Search Result
Results for "
Aldolase b Inhibitors
" in MCE Product Catalog:
3350
Inhibitors & Agonists
34
Biochemical Assay Reagents
220
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
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- HY-P2977
-
|
N-Acetylneuraminate lyase (CgNal)
Sialic acid Aldolase (CgNal)
|
Endogenous Metabolite
|
Others
|
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N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac).
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-
- HY-P2726
-
-
- HY-147061
-
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2-Deoxyribose 5-phosphate disodium
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Others
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Others
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2-Deoxyribose 5-phosphate disodium is a substrate of 2-deoxyribose-5-phosphate aldolase (DERA). DERA belongs to the class I aldolases and catalyzes the reversible aldol condensation reaction without any cofactors.
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-
- HY-148077
-
-
- HY-147064
-
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DL-4-Hydroxy-2-ketoglutarate lithium
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Others
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Others
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DL-4-Hydroxy-2-ketoglutarate lithium is the substrate of 4-hydroxy-2-oxoglutarate aldolase (HOGA). DL-4-Hydroxy-2-ketoglutarate lithium can be cleaved by HOGA to produce pyruvate and glyoxylate.
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- HY-143899
-
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FBA-IN-1
|
Fungal
|
Infection
|
|
FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL.
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-
- HY-N10694
-
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Rehmannioside B
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Others
|
Others
|
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Rehmannioside B is a desacyl derivative of Picrorhizaoside B, which can be isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae).
|
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- HY-151210
-
-
- HY-114314
-
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BA-53038B
|
HBV
|
Infection
|
|
BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B.
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-
- HY-120980
-
-
- HY-147945
-
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DNA gyrase B-IN-1
|
DNA/RNA Synthesis
Bacterial
|
Infection
|
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DNA gyrase B-IN-1 (compound 13) is a potent DNA gyrase B inhibitor. DNA gyrase B-IN-1 shows inhibition of P. aeruginosa DNA gyrase B, with an IC50 of 2.2 μM. DNA gyrase B-IN-1 has good binding affinity and stability.
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- HY-P4042
-
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Hepatitis B Virus Receptor Binding Fragment
hepatitis B peptide 4980
|
HBV
|
Infection
Inflammation/Immunology
|
|
Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) is a synthetic peptide analog which specifically binds to Hep G2 cells. Hepatitis B Virus Receptor Binding Fragment is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization.
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- HY-P3850
-
-
- HY-B0511A
-
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Biotin sodium
Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
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Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
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- HY-B0511
-
|
Biotin
Vitamin B7; Vitamin H; D-Biotin
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Endogenous Metabolite
|
Metabolic Disease
|
|
Biotin (Vitamin B7) is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
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- HY-18299
-
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Purvalanol B
NG 95
|
CDK
Parasite
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Cancer
Infection
|
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Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum.
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- HY-16909
-
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Leptomycin B
CI 940; LMB
|
CRM1
Fungal
Antibiotic
|
Cancer
Infection
|
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Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
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- HY-17624
-
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Framycetin
Neomycin B; Fradiomycin B
|
Bacterial
Antibiotic
|
Infection
|
|
Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.
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- HY-B0430B
-
|
(±)-Pantothenic acid
(±)-Pantothenate; (±)-Vitamin B5
|
Others
|
Metabolic Disease
Neurological Disease
|
|
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice.
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- HY-17624A
-
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Framycetin sulfate
Neomycin B sulfate; Fradiomycin B sulfate
|
Antibiotic
Bacterial
|
Infection
|
|
Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections.
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- HY-112462
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- HY-N0695
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- HY-P3232
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- HY-P99541
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Tuvirumab
anti-hepatitis B; OST 577; SDZ-OST 577
|
HBV
|
Infection
|
|
Tuvirumab (OST 577; SDZ-OST 577) is a human IgG1 subclass monoclonal antibody directed against HBV surface antigen (HBsAg). Tuvirumab binds specifically and with high affinity (K=3.6 nM) to HBsAg. Tuvirumab has the potential for chronic hepatitis B research.
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- HY-117422
-
|
CAY10410
11-Oxo-prosta-5Z,12E,14Z-trien-1-oic acid
|
PPAR
|
Cancer
|
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CAY10410 (11-Oxo-prosta-5Z), a 15d-PGJ2 analog, is a potent PPARγ agonist. CAY10410 has the ability to activate PPARγ in human B cells without killing B lymphocytes.
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- HY-N2132
-
|
Flavokawain B
Flavokavain B
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Apoptosis
|
Cancer
|
|
Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations.
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- HY-114269
-
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- HY-N2509
-
|
Iristectorigenin B
Iristectrigenin B
|
LXR
|
Cardiovascular Disease
|
|
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β.
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- HY-D0004
-
|
Azure B
Azure B chloride
|
Monoamine Oxidase
|
Neurological Disease
|
|
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects.
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- HY-142074
-
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Inophyllum B
(+)-Inophyllum B
|
Reverse Transcriptase
HIV
|
Infection
|
|
Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC50 value of 38 nM. Inophyllum B inhibits HIV-1 (IC50=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica.
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- HY-W012206S1
-
-
- HY-N9395
-
-
- HY-N1120
-
|
Triptoquinone B
(+)-Triptoquinone B
|
Interleukin Related
|
Inflammation/Immunology
|
|
Triptoquinone B ((+)-Triptoquinone B), a sesquiterpene alkaloid, is an interleukin-1 inhibitor. Triptoquinone B shows potent inhibitory activities against interleukin 1α and β releases for human peripheral mononuclear cells.
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- HY-N3729
-
|
(-)-Denudatin B
Denudatin B
|
Calcium Channel
|
Cardiovascular Disease
|
|
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels. And (-)-Denudatin B has nonspecific antiplatelet action
|
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- HY-N3205
-
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Neochamaejasmin B
(+)-Neochamaejasmin B
|
Others
|
Others
|
|
Neochamaejasmin B is a biflavanone compound. Neochamaejasmin B is isolated from Stellera chamaejasme L. (Thymelaeaceae). Neochamaejasmin B has the cis-trans geometry at the C-2/C-3 and C-2″/C-3″ positions.
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- HY-107208
-
-
- HY-44307
-
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84-B10
|
Ferroptosis
|
Cancer
|
|
84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI).
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- HY-N10961
-
|
Daphnodorin B
|
Others
|
Cancer
|
|
Daphnodorin B is a flavonoid. Daphnodorin B can be isolated from the roots of Daphne genkwa. Daphnodorin B can be used for the research of tumor.
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- HY-N7486
-
|
Chamaejasmenin B
|
Others
|
Cancer
|
|
Chamaejasmenin B can be extracted from Stellera chamaejasme L. Chamaejasmenin B suppresses cancer cells migration and invasion. Chamaejasmenin B inhibits tumor metastasis. Chamaejasmenin B can be used in the research of cancers, such as breast cancers.
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- HY-P99693
-
|
Lenvervimab
GC1102
|
HBV
|
Infection
|
|
Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection.
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- HY-W018791
-
|
Bifendate
DDB
|
HBV
|
Infection
|
|
Bifendate (DDB) is a synthetic intermediate of Schisandrin C with anti-HBV efficacy in research of chronic hepatitis B.
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-
- HY-125729
-
-
- HY-N1818
-
|
Deoxysappanone B
3-Deoxysappanone B
|
p38 MAPK
|
Inflammation/Immunology
Neurological Disease
|
|
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage.
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-
- HY-N3345
-
|
Macrocarpal B
|
Bacterial
|
Infection
|
|
Macrocarpal B is an antibacterial compounds. Macrocarpal B can be isolated from the branch of Eucalyptus globulus. Macrocarpal B can be used for the research of periodontal disease.
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- HY-N0805
-
|
Alisol B 23-acetate
23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate
|
Apoptosis
|
Others
|
|
Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.
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- HY-P3985
-
|
Bradykinin potentiator B
Bradykinin potentiating peptide B
|
Angiotensin-converting Enzyme (ACE)
|
Others
|
|
Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. Bradykinin potentiator B is a potent ACE inhibitor. Bradykinin potentiator inhibits the activity of bradykinin inhibitory peptidase.
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- HY-P1349
-
-
- HY-16399
-
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Pladienolide B
|
Apoptosis
|
Cancer
|
|
Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis.
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-
- HY-130237
-
|
Cinnamtannin B-1
|
Reactive Oxygen Species
|
Cancer
Metabolic Disease
|
|
Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects and inhibiting the production of reactive oxygen species (ROS). Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers.
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- HY-N2267
-
-
- HY-N8084
-
|
Epimedin B1
|
Others
|
Others
|
|
Epimedin B1 is initially isolated from E. Wushanense and is a Chemical marker of E. sagittatum in agent Yin-Yang-Huo. Epimedin B1 is the isomer of Epimedin B.
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- HY-145891
-
-
- HY-110181
-
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M8-B
|
TRP Channel
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Metabolic Disease
|
|
M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb).
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- HY-15311
-
-
- HY-101462
-
-
- HY-N10582
-
-
- HY-107707
-
-
- HY-108842
-
|
Peginterferon alfa-2b
PegIFN a-2b; Sch 54031; Sylatron; ViraferonPeg
|
HIV
|
Cancer
Infection
Inflammation/Immunology
|
|
Peginterferon alfa-2b (Sch 54031) is an immunomodulator. Peginterferon alfa-2b is a recombinant alfa-2b interferon covalently linked PEG. Peginterferon alfa-2b in decreasing viral DNA in HIV. Peginterferon alfa-2b can be used in research of melanoma.
|
-
- HY-148189
-
|
Aldometanib
LXY-05-029
|
AMPK
|
Metabolic Disease
|
|
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.
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-
- HY-101007A
-
|
(+)-Tyrphostin B44
Tyrphostin AG 835; Tyrphostin B 50
|
EGFR
|
Cancer
|
|
(+)-Tyrphostin B44 (Tyrphostin AG 835) (Compound B50) is an EGRF inhibitor with antitumor activities.
|
-
- HY-N7688
-
-
- HY-136453A
-
|
CR-1-30-B
|
Others
|
Cancer
|
|
CR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation.
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- HY-125666
-
-
- HY-N2303
-
-
- HY-N6696
-
|
Aflatoxin B2
|
Bacterial
Antibiotic
Parasite
|
Cancer
Infection
|
|
Aflatoxin B2 is a major naturally produced aflatoxin. Aflatoxin B2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2.
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- HY-P99735
-
|
Mipeginterferon alfa-2b
|
IFNAR
|
Infection
|
|
Mipeginterferon alfa-2b is an interferon alpha-2b (IFNA2b) analogue, with an average number of 5 substituted among 11 amino groups (one N-terminal and 10 lysine N6). Mipeginterferon alfa-2b has the relative molecular mass of 40 kDa.
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-
- HY-15473
-
|
MLN120B
ML120B
|
IKK
|
Cancer
|
|
MLN120B (ML120B) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis.
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-
- HY-15473A
-
|
MLN120B dihydrochloride
ML120B dihydrochloride
|
IKK
|
Cancer
Inflammation/Immunology
|
|
MLN120B dihydrochloride (ML120B dihydrochloride) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis.
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-
- HY-101749
-
-
- HY-N6261
-
|
Epimagnolin B
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Others
|
Inflammation/Immunology
|
|
Epimagnolin B is a bisepoxylignan isolated from Magnolia fargesii, with anti-inflammatory activity and antiallergic effects. Epimagnolin B inhibits NO production in LPS-activated microglia. Epimagnolin B exhibited antiallergic effects.
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-
- HY-144401
-
|
DS-3801b
|
Motilin Receptor
|
Metabolic Disease
|
|
DS-3801b is a potent and non-macrolide agonist of GPR38. DS-3801b is expected to be novel gastrointestinal prokinetic agents for the research of functional gastrointestinal disorders such as gastroparesis and chronic constipation.
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-
- HY-N0800
-
|
Protosappanin B
(-)-Protosappanin B
|
Apoptosis
|
Cancer
|
|
Protosappanin B is a phenolic compound extracted from Caesalpinia sappan. Anti-cancer activity. Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells.
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-
- HY-N11083
-
-
- HY-N3388
-
-
- HY-N8334
-
|
Stachybotrysin B
|
Others
|
Others
|
|
Stachybotrysin B is a phenylspirodrimane derivative. Stachybotrysin B is isolated from Stachybotrys chartarum CGMCC 3.5365.
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-
- HY-P99348
-
|
Ropeginterferon alfa-2b
Ropeginterferon alfa-2b-njft; PEG-proline-interferon alpha-2b
|
Apoptosis
|
Cancer
|
|
Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms.
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-
- HY-137500
-
|
NT1-014B
|
Others
|
Neurological Disease
|
|
NT1-014B is a potent NT1-lipidoid encapsulated AmB (amphotericin B). NT1-014B dopes the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. NT1-014B enhances brain delivery through intravenous injection.
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-
- HY-141432
-
|
Cbl-b-IN-3
|
E1/E2/E3 Enzyme
|
Cancer
|
|
Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation.
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-
- HY-113042S
-
-
- HY-N8472
-
|
Chrodrimanin B
|
GABA Receptor
|
Infection
|
|
Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on B. mori GABAR RDL with an IC50 of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50 of 1.66 nM. Chrodrimanin B, a meroterpenoid, shows insecticidal activity.
|
-
- HY-N11439
-
|
Albanol B
|
CDK
Akt
ERK
Apoptosis
Bacterial
|
Cancer
Infection
Neurological Disease
|
|
Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2.
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-
- HY-112543
-
|
S119-8
|
Influenza Virus
|
Infection
|
|
S119-8 is a broad spectrum inhibitor of influenza A and B viruses, showing activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV).
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-
- HY-114673
-
-
- HY-N10894
-
|
Murrayacarpin B
|
Others
|
Others
|
|
Murrayacarpin B is a phenolic compound. Murrayacarpin B can be isolated from the leaves and fruits of F. carica.
|
-
- HY-N10265
-
|
Stephacidin B
|
Endogenous Metabolite
|
Cancer
|
|
Stephacidin B is a fungal metabolite. Stephacidin B shows in vitro cytotoxicity against a panel of human tumor cell lines. Stephacidin B shows the strongest cytotoxicity against testosterone-dependent prostate LNCaP cancer cells.
|
-
- HY-111320
-
|
Chrysomycin B
|
Bacterial
Antibiotic
|
Cancer
|
|
Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. Chrysomycin B causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B suppresses the growth of transplantable tumors in mice.
|
-
- HY-114275
-
-
- HY-N10538
-
|
Shishijimicin B
|
Others
|
Cancer
|
|
Shishijimicin B is an active compound of the enediyne class. Shishijimicin B shows extremely potent cytotoxicity with IC50 values of 2.0-3.3 nM. Shishijimicin B has antitumor activity and can be used for the research of cancer.
|
-
- HY-128129
-
|
UT-B-IN-1
|
Urea Transporter
|
Metabolic Disease
|
|
UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.
|
-
- HY-150229
-
|
306-N16B
|
Others
|
Cancer
|
|
306-N16B is a lipidnanoparticle, and allows systemic codelivery of Cas9 mRNA and sgRNA. 306-N16B can transport mRNA to the pulmonaryendothelial cell. 306-N16B can be used for research of genome editing-based therapies.
|
-
- HY-N3013
-
-
- HY-N7046
-
|
Silybin B
Silibinin B
|
Amyloid-β
|
Cancer
Neurological Disease
|
|
Silybin B, a flavonolignan separated from Silybum marianum, has anti-tumor activity. Silybin B is the most potent antifibrillogenic and anti-oligomeric component of silymarin and proposes it as a promising anti Alzheimer’s disease agent candidate.
|
-
- HY-10704
-
|
PTP1B-IN-1
PTP1B inhibitor
|
Phosphatase
|
Metabolic Disease
|
|
PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.
|
-
- HY-133108
-
-
- HY-N6939
-
-
- HY-N10541
-
|
Aplyronine B
|
Others
|
Cancer
|
|
Aplyronine B is an active compound. Aplyronine B shows potent antitumor activity and has cytotoxicity against HeLa-S3 cells with an IC50 values of 2.9 nM. Aplyronine B can be used for the research of cancer.
|
-
- HY-N3267
-
-
- HY-N0976
-
|
1,11b-Dihydro-11b-hydroxymedicarpin
11b-Hydroxy-11b,1-dihydromedicarpin
|
Interleukin Related
|
Inflammation/Immunology
|
|
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice.
|
-
- HY-147362
-
-
- HY-N11621
-
|
Sadopeptins B
|
Proteasome
|
Others
|
|
Sadopeptins B is a nature product that could be isolated from Streptomyces sp. Sadopeptins B is a potent proteasome inhibitor.
|
-
- HY-N5085
-
|
Nudicaucin B
|
Fungal
|
Infection
|
|
Nudicaucin B is a triterpenoid saponi found in Hedyotis nudicaulis. Nudicaucin B has antifungal activities.
|
-
- HY-N6248
-
-
- HY-N2981
-
-
- HY-N8200
-
-
- HY-127018
-
|
Maltoheptaose
|
Others
|
Metabolic Disease
|
|
Maltoheptaose is an activator of phosphorylase B to prepare heptulose-2-phosphate. Maltoheptaose is a maltooligosaccharide contanins seven glucose units.
|
-
- HY-127018A
-
-
- HY-N1453
-
|
Hypocrellin B
|
Apoptosis
Fungal
Parasite
|
Cancer
Infection
|
|
Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities.
|
-
- HY-N10536
-
|
Halichondrin B
|
Others
|
Cancer
|
|
Halichondrin B is found from the sponge Halichondria okadai. Halichondrin B is a noncompetitive inhibitor of Vinca-alkaloid binding to tubulin (IC50 for tubulin polymerization of 1.2-1.4 μM). Halichondrin B shows anti-tumor activity.
|
-
- HY-N10226
-
|
Thielavin B
|
Prostaglandin Receptor
|
Endocrinology
Cardiovascular Disease
|
|
Thielavin B is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin B effectively influences the prostaglandin E2 synthesis from the endoperoxide. Thielavin B is significantly effective on carrageenan-induced oedema of rats when administered intravenously.
|
-
- HY-15335
-
-
- HY-N6734
-
|
K-252b
|
PKC
|
Infection
|
|
K-252b, an indolocarbazole isolated from the actinomycete Nocardiopsis, is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in culture because it can’t pass through cell membrane freely .
|
-
- HY-N2148
-
|
Cytosporone B
Csn-B; Dothiorelone G
|
Others
|
Cancer
|
|
Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM.
|
-
- HY-N10009
-
|
Cudraflavone B
|
NF-κB
TNF Receptor
COX
ERK
p38 MAPK
Sirtuin
|
Inflammation/Immunology
|
|
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells.
|
-
- HY-P99497
-
|
Cepeginterferon alfa-2b
|
Integrin
HCV
|
Infection
|
|
Cepeginterferon alfa-2b is a pegylated interferon. And Cepeginterferon alfa-2b has PEG with molecular weight of 20 kDa as a pegylated base. Cepeginterferon alfa-2b can be used for research of various diseases, such as hepatitis C virus (HCV), polycythemia vera (PV) and essential thrombocythemia (ET).
|
-
- HY-N1337
-
-
- HY-N10000
-
|
Hirudonucleodisulfide B
|
Others
|
Others
|
|
Hirudonucleodisulfide B is a heterocyclic compound that can be found in Whitmania pigra. Hirudonucleodisulfide B shows moderately anti-anoxic activity.
|
-
- HY-A0248A
-
|
Polymyxin B1
|
Bacterial
|
Infection
|
|
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.
|
-
- HY-146149
-
-
- HY-146150
-
-
- HY-N0975
-
-
- HY-13992
-
|
AP20187
B/B Homodimerizer
|
FKBP
|
Metabolic Disease
|
|
AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
|
-
- HY-136453
-
|
CR-1-31-B
|
Eukaryotic Initiation Factor (eIF)
Apoptosis
|
Cancer
|
|
CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor. CR-1-31-B exhibits powerful inhibitory effects over eIF4A by perturbing the interaction between eIF4A and RNA, sequentially impeding initiation during protein synthesis. CR-1-31-B perturbs association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA. CR-1-31-B induces apoptosis of neuroblastoma and gallbladder cancer cells.
|
-
- HY-W083062
-
|
hMAO-B-IN-5
|
Monoamine Oxidase
|
Neurological Disease
|
|
hMAO-B-IN-5(B15) is a potent, selective and reversible inhibitor of human monoamine oxidase hMAO-B with IC50 of 0.12 μM. hMAO-B-IN-5 can pass through the blood-brain barrier and can be used in the research of neurodegenerative diseases.
|
-
- HY-N2006
-
|
Ganoderic acid B
|
HIV Protease
|
Infection
|
|
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease.
|
-
- HY-N9067
-
|
Sanggenofuran B
|
Others
|
Cancer
|
|
Sanggenofuran B is 2-arylbenzofuran with anti-cancer activity. Sanggenofuran B inhibits A2780 cell line with an IC50 value of 57.1 μM. Sanggenofuran B can be isolated from the root bark of Chinese Morus cathayana.
|
-
- HY-N0811
-
|
Anemarsaponin B
|
NO Synthase
COX
NF-κB
MEK
|
Inflammation/Immunology
|
|
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .
|
-
- HY-N3947
-
|
Glepidotin B
|
Bacterial
|
Infection
|
|
Glepidotin B is a dihydroflavonol compound isolated from the extracts of American licorice, Glycyrrhiza lepidota (Leguminosae). Glepidotin B is an antimicrobial agent.
|
-
- HY-N0660
-
-
- HY-N3222
-
-
- HY-123899
-
|
Cleomiscosin B
|
Others
|
Others
|
|
Cleomiscosin B, a coumarinolignoid, is could isloted from the seeds of Hyoscyamus niger. Cleomiscosin B has potent liver protective.
|
-
- HY-16943
-
|
Moiramide B
|
Bacterial
|
Infection
|
|
Moiramide B is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of 6 nM. Moiramide B has antibacterial activity.
|
-
- HY-147780
-
|
Fissitungfine B
|
Others
|
Cancer
|
|
Fissitungfine B is a compound extracted from the tropical medicinal plant Fissistigma tungfangense. Fissitungfine B has strong anticancer activity.
|
-
- HY-N3697
-
-
- HY-N0259
-
|
Epimedin B
Epmedin B
|
Others
|
Others
|
|
Epimedin B, a component extracted from Epimedii Folium, is reported to have antiosteoporotic activity.
|
-
- HY-151208
-
-
- HY-131055
-
|
Mytoxin B
|
ADC Cytotoxin
PI3K
Apoptosis
|
Cancer
|
|
Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002 (HY-10108). Mytoxin B induces cell apoptosis via PI3K/Akt pathway.
|
-
- HY-N0582
-
|
Qingyangshengenin B
|
Amyloid-β
|
Neurological Disease
|
|
Qingyangshengenin B, a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic activity.
|
-
- HY-B0586
-
-
- HY-P1349A
-
|
Orexin B, rat, mouse TFA
Rat orexin B TFA; Orexin B (mouse) (TFA)
|
Orexin Receptor (OX Receptor)
|
Endocrinology
Neurological Disease
|
|
Orexin B, rat, mouse (Rat orexin B) TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. Orexin B, rat, mouse TFA stimulates food intake and energy expenditure and plays a significant role in sleep-wakefulness regulation.
|
-
- HY-135327A
-
|
Amphotericin B methyl ester hydrochloride
|
HIV
Fungal
|
Infection
|
|
Amphotericin B methyl ester hydrochloride is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester hydrochloride is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester hydrochloride disrupts HIV-1 particle production and potently inhibits HIV-1 replication.
|
-
- HY-135327
-
|
Amphotericin B methyl ester
|
HIV
Fungal
|
Infection
|
|
Amphotericin B methyl ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester disrupts HIV-1 particle production and potently inhibits HIV-1 replication.
|
-
- HY-112051
-
-
- HY-N7643
-
-
- HY-117313
-
-
- HY-N10887
-
-
- HY-N9314
-
-
- HY-N1476
-
|
Heterophyllin B
|
PI3K
|
Cancer
|
|
Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer.
|
-
- HY-N4189
-
|
Isocucurbitacin B
|
Others
|
Cancer
|
|
Isocucurbitacin B is a potent cytotoxic compound isolated from Helicteres rswa L. (Sterculiaceae). Isocucurbitacin B possesses anti-tumor acticity.
|
-
- HY-N3303
-
|
Meliasenin B
|
Others
|
Others
|
|
Meliasenin B (compound 2) is an apotirucallane-type triterpenoid. Meliasenin B is a nature product that could be isolated from the fruits of Melia azedarach.
|
-
- HY-108935
-
|
Lavendustin B
|
HIV Integrase
GLUT
Tyrosinase
|
Cancer
|
|
Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 µM. Lavendustin B is also a weak inhibitor of tyrosine kinases.
|
-
- HY-N10431
-
|
Stigmane B
|
Keap1-Nrf2
|
Neurological Disease
|
|
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects.
|
-
- HY-P1169
-
-
- HY-A0248
-
|
Polymyxin B Sulfate
|
Bacterial
Antibiotic
|
Infection
|
|
Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo.
|
-
- HY-N0704
-
|
Agrimol B
|
Sirtuin
PPAR
Fatty Acid Synthase (FASN)
c-Myc
Bacterial
|
Cancer
Infection
Metabolic Disease
|
|
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27.
|
-
- HY-N3426
-
|
Kazinol B
|
NO Synthase
Akt
AMPK
|
Metabolic Disease
|
|
Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research.
|
-
- HY-16937
-
-
- HY-D0949
-
|
Pyronine B
|
Fluorescent Dye
|
Others
|
|
Pyronine B is an organic cationic dye. Pyronin B as a solution-processable and heating-free n-type dopant can be used for soft electronics.
|
-
- HY-N7680A
-
|
Neopuerarin B
|
Others
|
Metabolic Disease
|
|
Neopuerarin B is an isoflavones isolated from the water extraction of the dried roots of Pueraria lobata (Willd.). Neopuerarin B shows significant hepatoprotective effect.
|
-
- HY-N6808
-
|
Rebaudioside B
|
Others
|
Others
|
|
Rebaudioside B is the minor constituent isolated from the leaves of Stevia rebaudiana Bertoni. Rebaudioside B tastes about 150 times sweeter than sucrose .
|
-
- HY-N8150
-
|
Hythiemoside B
|
Others
|
Others
|
|
Hythiemoside B is isolated as a white amorphous powder. Hythiemoside B is an ent-pimarane glucoside isolated from the aerial part of Siegesbecikia orientalis L. (Asteraceae).
|
-
- HY-N6037
-
|
Gardenin B
|
Apoptosis
|
Cancer
|
|
Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B induces cell death in human leukemia cells involves multiple caspases.
|
-
- HY-126765
-
-
- HY-N0429
-
-
- HY-N6025
-
|
Clemastanin B
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities.
|
-
- HY-N3806
-
-
- HY-N4268
-
|
Tenuifoliside B
|
Others
|
Neurological Disease
|
|
Tenuifoliside B, a component isolated from Polygalae Radix, inhibits potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment. Tenuifoliside B shows potential cognitive improvement and cerebral protective effects. Tenuifoliside B has potential to become an anti-AD lead compound.
|
-
- HY-152671
-
|
hMAO-B-IN-4
|
Monoamine Oxidase
|
Neurological Disease
|
|
hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B (hMAO-B) inhibitor with an IC50 value and a Ki value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an IC50 value of 33.82 μM. hMAO-B-IN-4 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research.
|
-
- HY-144310
-
|
DX3-213B
|
Mitochondrial Metabolism
|
Cancer
|
|
DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor (IC50=3.6 nM). DX3-213B impairs ATP generation (IC50=11 nM), and blocks MIA PaCa-2 cell growth (GI50=11 nM). DX3-213B is used for the research of the pancreatic cancer.
|
-
- HY-146670
-
|
KDM5B-IN-3
|
Histone Demethylase
|
Cancer
|
|
KDM5B-IN-3 (Compound 5) is a histone lysine specific demethylase 5B (KDM5B/JARID1B) inhibitor with an IC50 of 9.32 μM. KDM5B-IN-3 can be used for the research of gastric cancer.
|
-
- HY-130999
-
|
Microcolin B
|
Others
|
Inflammation/Immunology
|
|
Microcolin B is an extremely potent unusual acylpeptide, proline-containing potent immunosuppressant. Microcolin B is isolated from blue-green alga Lyngbya majuscule.
|
-
- HY-N7292
-
-
- HY-N2807
-
-
- HY-129566
-
-
- HY-N6780
-
|
Ophiobolin B
|
Fungal
|
Infection
|
|
Ophiobolin B, a sesterterpene metabolite of Helminthosporium oryzae, inhibits proton extrusion from maize coleoptiles. Ophiobolin B inhibits fusicoccin (FC) promoted proton extrusion, potassium uptake and cell enlargement. The MIC values with the antifungal effect of Ophiobolins B on different zygomycetes is 25–50 μg/mL.
|
-
- HY-149066
-
|
Diaporthein B
|
Bacterial
|
Cancer
Infection
|
|
Diaporthein B is one of the most highly oxidized pimarane diterpenes. Diaporthein B exhibits activity against M. tuberculosis, with a MIC of 3.1 μg/mL. Diaporthein B reveals IC50s of 1.5-3 μM/L against HCT 116 and LoVo colon cancer cells.
|
-
- HY-N0539
-
|
Calceolarioside B
|
Aldose Reductase
|
Cancer
|
|
Calceolarioside B is a natural product isolated from Akebia quinata leaves. Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC50 of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC50 of 94.60 μM .
|
-
- HY-148692
-
|
OSM-SMI-10B
|
STAT
|
Cancer
|
|
OSM-SMI-10B a derivative of OSM-SMI-10. OSM-SMI-10B significantly reduces OSM-induced STAT3 phosphorylation in cancer cells upon co-incubation with OSM (Oncostatin M).
|
-
- HY-N6701
-
|
Dihydrocytochalasin B
|
Arp2/3 Complex
|
Cancer
|
|
Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis. Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca 2+increase in the mucosal scrapings.
|
-
- HY-120553
-
|
B-355252
|
Apoptosis
|
Neurological Disease
|
|
B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD).
|
-
- HY-113331
-
-
- HY-122615
-
|
SPOP-IN-6b
|
Others
|
Cancer
|
|
SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM (patent CN 107141287, SPOP-B-88).
|
-
- HY-D1440
-
-
- HY-N10835
-
-
- HY-126804
-
|
Safracin B
|
Antibiotic
|
Cancer
Infection
|
|
Safracin B, a tetrahydroisoquinoline (THIQ) alkaloid, is a naturally occurring antibiotic from Pseudomonas fluorescens. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities.
|
-
- HY-143242
-
|
Phidianidine B
|
Others
|
Others
|
|
Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk.
|
-
- HY-N8513
-
|
Brevicompanine B
|
Parasite
|
Infection
|
|
Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC50 of 35 mg/mL.
|
-
- HY-N7229
-
|
Rabdosin B
|
DNA/RNA Synthesis
|
Cancer
|
|
Rabdosin B is an ent-kaurene diterpenoid with anticancer effects. Rabdosin B induces DNA damage in cells, and inhibits lettuce root hair development of seedlings.
|
-
- HY-135281
-
-
- HY-N6839
-
-
- HY-N0886
-
|
Aloin B
Aloin-B; Isobarbaloin
|
Others
|
Others
|
|
Aloin B is one isomer of Aloin; Aloin is a physiologically active anthraquinone present in aloe.
|
-
- HY-N3807
-
|
Enniatin B1
|
Acyltransferase
ERK
NF-κB
|
Cancer
Infection
Cardiovascular Disease
|
|
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes. Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.
|
-
- HY-N10307
-
|
Anserinone B
|
Fungal
Bacterial
Endogenous Metabolite
|
Cancer
Infection
|
|
Anserinone B is an antifungal and antibacterial benzoquinone. Anserinone B causes radial growth reductions of 50% and 37% against S.fimicola and A. furfuraceus, respectively. Anserinones B also displays moderate cytotoxicity in the NCI’s 60 human tumor cell line panel (GI50=4.4 µg/mL).
|
-
- HY-N3831
-
|
Epimedokoreanin B
|
Bacterial
Apoptosis
|
Cancer
Infection
Inflammation/Immunology
|
|
Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.
|
-
- HY-N10313
-
|
Dehydrobruceine B
|
Bcl-2 Family
Keap1-Nrf2
Apoptosis
|
Cancer
|
|
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2.
|
-
- HY-N10965
-
|
Gambogic acid B
|
Others
|
Cancer
|
|
Gambogic acid B is an active compound. Gambogic acid B can be isolated from the resin of Garcinia hanburyi.. Gambogic acid B has cytotoxicity against A549, HCT116 and MDA‑MB‑231 cells with IC50 values of 1.60 μM, 6.88 μM and 0.87 μM, respectively.
|
-
- HY-N3028
-
|
Taccalonolide B
|
Microtubule/Tubulin
|
Cancer
|
|
Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.
|
-
- HY-122590
-
|
Glabrescione B
|
Gli
|
Cancer
|
|
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells.
|
-
- HY-N0796
-
-
- HY-N0373
-
|
Licochalcone B
|
Amyloid-β
Apoptosis
NOD-like Receptor (NLR)
|
Neurological Disease
|
|
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
|
-
- HY-B0315A
-
-
- HY-N2393S
-
-
- HY-N10438
-
-
- HY-N10381
-
-
- HY-16942
-
|
Damulin B
|
Apoptosis
|
Cancer
|
|
Damulin B is a dammarane-type saponin found in Gynostemma pentaphyllum.Damulin B can induce cell apoptosis and has anti-cancer activities in vitro.
|
-
- HY-N7637
-
|
Tubuloside B
|
Apoptosis
|
Cancer
|
|
Tubuloside B, one of the phenylethanoids isolated from the stems of Cistanche salsa, inhibits TNFα-induced apoptosis. Tubuloside B possesses antioxidative effects.
|
-
- HY-U00343
-
-
- HY-113042
-
-
- HY-136128
-
|
H3B-120
|
Potassium Channel
|
Cancer
|
|
H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor with an IC50 of 1.5 μM and a Ki of 1.4 μM. H3B-120 has anti-cancer activity.
|
-
- HY-147203
-
-
- HY-146347
-
|
MAO-B-IN-10
|
Monoamine Oxidase
Amyloid-β
|
Neurological Disease
|
|
MAO-B-IN-10 (compound 4f) is a potent, selective, BBB-penetrated MAO-B (monoamine oxidase-B) inhibitor, with IC50 of 5.3 μM. MAO-B-IN-10 can inhibit (58.2%) and disaggregate (43.3%) self-mediated Aβ (amyloid β) aggregation. MAO-B-IN-10 can be use for Alzheimer’s disease research.
|
-
- HY-146429
-
|
NaPi2b-IN-3
|
Others
|
Metabolic Disease
|
|
NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia.
|
-
- HY-114357A
-
|
DS-1205b free base
|
TAM Receptor
c-Met/HGFR
Trk Receptor
|
Cancer
|
|
DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo.
|
-
- HY-146958
-
|
MAO-B-IN-8
|
Monoamine Oxidase
|
Neurological Disease
|
|
MAO-B-IN-8 is a potent reversible MAO-B inhibitor and an inhibitor of microglial production of neuroinflammatory mediator. MAO-B-IN-8 can be used for neurodegenerative disease research.
|
-
- HY-126307
-
|
Urolithin B
|
NF-κB
JNK
ERK
Akt
AMPK
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.
|
-
- HY-P1178
-
|
Cyclotraxin B
|
Trk Receptor
|
Neurological Disease
|
|
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC50 of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects.
|
-
- HY-153018
-
|
PTP1B-IN-22
|
Phosphatase
|
Metabolic Disease
|
|
PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes.
|
-
- HY-149242
-
|
MAO-B-IN-20
|
Monoamine Oxidase
|
Neurological Disease
|
|
MAO-B-IN-20 (Compound C14) is a potent MAO-B inhibitor with an IC50 of 0.037 μM. MAO-B-IN-20 displays good metabolic stability and brain-blood barrier permeability. MAO-B-IN-20 can be used for the research of Parkinson's disease.
|
-
- HY-115987
-
|
MAO-B-IN-6
|
Monoamine Oxidase
|
Neurological Disease
|
|
MAO-B-IN-6 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.019 µM. MAO-B-IN-6 shows more efficacious than Safinamide in vitro and in vivo. MAO-B-IN-6 has the potential for the research of parkinson's disease (PD).
|
-
- HY-N2893
-
|
Cepharanone B
Aristolactam B II
|
Others
|
Others
|
|
Cepharanone B is a fluorescent component isolated from the callus tissue of stephania cephaiuntha.
|
-
- HY-P1114
-
|
2B-(SP)
|
GSK-3
|
Neurological Disease
|
|
2B-(SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) is readily phosphorylated by both the α and β isoforms of GSK-3.
|
-
- HY-N6719
-
|
Fumonisin B1
|
Acyltransferase
|
Infection
|
|
Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin.
|
-
- HY-100462
-
-
- HY-N10304
-
|
Isodispar B
|
Apoptosis
|
Cancer
|
|
Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines.
|
-
- HY-N10305
-
|
Clionamine B
|
Autophagy
|
Cancer
|
|
Clionamine B is an autophagy stimulating aminosteroid isolated from the sponge Cliona celata. Clionamine B strongly stimulates autophagy in human breast cancer MCF-7 cells.
|
-
- HY-N8493
-
|
Mycalolide B
|
Others
|
Others
|
|
Mycalolide-B is a specific inhibitor of actomyosin ATPase isolated from marine sponge. Mycalolide-B inhibits ATP-induced contraction and Mg 2+-ATPase activity in the absence of Ca 2+.
|
-
- HY-N7693
-
|
Polyporusterone B
|
Others
|
Others
|
|
Polyporusterone B is a triterpene carboxylic acid isolated from Polyporus umbellatus Fries. Polyporusterone B has inhibitory effect on free radical-induced lysis of red blood cells (hemolysis).
|
-
- HY-141431
-
|
Cbl-b-IN-2
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
Inflammation/Immunology
|
|
Cbl-b-IN-2 (Example 8) is an orally bioavailable compound, can inhibit the E3 enzyme Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) in the ubiquitin proteasome pathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases amenable to immune system modulation. Cbl-b-IN-2 (Example 8) also may be administered to an individual with cancer, either alone or as part of a combination, with one or more of an immune checkpoint inhibitor, an anti-neoplastic agent, and radiation agent.
|
-
- HY-120766
-
-
- HY-P99139
-
-
- HY-147605
-
-
- HY-N0692
-
|
Schisandrol B
Gomisin-A; TJN-101; Wuweizi alcohol-B
|
Reactive Oxygen Species
Cytochrome P450
Autophagy
|
Cancer
|
|
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities.
|
-
- HY-12054A
-
-
- HY-D1122
-
|
Janus green B
|
Fluorescent Dye
|
Others
|
|
Janus green B is a supravital stain. Janus green B staining reaction is oxygen dependent, and is reversibly inhibited by cyanide. Janus green B has been used for staining peripheral nerves in live insects, lymphatic vessels of rabbits and mitochondria.
|
-
- HY-107586
-
|
Demethylasterriquinone B1
DAQ B1; L-783281; Dimethylasterriquinone
|
Insulin Receptor
Akt
|
Endocrinology
|
|
Demethylasterriquinone B1 is a selective insulin receptor activator. Demethylasterriquinone B1 stimulates tyrosine phosphorylation of the IR β subunit, and the activation of PIK3 and AKT.
|
-
- HY-117391
-
-
- HY-151800
-
-
- HY-145894
-
|
NaPi2b-IN-2
|
Others
|
Others
|
|
NaPi2b-IN-2 (compound 5) is a potent inhibitor of sodium-dependent transport protein 2b (SLC34A2, NaPi2b), with an IC50 of 38 nM for human NaPi2b. NaPi2b-IN-2 can be used for the research of hyperphosphatemia.
|
-
- HY-19505
-
|
TPA-023B
|
GABA Receptor
|
Neurological Disease
|
|
TPA-023B is a high-affinity and orally active GABAA receptor α2/α3 subtype (Kis of 0.73 nM/2 nM) partial agonist and a α1 subtype (Ki of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties.
|
-
- HY-139696
-
|
AKR1B10-IN-1
|
Aldose Reductase
|
Cancer
|
|
AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells.
|
-
- HY-N6074
-
|
Soyasapogenol B
|
Autophagy
Apoptosis
|
Cancer
|
|
Soyasapogenol B, an ingredient of soybean, exerts anti-proliferative, anti-metastatic activities. Soyasapogenol B triggers endoplasmic reticulum stress, which mediates apoptosis and autophagy in colorectal cancer.
|
-
- HY-117934
-
|
Isokotanin B
|
Drug Metabolite
|
Infection
|
|
Isokotanin B is a metabolite of bicoumarin isolated from the sclerotia of Aspergillus alliaceus. Isokotanin B shows activity against the corn earworm Helicoverpa zea and the dried fruit bettle Carpophilus hemipterus.
|
-
- HY-N8152
-
-
- HY-101848
-
|
Latrunculin B
|
Fungal
|
Infection
|
|
Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity.
|
-
- HY-N2043
-
-
- HY-N4301
-
|
Monensin B
|
Others
|
Others
|
|
Monensin B is a polyketide produced by Streptomyces cinnamonensis. Fermentations of Streptomyces cinnamonensis produce a mixture of Monensin A and Monensin B in a ratio dependent upon the relative concentrations of ethylmalonyl-CoA and methylmalonyl-CoA.
|
-
- HY-N10387
-
|
Glucodichotomine B
|
Others
|
Cancer
|
|
Glucodichotomine B (Compound 13) is a natural product which can be isolated from the roots of Chinese medicinal plant Stellaria dichotoma L. var. lanceolata. Glucodichotomine B shows antitumor activity.
|
-
- HY-147953
-
|
MAO-B-IN-13
|
Monoamine Oxidase
|
Neurological Disease
|
|
MAO-B-IN-13 (compound 12a) is a highly potent, reversible and blood-brain barrier (BBB) penetrant MAO-B inhibitor with an IC50 value of 10 nM. MAO-B-IN-13 has neuroprotective and antioxidant activity. MAO-B-IN-13 can be used for researching Parkinson’s disease.
|
-
- HY-143458
-
|
FAK PROTAC B5
|
FAK
PROTACs
|
Cancer
|
|
FAK PROTAC B5 (Compound B5) is a FAK PROTAC degrader with an IC50 value of 14.9 nM. FAK PROTAC B5 presents strong FAK degradation activity, antiproliferative activity, outstanding plasma stability and moderate membrane permeability. FAK PROTAC B5 inhibits cell migration and invasion.
|
-
- HY-N7384
-
-
- HY-143499
-
|
hMAO-B-IN-3
|
Monoamine Oxidase
|
Neurological Disease
|
|
hMAO-B-IN-3 (Compound 15) is a potent inhibitor of hMAO-B with an IC50 of 47.4 nM. hMAO-B-IN-3 is playing favourable agent-like properties and a broad safety window. hMAO-B-IN-3 is thus a suitable candidate for lead optimization and the development of multitarget-directed ligands.
|
-
- HY-N1280
-
|
Semilicoisoflavone B
|
Amyloid-β
|
Neurological Disease
|
|
Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation.
|
-
- HY-115986
-
-
- HY-143990S
-
-
- HY-W110905
-
|
Naphthol green B
|
Fluorescent Dye
|
Others
|
|
Naphthol green B is an iron-complex dye. Naphthol green B can be used in wool dyeing, silk dyeing and polyamide dyeing. Naphthol green B can be used to fabricate electrochemical sensor for the detection of H2O2.
|
-
- HY-N10804
-
-
- HY-N1339
-
|
Rosthornin B
(-)-Rosthornin B
|
Others
|
Others
|
|
Rosthornin B is a ent-kaurene diterpenoid compound, isolated from the ether extract of the dried leaves of Rabdosia rosthornii.
|
-
- HY-N10446
-
-
- HY-N11544
-
|
Inflexuside B
|
NO Synthase
|
Inflammation/Immunology
|
|
Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages.
|
-
- HY-126420
-
-
- HY-151140
-
|
CYP11B1-IN-2
|
Cytochrome P450
|
Others
|
|
CYP11B1-IN-2 (compound 7aa) is an orally active, potent and selective CYP11B1 inhibitor, with IC50 values of 9 nM and 25 nM for human CYP11B1 and rat CYP11B1, respectively. CYP11B1-IN-2 can be used for the research of diseases caused by excessive cortisol.
|
-
- HY-152079
-
|
CYP1B1-IN-3
|
Cytochrome P450
|
Cancer
|
|
CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways.
|
-
- HY-146762
-
-
- HY-D0213
-
|
Sudan Black B
|
Fluorescent Dye
|
Others
|
|
Sudan Black B, a fat-soluble diazo dye, is a histochemical stain. Sudan Black B can be used for staining of neutral triglycerides and lipids.
|
-
- HY-N8371
-
|
Shizukaol B
|
NO Synthase
COX
Interleukin Related
TNF Receptor
|
Inflammation/Immunology
|
|
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression.
|
-
- HY-142820
-
|
B-Raf IN 5
|
Raf
|
Cancer
|
|
B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease.
|
-
- HY-N2943
-
-
- HY-N8201
-
-
- HY-N3216
-
-
- HY-N4056
-
-
- HY-N1448
-
-
- HY-N3587
-
-
- HY-108196
-
|
PTP1B-IN-15
|
Phosphatase
|
Endocrinology
|
|
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity.
|
-
- HY-147606
-
-
- HY-N6955
-
|
Eupalinilide B
|
Others
|
Cancer
|
|
Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines.
|
-
- HY-144243S
-
-
- HY-N10469
-
|
Bleomycin B4
Phleomycin F
|
Antibiotic
|
Cancer
|
|
Bleomycin B4 (Phleomycin F) is an antibiotic. Bleomycin B4 has antitumor activity. Bleomycin B4 can be used for the research of cancer.
|
-
- HY-139601
-
|
KDM2B-IN-4
|
Histone Demethylase
|
Cancer
|
|
KDM2B-IN-4 is a histone demethylase KDM2B inhibitor extracted from patent WO2016112284A1, compound 182b. KDM2B-IN-4 can be used for the research of cancer.
|
-
- HY-126415
-
-
- HY-113420S
-
-
- HY-N6696S
-
|
Aflatoxin B2-13C17
|
Isotope-Labeled Compounds
|
Cancer
|
|
Aflatoxin B2- 13C17 is 13C- and 15N-labeled Aflatoxin B2 (HY-N6696). Aflatoxin B2 is a major naturally produced aflatoxin. Aflatoxin B2 is a mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus.The level of toxicity associated with Aflatoxin is Aflatoxin B1>Aflatoxin M1>Aflatoxin G1>Aflatoxin B2>Aflatoxin M2>Aflatoxin G2.
|
-
- HY-147607
-
-
- HY-147604
-
-
- HY-P3148
-
|
Astin B
|
Apoptosis
Autophagy
Reactive Oxygen Species
JNK
Bcl-2 Family
Caspase
|
Metabolic Disease
|
|
Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression.
|
-
- HY-136556
-
-
- HY-N10632
-
-
- HY-N6786
-
|
Ochratoxin B
|
Endogenous Metabolite
|
Cancer
|
|
Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents.
|
-
- HY-D1543
-
|
Pyronin B
|
DNA Stain
|
Infection
|
|
Pyronin B is an organic cationic dye used for the staining of bacteria, mycobacteria and ribonucleic acids. Pyronin B is also used as a small hydrophobic (SH) protein channel inhibitor. Storage: protect from light.
|
-
- HY-N10190
-
|
Asperaculane B
|
Parasite
Endogenous Metabolite
|
Infection
|
|
Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells.
|
-
- HY-N0753
-
|
Eupalinolide B
|
Others
|
Cancer
|
|
Eupalinolide B is a germacrane sesquiterpene isolated from Eupatorium lindleyanum. Eupalinolide B demonstrates potent cytotoxicity against A-549, BGC-823 and HL-60 tumour cell lines.
|
-
- HY-137322
-
-
- HY-142957
-
|
NaPi2b-IN-1
|
Others
|
Others
|
|
NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC50 of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia.
|
-
- HY-146314
-
|
MAO-B-IN-9
|
Monoamine Oxidase
Amyloid-β
|
Neurological Disease
|
|
MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible and time-dependent MAO-B (monoamine oxidase B) inhibitor, with an IC50 of 0.18 μM. MAO-B-IN-9 prevents Aβ1-42-induced neuronal cell death. MAO-B-IN-9 shows neuroprotective effects, which may be the result of its Aβ1-42 anti-aggregation effects.
|
-
- HY-122306
-
|
Ansatrienin B
Mycotrienin II
|
Antibiotic
Bacterial
|
Cancer
Infection
|
|
Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin.
|
-
- HY-N7776
-
|
7-Xylosyl-10-Deacetyltaxol B
7-xylosyl-10-Deacetylpaclitaxel B
|
Others
|
Cancer
|
|
7-Xylosyl-10-Deacetyltaxol B (7-xylosyl-10-Deacetylpaclitaxel B) is a paclitaxel derivative derived from T. cuspidate. 7-Xylosyl-10-Deacetyltaxol B has anti-tumor activity and inhibits the growth of S180 sarcoma.
|
-
- HY-B0221A
-
-
- HY-110015
-
|
(-)-Chromanol 293B
|
Others
|
Cardiovascular Disease
|
|
(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K + current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic.
|
-
- HY-134673B
-
|
UZH1b
|
Others
|
Others
|
|
UZH1b is an enantiomer of UZH1a (a METTL3 inhibitor). UZH1b is essentially inactive for METTL3 (IC50=28 µM).
|
-
- HY-144062
-
|
INSCoV-614(1B)
|
SARS-CoV
|
Infection
|
|
INSCoV-614(1B) is a potent inhibitor of M pro (3CL pro). Proteases (PL pro and 3CL pro) are involved with transcription and replication of the virus. INSCoV-614(1B) has the potential for the research of SARS-CoV-2 infection (extracted from patent WO2021219089A1).
|
-
- HY-N8678
-
-
- HY-P1703
-
-
- HY-N4319
-
-
- HY-15133
-
-
- HY-121513
-
|
Torcitabine
2'-Deoxy-L-cytidine; L-dC
|
HBV
|
Infection
|
|
Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment.
|
-
- HY-145708
-
-
- HY-N1570
-
-
- HY-N10791
-
|
Neobritannilactone B
|
Others
|
Infection
|
|
Neobritannilactone B, a sesquiterpene, can be isolated from the chloroform fraction of the I. britannica. Neobritannilactone B is cytotoxic. Other extracts of I. britannica are also Dihydrofolate reductase (DHFR) inhibitors, which inhibit Shigella dysenteriae type 1.
|
-
- HY-N8517
-
-
- HY-N7289
-
|
Taxuspine B
|
Others
|
Cancer
|
|
Taxuspine B is a natural product, that can be isolated from Japanese yew Taxus. Taxuspine B exhibits appreciable taxol-like activity to reduce CaCl2-induced depolymerixation of microtubules among the taxoids.
|
-
- HY-N9561
-
|
Vanicoside B
|
CDK
STAT
|
Cancer
|
|
Vanicoside B is a phenylpropanoyl sucrose derivative, can be isolated from the herb Persicaria dissitiflora. Vanicoside B targets cyclin-dependent kinase 8 (CDK8) and exhibits anti-tumor activity. The potential mechanism is Vanicoside B blocks CDK8-mediated signaling pathways and decreases the expression of epithelial-mesenchymal transition proteins, so that it leads to cell cycle arrest and apoptosis.
|
-
- HY-106783
-
|
Polymyxin B nonapeptide
|
Bacterial
Antibiotic
|
Infection
|
|
Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.
|
-
- HY-151209
-
-
- HY-150557
-
-
- HY-139561
-
-
- HY-N9077
-
-
- HY-138098
-
|
Sartorypyrone B
|
Others
|
Cancer
|
|
Sartorypyrone B is a 2β-acetoxyl analogue of chevalone C. Sartorypyrone B is yielded from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213). Sartorypyrone B exhibits strong growth inhibitory activity, having GI50s of 17.8, 20.5, and 25.0 μM, respectively, for MCF-7, NCI-H460, and A375-C5. Sartorypyrone B has the potential for the research of breast adenocarcinoma, non-small cell lung cancer, and melanoma diseases.
|
-
- HY-N11640
-
-
- HY-146691
-
|
hMAO-B-IN-2
|
Monoamine Oxidase
|
Neurological Disease
|
|
hMAO-B-IN-2 (compound 6j) is an orally active, potent, selective and BBB penetrated and competitive reversible hMAO-B inhibitor, with an IC50 of 4 nM. hMAO-B-IN-2 shows low toxicity and good neuroprotective effects in SH-SY5Y cell. hMAO-B-IN-2 can be used for alzheimer’s disease research.
|
-
- HY-118207
-
|
LU-32-176B
|
GABA Receptor
|
Cancer
|
|
LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively.
|
-
- HY-W011900S
-
-
- HY-112790
-
-
- HY-N8092
-
-
- HY-116213
-
-
- HY-N7765
-
-
- HY-150558
-
-
- HY-152196
-
-
- HY-77113
-
|
B-Raf IN 11
|
Raf
|
Cancer
|
|
B-Raf IN 11 (ZINC72115182) is a selective B-Raf V600E inhibitor (IC50=76 nM), shows selectivity for B-Raf V600E over B-Raf WT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research
|
-
- HY-144718
-
|
PTP1B-IN-17
|
Phosphatase
|
Metabolic Disease
|
|
PTP1B-IN-17 (Compound 45), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 30.2 μM. PTP1B-IN-17 can be used for the research of type 2 diabetes.
|
-
- HY-144716
-
|
PTP1B-IN-19
|
Phosphatase
|
Metabolic Disease
|
|
PTP1B-IN-19 (Compound 43), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 23.3 μM. PTP1B-IN-19 can be used for the research of type 2 diabetes.
|
-
- HY-144713
-
|
PTP1B-IN-16
|
Phosphatase
|
Metabolic Disease
|
|
PTP1B-IN-16 (Compound 46), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 12.6 μM. PTP1B-IN-16 can be used for the research of type 2 diabetes.
|
-
- HY-144717
-
|
PTP1B-IN-18
|
Phosphatase
|
Metabolic Disease
|
|
PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research.
|
-
- HY-P3510
-
-
- HY-101799
-
-
- HY-132907
-
-
- HY-122615B
-
-
- HY-122615A
-
-
- HY-N0307
-
|
Ciwujianoside B
|
Bcl-2 Family
|
Neurological Disease
|
|
Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory.
Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of Bax/Bcl-2 in bone marrow cells exposed to radiation.
|
-
- HY-117359
-
|
UCD38B hydrochloride
|
PAI-1
Apoptosis
|
Cancer
|
|
UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis.
|
-
- HY-N8148
-
-
- HY-N4249
-
-
- HY-N2171
-
-
- HY-N2250
-
-
- HY-N6897
-
-
- HY-N1145
-
-
- HY-N6922
-
-
- HY-N0266
-
-
- HY-152111
-
-
- HY-N4219
-
-
- HY-N2223
-
-
- HY-N1514
-
|
Ganoderenic acid B
|
P-glycoprotein
|
Cancer
|
|
Ganoderenic acid B is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid B exhibits potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to Doxorubicin.
|
-
- HY-N10913
-
-
- HY-N0511
-
|
Aristolochic acid B
|
Others
|
Cancer
|
|
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo.
|
-
- HY-120501
-
|
B022
|
NF-κB
|
Inflammation/Immunology
|
|
B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki of 4.2 nM; IC50=15.1 nM). B022 protects liver from toxin-induced inflammation, oxidative stress, and injury.
|
-
- HY-P0242
-
-
- HY-137175A
-
-
- HY-B0315S
-
-
- HY-147255A
-
|
(S)-Canocapavir
(S)-ZM-H1505R
|
Others
|
Infection
|
|
(S)-Canocapavir is the isomer of Canocapavir (HY-147255A). Canocapavir (ZM-H1505R) has orally antiviral activity. Canocapavir is a HBV capsid inhibitor that can be used in the research of Chronic hepatitis B.
|
-
- HY-P1114A
-
|
2B-(SP) (TFA)
|
GSK-3
|
Cancer
|
|
2B-(SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3.
|
-
- HY-N6690
-
|
Destruxin B
|
Bcl-2 Family
Caspase
Apoptosis
|
Cancer
Infection
|
|
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo.
|
-
- HY-P3511
-
-
- HY-A0040
-
-
- HY-P9952
-
|
Belimumab
LymphoStat B
|
TNF Receptor
|
Inflammation/Immunology
|
|
Belimumab (LymphoStat B) is a human IgG1λ monoclonal antibody that inhibits B-cell activating factor (BAFF). Belimumab can be used for systemic lupus erythematosus (SLE) research.
|
-
- HY-N7439
-
|
Mogroside VI B
|
PGC-1α
|
Metabolic Disease
|
|
Mogroside VI B, a cucurbitane glucoside, separated from the crude extract of Siraitia grosvenorii. Mogroside VI B shows effect on activating PGC-1α transcription.
|
-
- HY-115718B
-
|
PZ703b hydrochloride
|
PROTACs
Apoptosis
|
Cancer
|
|
PZ703b hydrochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b hydrochloride can be used for the research of bladder cancer research.
|
-
- HY-108518
-
-
- HY-115718
-
|
PZ703b
|
PROTACs
|
Cancer
|
|
PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research.
|
-
- HY-N2016
-
|
Arteannuin B
|
SARS-CoV
Ferroptosis
|
Infection
|
|
Arteannuin B co-occurs with artemisinin, which is the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae). Arteannuin B shows anti-SARS-CoV-2 potential with an EC50 of 10.28 μM.
|
-
- HY-N7045
-
|
Isosilybin B
|
Androgen Receptor
Apoptosis
|
Cancer
|
|
Isosilybin B, a flavonolignan isolated from Silybum marianum, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation.
|
-
- HY-N1504
-
|
Loureirin B
|
PAI-1
Potassium Channel
ERK
JNK
|
Metabolic Disease
|
|
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
|
-
- HY-P1178A
-
|
Cyclotraxin B TFA
|
Trk Receptor
|
Neurological Disease
|
|
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced TrkB activity with an IC50 of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects.
|
-
- HY-B0143
-
|
Niacin
Nicotinic acid; Vitamin B3
|
Autophagy
Endogenous Metabolite
|
Cancer
Metabolic Disease
Cardiovascular Disease
|
|
Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases.
|
-
- HY-152118
-
|
CYP1B1-IN-4
|
Cytochrome P450
|
Cancer
|
|
CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes.
|
-
- HY-147830
-
-
- HY-18227
-
|
B-Raf IN 1
|
Raf
|
Cancer
|
|
B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.
|
-
- HY-107314
-
-
- HY-N10684
-
-
- HY-P0241
-
-
- HY-N8182
-
-
- HY-N7977
-
-
- HY-136339
-
-
- HY-N5135
-
|
Liriopesides B
Nolinospiroside F
|
Others
|
Others
|
|
Liriopesides B (Nolinospiroside F) is a steroidal saponin isolated from Ophiopogon japonicas. Liriopesides B has anti-oxidative and anti-aging effects.
|
-
- HY-B0315
-
-
- HY-N10219
-
|
Dihydroaltenuene B
|
Tyrosinase
Fungal
|
Infection
|
|
Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC50 of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase.
|
-
- HY-N7330
-
|
Integracin B
|
HIV Integrase
HIV
|
Infection
|
|
Integracin B is a potent dimeric alkyl aromatic inhibitor of HIV-1 integrase discovered from the screening of fungal extracts using an in vitro assay. Integracin B inhibits both coupled and strand transfer activity of HIV-1 integrase.
|
-
- HY-N11646
-
|
Ganorbiformin B
|
Bacterial
|
Infection
|
|
Ganorbiformin B is a lanostane triterpenoid. Ganorbiformin B shares the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T exhibits potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra.
|
-
- HY-N2099
-
|
Onjisaponin B
|
Autophagy
|
Neurological Disease
|
|
Onjisaponin B is a natural product derived from Polygala tenuifolia. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease.
|
-
- HY-16928
-
|
Cytochalasin B
Phomin
|
Arp2/3 Complex
|
Cancer
|
|
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.
|
-
- HY-P1339
-
-
- HY-N6786S
-
|
Ochratoxin B-13C20
|
Isotope-Labeled Compounds
|
Cancer
|
|
Ochratoxin B- 13C20 is 13C-labeled Ochratoxin B (HY-N6786). Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents.
|
-
- HY-149984
-
|
MAO-B-IN-21
|
Monoamine Oxidase
|
Inflammation/Immunology
Neurological Disease
|
|
MAO-B-IN-21 is an excellent MAO-B inhibitor with antioxidant activity and anti-Aβ aggregation activity. MAO-B-IN-21 also exhibits metal-ion chelating ability, anti-neuroinflammation (NO, TNF-α), neuroprotective activity and BBB permeability. MAO-B-IN-21 significantly improves the memory and cognitive impairment in Aβ1-42 induced Alzheimer's disease mice model.
|
-
- HY-N6730
-
-
- HY-142830
-
|
B-Raf IN 6
|
Raf
|
Cancer
|
|
B-Raf IN 6 (compound 2c) is a potent inhibitor of protein kinase B-Raf with an IC50 of 1.7 nM. B-Raf IN 6 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease.
|
-
- HY-N0333
-
-
- HY-N0029
-
|
Forsythoside B
|
TNF Receptor
NF-κB
|
Inflammation/Immunology
|
|
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB.
|
-
- HY-N2947
-
|
Boeravinone B
|
P-glycoprotein
|
Infection
Inflammation/Immunology
|
|
Boeravinone B, a dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress.
|
-
- HY-N6861
-
|
Lucidenic acid B
|
Apoptosis
|
Cancer
|
|
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells.
|
-
- HY-104047
-
-
- HY-139306
-
|
BAMEA-O16B
|
Liposome
|
Inflammation/Immunology
|
|
BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing.
|
-
- HY-P1774
-
-
- HY-117468
-
|
Lissamine rhodamine B
|
Fluorescent Dye
|
Others
|
|
Lissamine rhodamine B is a red-fluorescent dye, it is a derivative of rhodamine. Lissamine rhodamine B can be used as a fluorescent probe to develop competitive aptamer fluorescence anisotropy/polarization (FA/FP) assays.
|
-
- HY-129545
-
-
- HY-N0247
-
|
Saikosaponin B1
|
Smo
|
Cancer
|
|
Saikosaponin B1 is a bioactive constituent of Radix Bupleuri with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in Medulloblastoma (MB) model by inhibiting the Hedgehog pathway through targeting SMO.
|
-
- HY-N6719S
-
|
Fumonisin B1-13C34
|
Isotope-Labeled Compounds
|
Infection
|
|
Fumonisin B1- 13C34 is the 13C labeled Fumonisin B1 (HY-N6719). Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin.
|
-
- HY-147854
-
|
B-Raf IN 9
|
Raf
Apoptosis
|
Cancer
|
|
B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC50 of 7.83 µM.
|
-
- HY-N2865
-
-
- HY-N3731
-
-
- HY-N6916
-
-
- HY-115689
-
-
- HY-N10875
-
-
- HY-N4135
-
-
- HY-N7620
-
-
- HY-N10444
-
-
- HY-18219
-
-
- HY-P0092
-
-
- HY-N1257
-
-
- HY-N2088
-
-
- HY-126246
-
|
CDC25B-IN-1
|
Phosphatase
|
Cancer
|
|
CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase.
|
-
- HY-115687
-
-
- HY-N0366
-
|
Sennoside B
|
PDGFR
|
Cancer
|
|
Sennoside B is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia). Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway.
|
-
- HY-125664
-
|
Lucialdehyde B
|
Antibiotic
|
Cancer
|
|
Lucialdehyde B is a tetracyclic triterpene isolated from the substrates of Ganoderma lucidum with antiviral and cytotoxic activities. Lucialdehyde B has cytotoxic effects against Lewis lung cancer (LLC), T-47D, Sarcoma 180 and Meth-A tumor cell lines.
|
-
- HY-149086
-
|
BPA-B9
|
RAR/RXR
Apoptosis
PARP
Bcl-2 Family
|
Cancer
|
|
BPA-B9 is a RXRα ligand and antagonist targeting the pRXRα-PLK1 interaction. BPA-B9 has excellent RXRα-binding affinity (KD=39.29 ± 1.12 nM). BPA-B9 inhibits the proliferation of cancer cells by inducing mitotic arrest and cell apoptosis.
|
-
- HY-N8498
-
|
GKK1032B
|
Apoptosis
|
Cancer
|
|
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation.
|
-
- HY-P4038
-
|
Hepatitis C Virus S5A/5B
|
HCV Protease
|
Infection
|
|
Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity.
|
-
- HY-146393
-
|
PROTAC CYP1B1 degrader-1
|
PROTACs
Cytochrome P450
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Cancer
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PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated agent resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer.
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- HY-N1435
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Oroxin B
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Apoptosis
PI3K
PTEN
Autophagy
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Cancer
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Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent.
Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT.
Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells.
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- HY-15133A
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- HY-151388
-
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hMAO-B/MB-COMT-IN-1
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Monoamine Oxidase
COMT
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Neurological Disease
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hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-1 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).
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- HY-151390
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hMAO-B/MB-COMT-IN-2
|
Monoamine Oxidase
COMT
|
Neurological Disease
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hMAO-B/MB-COMT-IN-2 is a dual MAO-B/MB-COMT inhibitor (IC50s: 4.27 μΜ for hMAO-B, 2.69 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-2 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-2 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).
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- HY-122959
-
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Kihadanin B
|
Akt
PPAR
|
Metabolic Disease
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Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
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- HY-N10624
-
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Koshidacin B
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Parasite
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Infection
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Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection.
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- HY-146081
-
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CD22 ligand-1
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CD22
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Cancer
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CD22 ligand-1 (compound 12) is a potent and selective CD22 ligand with KD of 0.335, 30.7 µM for hCD22 and MAG, respectively. CD22 ligand-1 has the potential for the research of B-cell related disease.
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- HY-N0639
-
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Punicalin
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HBV
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Infection
Inflammation/Immunology
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Punicalin is a hydrolyzable tannin isolated from Punica granatum L. or the leaves of Terminalia catappa L.. Punicalin is a anti-hepatitis B virus (HBV) agent and has anti-inflammatory activity.
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- HY-15308
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- HY-18299B
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(S)-Purvalanol B
(S)-NG 95
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Others
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Others
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(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is a cyclin-dependent kinase inhibitor.
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- HY-N9540
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- HY-W127711
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Fast Blue B Salt
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Fluorescent Dye
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Others
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Fast Blue B Salt is a coloring agent that dissolves fats and phenolic compounds extracted from rye, as well as diazonium. Fast Blue B Salt can be used for the semiquantification of alkylresorcinols in rye and produces a color precipitate in the presence of acetone.
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- HY-102090
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- HY-N3747
-
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- HY-N3367
-
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- HY-N10242
-
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- HY-N11046
-
-
- HY-N10389
-
-
- HY-N9758
-
-
- HY-N5008
-
-
- HY-N4124
-
-
- HY-N11453
-
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- HY-126484
-
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Eremofortin B
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Others
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Others
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Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT).
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- HY-N0874
-
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- HY-N10813
-
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- HY-N10745
-
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Angulatin B
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Others
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Others
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Angulatin B is a natural product that can be found in the root bark of Celastrus angulatus.
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- HY-N11546
-
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Sapindoside B
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Others
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Others
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Sapindoside B is a natural product that can be isolated from the leaves of Acanthopanax sieboldianus.
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- HY-N10778
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(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol
|
Others
|
Others
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(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol is a cucurbitane-type triterpenoid. (19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol has been tested to no effect against 5 cancer cell lines, MCF-7, HepG2, Du145, Colon205 and HL-60 by MTT assay.
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- HY-113420
-
-
- HY-15756
-
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PTP1B-IN-4
|
Phosphatase
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Metabolic Disease
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PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes.
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- HY-N10845
-
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- HY-112611
-
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H3B-5942
|
Estrogen Receptor/ERR
|
Cancer
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H3B-5942 is a selective, irreversible and orally active estrogen receptor covalent antagonist, inactivates both wild-type and mutant ERα by targeting Cys530, with Kis of 1 nM and 0.41 nM, respectively. H3B-5942 reduces ERα target gene GREB1, shows potent antitumor activity both in multiple cell lines or animals bearing ERα WT or ERα mutations.
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- HY-103158
-
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BW B70C
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Lipoxygenase
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Others
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BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent.
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- HY-N0505
-
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- HY-106783A
-
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Polymyxin B nonapeptide TFA
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Bacterial
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Infection
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Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.
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- HY-108431
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MN58b
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Apoptosis
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Cancer
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MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity.
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- HY-N6731
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Hydrolyzed Fumonisin B2
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Others
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Infection
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Hydrolyzed Fumonisin B2 (HFB2) is a hydrolysis product of fumonisins (HF), which retains biological activity. Hydrolyzed Fumonisin B2 (HFB2) exhibits phytotoxicity.
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- HY-N1362
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Salvianolic acid B
Lithospermic acid B
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Autophagy
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Cardiovascular Disease
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Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.
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- HY-N10281
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Asperglaucin B
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Bacterial
|
Infection
|
|
Asperglaucin B is an alkylated salicylaldehyde derivative from the fungus Aspergillus chevalieri SQ-8, with antibacterial activities. Asperglaucin B displays potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM.
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- HY-W013935
-
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Bisphenol B
|
Endogenous Metabolite
|
Endocrinology
|
|
Bisphenol B is a very close structural analog of Bisphenol A (HY-18260), an endocrine disrupting chemical (EDC) and a substance of very high concern (SVHC) in the European Union (EU) for both human health. Bisphenol B shows endocrine disruptive properties or other adverse effects on animal models.
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- HY-139641
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- HY-139600
-
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KDM2B-IN-3
|
Histone Demethylase
|
Cancer
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KDM2B-IN-3 is a histone demethylase KDM2B inhibitor extracted from patent WO2016112284A1, compound 183c. KDM2B-IN-3 can be used for the research of cancer.
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- HY-129357
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- HY-117289
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- HY-N2218
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- HY-B0490
-
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- HY-W017086S
-
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- HY-N6726S
-
-
- HY-108575
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- HY-151259
-
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TK4b
|
JAK
|
Cancer
|
|
TK4b is a Janus kinase (JAK) inhibitor with the IC50 values of 19.40 nM and 18.42 nM for JAK2 and JAK3, respectively. TK4b can be used in lymphoid-derived diseases and leukemia cancer research.
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- HY-N0416
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-
- HY-N2234
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- HY-N10422
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Aloenin B
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Others
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Others
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Aloenin B (Compound 16) is a compound isolated from the leaves and roots of Aloe hijazensis.
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- HY-141858
-
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Lynamicin B
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Others
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Others
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Lynamicin B is a potential pesticide by acting as a lepidoptera-exclusive chitinase inhibitor with a Ki value of 8.76 μM.
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- HY-107245
-
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- HY-N2605
-
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- HY-N0805A
-
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Alisol B
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Others
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Metabolic Disease
|
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Alisol B is a potentially novel therapeutic compound for bone disorders by targeting the differentiation of osteoclasts as well as their functions.
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- HY-131099
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Enduracidin B
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Antibiotic
|
Infection
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Enduracidin B is a major component of Enduracidin. Enduracidin is a polypeptide antibiotic produced by Streptomyces fungicides.
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- HY-N2634
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Uvarigranol B
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Others
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Others
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Uvarigranol B, a polyoxygenated cyclohexene, is obtained from the roots of Uvaria grandiflora Roxb (Annonaceae).
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- HY-N9390
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- HY-N10747
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- HY-N3322
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Maoecrystal B
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Others
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Others
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Maoecrystal B is a diterpenoids compound isolated from the leaves of Isodon eriocalyx var. laxiflora.
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- HY-N10286
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- HY-N5052
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- HY-N7903
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- HY-143245
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Monoamine Oxidase B inhibitor 2
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Monoamine Oxidase
|
Neurological Disease
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Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active and selective monoamine oxidase B (MAO-B) inhibitor with an IC50 of 1.33 nM. Monoamine Oxidase B inhibitor 2 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 2 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study.
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- HY-143244
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Monoamine Oxidase B inhibitor 1
|
Monoamine Oxidase
|
Neurological Disease
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Monoamine Oxidase B inhibitor 1 is a potent, reversible, orally active and selective monoamine oxidase B (MAO-B) inhibitor with an IC50 of 0.02 nM. Monoamine Oxidase B inhibitor 1 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 1 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study.
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- HY-145426
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MPT0B390
|
HDAC
|
Cancer
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MPT0B390 is an arylsulfonamide-based derivative with potent HDAC inhibitory ability. MPT0B390, TIMP3 inducer, inhibits tumor growth, metastasis and angiogenesis. MPT0B390 shows antiproliferative activity against human colon cancer cell line HCT116 with the GI50 of 0.03 μM.
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- HY-139640
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- HY-17578
-
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Pneumocandin B0
L-688786
|
Fungal
Antibiotic
|
Infection
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|
Pneumocandin B0(L-688786), a key intermediate in the synthesis of the antifungal agent, Cancidas, has led to the identification of several materials with potential for improved performance.
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- HY-139560
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- HY-N7384A
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- HY-N10153
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Safflor yellow B
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Others
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Neurological Disease
|
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Safflor yellow B suppresses angiotensin II-mediated human umbilical vein cell injury via regulation of Bcl-2/p22(phox) expression. Safflor yellow B exhibits neuroprotective effects.
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- HY-P0242A
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- HY-148870
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Maytansinoid B
|
ADC Cytotoxin
|
Cancer
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Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis.
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- HY-N2438
-
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Methylophiopogonanone B
|
Ras
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Others
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Methylophiopogonanone B, homoisoflavonoid, is extracted from the root of Ophiopogon japonicas, shows high antioxidant ability. Methylophiopogonanone B increases GTP-Rho and acts via the Rho signaling pathway, inducing cell morphological change via actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation.
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- HY-P3362
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Ac-IETD-AMC
|
Fluorescent Dye
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Others
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Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity.
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- HY-112336
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- HY-107400
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B I09
|
IRE1
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Cancer
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B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.
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- HY-D0259
-
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Erythrosine B
Erythrosin extra bluish
|
Fluorescent Dye
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Others
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Erythrosine B is an artificial dye widely used in the food and textile industries. Erythrosine B is also a novel photosensitizer which has been used to develop animal models.
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- HY-N2124
-
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Parishin B
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Others
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Cancer
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Parishin B, a parishin derivative isolated from Gastrodia elata, may have antioxidant property.
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- HY-N6819
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- HY-N3570
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Cerebroside B
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Fungal
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Infection
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Cerebroside B, a sphingolipid compound, is a non-racespecific elicitor, which elicits defense responses in rice.
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- HY-N8399
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- HY-N11452
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Cernuoside B
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Others
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Others
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Cernuoside B is a natural triterpenoid saponin that can be isolated from the roots of Pulsatilla koreana Nakai.
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- HY-116151B
-
-
- HY-N10585
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- HY-137787
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-
- HY-131054
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- HY-N2944
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Blumenol B
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Others
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Others
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Blumenol B, a C13 nor-isoprenoid, can be isolated from the leaves of Casearia sylvestris.
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- HY-P1751
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Ceratotoxin B
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Bacterial
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Infection
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Ceratotoxins B is antibacterial peptide produced by the sexually mature females of Ceratitis capitata. Lytic and antibacterial activity .
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- HY-125706
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-
- HY-P2009
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-
- HY-146312
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-
- HY-N6256
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- HY-122675
-
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ACG416B
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Others
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Cancer
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ACG416B (compound 18) is a potent inhibitor of ChoK (choline kinase) with an IC50 of 0.4 μM. ACG416B renders higher ChoK inhibitory and antiproliferative activities against the HT-29 human colon cancer cell.
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- HY-135646
-
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Eleutheroside B1
|
Influenza Virus
|
Infection
Inflammation/Immunology
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Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities.
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- HY-P9929
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-
- HY-152114
-
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AChE/BChE/MAO-B-IN-4
|
Monoamine Oxidase
Cholinesterase (ChE)
|
Neurological Disease
|
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AChE/BChE/MAO-B-IN-4, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC50 of 0.0393 μM for human MAO-B. AChE/BChE/MAO-B-IN-4 is a potent AChE and BChE enzyme inhibitor, with IC50s of 0.0458 μM and 0.075 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-4 shows significant antioxidant activity and prevent β-amyloid plaque aggregation. AChE/BChE/MAO-B-IN-4 has the potential for Alzheimer's disease (AD) research.
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- HY-145370
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-
- HY-144636
-
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Atg4B-IN-2
|
Cathepsin
Phospholipase
Autophagy
|
Cancer
|
|
Atg4B-IN-2 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition.
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- HY-129995
-
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TSHR antagonist S37b
|
TSH Receptor
|
Endocrinology
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TSHR antagonist S37b is the less effective enantiomer of TSHR antagonist S37a (HY-129995A). TSHR antagonist S37b shows only a minor effect for thyrotropin receptor (TSHR) inhibition. TSHR antagonist S37b can be used for the research of thyroid function.
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- HY-N3489
-
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Isodihydrofutoquinol B
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Others
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Neurological Disease
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Isodihydrofutoquinol B (compound 9), an active compound, can be isolated from the stems of Piper kadsura (Choisy) Ohwi. Isodihydrofutoquinol B has A neuroprotective effect on Aβ25-35-induced PC12 cell damage with E50 values of 3.06-29.3μM.
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- HY-145845
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HDAC1/MAO-B-IN-1
|
HDAC
Monoamine Oxidase
|
Neurological Disease
|
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HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease.
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- HY-N9351
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-
- HY-N6868
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-
- HY-112596A
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-
- HY-112596
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H3B-6545
|
Estrogen Receptor/ERR
|
Cancer
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H3B-6545 is an oral, selective estrogen receptor covalent antagonist (SERCA) for the research of metastatic ER-positive, HER2-negative breast cancer.
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- HY-N2393
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-
- HY-N1432
-
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Lirioprolioside B
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Others
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Cancer
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Lirioprolioside B is a steroidal glycoside that can be isolated from the underground organs of Liriope spicata var. prolifera.
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- HY-N10892
-
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Officinaruminane B
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Others
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Others
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Officinaruminane B (compound 2), a diarylheptanoid, is a nature product that could be isolated from the rhizome of Alpinia officinarum.
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-
- HY-146337
-
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Dyrk1A/B-IN-1
|
DYRK
|
Cancer
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|
Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable DYRK1A and DYRK1B inhibitor with Kis of 67.8 nM and 237.9 nM, and IC50s of 1.1 μM and 0.8 μM, respectively. Dyrk1A/B-IN-1 is not toxic to human cells. Dyrk1A/B-IN-1 can be used for researching DYRK1A and DYRK1B cellular functions and their role in pathologies.
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-
- HY-152113
-
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AChE/BChE/MAO-B-IN-3
|
Monoamine Oxidase
Cholinesterase (ChE)
|
Neurological Disease
|
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AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC50 of 0.0359 μM for human MAO-B. AChE/BChE/MAO-B-IN-3 is a potent AChE and BChE enzyme inhibitor, with IC50s of 0.0473 μM and 0.0782 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-3 shows significant antioxidant activity and has the potential for Alzheimer's disease (AD) research.
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- HY-147002
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-
- HY-100944
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-
- HY-N7893
-
-
- HY-113380
-
-
- HY-122140
-
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ACG548B
|
Cholinesterase (ChE)
|
Neurological Disease
|
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ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase).
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- HY-W127703
-
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Octadecyl Rhodamine B chloride
|
Fluorescent Dye
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Others
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Octadecyl Rhodamine B chloride is a cationic amphiphile that can be used for staining cell membranes. Octadecyl Rhodamine B chloride can be used in numerous studies including electronic energy transfer in organized molecular assemblies, membrane structure, and distances of closest approach between protein domains and membranes.
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- HY-12054
-
|
Hesperadin
|
Aurora Kinase
Autophagy
Influenza Virus
Parasite
|
Cancer
|
|
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral.
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-
- HY-N7761
-
|
Trijuganone B
Tetrahydro tanshinone I
|
Others
|
Cancer
|
|
Trijuganone B (Tetrahydro tanshinone I) can be extracted from from the roots of Salvia miltiorrhiza f. alba. Trijuganone B inhibits the proliferation of leukemia cells.
|
-
- HY-N1009
-
-
- HY-100241
-
-
- HY-W009006
-
-
- HY-101585
-
-
- HY-U00321
-
-
- HY-120994A
-
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Rp-8-CPT-cAMPS
|
PKA
|
Inflammation/Immunology
Neurological Disease
|
|
Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI.
|
-
- HY-120994
-
-
- HY-150583
-
|
Chitin synthase inhibitor 2
|
Fungal
Antibiotic
|
Inflammation/Immunology
|
|
Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B.
|
-
- HY-P1339A
-
-
- HY-147261
-
|
B026
|
Histone Acetyltransferase
|
Cancer
|
|
B026 is a selective, potent, orally active p300/CBP histone acetyltransferase (HAT) inhibitor with IC50 values of 1.8 nM and 9.5 nM for p300 and CBP enzyme, respectively. B026 has anticancer activity for androgen receptor-positive (AR+) prostate cancer cell lines.
|
-
- HY-W127709
-
|
Chlorophyll b
|
Biochemical Assay Reagents
|
Others
|
|
Chlorophyll b is decomposed by chlorophyllase to form pheophytin b. This causes its color to change from green to olive brown. It is involved in the harvesting of light energy and its subsequent conversion into chemical energy during photosynthesis. Along with chlorophyll a, it plays a key role in the ability of plants to adapt to varying light intensities. The visible spectrum that is not absorbed when only chlorophyll a is present in the LHC.
|
-
- HY-N7695
-
|
Physalin B
|
Apoptosis
Autophagy
|
Cancer
|
|
Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro.
|
-
- HY-108417
-
|
Debio 0617B
|
STAT
JAK
Bcr-Abl
|
Cancer
|
|
Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34 + stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors.
|
-
- HY-105118A
-
|
Zaldaride maleate
CGS-9343B; KW 5617
|
nAChR
|
Metabolic Disease
Inflammation/Immunology
Neurological Disease
|
|
Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na +, Ca 2+ and K + currents in PC12 cells and inhibits nAChR.
|
-
- HY-N6013
-
|
Aloin(mixture of A&B)
|
MMP
Bacterial
Fungal
|
Cancer
Infection
Inflammation/Immunology
|
|
Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases (MMPs).
|
-
- HY-N8167
-
|
Plantanone B
Kaempferol 3-O-rhamnosylgentiobioside
|
COX
|
Inflammation/Immunology
|
|
Plantanone B is a moderate antioxidant-agent with an IC50 of 169.8±5.2 μM. Plantanone B shows significant ovine COX-1 and moderate COX-2 inhibitory activities. Plantanone B has the potential for inflammation-related diseases research.
|
-
- HY-N10419
-
|
Cannabisin B
|
Others
|
Others
|
|
Cannabisin B (Compound 7) is a compound isolated from the aerial part of Tetragonia tetragonioides (New Zealand spinach).
|
-
- HY-N11436
-
-
- HY-R01567
-
|
hsa-miR-518b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-518b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00168
-
|
hsa-miR-1260b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-1260b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04219
-
|
rno-miR-122b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-122b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02680
-
|
mmu-miR-145b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-145b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01140
-
|
hsa-miR-451b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-451b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04456
-
|
rno-miR-409b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-409b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03154
-
|
mmu-miR-451b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-451b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00605
-
|
hsa-miR-3155b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-3155b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01760
-
|
hsa-miR-5681b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-5681b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01083
-
|
hsa-miR-4477b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4477b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04221
-
|
rno-miR-126b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-126b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01221
-
|
hsa-miR-4662b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4662b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00253
-
|
hsa-miR-133b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-133b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00845
-
|
hsa-miR-378b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-378b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02778
-
|
mmu-miR-195b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-195b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04439
-
|
rno-miR-3596b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-3596b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02843
-
|
mmu-miR-21b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-21b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04320
-
|
rno-miR-291b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-291b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01628
-
|
hsa-miR-544b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-544b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04450
-
|
rno-miR-378b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-378b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02860
-
|
mmu-miR-28b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-28b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02505
-
|
hsa-miR-892b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-892b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00304
-
|
hsa-miR-151b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-151b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01985
-
|
hsa-miR-663b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-663b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03066
-
|
mmu-miR-3473b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-3473b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00180
-
|
hsa-miR-1268b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-1268b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02763
-
|
mmu-miR-1946b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-1946b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04346
-
|
rno-miR-31b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-31b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00182
-
|
hsa-miR-1269b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-1269b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04310
-
|
rno-miR-218b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-218b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03147
-
|
mmu-miR-449b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-449b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00673
-
|
hsa-miR-320b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-320b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02676
-
|
mmu-miR-142b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-142b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03114
-
|
mmu-miR-378b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-378b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03227
-
|
mmu-miR-496b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-496b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03230
-
|
mmu-miR-497b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-497b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03062
-
|
mmu-miR-3470b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-3470b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01229
-
|
hsa-miR-4666b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4666b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01772
-
|
hsa-miR-5692b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-5692b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02503
-
|
hsa-miR-891b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-891b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00574
-
|
hsa-miR-3135b mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-3135b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04391
-
|
rno-miR-3556b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-3556b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04580
-
|
rno-miR-7b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-7b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04268
-
|
rno-miR-191b mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-191b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04173
-
|
mmu-miR-873b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-873b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03269
-
|
mmu-miR-5124b mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-5124b mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-150532S
-
-
- HY-100312
-
-
- HY-N6726
-
-
- HY-N0947
-
-
- HY-148059
-
|
B-Raf IN 10
|
Raf
|
Cancer
|
|
B-Raf IN 10 (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. B-Raf IN 10 shows antitumor activity.
|
-
- HY-N5044
-
-
- HY-N0082
-
-
- HY-N6615
-
|
Aflatoxin B1
|
Bacterial
Endogenous Metabolite
Parasite
|
Cancer
Infection
|
|
Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation.
|
-
- HY-B2209A
-
|
Hydroxocobalamin monohydrochloride
Vitamin B12a monohydrochloride
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia.
|
-
- HY-N0089
-
-
- HY-N6784
-
-
- HY-N10386
-
-
- HY-100272
-
|
B220
|
HSV
CMV
|
Cancer
Infection
|
|
B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV).
|
-
- HY-123903
-
|
Tanshindiol B
|
Others
|
Cancer
|
|
Tanshindiol B, a naphthaquinone diterpene, inhibits GBM growth by induction of noptosis (NQO1-dependent necrosis).
|
-
- HY-N0732
-
|
Jolkinolide B
|
Apoptosis
|
Cancer
|
|
Jolkinolide B, a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud, is known to induce apoptosis in cancer cells.
|
-
- HY-N8783
-
|
Kuwanon B
|
Others
|
Others
|
|
Kuwanon B is a flavone derivative that can be found in the root bark of the cultivated mulberry tree (a variety of Morus alba L.).
|
-
- HY-113262
-
-
- HY-120994B
-
|
Sp-8-CPT-cAMPS
|
PKA
|
Inflammation/Immunology
Neurological Disease
|
|
Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold.
|
-
- HY-N9814
-
|
Shanciol B
|
NO Synthase
|
Inflammation/Immunology
|
|
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity. Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity.
|
-
- HY-N10648
-
|
PTP1B-IN-20
|
Phosphatase
|
Metabolic Disease
|
|
PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM), which is a key target for type 2 diabetes inhibition.
|
-
- HY-N10649
-
|
PTP1B-IN-21
|
Phosphatase
|
Metabolic Disease
|
|
PTP1B-IN-21 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.56 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50>100 μM), which is a key target for type 2 diabetes inhibition.
|
-
- HY-147646
-
|
CDK1/Cyc B-IN-1
|
CDK
Apoptosis
|
Cancer
|
|
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines.
|
-
- HY-151885
-
|
Dual AChE-MAO B-IN-3
|
Cholinesterase (ChE)
Monoamine Oxidase
|
Neurological Disease
|
|
Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitior, with IC50 values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. Dual AChE-MAO B-IN-3 can be used for Alzheimer’s disease (AD) research.
|
-
- HY-N6615S
-
|
Aflatoxin B1-13C17
|
Isotope-Labeled Compounds
|
Cancer
|
|
Aflatoxin B1- 13C17 is 13C- and 15N-labeled Aflatoxin B1 (HY-N6615). Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation.
|
-
- HY-P1337
-
-
- HY-N8173
-
-
- HY-N0306
-
|
Hederasaponin B
|
Enterovirus
|
Infection
|
|
Hederasaponin B, isolated from Hedera helix, has broad-spectrum antiviral activity against various subgenotypes of Enterovirus 71 (EV71).
|
-
- HY-N8198
-
-
- HY-N2345
-
|
Procyanidin B3
|
Histone Acetyltransferase
|
Cancer
|
|
Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase).
|
-
- HY-N1535
-
|
Ponicidin
Rubescensine B
|
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3.
|
-
- HY-121519
-
|
GSK2332255B
|
TRP Channel
|
Cardiovascular Disease
|
|
GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels.
|
-
- HY-120758
-
|
SEL24-B489
|
Pim
FLT3
Apoptosis
|
Cancer
|
SEL24-B489 is a potent, type I, orally active, dual PIM and FLT3-ITD inhibitor, with Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively.
|
-
- HY-103212
-
|
Azepexole dihydrochloride
B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride
|
Adrenergic Receptor
|
Endocrinology
Cardiovascular Disease
|
|
Azepexole (B-HT 933) dihydrochloride is a potent and selective alpha 2-adrenoceptor agonist with pKis of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC50= 78.72 nM).
|
-
- HY-P4051
-
-
- HY-N6723S
-
|
Fumonisin B2-13C34
|
Isotope-Labeled Compounds
|
Infection
|
|
Fumonisin B2- 13C34 is the 13C labeled Fumonisin B2 (HY-N6723). Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis.
|
-
- HY-152112
-
-
- HY-133247
-
-
- HY-N7940
-
-
- HY-B1916
-
|
Acetylspiramycin
Spiramycin B; Spiramycin II; Foromacidin B
|
Antibiotic
Bacterial
Parasite
|
Infection
|
|
Acetylspiramycin (Spiramycin B; Spiramycin II; Foromacidin B) is a potent and orally active macrolide antibiotic produced by various Streptomyces species, an acetylated derivative of Spiramycin (HY-100593). Acetylspiramycin is an antimicrobial agent with activity against gram-positive organisms, including Streptococcus pyogenes, S. viridans, Corynebacterium diphtheriae and methicillin-sensitive Staphylococcus aureus. Acetylspiramycin is also a potent antiprotozoal agent that against parasitic infection caused by Cryptosporidium spp.
|
-
- HY-137499
-
|
NT1-O12B
|
Liposome
Endogenous Metabolite
|
Neurological Disease
|
|
NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination.
|
-
- HY-151562
-
|
AChE/BuChE/MAO-B-IN-1
|
Cholinesterase (ChE)
Monoamine Oxidase
|
Neurological Disease
|
|
AChE/BuChE/MAO-B-IN-1 (compound 19) is an inhibitor of human acetyl- (hAChE), butyrylcholinesterase (hBuChE) and monoamine oxidase-B (hMAO-B) with IC50s of 4.8 μM, 13.7 μM, and 1.11 μM, respectively. AChE/BuChE/MAO-B-IN-1 also exhibits high affinity to both the σ1 and σ2 receptors with Ki values of 42.8 nM (human σ1 receptor) and 191 nM (rat σ2 receptor), respectively. AChE/BuChE/MAO-B-IN-1 can be used for Alzheimer’s disease research.
|
-
- HY-144740
-
|
NS2B/NS3-IN-5
|
Virus Protease
|
Infection
|
|
NS2B/NS3-IN-5 (Compound 25b) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.67 µM and 4.38 µM against ZIKV and DENV2 NS2B/NS3 proteases, respectively.
|
-
- HY-N0682
-
-
- HY-N4231
-
-
- HY-N0901A
-
|
Corynoxine B
|
Autophagy
|
Cancer
|
|
Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer.
|
-
- HY-N6672
-
-
- HY-N10061
-
-
- HY-W039112
-
-
- HY-114267
-
|
Cbz-B3A
|
mTOR
|
Others
|
|
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).
|
-
- HY-137067
-
|
IMT1B
LDC203974
|
DNA/RNA Synthesis
|
Cancer
|
|
IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects.
|
-
- HY-117800
-
|
BJE6-106
B106
|
PKC
Apoptosis
|
Cancer
Inflammation/Immunology
|
|
BJE6-106 (B106) is a potent, selective 3 rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.
|
-
- HY-U00304
-
-
- HY-145120
-
|
B-Raf IN 2
|
Raf
|
Cancer
|
|
B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. B-Raf IN 2 can be used for the research of cancer.
|
-
- HY-N11502
-
-
- HY-N2047
-
|
Jujuboside B1
|
Others
|
Others
|
|
Jujuboside B1, a dammarane-type triterpene oligoglycoside, is isolated from Ziziphi Spinosae Semen.
|
-
- HY-N9340
-
|
Hypoglaunine D
|
HIV
|
Infection
|
|
Hypoglaunine D is an analogue of Triptonine B and acts as an anti-HIV compound. Hypoglaunine D inhibits HIV replication in H9 lymphocytes with an EC50 value of 22 μg/ml.
|
-
- HY-B0221
-
-
- HY-N11540
-
|
Cnidioside B
|
Others
|
Others
|
|
Cnidioside B is a glycoside compound, which can be isolated from Leptothyrsa sprucei, C. monnieri and the ripe fruit of Cnidium monieri.
|
-
- HY-N10204
-
-
- HY-P2746
-
|
Carboxypeptidase B
EC 3.4.2.2
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Carboxypeptidase B is a peptide exonuclease that can specifically degrade peptide chains. Carboxypeptidase B is progressively degraded from the C-terminal to release free amino acids. Carboxypeptidase B hydrolyzes only peptide bonds with basic amino acids (such as arginine and lysine) as C-terminal residues.
|
-
- HY-145695
-
-
- HY-100683
-
|
A12B4C3
|
Phosphatase
|
Cancer
|
|
A12B4C3 is a potent human polynucleotide kinase/phosphatase (hPNKP) inhibitor with an IC50 value of 0.06 μM. A12B4C3 has antiproliferative activity against cancer cells. A12B4C3 can also enhance the radiosensitivity of certain cancer cells.
|
-
- HY-D1479
-
-
- HY-N0467
-
-
- HY-N5036
-
-
- HY-N8118
-
-
- HY-N8083
-
|
Icariside B1
|
Others
|
Cancer
|
|
Icariside B1 is a megastigmane glycoside compound isolated from Petasites tricholobus Franch, with an anticancer effect.
|
-
- HY-N11054
-
-
- HY-N4334
-
-
- HY-N3511
-
|
Triptonine B
|
HIV
|
Infection
|
|
Triptonine B, a sesquiterpene pyridine alkaloid, inhibits HIV replication in H9 lymphocytes with an EC50 value of <0.10 μg/mL.
|
-
- HY-P3461
-
|
Argadin
|
Parasite
|
Infection
|
|
Argadin is a cyclopentapeptide chitinase inhibitor. Argadin inhibits chitinase B (ChiB) with a Ki value of 20 nM. Argadin can be used for the research of fungicid and insecticid.
|
-
- HY-129390
-
|
Orelabrutinib
ICP-022
|
Btk
|
Cancer
|
|
Orelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK.
|
-
- HY-P3433
-
|
Sarafotoxin S6b
|
Endothelin Receptor
|
Cardiovascular Disease
|
|
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the Ki values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively.
|
-
- HY-111758
-
|
PROTAC B-Raf degrader 1
|
PROTACs
Raf
|
Cancer
|
|
PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity.
|
-
- HY-101287
-
|
MPT0B392
|
Microtubule/Tubulin
JNK
Apoptosis
Caspase
|
Cancer
|
|
MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line.
|
-
- HY-N5041
-
-
- HY-18683
-
-
- HY-N0479
-
|
Licarin B
(-)-Licarin B
|
PPAR
GLUT
|
Metabolic Disease
|
|
Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway.
|
-
- HY-139314
-
-
- HY-N4218
-
-
- HY-117601
-
-
- HY-126937
-
|
Ivermectin B1a
|
Parasite
SARS-CoV
|
Infection
|
|
Ivermectin B1a, a derivative of Avermectin B1a (HY-15308), is a main component of Ivermectin (HY-15310). Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19.
|
-
- HY-N2442
-
-
- HY-N10377
-
|
Anhuienoside B
|
Others
|
Others
|
|
Anhuienoside B is a natural product that can be isolated from the fresh leaves of C. anhuiensis K. F. Wu in response to abiotic stress elicitation by CuCl2.
|
-
- HY-120786
-
|
MPT0B014
6-(3′,4′,5′-Trimethoxybenzoyl)quinoline
|
Microtubule/Tubulin
Apoptosis
|
Cancer
|
|
MPT0B014 is a tubulin polymerization inhibitor. MPT0B014 induces cancer cell apoptosis. MPT0B014 can be used for the research of cancer.
|
-
- HY-P4046
-
|
HBV Seq2 aa:179-186
|
HIV
|
Inflammation/Immunology
|
|
HBV Seq2 aa:179-186 serve as effective motifs for CTL response in H-2b system after in vitro restimulation of the primed T cells. HBV Seq2 aa:179-186 is a novel epitope identified on the surface antigen of hepatitis B virus.
|
-
- HY-P0111
-
|
Z-WEHD-FMK
|
Caspase
Cathepsin
|
Cancer
|
|
Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis.
|
-
- HY-N4235
-
|
Angelol B
|
Others
|
Inflammation/Immunology
|
|
Angelol B is a coumarin isolated from the roots of Angelica pubescens f. biserrata, which is passive diffusion as the dominating process in Caco-2 cell monolayer model.
|
-
- HY-N4230
-
-
- HY-B2226
-
-
- HY-N2397
-
-
- HY-N11533
-
-
- HY-139623
-
-
- HY-125702
-
|
Pulsatilloside E
Chinensioside B
|
Others
|
Others
|
|
Pulsatilloside E (Chinensioside B) is a triterpenoidal saponin isolated from the roots of Pulsatilla chinensis (Ranunculaceae).
|
-
- HY-147255
-
|
Canocapavir
ZM-H1505R
|
HBV
|
Infection
|
|
Canocapavir (ZM-H1505R) has orally antiviral activity. Canocapavir is a HBV capsid inhibitor that can be used in the research of Chronic hepatitis B. .
|
-
- HY-129671
-
|
Polypodine B
5β-Hydroxyecdysterone
|
Others
|
Others
|
|
Polypodine B is a natural ecdysone ester isolated from the bark of Dacrydium intermedium.
|
-
- HY-N2720
-
-
- HY-P1337A
-
-
- HY-B0143A
-
|
Niacin hydrochloride
Nicotinic acid hydrochloride; Vitamin B3 hydrochloride
|
Endogenous Metabolite
Apoptosis
|
Cancer
Metabolic Disease
Cardiovascular Disease
|
|
Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases.
|
-
- HY-114132
-
|
Botulinum toxin type B
|
Histone Acetyltransferase
|
Neurological Disease
|
|
Botulinum toxin type B is an antigen-specific botulinum toxin. Botulinum toxin type B can be used in the study of neck dystonia. Botulinum toxin is an exotoxin produced by the anaerobic bacterium Clostridium botulinum. Botulinum toxin works by inhibiting the release of Acetylcholine from the neuromuscular junction, resulting in relaxation paralysis or muscle weakening of the injected muscle.
|
-
- HY-70020
-
|
Cevimeline
AF102B
|
mAChR
|
Neurological Disease
|
|
Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline can cross the blood-brain barrier (BBB).
|
-
- HY-N10274
-
-
- HY-144644
-
-
- HY-N1141
-
-
- HY-B1174
-
|
Bekanamycin
Kanamycin B
|
Antibiotic
Bacterial
|
Infection
|
|
Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain.
|
-
- HY-121872
-
|
DP-b99
|
Others
|
Neurological Disease
|
|
DP-b99 is a chelator of zinc and calcium ions that acts selectively within cell membranes and has neuroprotective properties in animal models of stroke.
|
-
- HY-A0008
-
-
- HY-N1597
-
-
- HY-N0864
-
|
Macranthoidin B
Macranthoiside I
|
Others
|
Cancer
|
|
Macranthoidin B is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae.
|
-
- HY-144432S
-
-
- HY-N1598
-
-
- HY-N10362
-
-
- HY-N7646
-
|
Curculigoside B
|
Others
|
Others
|
|
Curculigoside B, a phenolic glycoside isolated from Curculigo orchioides, enhances the osteoblast proliferation, decreases the area of bone resorption pit, osteoclastic formation and TRAP activity. Antiosteoporotic and antioxidative activities.
|
-
- HY-P3862
-
-
- HY-150600
-
|
NS2B/NS3-IN-7
|
Virus Protease
|
Infection
|
|
NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells.
|
-
- HY-Y0073
-
|
4-Hydroxyacetophenone
P-hydroxyacetophenone
|
HBV
|
Infection
Inflammation/Immunology
|
|
4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect.
|
-
- HY-P4045
-
|
HBV Seq2 aa:208-216
|
HBV
|
Infection
|
|
HBV Seq2 aa:208-216, a HBsAg derived CD8 epitope peptide, is studied as part of Large envelope protein from Hepatitis B virus.
|
-
- HY-P99589
-
|
Sotevtamab
16B5; AB-16B5
|
Apoptosis
|
Cancer
|
|
Sotevtamab (16B5) is a humanized IgG2 anti-clusterin monoclonal antibody (mAb). Sotevtamab is an inhibitor of the epithelial to mesenchymal transition. Sotevtamab can be used for cancer research.
|
-
- HY-147853
-
|
B-Raf IN 8
|
Raf
|
Cancer
|
|
B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC50 values of 9.78, 13.78, 18.52 and 29.85 µM.
|
-
- HY-W094748S
-
-
- HY-12459
-
|
Pyrindamycin B
|
Bacterial
|
Infection
|
|
Pyrindamycin B is an antibiotic, actives against gram-positive and gram-negative bacterias, and exhibits strong therapeutic effects against both agent-sensitive and resistant cells of P388 leukemia in mice.
|
-
- HY-N4184
-
|
Licoflavone B
|
Parasite
|
Infection
|
|
Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni ATPase (IC50, 23.78 µM) and ADPase (IC50, 31.50 µM) activity. Anti-schistosomiasis activity.
|
-
- HY-113483
-
|
20-Carboxy-Leukotriene B4
20-COOH LTB4
|
Drug Metabolite
|
Metabolic Disease
|
|
20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis).
|
-
- HY-P3383
-
|
Peceleganan
PL-5
|
Bacterial
|
Infection
|
|
Peceleganan (PL-5) is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan inhibits wound infection.
|
-
- HY-P3383A
-
|
Peceleganan acetate
PL-5 acetate
|
Bacterial
|
Infection
|
|
Peceleganan (PL-5) acetate is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan acetate inhibits wound infection.
|
-
- HY-144612
-
|
NS2B/NS3-IN-2
|
Virus Protease
|
Infection
|
|
NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 µM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate.
|
-
- HY-113442A
-
-
- HY-10264B
-
|
Edoxaban tosylate monohydrate
DU-176b monohydrate
|
Factor Xa
Thrombin
|
Cardiovascular Disease
Cancer
|
|
Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research.
|
-
- HY-10264A
-
|
Edoxaban tosylate
DU-176b
|
Factor Xa
Thrombin
|
Cardiovascular Disease
Cancer
|
|
Edoxaban (DU-176b) tosylate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban tosylate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban tosylate can be used for preventing thromboembolic disease research.
|
-
- HY-R04353
-
|
rno-miR-328b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-328b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00400
-
|
hsa-miR-199b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-199b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03458
-
|
mmu-miR-669b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-669b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02650
-
|
mmu-miR-126b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-126b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00293
-
|
hsa-miR-147b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-147b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01987
-
|
hsa-miR-664b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-664b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00536
-
|
hsa-miR-30b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-30b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02851
-
|
mmu-miR-23b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-23b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01111
-
|
hsa-miR-449b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-449b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00423
-
|
hsa-miR-208b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-208b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01214
-
|
hsa-miR-4659b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4659b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00424
-
|
hsa-miR-208b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-208b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00482
-
|
hsa-miR-23b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-23b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02707
-
|
mmu-miR-1843b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-1843b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03297
-
|
mmu-miR-551b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-551b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02697
-
|
mmu-miR-181b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-181b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01673
-
|
hsa-miR-548b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-548b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03676
-
|
mmu-miR-6973b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-6973b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03169
-
|
mmu-miR-466b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-466b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00679
-
|
hsa-miR-323b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-323b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04343
-
|
rno-miR-3084b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-3084b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04330
-
|
rno-miR-299b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-299b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04031
-
|
mmu-miR-743b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-743b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03217
-
|
mmu-miR-487b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-487b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00807
-
|
hsa-miR-3689b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-3689b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01550
-
|
hsa-miR-514b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-514b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00678
-
|
hsa-miR-323b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-323b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03677
-
|
mmu-miR-6973b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-6973b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01150
-
|
hsa-miR-4524b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4524b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01505
-
|
hsa-miR-500b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-500b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04365
-
|
rno-miR-344b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-344b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01551
-
|
hsa-miR-514b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-514b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02577
-
|
mmu-miR-1191b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-1191b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04297
-
|
rno-miR-208b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-208b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03042
-
|
mmu-miR-344b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-344b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02869
-
|
mmu-miR-291b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-291b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01616
-
|
hsa-miR-526b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-526b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02578
-
|
mmu-miR-1191b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-1191b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04271
-
|
rno-miR-193b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-193b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04306
-
|
rno-miR-216b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-216b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02724
-
|
mmu-miR-18b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-18b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02515
-
|
hsa-miR-92b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-92b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00427
-
|
hsa-miR-20b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-20b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00355
-
|
hsa-miR-18b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-18b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04317
-
|
rno-miR-27b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-27b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02896
-
|
mmu-miR-302b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-302b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01556
-
|
hsa-miR-516b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-516b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02893
-
|
mmu-miR-301b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-301b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02873
-
|
mmu-miR-292b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-292b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01128
-
|
hsa-miR-450b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-450b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02887
-
|
mmu-miR-299b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-299b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04227
-
|
rno-miR-133b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-133b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00296
-
|
hsa-miR-148b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-148b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04296
-
|
rno-miR-208b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-208b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04203
-
|
mmu-miR-9b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-9b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00142
-
|
hsa-miR-1245b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-1245b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03041
-
|
mmu-miR-344b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-344b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03153
-
|
mmu-miR-450b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-450b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01919
-
|
hsa-miR-642b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-642b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01151
-
|
hsa-miR-4524b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4524b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00705
-
|
hsa-miR-33b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-33b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01672
-
|
hsa-miR-548b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-548b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00413
-
|
hsa-miR-203b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-203b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01713
-
|
hsa-miR-551b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-551b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02651
-
|
mmu-miR-126b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-126b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02957
-
|
mmu-miR-3083b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-3083b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02638
-
|
mmu-miR-122b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-122b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00261
-
|
hsa-miR-135b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-135b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01710
-
|
hsa-miR-550b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-550b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00060
-
|
hsa-miR-10b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-10b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00715
-
|
hsa-miR-34b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-34b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02564
-
|
mmu-miR-101b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-101b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03497
-
|
mmu-miR-6769b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-6769b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02794
-
|
mmu-miR-1970b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-1970b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03152
-
|
mmu-miR-450b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-450b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04483
-
|
rno-miR-466b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-466b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03459
-
|
mmu-miR-669b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-669b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00056
-
|
hsa-miR-106b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-106b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00391
-
|
hsa-miR-196b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-196b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02852
-
|
mmu-miR-23b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-23b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00031
-
|
hsa-miR-10396b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-10396b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04265
-
|
rno-miR-190b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-190b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01617
-
|
hsa-miR-526b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-526b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00382
-
|
hsa-miR-193b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-193b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02888
-
|
mmu-miR-299b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-299b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01951
-
|
hsa-miR-6511b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-6511b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04270
-
|
rno-miR-193b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-193b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04237
-
|
rno-miR-146b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-146b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01213
-
|
hsa-miR-4659b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4659b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02882
-
|
mmu-miR-297b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-297b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02685
-
|
mmu-miR-148b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-148b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01461
-
|
hsa-miR-487b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-487b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02662
-
|
mmu-miR-130b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-130b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01035
-
|
hsa-miR-4433b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4433b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00167
-
|
hsa-miR-125b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-125b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01995
-
|
hsa-miR-6715b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-6715b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00363
-
|
hsa-miR-190b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-190b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00221
-
|
hsa-miR-1295b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-1295b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02101
-
|
hsa-miR-6769b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-6769b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02644
-
|
mmu-miR-124b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-124b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02816
-
|
mmu-miR-203b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-203b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02865
-
|
mmu-miR-290b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-290b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02987
-
|
mmu-miR-30b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-30b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03196
-
|
mmu-miR-467b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-467b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00823
-
|
hsa-miR-371b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-371b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00159
-
|
hsa-miR-1255b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-1255b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00141
-
|
hsa-miR-1245b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-1245b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01988
-
|
hsa-miR-664b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-664b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00830
-
|
hsa-miR-374b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-374b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03814
-
|
mmu-miR-7036b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-7036b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02571
-
|
mmu-miR-10b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-10b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00463
-
|
hsa-miR-219b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-219b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00406
-
|
hsa-miR-200b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-200b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02935
-
|
mmu-miR-3073b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-3073b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02832
-
|
mmu-miR-216b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-216b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02124
-
|
hsa-miR-6780b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-6780b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00297
-
|
hsa-miR-148b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-148b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00414
-
|
hsa-miR-203b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-203b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00496
-
|
hsa-miR-26b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-26b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00055
-
|
hsa-miR-106b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-106b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02872
-
|
mmu-miR-292b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-292b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03103
-
|
mmu-miR-374b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-374b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02864
-
|
mmu-miR-290b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-290b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04482
-
|
rno-miR-466b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-466b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04241
-
|
rno-miR-148b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-148b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04472
-
|
rno-miR-450b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-450b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02658
-
|
mmu-miR-129b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-129b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04299
-
|
rno-miR-20b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-20b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00004
-
|
hsa-let-7b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-let-7b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00288
-
|
hsa-miR-146b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-146b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02754
-
|
mmu-miR-193b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-193b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00537
-
|
hsa-miR-30b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-30b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01597
-
|
hsa-miR-520b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-520b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00831
-
|
hsa-miR-374b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-374b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01110
-
|
hsa-miR-449b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-449b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04195
-
|
mmu-miR-92b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-92b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04519
-
|
rno-miR-551b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-551b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00125
-
|
hsa-miR-122b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-122b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00289
-
|
hsa-miR-146b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-146b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00838
-
|
hsa-miR-376b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-376b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00005
-
|
hsa-let-7b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-let-7b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04490
-
|
rno-miR-487b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-487b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00596
-
|
hsa-miR-3150b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-3150b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02555
-
|
hsa-miR-99b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-99b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00381
-
|
hsa-miR-193b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-193b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04276
-
|
rno-miR-196b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-196b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00390
-
|
hsa-miR-196b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-196b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00362
-
|
hsa-miR-190b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-190b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03496
-
|
mmu-miR-6769b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-6769b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03197
-
|
mmu-miR-467b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-467b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01034
-
|
hsa-miR-4433b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4433b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04191
-
|
mmu-miR-883b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-883b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01484
-
|
hsa-miR-499b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-499b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02803
-
|
mmu-miR-199b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-199b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01589
-
|
hsa-miR-519b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-519b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01712
-
|
hsa-miR-551b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-551b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01504
-
|
hsa-miR-500b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-500b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00452
-
|
hsa-miR-216b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-216b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03216
-
|
mmu-miR-486b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-486b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00030
-
|
hsa-miR-10396b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-10396b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01544
-
|
hsa-miR-513b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-513b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00126
-
|
hsa-miR-122b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-122b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00320
-
|
hsa-miR-15b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-15b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02682
-
|
mmu-miR-146b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-146b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00243
-
|
hsa-miR-130b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-130b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03170
-
|
mmu-miR-466b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-466b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00244
-
|
hsa-miR-130b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-130b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04283
-
|
rno-miR-200b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-200b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04207
-
|
rno-miR-101b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-101b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02666
-
|
mmu-miR-133b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-133b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02706
-
|
mmu-miR-1843b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-1843b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01460
-
|
hsa-miR-487b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-487b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00462
-
|
hsa-miR-219b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-219b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02733
-
|
mmu-miR-190b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-190b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00453
-
|
hsa-miR-216b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-216b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04571
-
|
rno-miR-743b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-743b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00260
-
|
hsa-miR-135b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-135b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00321
-
|
hsa-miR-15b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-15b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00354
-
|
hsa-miR-18b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-18b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01545
-
|
hsa-miR-513b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-513b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04211
-
|
rno-miR-10b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-10b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03163
-
|
mmu-miR-465b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-465b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04331
-
|
rno-miR-299b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-299b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04595
-
|
rno-miR-92b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-92b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04257
-
|
rno-miR-1843b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-1843b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00497
-
|
hsa-miR-26b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-26b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00597
-
|
hsa-miR-3150b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-3150b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00839
-
|
hsa-miR-376b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-376b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04238
-
|
rno-miR-146b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-146b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02809
-
|
mmu-miR-1b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-1b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02723
-
|
mmu-miR-18b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-18b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01952
-
|
hsa-miR-6511b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-6511b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00061
-
|
hsa-miR-10b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-10b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04212
-
|
rno-miR-10b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-10b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04264
-
|
rno-miR-190b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-190b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01483
-
|
hsa-miR-499b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-499b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00716
-
|
hsa-miR-34b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-34b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04256
-
|
rno-miR-1843b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-1843b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03250
-
|
mmu-miR-5104b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-5104b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04190
-
|
mmu-miR-883b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-883b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03813
-
|
mmu-miR-7036b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-7036b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00748
-
|
hsa-miR-3622b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-3622b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02565
-
|
mmu-miR-101b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-101b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00332
-
|
hsa-miR-181b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-181b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04344
-
|
rno-miR-3084b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-3084b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02514
-
|
hsa-miR-92b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-92b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00766
-
|
hsa-miR-365b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-365b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02125
-
|
hsa-miR-6780b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-6780b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02857
-
|
mmu-miR-26b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-26b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00222
-
|
hsa-miR-1295b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-1295b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02100
-
|
hsa-miR-6769b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-6769b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02808
-
|
mmu-miR-1b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-1b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01127
-
|
hsa-miR-450b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-450b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02659
-
|
mmu-miR-129b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-129b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04471
-
|
rno-miR-450b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-450b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01040
-
|
hsa-miR-4436b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4436b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03109
-
|
mmu-miR-376b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-376b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00822
-
|
hsa-miR-371b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-371b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02934
-
|
mmu-miR-3073b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-3073b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00520
-
|
hsa-miR-302b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-302b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04572
-
|
rno-miR-743b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-743b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00331
-
|
hsa-miR-181b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-181b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04601
-
|
rno-miR-9b-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-9b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00704
-
|
hsa-miR-33b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-33b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04204
-
|
mmu-miR-9b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-9b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00404
-
|
hsa-miR-19b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-19b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01039
-
|
hsa-miR-4436b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-4436b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02821
-
|
mmu-miR-20b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-20b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02815
-
|
mmu-miR-203b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-203b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00500
-
|
hsa-miR-27b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-27b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02956
-
|
mmu-miR-3083b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-3083b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00747
-
|
hsa-miR-3622b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-3622b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02894
-
|
mmu-miR-301b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-301b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00428
-
|
hsa-miR-20b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-20b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04032
-
|
mmu-miR-743b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-743b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03110
-
|
mmu-miR-376b-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-376b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01996
-
|
hsa-miR-6715b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-6715b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01918
-
|
hsa-miR-642b-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-642b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04600
-
|
rno-miR-9b-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-9b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04134
-
|
mmu-miR-7b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-7b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02868
-
|
mmu-miR-291b-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-291b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02556
-
|
hsa-miR-99b-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-99b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-N0891
-
|
Tubeimoside II
Tubeimoside-B
|
Others
|
Cancer
|
|
Tubeimoside II(Tubeimoside-B) is a natural analogue of oleanane type of triterpenoid saponin; show anti-inflammatory, antitumor, and antitumor-promoting effects.
|
-
- HY-144736
-
|
NS2B/NS3-IN-4
|
Virus Protease
|
Infection
|
|
NS2B/NS3-IN-4 (Compound 34e) is an allosteric DENV2 and ZIKV NS2B/NS3 protease inhibitor with IC50 values of 0.69 µM and 1.04 µM against DENV2 and ZIKV NS2B/NS3 proteases, respectively.
|
-
- HY-143846S
-
-
- HY-N0248
-
|
Saikosaponin B2
|
HCV
|
Cancer
Infection
|
|
Saikosaponin B2 is an active component from Bupleurum chinensis root, acts as an entry inhibitor against HCV infection. Anti-cancer activity.
|
-
- HY-I0719
-
|
Sofosbuvir impurity B
|
Drug Metabolite
|
Others
|
|
Sofosbuvir impurity B is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
|
-
- HY-P2895
-
|
Clostripain
Clostridiopeptidase B
|
Endogenous Metabolite
|
Others
|
|
Clostripain (Clostridiopeptidase B) is a proteolytic enzyme isolated from Clostridium histolyticum with esterase, amidase and protease activities and is a highly specific carboxypeptide targeting arginine key protease.
|
-
- HY-N5021
-
|
Anhydrosafflor yellow B
AHSYB
|
Others
|
Neurological Disease
|
|
Anhydrosafflor yellow B (AHSYB) is a quinochalcone C-glycoside isolated from Carthamus tinctorius. Anhydrosafflor yellow B inhibits ADP-induced platelet aggregation, exhibits significant anti-oxidative effects in vitro, and possesses certain activity against H2O2-induced cytotoxicity in cultured PC12 cells and primary neuronal cells.
|
-
- HY-N2113
-
|
Glaucocalyxin B
|
Autophagy
|
Cancer
|
|
Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC50 of approximately 5.86 μM at 24 h.
|
-
- HY-N4171
-
|
Dihydrocucurbitacin B
|
Apoptosis
|
Inflammation/Immunology
|
|
Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity.
|
-
- HY-138945
-
-
- HY-107020
-
|
BMS 310705
21-Aminoepothilone B
|
Apoptosis
|
Cancer
|
|
BMS 310705 (21-Aminoepothilone B) is an analog of Epothilone B (HY-17029), targeting to malignancies such as ovarian, renal, bladder, and lung carcinoma. BMS 310705 induces significant apoptosis via mitochondrial-mediated pathway.
|
-
- HY-147852
-
|
B-Raf IN 7
|
Raf
|
Cancer
|
|
B-Raf IN 7 (compound 6a) is a potent B-Raf inhibitor, with an IC50 of 110.23 nM. B-Raf IN 7 exhibits antitumor activity against colon carcinoma (HCT-116), mammary gland (MCF-7), hepatocellular carcinoma (HEPG-2), human cervical carcinoma (Hela) and human prostate cancer (PC-3) cells, with IC50 values of 7.50, 9.87, 10.57, 11.63 and 12.83 µM.
|
-
- HY-N0795
-
-
- HY-N6738
-
-
- HY-111173
-
|
Diprotin B
|
Dipeptidyl Peptidase
|
Others
|
|
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue.
|
-
- HY-Y0016
-
|
Rhodamine B
Basic Violet 10; Brilliant Pink B; Rhodamine O; Tetraethylrhodamine
|
Fluorescent Dye
|
Others
|
|
Rhodamine B is a staining fluorescent dye, commonly used for dyeing textiles, paper, soap, leather, and agents. Storage: protect from light.
|
-
- HY-112697
-
-
- HY-131152
-
-
- HY-N1650
-
|
Pygenic acid B
2α,3α,24-Trihydroxyurs-12-en-28-oic acid
|
Fungal
|
Infection
|
|
Pygenic acid B is a triterpenoid that can be isolated from the leaves of Glochidion obliquum. Pygenic acid B shows antifungal activity against C. musae. Pygenic acid B shows ONOO- scavenging activity.
|
-
- HY-N0784
-
-
- HY-N6723
-
|
Fumonisin B2
|
Acyltransferase
|
Infection
|
|
Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis.
|
-
- HY-Y0695
-
|
Amido Black 10B
Naphthol Blue Black
|
Fluorescent Dye
|
Others
|
|
Amido Black 10B (Naphthol Blue Black) is a highly toxic azo dye for amino acid staining. Amido Black 10B can create several problems in the human respiratory system and may also cause skin and eye irritations.
|
-
- HY-N11486
-
-
- HY-134790
-
|
GST-HG131
|
HBV
|
Infection
|
|
GST-HG131 is a specific inbihitor of hepatitis B virus (HBV) surface antigen, belongs to dihydrobenzopyridooxazepine (DBP) series. GST-HG131 exhibits excellent and specific HBV antigens inhibition with EC50 of 28.2 nM (HBsAg) and 16.0 nM (HBeAg), respectively, but also it is safety for animal.
|
-
- HY-N11050
-
|
Xerophilusin B
|
Apoptosis
|
Cancer
|
|
Xerophilusin B, an anticancer agent isolated from Isodon xerophilus, exhibits antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines, induces G2/M cell cycle arrest, and mediates apoptosis.
|
-
- HY-N2301
-
-
- HY-N6938
-
-
- HY-101690
-
-
- HY-N1621
-
|
1-Deacetylnimbolinin B
|
Fungal
Parasite
|
Infection
|
|
1-Deacetylnimbolinin B is a nimbolinin-type limonoid isolated from the fruits of Melia toosendan. Limonoids are a class of highly oxygenated nortriterpenoids that exhibit insecticidal, antifungal, nematicidal and cytotoxic properties.
|
-
- HY-N6806
-
-
- HY-135890
-
-
- HY-103164
-
-
- HY-R04220
-
|
rno-miR-125b-2-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-125b-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02696
-
|
mmu-miR-181b-2-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-181b-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04481
-
|
rno-miR-466b-2-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-466b-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00165
-
|
hsa-miR-125b-1-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-125b-1-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04332
-
|
rno-miR-29b-1-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-29b-1-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00403
-
|
hsa-miR-19b-2-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-19b-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04364
-
|
rno-miR-344b-1-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-344b-1-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-P99384
-
|
Vofatamab
B-701; MFGR-1877S; RG-7444
|
FGFR
|
Cancer
|
|
Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC).
|
-
- HY-R00513
-
|
hsa-miR-29b-2-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-29b-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R01709
-
|
hsa-miR-550b-2-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-550b-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04281
-
|
rno-miR-19b-2-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-19b-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02889
-
|
mmu-miR-29b-1-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-29b-1-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00330
-
|
hsa-miR-181b-2-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-181b-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02647
-
|
mmu-miR-125b-2-3p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-125b-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R03936
-
|
mmu-miR-7094b-2-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-7094b-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
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-
- HY-R04252
-
|
rno-miR-181b-2-3p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-181b-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02890
-
|
mmu-miR-29b-2-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-29b-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00166
-
|
hsa-miR-125b-2-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-125b-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R02805
-
|
mmu-miR-19b-2-5p mimic
|
MicroRNA
|
Cancer
|
|
mmu-miR-19b-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R04280
-
|
rno-miR-19b-1-5p mimic
|
MicroRNA
|
Cancer
|
|
rno-miR-19b-1-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00512
-
|
hsa-miR-29b-1-5p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-29b-1-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-R00158
-
|
hsa-miR-1255b-2-3p mimic
|
MicroRNA
|
Cancer
|
|
hsa-miR-1255b-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
|
-
- HY-P3976
-
-
- HY-P1791
-
|
Lactoferrin (17-41)
Lactoferricin B; Lfcin B
|
Bacterial
Fungal
Apoptosis
|
Cancer
Infection
|
|
Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities.
|
-
- HY-16637A
-
|
Folic acid sodium
Vitamin B9 sodium; Vitamin M sodium
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Neurological Disease
|
|
Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.
|
-
- HY-16637
-
|
Folic acid
Vitamin B9; Vitamin M
|
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
Neurological Disease
|
|
Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.
|
-
- HY-115718A
-
|
PZ703b TFA
|
PROTACs
|
Cancer
|
|
PZ703b TFA is a Bcl-xl PROTAC degradation agent that induces apoptosis and inhibits cancer cell proliferation for bladder cancer research.
|
-
- HY-13204S3
-
-
- HY-145713
-
|
HBV-IN-19
|
HBV
|
Infection
|
|
HBV-IN-19 inhibits hepatitis B virus (HBV) infection. Inhibiting HBsAg secretion and/or production is a strategy for the treatment of HBV infection, including chronic HBV infection.
|
-
- HY-N4328
-
-
- HY-P1742
-
-
- HY-145713A
-
|
HBV-IN-19 TFA
|
HBV
|
Infection
|
|
HBV-IN-19 TFA inhibits hepatitis B virus (HBV) infection. Inhibiting HBsAg secretion and/or production is a strategy for the treatment of HBV infection, including chronic HBV infection.
|
-
- HY-146677
-
-
- HY-N3944
-
|
Glaucin B
6β-Acetoxy-5-epilimonin
|
Others
|
Others
|
|
Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca.
|
-
- HY-13989
-
-
- HY-N3385
-
|
Licorisoflavan A
7-O-Methyllicorisoflavan B
|
Others
|
Others
|
|
Licorisoflavan A (7-O-Methyllicorisoflavan B) is a isoflavan-quinone, that can be isolated from Glycyrrhiza uralensis.
|
-
- HY-120419
-
|
PF9601N
|
Monoamine Oxidase
|
Neurological Disease
|
|
PF9601N, an monoamine oxidase B (MAO-B) inhibitor, possesses neuroprotective properties in several in vitro and in vivo models of Parkinson's disease (PD). PF9601N can be used for the research of neurodegenerative diseases mediated by excitotoxicity.
|
-
- HY-N1261
-
|
Scutebarbatine B
|
Others
|
Cancer
|
|
Scutebarbatine B shows significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC50 values in the range 3.5-8.1 mM[1]<
|
-
- HY-N10294
-
|
Epicoccone B
|
HIV
|
Infection
Inflammation/Immunology
|
|
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC50 value of 10.8 μM, and has potent α-glucosidase inhibition with IC50 value of 27.3 μM. Anti-HIV activity.
|
-
- HY-N2236
-
|
Dipsanoside B
|
Others
|
Infection
|
|
Dipsanoside B is a novel tetrairidoid glucoside from Dipsacus asper. Dipsacus asper Wall., a perennial plant widespread in China, has been used in traditional Chinese medicine for hundreds of years as a tonic for refreshment, as a fissiparism promoter of the osseous cells, and as an embryo security agent, etc.
|
-
- HY-113315
-
-
- HY-12546
-
|
Brevetoxin B
Brevetoxin-2; PbTx-2
|
Sodium Channel
|
Neurological Disease
|
|
Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.
|
-
- HY-P1791B
-
|
Lactoferrin (17-41) (acetate)
Lactoferricin B acetate; Lfcin B acetate
|
Bacterial
Fungal
Apoptosis
|
Cancer
Infection
|
|
Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities.
|
-
