn 2+-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B (hemisulfate) Arphamenine B (hemisulfate) is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B (hemisulfate) enhances the immune response and is used to characterize novel proteases .
    Arphamenine B hemisulfate
  • HY-151210
    MAO-B-IN-17

    		Monoamine Oxidase Neurological Disease
    MAO-B-IN-17 is a selective monoamine oxidase B (MAO-B) inhibitor with the IC50 value of 5.08 μM. MAO-B-IN-17 can be used in Parkinson’s disease research .
    MAO-B-IN-17
  • HY-123898
    Cepharadione B

    		Tyrosinase Endogenous Metabolite Cancer
    Cepharadione B (compound 22) is a natural compound isolated from the leaves of Piper sanctum. Cepharadione B is a tyrosinase inhibitor with an IC50 value of 170 μM, and inhibits cell growth in A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cells .
    Cepharadione B
  • HY-122370A
    Tripolin B

    		Aurora Kinase Cancer
    Tripolin B is an ATP-competitive Aurora kinase inhibitor with IC50 values of 2.5 µM and 6 µM for Aurora A and Aurora B kinases, respectively. Tripolin B does not inhibit Aurora kinase in cells .
    Tripolin B
  • HY-114314
    BA-53038B

    		HBV Infection
    BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B .
    BA-53038B
  • HY-160002
    MAO-B-IN-27

    		Monoamine Oxidase Neurological Disease
    MAO-B-IN-27 (Compound 12c) is a monoamine oxidase B (MAO-B) inhibitor. MAO-B-IN-27 has potent and selective MAO-B inhibitory effect for hMAO-B with an IC50 values of 8.9 nM. MAO-B-IN-27 can be used for the research of parkinson's disease (PD) .
    MAO-B-IN-27
  • HY-120980
    Thromboxane B1

    TXB1

    		 Prostaglandin Receptor Cardiovascular Disease
    Thromboxane B1 (TXB1) is one of thromboxane B (TXB) family members. Thromboxane is a member of the family of lipids known as eicosanoids. Thromboxane is named for its role in blood clot formation (thrombosis) .
    Thromboxane B1
  • HY-149234
    MAO-B-IN-18

    		Monoamine Oxidase Neurological Disease
    MAO-B-IN-18 is a potent and selective MAO B inhibitor with IC50s of 52 nM and 14 μM for hMAO B and hMAO A, respectively. MAO-B-IN-18 enables promising cytoprotective effects against hydrogen peroxide insults in neuroblastoma and astrocytes cultures .
    MAO-B-IN-18
  • HY-N1274
    (rac)-Secodihydro-hydramicromelin B

    		Others Others
    (rac)-Secodihydro-hydramicromelin B is a natural product that can be isolated from Equisetum hyemale L .
    (rac)-Secodihydro-hydramicromelin B
  • HY-N1575
    Podocarpusflavone B

    Putraflavone

    		 Others Others
    Podocarpusflavone B is a bisflavone that can be isolated from Padocarpus macraphylla .
    Podocarpusflavone B
  • HY-155477
    Cbl-b-IN-15

    		E1/E2/E3 Enzyme Cancer
    Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ligase Cbl (IC50: 15 nM). Cbl-b refers to Casitas B-lineage lymphoma proto-oncogene-b, which inhibits T-cell, natural killer (NK) cell, and B-cell activation. Cbl-b-IN-15 activates T cell function with EC50=0.41 μM .
    Cbl-b-IN-15
  • HY-N3526
    Calyxamine B

    		Others Others
    Calyxamine B is a piperidine alkaloid that can be isolated from Calyx podatypa .
    Calyxamine B
  • HY-117431
    Prostaglandin B3

    PGB3

    		 PPAR Endogenous Metabolite Metabolic Disease
    Prostaglandin B3 (PGB3) is a member of the class of prostaglandins B and a secondary alcohol. PGB3 exhibits a rather low affinity to human PPARγ with a Ki value greater than 1 mM compared with Ki values of 26.28 ± 8.7 μM for PGB1 and 77 ± 37.7 μM for PGB2 .
    Prostaglandin B3
  • HY-147945
    DNA gyrase B-IN-1

    		DNA/RNA Synthesis Bacterial Infection
    DNA gyrase B-IN-1 (compound 13) is a potent DNA gyrase B inhibitor. DNA gyrase B-IN-1 shows inhibition of P. aeruginosa DNA gyrase B, with an IC50 of 2.2 μM. DNA gyrase B-IN-1 has good binding affinity and stability .
    DNA gyrase B-IN-1
  • HY-P4042
    Hepatitis B Virus Receptor Binding Fragment

    hepatitis B peptide 4980

    		 HBV Infection Inflammation/Immunology
    Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization .
    Hepatitis B Virus Receptor Binding Fragment
  • HY-N12360A
    2,3-Dehydrosilybin B

    		Others Others
    2,3-Dehydrosilybin B is an enantiomer formed by the oxidation of the natural flavonolignans silybin A .
    2,3-Dehydrosilybin B
  • HY-169005
    Cbl-b-IN-27

    		Others Inflammation/Immunology
    Cbl-b-IN-27 is a casitas B-lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 value of 7 nM. Cbl-b-IN-27 is promising for research of effector T cell function, T cell, natural killer (NK) cell and B cell activation regulation .
    Cbl-b-IN-27
  • HY-P3850
    (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B

    		Neurokinin Receptor Neurological Disease
    (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A .
    (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B
  • HY-B0511A
    Biotin sodium

    Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium

    		 Endogenous Metabolite Metabolic Disease
    Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
    Biotin sodium
  • HY-163031
    MAO-B-IN-28

    		Monoamine Oxidase Neurological Disease
    MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 of 1.9±0.5 nM. MAO-B-IN-28 can be used as a candidate for neurodegenerative diseases research .
    MAO-B-IN-28
  • HY-155007
    DNA gyrase B-IN-2

    		Bacterial Infection
    DNA gyrase B-IN-2 (Compound E) is a 2-aminobenzothiazole-based DNA gyrase B inhibitor with promising activity against ESKAPE bacterial pathogens. DNA gyrase B-IN-2 showed low nanomolar inhibition of DNA gyrase (IC50 < 10 nM) and broad-spectrum antibacterial activity against pathogens belonging to the ESKAPE group, with the minimum inhibitory concentration < 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against Gram-negative E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.DNA gyrase B-IN-2 can be used for the research of infection .
    DNA gyrase B-IN-2
  • HY-18299
    Purvalanol B
    1 Publications Verification

    NG 95

    		 CDK Parasite Infection Cancer
    Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum .
    Purvalanol B
  • HY-17624
    Framycetin

    Neomycin B; Fradiomycin B

    		 Bacterial Antibiotic Infection
    Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections .
    Framycetin
  • HY-16909
    Leptomycin B
    5+ Cited Publications

    CI 940; LMB

    		 CRM1 Fungal Antibiotic Infection Cancer
    Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle .
    Leptomycin B
  • HY-108719
    Insulin glargine

    		Insulin Receptor Metabolic Disease
    Insulin glargine is a long-acting insulin analog. Insulin glargine can be used for the diabetes mellitus .
    Insulin glargine
  • HY-B0430B
    (±)-Pantothenic acid

    (±)-Pantothenate; (±)-Vitamin B5

    		 Others Neurological Disease Metabolic Disease
    (±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .
    (±)-Pantothenic acid
  • HY-B0511
    Biotin
    10+ Cited Publications

    Vitamin B7; Vitamin H; D-Biotin

    		 Endogenous Metabolite Metabolic Disease
    Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
    Biotin
  • HY-17624A
    Framycetin sulfate

    Neomycin B sulfate; Fradiomycin B sulfate

    		 Antibiotic Bacterial Infection
    Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections .
    Framycetin sulfate
  • HY-N0695
    Schisantherin B

    Gomisin-B; Wuweizi ester-B; Schisantherin-B

    		 Amyloid-β Inflammation/Immunology
    Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a natural product.
    Schisantherin B
  • HY-B0511R
    Biotin (Standard)

    Vitamin B7 (Standard); Vitamin H (Standard); D-Biotin (Standard)

    		 Endogenous Metabolite Metabolic Disease
    Biotin (Standard) is the analytical standard of Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
    Biotin (Standard)
  • HY-P3232
    B 9430

    		Bradykinin Receptor Inflammation/Immunology Endocrinology
    B 9430 is a potent bradykinin B1/B2 receptor antagonist .
    B 9430
  • HY-148189
    Aldometanib
    4 Publications Verification

    LXY-05-029

    		 AMPK Metabolic Disease
    Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis .
    Aldometanib
  • HY-117422
    CAY10410

    11-Oxo-prosta-5Z,12E,14Z-trien-1-oic acid

    		 PPAR Cancer
    CAY10410 (11-Oxo-prosta-5Z), a 15d-PGJ2 analog, is a potent PPARγ agonist. CAY10410 has the ability to activate PPARγ in human B cells without killing B lymphocytes .
    CAY10410
  • HY-P99541
    Tuvirumab

    anti-hepatitis B; OST 577; SDZ-OST 577

    		 HBV Infection
    Tuvirumab (OST 577; SDZ-OST 577) is a human IgG1 subclass monoclonal antibody directed against HBV surface antigen (HBsAg). Tuvirumab binds specifically and with high affinity (K=3.6 nM) to HBsAg. Tuvirumab has the potential for chronic hepatitis B research .
    Tuvirumab
  • HY-134434
    Z-Arg-Arg-AMC hydrochloride

    		Cathepsin Others
    Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B .
    Z-Arg-Arg-AMC hydrochloride
  • HY-N2826
    Aglaine B

    (+)-Aglain B; Aglain B

    		 Others Others
    Aglaine B (Aglain B) is a product that can be isolated from .
    Aglaine B
  • HY-112462
    Cdk1/2 Inhibitor III

    		CDK Cancer
    Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor, with an IC50 of 2.1 μM for CDK1/cyclin B .
    Cdk1/2 Inhibitor III
  • HY-12240
    B32B3

    		Others Cancer
    B32B3 is an inhibitor of VprBP with an IC50 value of 0.5 μM at the H2AT120p cell. B32B3 can suppress tumor growth .
    B32B3